Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages

  Cristino, Luigia ^a   Busetto, Giuseppe ^b,c   Imperatore, Roberta ^a   Ferrandino, Ida ^d   Palomba, Letizia ^a,e   Silvestri, Cristoforo ^a   Petrosino, Stefania ^a   Orlando, Pierangelo ^f   Bentivoglio, Marina ^b   Mackie, Kenneth ^g   Marzo, Vincenzo Di ^a  

^a CNR   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c National Institute of Neuroscience   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF URBINO   (Italy)

^f INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^g INDIANA UNIVERSITY   (United States)

Author keywords

Food intake; High fat diet; Orexin A hypocretin 1; Retrograde signaling

Indexed keywords

CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; OREXIN A; S6 KINASE; STAT3 PROTEIN;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; BIOSYNTHESIS; BRAIN NERVE CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITE; DIET; GABAERGIC TRANSMISSION; HYPERPHAGIA; IMMUNOREACTIVITY; INHIBITION KINETICS; INNERVATION; LEAN BODY WEIGHT; MOUSE; NERVE ENDING; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; OBESITY; OREXINERGIC NEURON; PHENOTYPE; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; SEQUENCE ANALYSIS; SYNAPTIC TRANSMISSION; UPREGULATION;

FOOD INTAKE; HIGH-FAT DIET; OREXIN-A/HYPOCRETIN 1; RETROGRADE SIGNALING;

ANIMALS; ARACHIDONIC ACIDS; ARCUATE NUCLEUS; ENDOCANNABINOIDS; GLYCERIDES; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; OBESITY; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TOR SERINE-THREONINE KINASES;

MAMMALIA; MUS;

EID: 84878996500     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219485110     Document Type: Article

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