Insulin increases resistance to burn wound infection-associated sepsis

Critical Care Medicine

Volumn 38, Issue 1, 2010, Pages 202-208

  Gauglitz, Gerd G ^a,c   Toliver Kinsky, Tracy E ^a,b   Williams, Felicia N ^a,b   Song, Juquan ^a,b   Cui, Weihua ^a   Herndon, David N ^a,b   Jeschke, Marc G ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Burn; Inflammation; Insulin; Interleukin 6; Wound infection

Indexed keywords

INSULIN GLARGINE; INTERLEUKIN 6; SODIUM CHLORIDE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BURN INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; IMMUNE RESPONSE; INOCULATION; LOW DRUG DOSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; RAT; SEPSIS; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE; ANIMAL; BACTEREMIA; BURN; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; FLOW CYTOMETRY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MORTALITY; MULTIVARIATE ANALYSIS; NONPARAMETRIC TEST; PHYSIOLOGY; PROBABILITY; RANDOMIZATION; RISK FACTOR; SPRAGUE DAWLEY RAT; SURVIVAL RATE; WOUND HEALING; WOUND INFECTION;

ANIMALS; BACTEREMIA; BURNS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FLOW CYTOMETRY; INFLAMMATION; INSULIN; LYMPHOCYTE ACTIVATION; MULTIVARIATE ANALYSIS; PROBABILITY; PSEUDOMONAS INFECTIONS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RISK FACTORS; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; WOUND HEALING; WOUND INFECTION;

EID: 74049113217     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181b43236     Document Type: Article

References (47)

1. Murray CK: Infections in burns. J Trauma 2007; 62:S73
2. Schwacha MG: Macrophages and post-burn immune dysfunction. Burns 2003; 29:1-14
3. Sparkes BG: Immunological responses to thermal injury. Burns 1997; 23:106-113
4. Appelgren P, Bjornhagen V, Bragderyd K, et al: A prospective study of infections in burn patients. Burns 2002; 28:39-46
5. Shires GT, Dineen P: Sepsis following burns, trauma, and intra-abdominal infections. Arch Intern Med 1982; 142:2012-2022
6. Pruitt BA Jr, McManus AT, Kim SH, et al: Burn wound infections: Current status. World J Surg 1998; 22:135-145
7. Agnihotri N, Gupta V, Joshi RM: Aerobic bacterial isolates from burn wound infections and their antibiograms-a five-year study. Burns 2004; 30:241-243
8. Erol S, Altoparlak U, Akcay MN, et al: Changes of microbial flora and wound colonization in burned patients. Burns 2004; 30: 357-361
9. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
10. Finfer S, Chittock DR, Su SY, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 1283-1297
11. Jeschke MG, Einspanier R, Klein D, et al: Insulin attenuates the systemic inflammatory response to thermal trauma. Mol Med 2002; 8:443-450
12. Wu X, Thomas SJ, Herndon DN, et al: Insulin decreases hepatic acute phase protein levels in severely burned children. Surgery 2004; 135:196-202
13. Herndon DN, Wilmore DW, Mason AD Jr: Development and analysis of a small animal model simulating the human postburn hy-permetabolic response. J Surg Res 1978; 25: 394-403
14. Sherwood ER, Lin CY, Tao W, et al: Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 2003; 167:1641-1649
15. Toliver-Kinsky TE, Lin CY, Herndon DN, et al: Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice. Infect Immun 2003; 71: 3058-3067
16. Cortes-Barberena E, Gonzalez-Marquez H, Gomez-Olivares JL, et al: Effects of moderate and severe malnutrition in rats on splenic T lymphocyte subsets and activation assessed by flow cytometry. Clin Exp Immunol 2008; 152:585-592
17. Gridley DS, Baer JR, Cao JD, et al: TNF-alpha gene and proton radiotherapy in an ortho-topic brain tumor model. Int J Oncol 2002; 21:251-259
18. Neckers LM, Cossman J. Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleu-kin 2. Proc Natl Acad Sci U S A 1983; 80: 3494-3498
19. Pighetti GM, Eskew ML, Reddy CC, et al: Selenium and vitamin E deficiency impair transferrin receptor internalization but not IL-2, IL-2 receptor, or transferrin receptor expression. J Leukoc Biol 1998; 63:131-137
20. Brennan FR, Mikecz K, Glant TT, et al: CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: Implications for lymphocyte adhesion to en-dothelial cells and synoviocytes in vitro. Scand J Immunol 1997; 45:213-220
21. Haynes BF, Hale LP, Patton KL, et al: Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. Arthritis Rheum 1991; 34:1434-1443
22. Rodgers GL, Mortensen J, Fisher MC, et al: Predictors of infectious complications after burn injuries in children. Pediatr Infect Dis J 2000; 19:990-995
23. Dellinger RP, Carlet JM, Masur H, et al: Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873 (Pubitemid 38344143)
24. Estahbanati HK, Kashani PP, Ghanaatpisheh F: Frequency of Pseudomonas aeruginosa sero-types in burn wound infections and their resistance to antibiotics. Burns 2002; 28:340-348
25. Schlager T, Sadler J, Weber D, et al: Hospital-acquired infections in pediatric burn patients. South Med J 1994; 87:481-484
26. Marik PE, Raghavan M. Stress-hyperglyce-mia, insulin and immunomodulation in sepsis. Intensive Care Med 2004; 30:748-756
27. Mikos B, Barkai L. [Hyperglycemia and mortality in critically ill children.] Orv Hetil 2007; 148:683-688
28. Brunkhorst FM, Engel C, Bloos F, et al: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
29. Clement S, Braithwaite SS, Magee MF, et al: Management of diabetes and hyperglycemia in hospitals. Diabetes Care 2004; 27:553-591
30. Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79:992-1000
31. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
32. Vanhorebeek I, Langouche L, Van den Berghe G: Tight blood glucose control with insulin in the ICU: Facts and controversies. Chest 2007; 132:268-278
33. Biffl WL, Moore EE, Moore FA, et al: Inter-leukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 1996; 224:647-664
34. Taniguchi T, Koido Y, Aiboshi J, et al: Change in the ratio of interleukin-6 to inter-leukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome. Crit Care Med 1999; 27: 1262-1264
35. Yamada Y, Endo S, Inada K: Plasma cytokine levels in patients with severe burn injury-with reference to the relationship between infection and prognosis. Burns 1996; 22:587-593
36. Bohannon J, Cui W, Cox R, et al: Prophylactic treatment with fms-like tyrosine kinase-3 ligand after burn injury enhances global immune responses to infection. J Immunol 2008; 180:3038-3048
37. Cole N, Bao S, Stapleton F, et al: Pseudomo-nas aeruginosa keratitis in IL-6-deficient mice. Int Arch Allergy Immunol 2003; 130: 165-172
38. Jeschke MG, Klein D, Bolder U, et al: Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 2004; 145:4084-4093
39. Przkora R, Herndon DN, Finnerty CC, et al: Insulin attenuates the cytokine response in a burn wound infection model. Shock 2007; 27:205-208
40. Dandona P, Aljada A, Mohanty P, et al: Insulin inhibits intranuclear nuclear factor kap-paB and stimulates IkappaB in mononuclear cells in obese subjects: Evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001; 86:3257-3265
41. Nielsen L, Rontved CM, Nielsen MO, et al: Leukocytes from heifers at different ages express insulin and insulin-like growth factor-1 (IGF-1) receptors. Domest Anim Endocrinol 2003; 25:231-238
42. Brocardo MG, Schillaci R, Galeano A, et al: Early effects of insulin-like growth factor-1 in activated human T lymphocytes. J Leukoc Biol 2001; 70:297-305
43. DeBenedette M, Snow EC: Insulin modulates the interleukin 2 responsiveness of T lymphocytes. Reg Immunol 1990; 3: 82-87
44. Spagnoli A, Spadoni GL, Sesti G, et al: Effect of insulin on hydrogen peroxide production by human polymorphonuclear leukocytes. Studies with monoclonal anti-insulin receptor antibodies, and an agonist and an inhibitor of protein kinase C. Horm Res 1995; 43:286-293
45. Toliver-Kinsky TE, Varma TK, Lin CY, et al: Interferon-gamma production is suppressed in thermally injured mice: Decreased production of regulatory cytokines and corresponding receptors. Shock 2002; 18:322-330
46. Schwacha MG, Knoferl MW, Chaudry IH: Does burn wound excision after thermal injury attenuate subsequent macrophage hy-peractivity and immunosuppression? Shock 2000; 14:623-628
47. Grey NJ, Perdrizet GA: Reduction of nosoco-mial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 2004; 10 Suppl 2:46-52