The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway

Chemico-Biological Interactions

Volumn 244, Issue , 2016, Pages 1-8

  Wu, Jing ^a,b   Xue, Xia ^a   Zhang, Bin ^a   Jiang, Wen ^a   Cao, Hongmei ^c   Wang, Rongmei ^a   Sun, Deqing ^a   Guo, Ruichen ^d  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c People's Hospital of Zhangqiu   (China)

^d SHANDONG UNIVERSITY   (China)

Author keywords

Breast cancer; Epirubicin; Hepatotoxicity; Paeonol; PI3K Akt NF kB

Indexed keywords

CATALASE; EPIRUBICIN; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; PEONOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; ACETOPHENONE DERIVATIVE; HERBACEOUS AGENT; PAEONIA SUFFRUTICOSA; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG MECHANISM; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL PROLIFERATION; CHEMISTRY; COMPLICATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; DRUG-INDUCED LIVER INJURY; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; PAEONIA; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ACETOPHENONES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; EPIRUBICIN; FEMALE; HEPATOCYTES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NF-KAPPA B; OXIDATIVE STRESS; PAEONIA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949497572     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.11.025     Document Type: Article

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