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Volumn 144, Issue , 2016, Pages 185-193

Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway

Author keywords

Betulin; Inflammation; NF B; Sepsis; TLR4

Indexed keywords

BETULIN; CREATININE; CYTOMEGALOVIRUS ANTIGEN PP65; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITROGEN; TOLL LIKE RECEPTOR 4; UREA; TLR4 PROTEIN, RAT; TRANSCRIPTION FACTOR RELA; TRITERPENE;

EID: 84949603948     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.12.003     Document Type: Article
Times cited : (48)

References (45)
  • 1
    • 77955984085 scopus 로고    scopus 로고
    • The role of innate immunity in septic acute kidney injuries
    • Goncalves, Zamboni, and Camara The role of innate immunity in septic acute kidney injuries Shock 34 Suppl. 1 2010 22 26
    • (2010) Shock , vol.34 , pp. 22-26
    • Goncalves1    Zamboni2    Camara3
  • 2
    • 77949351028 scopus 로고    scopus 로고
    • Acute kidney injury associates with increased long-term mortality
    • Lafrance, and Miller Acute kidney injury associates with increased long-term mortality J. Am. Soc. Nephrol. 21 2010 345 352
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 345-352
    • Lafrance1    Miller2
  • 3
    • 58149485462 scopus 로고    scopus 로고
    • Acute kidney injury increases risk of ESRD among elderly
    • Ishani, Xue, Himmelfarb, Eggers, Kimmel, Molitoris, and et al. Acute kidney injury increases risk of ESRD among elderly J. Am. Soc. Nephrol. 20 2009 223 228
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 223-228
    • Ishani1    Xue2    Himmelfarb3    Eggers4    Kimmel5    Molitoris6
  • 4
    • 34548229961 scopus 로고    scopus 로고
    • Septic acute kidney injury in critically ill patients: Clinical characteristics and outcomes
    • Bagshaw, Uchino, Bellomo, Morimatsu, Morgera, Schetz, and et al. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes Clin. J. Am. Soc. Nephrol. 2 2007 431 439
    • (2007) Clin. J. Am. Soc. Nephrol. , vol.2 , pp. 431-439
    • Bagshaw1    Uchino2    Bellomo3    Morimatsu4    Morgera5    Schetz6
  • 5
    • 33747802067 scopus 로고    scopus 로고
    • Pharmacological properties of the ubiquitous natural product betulin
    • Alakurtti, Makela, Koskimies, and Yli-Kauhaluoma Pharmacological properties of the ubiquitous natural product betulin Eur. J. Pharm. Sci. 29 2006 1 13
    • (2006) Eur. J. Pharm. Sci. , vol.29 , pp. 1-13
    • Alakurtti1    Makela2    Koskimies3    Yli-Kauhaluoma4
  • 6
    • 0037049876 scopus 로고    scopus 로고
    • Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
    • Zuco, Supino, Righetti, Cleris, Marchesi, Gambacorti-Passerini, and et al. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells Cancer Lett. 175 2002 17 25
    • (2002) Cancer Lett. , vol.175 , pp. 17-25
    • Zuco1    Supino2    Righetti3    Cleris4    Marchesi5    Gambacorti-Passerini6
  • 7
    • 41649102467 scopus 로고    scopus 로고
    • Pathophysiology of septic acute kidney injury: What do we really know?
    • Wan, Bagshaw, Langenberg, Saotome, May, and Bellomo Pathophysiology of septic acute kidney injury: what do we really know? Crit. Care Med. 36 2008 S198 S203
    • (2008) Crit. Care Med. , vol.36 , pp. S198-S203
    • Wan1    Bagshaw2    Langenberg3    Saotome4    May5    Bellomo6
  • 8
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss, and Karl The pathophysiology and treatment of sepsis N. Engl. J. Med. 348 2003 138 150
    • (2003) N. Engl. J. Med. , vol.348 , pp. 138-150
    • Hotchkiss1    Karl2
  • 9
    • 84973434090 scopus 로고    scopus 로고
    • Dexmedetomidine protects against acute kidney injury through downregulating inflammatory reactions in endotoxemia rats
    • Tan, Chen, Yuan, Gong, Li, and Zhou Dexmedetomidine protects against acute kidney injury through downregulating inflammatory reactions in endotoxemia rats Biomed. Rep. 3 2015 365 370
    • (2015) Biomed. Rep. , vol.3 , pp. 365-370
    • Tan1    Chen2    Yuan3    Gong4    Li5    Zhou6
  • 10
    • 84935854517 scopus 로고    scopus 로고
    • MiR-15a/16 are upreuglated in the serum of neonatal sepsis patients and inhibit the LPS-induced inflammatory pathway
    • Wang, Wang, Liu, Wang, Xu, Hou, and et al. miR-15a/16 are upreuglated in the serum of neonatal sepsis patients and inhibit the LPS-induced inflammatory pathway Int. J. Clin. Exp. Med. 8 2015 5683 5690
    • (2015) Int. J. Clin. Exp. Med. , vol.8 , pp. 5683-5690
    • Wang1    Wang2    Liu3    Wang4    Xu5    Hou6
  • 11
    • 84938630574 scopus 로고    scopus 로고
    • Decoy receptor 3 improves survival in experimental sepsis by suppressing the inflammatory response and lymphocyte apoptosis
    • Liang, Hou, Lou, and Chen Decoy receptor 3 improves survival in experimental sepsis by suppressing the inflammatory response and lymphocyte apoptosis PLoS One 10 2015 e0131680
    • (2015) PLoS One , vol.10
    • Liang1    Hou2    Lou3    Chen4
  • 12
    • 84935505553 scopus 로고    scopus 로고
    • Rhein inhibits lipopolysaccharide-induced intestinal injury during sepsis by blocking the toll-like receptor 4 nuclear factor-kappaB pathway
    • Zhang, Jiao, Li, and Wang Rhein inhibits lipopolysaccharide-induced intestinal injury during sepsis by blocking the toll-like receptor 4 nuclear factor-kappaB pathway Mol. Med. Rep. 2015
    • (2015) Mol. Med. Rep.
    • Zhang1    Jiao2    Li3    Wang4
  • 13
    • 84895864300 scopus 로고    scopus 로고
    • Pleiotropic effects of Blastocystis spp. Subtypes 4 and 7 on ligand-specific toll-like receptor signaling and NF-kappaB activation in a human monocyte cell line
    • Teo, Macary, and Tan Pleiotropic effects of Blastocystis spp. Subtypes 4 and 7 on ligand-specific toll-like receptor signaling and NF-kappaB activation in a human monocyte cell line PLoS One 9 2014 e89036
    • (2014) PLoS One , vol.9
    • Teo1    MacAry2    Tan3
  • 14
    • 84928102563 scopus 로고    scopus 로고
    • Continuous hemodiafiltration therapy reduces damage of multi-organs by ameliorating of HMGB1/TLR4/NFkappaB in a dog sepsis model
    • Sun, Shi, Wang, Yu, Wang Continuous hemodiafiltration therapy reduces damage of multi-organs by ameliorating of HMGB1/TLR4/NFkappaB in a dog sepsis model Int. J. Clin. Exp. Pathol. 8 2015 1555 1564
    • (2015) Int. J. Clin. Exp. Pathol. , vol.8 , pp. 1555-1564
    • Sun1    Shi2    Wang3    Yu4    Wang5
  • 15
    • 84877272838 scopus 로고    scopus 로고
    • Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-kappaB pathway
    • Wu, Liu, Huang, Zhu, Zhang, Lu, and et al. Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-kappaB pathway Mediators. Inflamm. 2013 2013 562154
    • (2013) Mediators. Inflamm. , vol.2013 , pp. 562154
    • Wu1    Liu2    Huang3    Zhu4    Zhang5    Lu6
  • 16
    • 84855379544 scopus 로고    scopus 로고
    • Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction
    • Rodrigues, Sanches, Volpini, Shimizu, Kuriki, Camara, and et al. Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction PLoS One 7 2012 e29893
    • (2012) PLoS One , vol.7
    • Sanches1    Volpini2    Shimizu3    Kuriki4    Camara5
  • 17
    • 84941066671 scopus 로고    scopus 로고
    • Betulin inhibits pro-inflammatory cytokines expression through activation STAT3 signaling pathway in human cardiac cells
    • Zhang, Zhao, Fang, Yu Betulin inhibits pro-inflammatory cytokines expression through activation STAT3 signaling pathway in human cardiac cells Eur. Rev. Med. Pharmacol. Sci. 19 2015 455 460
    • (2015) Eur. Rev. Med. Pharmacol. Sci. , vol.19 , pp. 455-460
    • Zhang1    Zhao2    Fang3    Yu4
  • 18
    • 84908692664 scopus 로고    scopus 로고
    • Betulin protects mice from bacterial pneumonia and acute lung injury
    • Wu, Li, Qiu, Feng Betulin protects mice from bacterial pneumonia and acute lung injury Microb. Pathog. 75 2014 21 28
    • (2014) Microb. Pathog. , vol.75 , pp. 21-28
    • Wu1    Li2    Qiu3    Feng4
  • 19
    • 0142249406 scopus 로고    scopus 로고
    • Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice
    • Miyaji, Hu, Yuen, Muramatsu, Iyer, Hewitt, and et al. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice Kidney Int. 64 2003 1620 1631
    • (2003) Kidney Int. , vol.64 , pp. 1620-1631
    • Miyaji1    Hu2    Yuen3    Muramatsu4    Iyer5    Hewitt6
  • 20
    • 0018964280 scopus 로고
    • Sepsis and septic shock - A review of laboratory models and a proposal
    • Wichterman, Baue, Chaudry Sepsis and septic shock - a review of laboratory models and a proposal J. Surg. Res. 29 1980 189 201
    • (1980) J. Surg. Res. , vol.29 , pp. 189-201
    • Wichterman1    Baue2    Chaudry3
  • 21
    • 79953292076 scopus 로고    scopus 로고
    • Cecal ligation and puncture: The gold standard model for polymicrobial sepsis?
    • Dejager, Pinheiro, Dejonckheere, Libert Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends Microbiol. 19 2011 198 208
    • (2011) Trends Microbiol. , vol.19 , pp. 198-208
    • Dejager1    Pinheiro2    Dejonckheere3
  • 22
    • 84961288986 scopus 로고    scopus 로고
    • Betulinic acid attenuates renal oxidative stress and inflammation in experimental model of murine polymicrobial sepsis
    • Lingaraju, Pathak, Begum, Balaganur, Ramachandra, Bhat, and et al. Betulinic acid attenuates renal oxidative stress and inflammation in experimental model of murine polymicrobial sepsis Eur. J. Pharm. Sci. 70 2015 12 21
    • (2015) Eur. J. Pharm. Sci. , vol.70 , pp. 12-21
    • Lingaraju1    Pathak2    Begum3    Balaganur4    Ramachandra5    Bhat6
  • 23
    • 0029944101 scopus 로고    scopus 로고
    • Christman Sepsis and cytokines: Current status
    • Blackwell, Christman Sepsis and cytokines: current status Br. J. Anaesth. 77 1996 110 117
    • (1996) Br. J. Anaesth. , vol.77 , pp. 110-117
    • Blackwell1
  • 24
    • 0036738495 scopus 로고    scopus 로고
    • Cancer therapy and renal injury
    • Schrier Cancer therapy and renal injury J. Clin. Invest. 110 2002 743 745
    • (2002) J. Clin. Invest. , vol.110 , pp. 743-745
    • Schrier1
  • 25
    • 0036604216 scopus 로고    scopus 로고
    • Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    • Cunningham, Dyanov, Park, Wang, Newell, Quigg Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney J. Immunol. 168 2002 5817 5823
    • (2002) J. Immunol. , vol.168 , pp. 5817-5823
    • Cunningham1    Dyanov2    Park3    Wang4    Newell5
  • 26
    • 0029835023 scopus 로고    scopus 로고
    • Carlet INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group
    • Cohen, Carlet INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group Crit. Care Med. 24 1996 1431 1440
    • (1996) Crit. Care Med. , vol.24 , pp. 1431-1440
    • Cohen1
  • 27
    • 77954382754 scopus 로고    scopus 로고
    • The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture
    • Morishige, Yoshioka, Inakura, Tanabe, Yao, Narimatsu, and et al. The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture Biomaterials 31 2010 6833 6842
    • (2010) Biomaterials , vol.31 , pp. 6833-6842
    • Orishige1    Yoshioka2    Inakura3    Tanabe4    Yao5    Narimatsu6
  • 28
    • 48049096638 scopus 로고    scopus 로고
    • IL-6/IL-6R axis plays a critical role in acute kidney injury
    • Nechemia-Arbely, Barkan, Pizov, Shriki, Rose-John, Galun, and et al. IL-6/IL-6R axis plays a critical role in acute kidney injury J. Am. Soc. Nephrol. 19 2008 1106 1115
    • (2008) J. Am. Soc. Nephrol. , vol.19 , pp. 1106-1115
    • Barkan1    Pizov2    Shriki3    Rose-John4    Galun5
  • 29
    • 34548259894 scopus 로고    scopus 로고
    • Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis
    • Chawla, Seneff, Nelson, Williams, Levy, Kimmel, and et al. Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis Clin. J. Am. Soc. Nephrol. 2 2007 22 30
    • (2007) Clin. J. Am. Soc. Nephrol. , vol.2 , pp. 22-30
    • Seneff1    Nelson2    Williams3    Levy4    Kimmel5
  • 30
    • 0015857760 scopus 로고
    • A new group of chromatin-associated proteins with a high content of acidic and basic amino acids
    • Goodwin, Sanders, Johns A new group of chromatin-associated proteins with a high content of acidic and basic amino acids Eur. J. Biochem. 38 1973 14 19
    • (1973) Eur. J. Biochem. , vol.38 , pp. 14-19
    • Goodwin1    Sanders2    Johns3
  • 31
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang, Bloom, Zhang, Vishnubhakat, Ombrellino, Che, and et al. HMG-1 as a late mediator of endotoxin lethality in mice Science 285 1999 248 251
    • (1999) Science , vol.285 , pp. 248-251
    • Bloom1    Zhang2    Vishnubhakat3    Ombrellino4    Che5
  • 32
    • 48149096398 scopus 로고    scopus 로고
    • HMGB1: Endogenous danger signaling
    • Klune, Dhupar, Cardinal, Billiar, Tsung HMGB1: endogenous danger signaling Mol. Med. 14 2008 476 484
    • (2008) Mol. Med. , vol.14 , pp. 476-484
    • Klune1    Dhupar2    Cardinal3    Billiar4    Tsung5
  • 33
    • 79961120130 scopus 로고    scopus 로고
    • HMGB1 as an autophagy sensor in oxidative stress
    • Kang, Livesey, Zeh, Lotze, Tang HMGB1 as an autophagy sensor in oxidative stress Autophagy 7 2011 904 906
    • (2011) Autophagy , vol.7 , pp. 904-906
    • Kang1    Livesey2    Zeh3    Lotze4    Tang5
  • 34
    • 0141830087 scopus 로고    scopus 로고
    • IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    • Rendon-Mitchell, Ochani, Li, Han, Wang, Yang, and et al. IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism J. Immunol. 170 2003 3890 3897
    • (2003) J. Immunol. , vol.170 , pp. 3890-3897
    • Ochani1    Li2    Han3    Wang4    Yang5
  • 35
    • 33845867117 scopus 로고    scopus 로고
    • HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay
    • Wahamaa, Vallerskog, Qin, Lunderius, LaRosa, Andersson, and et al. HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay J. Leukoc. Biol. 81 2007 129 136
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 129-136
    • Vallerskog1    Qin2    Lunderius3    LaRosa4    Andersson5
  • 36
    • 79952366675 scopus 로고    scopus 로고
    • High-mobility group box 1, oxidative stress, and disease
    • Tang, Kang, Zeh, Lotze High-mobility group box 1, oxidative stress, and disease Antioxid. Redox Signal 14 2011 1315 1335
    • (2011) Antioxid. Redox Signal , vol.14 , pp. 1315-1335
    • Tang1    Kang2    Zeh3    Lotze4
  • 37
    • 33646578794 scopus 로고    scopus 로고
    • Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney
    • El-Achkar, Huang, Plotkin, Sandoval, Rhodes, Dagher Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney Am. J. Physiol. Renal Physiol. 290 2006 F1034 F1043
    • (2006) Am. J. Physiol. Renal Physiol. , vol.290 , pp. F1034-F1043
    • El-Achkar1    Huang2    Plotkin3    Sandoval4    Rhodes5    Dagher6
  • 38
    • 84940399401 scopus 로고    scopus 로고
    • Therapeutic effects of treatment with anti-TLR2 and anti-TLR4 monoclonal antibodies in polymicrobial sepsis
    • Lima, Souza, Amaral, Fagundes, Rodrigues, Alves-Filho, and et al. Therapeutic effects of treatment with anti-TLR2 and anti-TLR4 monoclonal antibodies in polymicrobial sepsis PLoS One 10 2015 e0132336
    • (2015) PLoS One , vol.10
    • Souza1    Amaral2    Fagundes3    Rodrigues4    Alves-Filho5
  • 39
    • 33645116785 scopus 로고    scopus 로고
    • NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    • Liu, Malik NF-kappa B activation as a pathological mechanism of septic shock and inflammation Am. J. Physiol. Lung. Cell. Mol. Physiol. 290 2006 L622 L645
    • (2006) Am. J. Physiol. Lung. Cell. Mol. Physiol. , vol.290 , pp. L622-L645
    • Malik, L.1
  • 40
    • 0030611086 scopus 로고    scopus 로고
    • Role of NFkappaB in the mortality of sepsis
    • Bohrer, Qiu, Zimmermann, Zhang, Jllmer, Mannel, and et al. Role of NFkappaB in the mortality of sepsis J. Clin. Invest. 100 1997 972 985
    • (1997) J. Clin. Invest. , vol.100 , pp. 972-985
    • Qiu1    Zimmermann2    Zhang3    Jllmer4    Mannel5
  • 41
    • 0036275030 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-kappaB activation by IRFI 042, protects against endotoxin-induced shock
    • Altavilla, Squadrito, Minutoli, Deodato, Bova, Sardella, and et al. Inhibition of nuclear factor-kappaB activation by IRFI 042, protects against endotoxin-induced shock Cardiovasc. Res. 54 2002 684 693
    • (2002) Cardiovasc. Res. , vol.54 , pp. 684-693
    • Squadrito1    Minutoli2    Deodato3    Bova4    Sardella5
  • 42
    • 33750860428 scopus 로고    scopus 로고
    • Increased levels of myocardial IkappaB-alpha protein promote tolerance to endotoxin
    • Shames, Meldrum, Selzman, Pulido, Cain, Banerjee, and et al. Increased levels of myocardial IkappaB-alpha protein promote tolerance to endotoxin Am. J. Physiol. 275 1998 H1084 H1091
    • (1998) Am. J. Physiol. , vol.275 , pp. H1084-H1091
    • Meldrum1    Selzman2    Pulido3    Cain4    Banerjee5
  • 43
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park, Svetkauskaite, He, Kim, Strassheim, Ishizaka, and et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein J. Biol. Chem. 279 2004 7370 7377
    • (2004) J. Biol. Chem. , vol.279 , pp. 7370-7377
    • Park1    Svetkauskaite2    He3    Kim4    Strassheim5    Ishizaka6
  • 44
    • 33645461206 scopus 로고    scopus 로고
    • High mobility group box 1 protein interacts with multiple Toll-like receptors
    • Park, Gamboni-Robertson, He, Svetkauskaite, Kim, Strassheim, and et al. High mobility group box 1 protein interacts with multiple Toll-like receptors Am. J. Physiol. Cell. Physiol. 290 2006 C917 C924
    • (2006) Am. J. Physiol. Cell. Physiol. , vol.290 , pp. C917-C924
    • Gamboni-Robertson1    He2    Svetkauskaite3    Kim4    Strassheim5
  • 45
    • 33847193122 scopus 로고    scopus 로고
    • A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    • Orlova, Choi, Xie, Chavakis, Bierhaus, Ihanus, and et al. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin EMBO J. 26 2007 1129 1139
    • (2007) EMBO J. , vol.26 , pp. 1129-1139
    • Choi1    Xie2    Chavakis3    Bierhaus4    Ihanus5


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