Additive manufacturing of scaffolds with dexamethasone controlled release for enhanced bone regeneration

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 541-550

  Costa, Pedro F ^a   Puga, Ana M ^b   Díaz Gomez, Luis ^b   Concheiro, Angel ^b   Busch, Dirk H ^a   Alvarez Lorenzo, Carmen ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Additive manufacturing; Bone regeneration; Controlled drug release; Regenerative medicine; Tissue engineering

Indexed keywords

DEXAMETHASONE; POLOXAMINE 908; POLYCAPROLACTONE; DELAYED RELEASE FORMULATION;

ARTICLE; BONE REGENERATION; CELL CULTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; NANOFABRICATION; OSSIFICATION; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THREE DIMENSIONAL PRINTING; CELL PROLIFERATION; CHEMISTRY; DELAYED RELEASE FORMULATION; TISSUE ENGINEERING; TISSUE SCAFFOLD;

BONE REGENERATION; CELL PROLIFERATION; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; HUMANS; PRINTING, THREE-DIMENSIONAL; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84949556700     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.10.055     Document Type: Article

References (44)

1. T.A. Bertram, E. Tentoff, P.C. Johnson, B. Tawil, M. Van Dyke, and K.B. Hellman Hurdles in tissue engineering/regenerative medicine product commercialization: a pilot survey of governmental funding agencies and the financial industry Tissue Eng. Part A 18 2012 2187 2194
2. S. Bose, M. Roy, and A. Bandyopadhyay Recent advances in bone tissue engineering scaffolds Trends Biotechnol. 30 2012 546 554
3. P. Brun, S.C. Dickinson, B. Zavan, R. Cortivo, A.P. Hollander, and G. Abatangelo Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation Arthritis Res. Ther. 10 2008
4. M. Chen, D.Q. Le, S. Hein, P. Li, J.V. Nygaard, M. Kassem, J. Kjems, F. Besenbacher, and C. Bunger Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release Int. J. Nanomed. 7 2012 4285 4297
5. P.F. Costa, A. Martins, N.M. Neves, M.E. Gomes, and R.L. Reis Automating the processing steps for obtaining bone tissue-engineered substitutes: from imaging tools to bioreactors Tissue Eng. Part B, Rev. 20 2014 567 577
6. P.F. Costa, C. Vaquette, J. Baldwin, M. Chhaya, M.E. Gomes, R.L. Reis, C. Theodoropoulos, and D.W. Hutmacher Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow Biofabrication 6 2014 035006
7. P.F. Costa, C. Vaquette, Q. Zhang, R.L. Reis, S. Ivanovski, and D.W. Hutmacher Advanced tissue engineering scaffold design for regeneration of the complex hierarchical periodontal structure J. Clin. Periodontol. 41 2014 283 294
8. P.F. Costa Biofabricated constructs as tissue models: a short review J. Mater. Sci. Mater. Med. 26 2015 1 6
9. P.F. Costa, D.W. Hutmacher, C. Theodoropoulos, M.E. Gomes, R.L. Reis, and C. Vaquette Adv. Healthcare Mater Additively manufactured device for dynamic culture of large arrays of 3D tissue engineered constructs 4 2015 864 873
10. P.D. Dalton, C. Vaquette, B.L. Farrugia, T.R. Dargaville, T.D. Brown, and D.W. Hutmacher Electrospinning and additive manufacturing: converging technologies Biomater. Sci. 1 2013 171 185
11. M.B. de Matos, A.P. Piedade, C. Alvarez-Lorenzo, A. Concheiro, M.E. Braga, and H.C. de Sousa Dexamethasone-loaded poly(epsilon-caprolactone)/silica nanoparticles composites prepared by supercritical CO2 foaming/mixing and deposition Int. J. Pharm. 456 2013 269 281
12. M.B.C. de Matos, A.M. Puga, C. Alvarez-Lorenzo, A. Concheiro, M.E.M. Braga, and H.C. de Sousa Osteogenic poly(μ-caprolactone)/poloxamine homogeneous blends prepared by supercritical foaming Int. J. Pharm. 479 2015 11 22
13. A.S. DeConde, D. Sidell, M. Lee, O. Bezouglaia, K. Low, D. Elashoff, T. Grogan, S. Tetradis, T. Aghaloo, and M. St John Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect Laryngoscope 123 2013 1149 1155
14. W.H. Eaglstein, and V. Falanga Tissue engineering and the development of Apligraf(R), a human skin equivalent Clin. Ther. 19 1997 894 905
15. D.S. Engstrom, B. Porter, M. Pacios, and H. Bhaskaran Additive nanomanufacturing - a review J. Mater. Res. 29 2014 1792 1816
16. S. Facca, C. Cortez, C. Mendoza-Palomares, N. Messadeq, A. Dierich, A.P. Johnston, D. Mainard, J.C. Voegel, F. Caruso, and N. Benkirane-Jessel Active multilayered capsules for in vivo bone formation Proc. Natl. Acad. Sci. U. S. A. 107 2010 3406 3411
17. R. Grylls Intricate parts from the inside out Mach. Des. 75 2003 56 62
18. D.W. Hutmacher A road map for a tissue engineering concept for restoring structure and function after limb loss J. Mater. Sci. Mater. Med. 24 2013 2659 2663
19. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro J. Cell. Biochem. 64 1997 295 312
20. M.S. Kamath, S.S. Ahmed, M. Dhanasekaran, and S.W. Santosh Polycaprolactone scaffold engineered for sustained release of resveratrol: therapeutic enhancement in bone tissue engineering Int. J. Nanomed. 9 2014 183 195
21. R.M. Klar, R. Duarte, T. Dix-Peek, and U. Ripamonti The induction of bone formation by the recombinant human transforming growth factor-beta3 Biomaterials 35 2014 2773 2788
22. J. Korpela, A. Kokkari, H. Korhonen, M. Malin, T. Narhi, and J. Seppala Biodegradable and bioactive porous scaffold structures prepared using fused deposition modeling J. Biomed. Mater. Res. Part B Appl. Biomater. 101 2013 610 619
23. C.X. Lam, D.W. Hutmacher, J.T. Schantz, M.A. Woodruff, and S.H. Teoh Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo J. Biomed. Mater. Res. A 90 2009 906 919
24. N.E. Lane An update on glucocorticoid-induced osteoporosis Rheumatic Dis. Clin. North Am. 27 2001 235 253
25. R. Langer, and J.P. Vacanti Tissue engineering Science 260 1993 920 926
26. A.C. Lima, A.M. Puga, J.F. Mano, A. Concheiro, and C. Alvarez-Lorenzo Free and copolymerized [gamma]-cyclodextrins regulate the performance of dexamethasone-loaded dextran microspheres for bone regeneration J. Mater. Chem. B 2 2014 4943 4956
27. M. Lloyd-Evans Regulating tissue engineering Mater Today 7 2004 48 55
28. E. Martínez-Sanz, O.P. Varghese, M. Kisiel, T. Engstrand, K.M. Reich, M. Bohner, K.B. Jonsson, T. Kohler, R. Müller, D.A. Ossipov, and J. Hilborn Minimally invasive mandibular bone augmentation using injectable hydrogels J. Tissue Eng. Regener. Med. 6 2012 s15 s23
29. C. Mason, and P. Dunnill The strong financial case for regenerative medicine and the regen industry Regener. Med. 3 2008 351 363
30. J.A. Motherway, P. Verschueren, G. Van der Perre, J. Vander Sloten, and M.D. Gilchrist The mechanical properties of cranial bone: the effect of loading rate and cranial sampling position J. Biomech. 42 2009 2129 2135
31. E.S. Place, N.D. Evans, and M.M. Stevens Complexity in biomaterials for tissue engineering Nat. Mater. 8 2009 457 470
32. A.M. Puga, A. Rey-Rico, B. Magarinos, C. Alvarez-Lorenzo, and A. Concheiro Hot melt poly-epsilon-caprolactone/poloxamine implantable matrices for sustained delivery of ciprofloxacin Acta Biomater. 8 2012 1507 1518
33. H. Pullisaar, J.E. Reseland, H.J. Haugen, J.E. Brinchmann, and E. Ostrup Simvastatin coating of TiO(2) scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells Biochem. Biophys. Res. Commun. 447 2014 139 144
34. R. Quarto, M. Mastrogiacomo, R. Cancedda, S.M. Kutepov, V. Mukhachev, A. Lavroukov, E. Kon, and M. Marcacci Repair of large bone defects with the use of autologous bone marrow stromal cells New Engl. J. Med. 344 2001 385 386
35. A. Rey-Rico, M. Silva, J. Couceiro, A. Concheiro, and C. Alvarez-Lorenzo Osteogenic efficiency of in situ gelling poloxamine systems with and without bone morphogenetic protein-2 Eur. Cell Mater. 21 2011 317 340
36. D.R. Rohindra, and J.R. Khurma Miscibility, melting and crystallization of poly(μ-caprolactone) and poly (vinyl formal) blend South Pacific J. Nat. Appl. Sci. 25 2007 53 60
37. D.M. Smith, J.J. Cray Jr., L.E. Weiss, E.K. Dai Fei, S. Shakir, S.A. Rottgers, J.E. Losee, P.G. Campbell, and G.M. Cooper Precise control of osteogenesis for craniofacial defect repair: the role of direct osteoprogenitor contact in BMP-2-based bioprinting Ann. Plast. Surg. 69 2012 485 488
38. R. Tavakoli-darestani, A. Manafi-rasi, and A. Kamrani-rad Dexamethasone-loaded hydroxyapatite enhances bone regeneration in rat calvarial defects Mol. Biol. Rep. 41 2014 423 428
39. J. Visser, B. Peters, T.J. Burger, J. Boomstra, W.J. Dhert, F.P. Melchels, and J. Malda Biofabrication of multi-material anatomically shaped tissue constructs Biofabrication 5 2013 035007
40. S. Walsh, G.R. Jordan, C. Jefferiss, K. Stewart, and J.N. Beresford High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of human osteoblast precursors in vitro: relevance to glucocorticoid-induced osteoporosis Rheumatology 40 2001 74 83
41. C. Wang, D. Zhong, X. Zhou, K. Yin, Q. Liao, L. Kong, and A. Liu Preparation of a new composite combining strengthened β-tricalcium phosphate with platelet-rich plasma as a potential scaffold for the repair of bone defects Exp. Ther. Med. 8 2014 1081 1086
42. R.S. Weinstein, R.L. Jilka, A.M. Parfitt, and S.C. Manolagas Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone J Clin. Invest. 102 1998 274 282
43. Z. Xing, L. Zha, and G. Yang Thermomechanical behavior and nonisothermal crystallization kinetics of poly(μ-caprolactone) and poly(μ-caprolactone)/poly(N-vinylpyrrolidone) blends E-Polymers 2010
44. N. Xu, X. Ye, D. Wei, J. Zhong, Y. Chen, G. Xu, and D. He 3D artificial bones for bone repair prepared by computed tomography-guided fused deposition modeling for bone repair ACS Appl. Mater. Interfaces 6 2014 14952 14963