Orexin-A and endocannabinoid activation of the descending antinociceptive pathway underlies altered pain perception in leptin signaling deficiency

Neuropsychopharmacology

Volumn 41, Issue 2, 2016, Pages 508-520

  Cristino, Luigia ^a   Luongo, Livio ^b   Imperatore, Roberta ^a   Boccella, Serena ^b   Becker, Thorsten ^a,c   Morello, Giovanna ^a,c   Piscitelli, Fabiana ^a   Busetto, Giuseppe ^c,d   Maione, Sabatino ^b   Di Marzo, Vincenzo ^a  

^a CNR   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d National Institute of Neuroscience   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; LEPTIN; OREXIN 1 RECEPTOR; OREXIN A; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; HCRTR1 PROTEIN, MOUSE; OREXIN; OREXIN RECEPTOR;

ADULT; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL ACTIVITY; CONTROLLED STUDY; EATING DISORDER; HYPOTHALAMUS; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOREACTIVITY; IN VIVO STUDY; LATERAL HYPOTHALAMUS; LEPTIN DEFICIENCY; MALE; MOUSE; NERVE EXCITABILITY; NOCICEPTION; NONHUMAN; NONSENSE MUTATION; PAIN THRESHOLD; PATCH CLAMP TECHNIQUE; PERIAQUEDUCTAL GRAY MATTER; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; ROSTRAL VENTROMEDIAL MEDULLA; SYNAPTIC POTENTIAL; ANIMAL; DISEASE MODEL; MEMBRANE POTENTIAL; METABOLISM; MOUSE MUTANT; NERVE CELL; NERVE TRACT; NOCICEPTIVE PAIN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE;

ANIMALS; ARACHIDONIC ACIDS; DISEASE MODELS, ANIMAL; ENDOCANNABINOIDS; GLYCERIDES; LEPTIN; MALE; MEMBRANE POTENTIALS; MICE, OBESE; NEURAL PATHWAYS; NEURONS; NOCICEPTIVE PAIN; OREXIN RECEPTORS; OREXINS; PAIN PERCEPTION; PERIAQUEDUCTAL GRAY; TISSUE CULTURE TECHNIQUES;

EID: 84949564102     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.173     Document Type: Article

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