Intra-periaqueductal gray matter microinjection of orexin-a decreases formalin-induced nociceptive behaviors in adult male rats

Journal of Pain

Volumn 12, Issue 2, 2011, Pages 280-287

  Azhdari Zarmehri, Hassan ^a,b   Semnanian, Saeed ^a   Fathollahi, Yaghoub ^a   Erami, Elaheh ^b   Khakpay, Roghaieh ^a   Azizi, Hossein ^a   Rohampour, Kambiz ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b QAZVIN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

formalin test; orexin receptor type 1; Orexin A; periaqueductal gray matter; SB 334867

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; FORMALDEHYDE; MORPHINE SULFATE; OREXIN 1 RECEPTOR; OREXIN A;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; MALE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PERIAQUEDUCTAL GRAY MATTER; RAT; TAIL FLICK TEST; TREATMENT RESPONSE;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; NEUROPEPTIDES; PAIN; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79551586474     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.09.006     Document Type: Article

References (28)

1. H. Azhdari-Zarmehri, S. Semnanian, Y. Fathollahi, H. Haghdoost-Yazdi, R. Khakpay, H. Azizi, and K. Rohampour Periaqueductal gray matter is involved in orexin-A induced analgesia in formalin test FENS Abstr 5 2010 140.1
2. F.V. Abbott, K.B. Franklin, and R.F. Westbrook The formalin test: Scoring properties of the first and second phases of the pain response in rats Pain 60 1995 91 102
3. M.M. Behbehani, M.R. Park, and M.E. Clement Interactions between the lateral hypothalamus and the periaqueductal gray J Neurosci 8 1988 2780 2787
4. S. Bingham, P.T. Davey, A.J. Babbs, E.A. Irving, M.J. Sammons, M. Wyles, P. Jeffrey, L. Cutler, I. Riba, A. Johns, R.A. Porter, N. Upton, A.J. Hunter, and A.A. Parsons Orexin-A, an hypothalamic peptide with analgesic properties Pain 92 2001 81 90
5. J.K. Cheng, R.C. Chou, L.L. Hwang, and L.C. Chiou Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain J Pharmacol Exp Ther 307 2003 1065 1071
6. Lecea L. de, T.S. Kilduff, C. Peyron, X. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L. Battenberg, V.T. Gautvik, F.S. Bartlett, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik, and J.G. Sutcliffe The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity Proc Natl Acad Sci U S A 95 1998 322 327
7. D. Dubuisson, and S.G. Dennis The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats Pain 4 1977 161 174
8. A.V. Ferguson, and W.K. Samson The orexin/hypocretin system: A critical regulator of neuroendocrine and autonomic function Front Neuroendocrinol 24 2003 141 150
9. K.B. Franklin, and F.V. Abbott Pentobarbital, diazepam, and ethanol abolish the interphase diminution of pain in the formalin test: Evidence for pain modulation by GABAA receptors Pharmacol Biochem Behav 46 1993 661 666
10. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 4th and 6th eds 2005 Academic Press New York, NY
11. I. Gaumond, P. Arsenault, and S. Marchand The role of sex hormones on formalin-induced nociceptive responses Brain Res 958 2002 139 145
12. J.L. Henry, K. Yashpal, G.M. Pitcher, and T.J. Coderre Physiological evidence that the interphase in the formalin test is due to active inhibition Pain 82 1999 57 63
13. T.L. Horvath, C. Peyron, S. Diano, A. Ivanov, G. Aston-Jones, T.S. Kilduff, and A.N. van den Pol Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system J Comp Neurol 415 1999 145 159
14. S. Hunskaar, O.G. Berge, and K. Hole Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test Pain 25 1986 125 132
15. S. Hunskaar, and K. Hole The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain Pain 30 1987 103 114
16. V.A. Lewis, and G.F. Gebhart Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci Brain Res 124 1977 283 303
17. J.I. Mobarakeh, K. Takahashi, S. Sakurada, S. Nishino, H. Watanabe, M. Kato, and K. Yanai Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice Peptides 26 2005 767 777 (Pubitemid 40461658)
18. J.I. Mobarakeh, K. Takahashi, S. Sakurada, S. Nishino, H. Watanabe, M. Kato, N. Naghdi, and K. Yanai Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice Pain 188 2005 254 262
19. C. Peyron, D.K. Tighe, A.N. van den Pol, L.L. de, H.C. Heller, J.G. Sutcliffe, and T.S. Kilduff Neurons containing hypocretin (orexin) project to multiple neuronal systems J Neurosci 18 1998 9996 10015
20. T. Sakurai Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis Sleep Med Rev 9 2005 231 241
21. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, and M. Yanagisawa Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 573 585
22. W.K. Samson, M.M. Taylor, and A.V. Ferguson Non-sleep effects of hypocretin/orexin Sleep Med Rev 9 2005 243 252
23. J.M. Siegel The narcoleptic borderland Sleep Med 4 2003 3 4
24. H. Suyama, M. Kawamoto, S. Shiraishi, S. Gaus, S. Kajiyama, and O. Yuge Analgesic effect of intrathecal administration of orexin on neuropathic pain in rats In Vivo 18 2004 119 123
25. R. Tao, Z. Ma, J.T. McKenna, M.M. Thakkar, S. Winston, R.E. Strecker, and R.W. McCarley Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats Neuroscience 141 2006 1101 1105
26. T. Yamamoto, N. Nozaki-Taguchi, and T. Chiba Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test Br J Pharmacol 137 2002 170 176
27. T. Yamamoto, O. Saito, K. Shono, and S. Hirasawa Activation of spinal orexin-1 receptor produces anti-allodynic effect in the rat carrageenan test Eur J Pharmacol 481 2003 175 180
28. J.C. Yeung, T.L. Yaksh, and T.A. Rudy Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat Pain 4 1977 23 40