An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 11, 2015, Pages L1367-L1375

  Pastukh, Viktor ^a   Roberts, Justin T ^b   Clark, David W ^a   Bardwell, Gina C ^a   Patel, Mita ^a   Al Mehdi, Abu Bakr ^a   Borchert, Glen M ^a,b   Gillespie, Mark N ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

DNA repair; Hypoxia; Reactive oxygen species; Transcriptional regulation

Indexed keywords

8 HYDROXYGUANINE; BASE EXCISION DNA REPAIR ENZYME; ENZYME; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULOTROPIN; 8-HYDROXYGUANINE; GUANINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SMALL INTERFERING RNA; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA MODIFICATION; DNA REPAIR; DNA SEQUENCE; ENDOTHELIUM CELL; EXCISION REPAIR; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; GENOME; HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PULMONARY ARTERY; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BINDING SITE; CELL HYPOXIA; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE MOTIF; OXIDATION REDUCTION REACTION; PATHOLOGY; TIME FACTOR;

ANIMALS; BINDING SITES; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; DNA REPAIR; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GUANINE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NUCLEOTIDE MOTIFS; OXIDATION-REDUCTION; PROMOTER REGIONS, GENETIC; PULMONARY ARTERY; RATS; RESPONSE ELEMENTS; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84949489780     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00236.2015     Document Type: Article

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