Pathophysiologic Response to Burns in the Elderly

EBioMedicine

Volumn 2, Issue 10, 2015, Pages 1536-1548

  Jeschke, Marc G ^a,b,c   Patsouris, David ^a,b,c   Stanojcic, Mile ^a,b,c   Abdullahi, Abdikarim ^a,b,c   Rehou, Sarah ^a,b,c   Pinto, Ruxandra ^a,b,c   Chen, Peter ^a,b,c   Burnett, Marjorie ^a,b,c   Amini Nik, Saeid ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c Canada   (Canada)

Author keywords

Burn; Elderly; Hypermetabolism; Inflammasome; Inflammation; Morbidity; Mortality; Pathophysiologic response; Skin healing; Stem cell

Indexed keywords

INFLAMMASOME; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; GLUCOSE BLOOD LEVEL;

ADULT; AGED; ARTICLE; BURN; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INCIDENCE; LENGTH OF STAY; LIPID COMPOSITION; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; MORBIDITY; MORTALITY; ORAL GLUCOSE TOLERANCE TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTING ENERGY EXPENDITURE; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; WOUND HEALING; BURNS; COHORT ANALYSIS; COMORBIDITY; DERMIS; ENERGY METABOLISM; EPIDERMIS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; PATHOLOGY; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOMARKERS; BLOOD GLUCOSE; BURNS; COHORT STUDIES; COMORBIDITY; CYTOKINES; DERMIS; ENERGY METABOLISM; EPIDERMIS; FEMALE; HUMANS; INFLAMMASOMES; INFLAMMATION MEDIATORS; LIPID METABOLISM; MALE; MIDDLE AGED; MORTALITY; SEVERITY OF ILLNESS INDEX; WOUND HEALING;

EID: 84949725348     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.07.040     Document Type: Article

References (54)

1. (WHO) OWH A Graphical Overview of the Global Burden of Injuries. The Injury Chart Book 2002, (Geneva).
2. Abdullahi A., Amini-Nik S., Jeschke M.G. Animal models in burn research. Cell. Mol. Life Sci. 2014, 71:3241-3255.
3. Albornoz C.R., Villegas J., Sylvester M., Pena V., Bravo I. Burns are more aggressive in the elderly: proportion of deep burn area/total burn area might have a role in mortality. Burns 2011, 37:1058-1061.
4. Amini Nik S., Ebrahim R.P., Van Dam K., Cassiman J.J., Tejpar S. TGF-beta modulates beta-catenin stability and signaling in mesenchymal proliferations. Exp. Cell Res. 2007, 313:2887-2895.
5. Amini-Nik S., Glancy D., Boimer C., Whetstone H., Keller C., Alman B.A. Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a beta-catenin mediated process. Stem Cells (Dayton, Ohio) 2011, 29:1371-1379.
6. Amini-Nik S., Cambridge E., Yu W., et al. Beta-catenin-regulated myeloid cell adhesion and migration determine wound healing. J. Clin. Invest. 2014, 124:2599-2610.
7. Bielefeld K.A., Amini-Nik S., Whetstone H., et al. Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J. Biol. Chem. 2011, 286:27687-27697.
8. Bielefeld K.A., Amini-Nik S., Alman B.A. Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell. Mol. Life Sci. 2013, 70:2059-2081.
9. Bringham P.A., McLoughlin E. Burn incidence and medical care use in the United States: estimates, trends and data sources. J. Burn Care Rehabil. 1996, 17:95-107.
10. Cazalis M.A., Friggeri A., Cave L., et al. Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit. Care (Lond. Engl.) 2013, 17:R287.
11. Demaret J., Walencik A., Jacob M.C., et al. Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples. Cytometry B Clin. Cytom. 2013, 84:59-62.
12. Diao L., Marshall A.H., Dai X., et al. Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1alpha in liver. Shock (Augusta, Ga) 2014, 41:138-144.
13. Fu S., Yang L., Li P., et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 2011, 473:528-531.
14. Gauglitz G.G., Finnerty C.C., Herndon D.N., Mlcak R.P., Jeschke M.G. Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?. Crit. Care 2008, 12:R81.
15. Gauglitz G.G., Song J., Herndon D.N., et al. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Shock 2008, 30:503-507.
16. Gauglitz G.G., Herndon D.N., Kulp G.A., Meyer W.J., Jeschke M.G. Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J. Clin. Endocrinol. Metab. 2009, 94:1656-1664.
17. Gauglitz G.G., Toliver-Kinsky T.E., Williams F.N., et al. Insulin increases resistance to burn wound infection-associated sepsis. Crit. Care Med. 2010, 38:202-208.
18. Gauglitz G.G., Halder S., Boehning D.F., et al. Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress. Shock 2010, 33:299-305.
19. Geiger H., Denkinger M., Schirmbeck R. Hematopoietic stem cell aging. Curr. Opin. Immunol. 2014, 29:86-92.
20. Gerstein A.D., Phillips T.J., Rogers G.S., Gilchrest B.A. Wound healing and aging. Dermatol. Clin. 1993, 11:749-757.
21. Greenhalgh D.G., Saffle J.R., Holmes JHt, et al. American Burn Association consensus conference to define sepsis and infection in burns. J. Burn Care Res. 2007, 28:776-790.
22. Grimble R.F. Inflammatory response in the elderly. Curr. Opin. Clin. Nutr. Metab. Care 2003, 6:21-29.
23. Hardman M.J., Ashcroft G.S. Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol. 2008, 9:R80.
24. Herndon D.N., Nguyen T.T., Wolfe R.R., et al. Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines. Arch. Surg. 1994, 129:1301-1304. (discussion 4-5).
25. Jeschke M.G., Mlcak R.P., Finnerty C.C., et al. Burn size determines the inflammatory and hypermetabolic response. Crit. Care 2007, 11:R90.
26. Jeschke M.G., Chinkes D.L., Finnerty C.C., et al. Pathophysiologic response to severe burn injury. Ann. Surg. 2008, 248:387-401.
27. Jeschke M.G., Mlcak R.P., Finnerty C.C., et al. Gender differences in pediatric burn patients: does it make a difference?. Ann. Surg. 2008, 248:126-136.
28. Jeschke M.G., Kulp G.A., Kraft R., et al. Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am. J. Respir. Crit. Care Med. 2010, 182:351-359.
29. Jeschke M.G., Gauglitz G.G., Kulp G.A., et al. Long-term persistence of the pathophysiologic response to severe burn injury. PLoS One 2011, 6:e21245.
30. Jeschke M.G., Finnerty C.C., Emdad F., et al. Mild obesity is protective after severe burn injury. Ann. Surg. 2013, 258:1119-1129.
31. Kim J.A., Wei Y., Sowers J.R. Role of mitochondrial dysfunction in insulin resistance. Circ. Res. 2008, 102:401-414.
32. Kraft R., Herndon D.N., Al-Mousawi A.M., Williams F.N., Finnerty C.C., Jeschke M.G. Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet 2012, 379:1013-1021.
33. Kraft R., Herndon D.N., Finnerty C.C., Hiyama Y., Jeschke M.G. Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children. J. Clin. Endocrinol. Metab. 2013, 98:314-321.
34. Kraft R., Herndon D.N., Finnerty C.C., Shahrokhi S., Jeschke M.G. Occurrence of multiorgan dysfunction in pediatric burn patients: incidence and clinical outcome. Ann. Surg. 2014, 259:381-387.
35. Kuang W., Xu X., Lin J., et al. Functional and molecular changes of MSCs in aging. Curr. Stem Cell Res. Ther. 2015, (Epub Ahead of print).
36. Lamkanfi M., Mueller J.L., Vitari A.C., et al. Glyburide inhibits the cryopyrin/Nalp3 inflammasome. J. Cell Biol. 2009, 187:61-70.
37. Lundgren R.S., Kramer C.B., Rivara F.P., et al. Influence of comorbidities and age on outcome following burn injury in older adults. J. Burn Care Res. 2009, 30:307-314.
38. Mahdavian Delavary B., van der Veer W.M., van Egmond M., Niessen F.B., Beelen R.H. Macrophages in skin injury and repair. Immunobiology 2011, 216:753-762.
39. Martin J.M., Stapleton R.D. Omega-3 fatty acids in critical illness. Nutr. Rev. 2010, 68:531-541.
40. Pham T.N., Kramer C.B., Wang J., et al. Epidemiology and outcomes of older adults with burn injury: an analysis of the National Burn Repository. J. Burn Care Res. 2009, 30:30-36.
41. Poon R., Nik S.A., Ahn J., Slade L., Alman B.A. Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. BMC Cell Biol. 2009, 10:38.
42. Rani M., Schwacha M.G. Aging and the pathogenic response to burn. Aging Dis. 2012, 3:171-180.
43. Riserus U., Willett W.C., Hu F.B. Dietary fats and prevention of type 2 diabetes. Prog. Lipid Res. 2009, 48:44-51.
44. Schneider L., Cammer M., Lehman J., et al. Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell. Physiol. Biochem. 2010, 25:279-292.
45. Schultz G.S., Davidson J.M., Kirsner R.S., Bornstein P., Herman I.M. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen. 2011, 19:134-148.
46. Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 2006, 116:3015-3025.
47. Shumakov V.I., Onishchenko N.A., Rasulov M.F., Krasheninnikov M.E., Zaidenov V.A. Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull. Exp. Biol. Med. 2003, 136:192-195.
48. Simopoulos A.P. Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 1991, 54:438-463.
49. Singer A.J., Clark R.A. Cutaneous wound healing. N. Engl. J. Med. 1999, 341:738-746.
50. Solinas G., Naugler W., Galimi F., Lee M.S., Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16454-16459.
51. Talukdar S., Olefsky J.M., Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol. Sci. 2011, 32:543-550.
52. Teta M., Long S.Y., Wartschow L.M., Rankin M.M., Kushner J.A. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005, 54:2557-2567.
53. van der Vusse G.J. Albumin as fatty acid transporter. Drug Metab. Pharmacokinet. 2009, 24:300-307.
54. Wolfe R.R., Herndon D.N., Peters E.J., Jahoor F., Desai M.H., Holland O.B. Regulation of lipolysis in severely burned children. Ann. Surg. 1987, 206:214-221.