T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 33, 2010, Pages 14857-14862

  Park, Cheongdahm ^a,b   Kim, Jong Hyun ^a,b   Yoon, Bo Eun ^a,c   Choi, Eui Ju ^b   Lee, C Justin ^a,c   Shin, Hee Sup ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

Author keywords

1G; Afterhyperpolarization; Calcium activated potassium channel; Morphine; Opioid descending analgesia; Stress

Indexed keywords

CALCIUM CHANNEL T TYPE; MU OPIATE RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BICUCULLINE; CACNA1G PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; NARCOTIC ANALGESIC AGENT;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; ELECTRICITY; ELECTROPHYSIOLOGY; GABAERGIC SYSTEM; GENE SILENCING; MAXIMUM ALLOWABLE CONCENTRATION; MOUSE; MOUSE MUTANT; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL MEMBRANE POTENTIAL; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; MALE; METABOLISM; METHODOLOGY; MOUSE STRAIN; NERVE CELL; PAIN; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE;

MUS;

ANALGESICS, OPIOID; ANIMALS; BICUCULLINE; CALCIUM CHANNELS, T-TYPE; FEMALE; GABA ANTAGONISTS; GREEN FLUORESCENT PROTEINS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEURONS; PAIN; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; RECEPTORS, GABA-A; RNA INTERFERENCE;

EID: 77957095286     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1009532107     Document Type: Article

References (30)

1. Yaksh TL, Yeung JC, Rudy TA (1976) Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray. Brain Res 114:83-103.
2. Reichling DB, Kwiat GC, Basbaum AI (1988) Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls. Prog Brain Res 77:31-46.
3. Dostrovsky JO, Deakin JFW (1977) Periaqueductal grey lesions reduce morphine analgesia in the rat. Neurosci Lett 4:99-103.
4. Lewis VA, Gebhart GF (1977) Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci. Brain Res 124:283-303.
5. Basbaum AI, Fields HL (1984) Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338.
6. Bandler R, Shipley MT (1994) Columnar organization in the midbrain periaqueductal gray: Modules for emotional expression? Trends Neurosci 17:379-389.
7. Terman GW, Shavit Y, Lewis JW, Cannon JT, Liebeskind JC (1984) Intrinsic mechanisms of pain inhibition: Activation by stress. Science 226:1270-1277. (Pubitemid 15215581)
8. North RA, Williams JT (1983) Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones. Br J Pharmacol 80:225-228.
9. Pan ZZ, Williams JT, Osborne PB (1990) Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro. J Physiol 427:519-532.
10. Jacquet YF (1988) The NMDA receptor: Central role in pain inhibition in rat periaqueductal gray. Eur J Pharmacol 154:271-276.
11. Dogrul A, Zagli U, Tulunay FC (2002) The role of T-type calcium channels in morphine analgesia, development of antinociceptive tolerance and dependence to morphine, and morphine abstinence syndrome. Life Sci 71:725-734. (Pubitemid 34632696)
12. Doǧrul A, Yeşilyurt O, Işimer A, Güzeldemir ME (2001) L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice. Pain 93:61-68.
13. Kim D, et al. (2003) Thalamic control of visceral nociception mediated by T-type Ca2+ channels. Science 302:117-119. (Pubitemid 37210701)
14. Cheong E, et al. (2008) Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamus. J Neurosci 28:13331-13340.
15. Talley EM, et al. (1999) Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci 19:1895-1911.
16. Kim D, et al. (2001) Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron 31:35-45. (Pubitemid 32757087)
17. Blanchet C, Lüscher C (2002) Desensitization of mu-opioid receptor-evoked potassium currents: Initiation at the receptor, expression at the effector. Proc Natl Acad Sci USA 99:4674-4679. (Pubitemid 34286043)
18. Llinás R, Ribary U (2001) Consciousness and the brain. The thalamocortical dialogue in health and disease. Ann N Y Acad Sci 929:166-175.
19. Huguenard JR (1996) Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol 58:329-348. (Pubitemid 26106724)
20. Sánchez D, Ribas J (1991) Properties and ionic basis of the action potentials in the periaqueductal grey neurones of the guinea-pig. J Physiol 440:167-187.
21. Chieng B, Christie MJ (1994) Hyperpolarization by opioids acting on mu-receptors of a sub-population of rat periaqueductal gray neurones in vitro. Br J Pharmacol 113: 121-128. (Pubitemid 24271727)
22. Behbehani MM, Jiang M, Chandler SD (1990) The effect of [Met]enkephalin on the periaqueductal gray neurons of the rat: An in vitro study. Neuroscience 38:373-380. (Pubitemid 20332418)
23. Rymar VV, Sasseville R, Luk KC, Sadikot AF (2004) Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum. J Comp Neurol 469:325-339. (Pubitemid 38140641)
24. Tepper JM, Bolam JP (2004) Functional diversity and specificity of neostriatal interneurons. Curr Opin Neurobiol 14:685-692. (Pubitemid 39576198)
25. McKay BE, et al. (2006) Ca(V)3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci 24: 2581-2594.
26. Wolfart J, Roeper J (2002) Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. J Neurosci 22:3404-3413. (Pubitemid 37465746)
27. Smith MR, Nelson AB, Du Lac S (2002) Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons. J Neurophysiol 87:2031-2042.
28. Jahnsen H, Llinás R (1984) Electrophysiological properties of guinea-pig thalamic neurones: An in vitro study. J Physiol 349:205-226. (Pubitemid 14060329)
29. Lee J, Kim D, Shin HS (2004) Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels. Proc Natl Acad Sci USA 101:18195-18199. (Pubitemid 40054096)
30. Shin HS, Cheong EJ, Choi S, Lee J, Na HS (2008) T-type Ca2+ channels as therapeutic targets in the nervous system. Curr Opin Pharmacol 8:33-41.