Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway

Journal of Veterinary Science

Volumn 14, Issue 3, 2013, Pages 281-289

  Deng, Sijun ^a   Yuan, Hui ^a   Yi, Jine ^a   Lu, Yin ^a   Wei, Qiang ^a   Guo, Chengzhi ^b   Wu, Jing ^a   Yuan, Liyun ^a   He, Zuping ^b,c  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Gossypol acetic acid; Mitochondrial signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GOSSYPOL; GOSSYPOL ACETIC ACID; REACTIVE OXYGEN METABOLITE;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CELL LINE; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL SIGNALING PATHWAY; MOUSE; SIGNAL TRANSDUCTION;

APOPTOSIS; GOSSYPOL ACETIC ACID; MITOCHONDRIAL SIGNALING PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GOSSYPOL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84885349259     PISSN: 1229845X     EISSN: 1976555X     Source Type: Journal    
DOI: 10.4142/jvs.2013.14.3.281     Document Type: Article

References (37)

1. Borutaite V. Mitochondria as decision-makers in cell death. Environ Mol Mutagen 2010, 51, 406-416.
2. Cheng W, Li Y, Yang D, Zhao Y. Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2009, 31, 527-532.
3. Chowdhury I, Tharakan B, Bhat GK. Current concepts in apoptosis: the physiological suicide program revisited. Cell Mol Biol Lett 2006, 11, 506-525.
4. Coutinho EM. Gossypol: a contraceptive for men. Contraception 2002, 65, 259-263.
5. Dao VT, Gaspard C, Mayer M, Werner GH, Nguyen SN, Michelot RJ. Synthesis and cytotoxicity of gossypol related compounds. Eur J Med Chem 2000, 35, 805-813.
6. Denault JB, Salvesen GS. Apoptotic caspase activation and activity. Methods Mol Biol 2008, 414, 191-220.
7. Deng S, Pawlak A, Pozniak B, Suszko A, Szczypka M, Yuan H, Obminska-Mrukowicz B. Effects of gossypol acetic acid on cellular and humoral immune response in non-immunized and SRBC-immunized mice. Centr Eur J Immunol 2012, 37, 11-19.
8. Dodou K, Anderson RJ, Small DA, Groundwater PW. Investigations on gossypol: past and present developments. Expert Opin Investig Drugs 2005, 14, 1419-1434.
9. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 1999, 68, 383-424.
10. Hass R, Pfannkuche HJ, Kharhanda S, Gunji H, Meyer G, Hartmann A, Hidaka H, Resch K, Kufe D, Goppelt-Strübe M. Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells. Cell Growth Differ 1991, 2, 541-548.
11. He X, Zeng Y, Xu L, Sun H, Li Z, Di J. Influences of protein kinase C inhibitors on the expression of IL-2 and IFN-γ by human T-lymphocytes. Chin J Pathophysiol 2002, 18, 522-525.
12. Hu CY, Jiang CH. The biological activities and mechanisms of gossypol. Foreign Medical Sciences (Family Planning/Reproductive Health Fascicle) 1997, 16, 68-72.
13. Huang MM, Shao XX, Xiong ZH, Mao YE, Ouyang YG. The experimental research of taurine sodium gossypol immunosuppression. Acta Med Univ Sci Technol Huazhong 1981, 10, 77.
14. Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 1997, 88, 347-354.
15. Kindt TJ, Osborne BA, Goldsby RA. Kuby Immunology. 6th ed. pp.37-44, W.H. Freeman, New York, 2006.
16. Ko CH, Shen SC, Yang LY. Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J Cancer 2007, 121, 1670-1679.
17. Liang L, Wang SM, Hu XG, Cao MM, Zhang JR. Effects of gossypol acetic acid on CNE2 cells apoptosis. J Pract Med 2008, 24, 1009-1101.
18. Lin HW, Chang TJ, Yang DJ, Chen YC, Wang M, Chang YY. Regulation of virus-induced inflammatory response by ß-carotene in RAW264.7 cells. Food Chem 2012, 134, 2169-2175.
19. Long A, Wu J, Yuan L, Yuan H. Effect of gossypol on proliferation and apoptosis of primary luteal cells in sow. Chin J Vet Sci 2009, 29, 1303-1306.
20. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med 1994, 120, 227-237.
21. Oliver CL, Miranda MB, Shangary S, Land S, Wang S, Johnson DE. (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance. Mol Cancer Ther 2005, 4, 23-31.
22. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007, 47, 143-183.
23. Prasad MRN, Diczfalusy E. Gossypol. Int J Androl 1982, 5 (Suppl 5), 53-70.
24. Robinson JM, Tanphaichitr N, Bellvé AR. Gossypolinduced damage to mitochondria of transformed Sertoli cells. Am J Pathol 1986, 125, 484-492.
25. Qian SZ, Wang ZG. Gossypol: a potential antifertility agent for males. Annu Rev Pharmacol Toxicol 1984, 24, 329-360.
26. Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5, 415-418.
27. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999, 144, 281-292.
28. Tiwari BS, Belenghi B, Levine A. Oxidative stress increased respiration and generation of reactive oxygen species, resulting in ATP depletion, opening of mitochondrial permeability transition, and programmed cell death. Plant Physiol 2002, 128, 1271-1281.
29. Wang X, Howell CP, Chen F, Yin J, Jiang Y. Gossypol-A Polyphenolic Compound from Cotton Plant. Adv Food Nutr Res 2009, 58, 215-263.
30. Wu J, Jing L, Yuan H, Peng S. T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway. Toxicol Lett 2011, 202, 168-177.
31. Ye YX, Bombick D, Hirst K, Zhang GX, Chang CC, Trosko JE, Akera T. The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. Fundam Appl Toxicol 1990, 14, 817-832.
32. Yurtcu E, Ergun MA, Menevse A. Apoptotic effect of gossypol on human lymphocytes. Cell Bio Int 2003, 27, 791-794.
33. Zhang M, Liu H, Tian Z, Griffith BN, Ji M, Li QQ. Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspaseindependent cell death pathways. Life Sci 2007, 80, 767-774.
34. Zhan WH, Yan G, Shao SP. Observation of apoptotic effect on human prostate cancer cell PC-3 and DU-145 induced by (-)-gossypol. Shandong Medicine 2008, 48, 86-87.
35. Zheng YH, Wu ZH, Fang L. Effect of gossypol acetic acid on hCG-stimulated progesterone prodouction of dissociated rat luteal cells. Yao Xue Xue Bao 1991, 26, 805-808.
36. Zhu L, Yuan H, Guo C, Lu Y, Deng S, Yang Y, Wei Q, Wen L, He Z. Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway. J Cell Physiol 2012, 227, 1814-1820.
37. Zirk NM, Hashmi SF, Ziegler HK. The polysaccharide portion of lipopolysaccharide regulates antigen-specific T-cell activation via effects on macrophage-mediated antigen processing. Infect Immun 1999, 67, 319-326.