Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

PLoS Medicine

Volumn 12, Issue 11, 2015, Pages

  Hölzemer, Angelique ^a,b,c   Thobakgale, Christina F ^a,d   Jimenez Cruz, Camilo A ^e   Garcia Beltran, Wilfredo F ^a   Carlson, Jonathan M ^f   van Teijlingen, Nienke H ^g   Mann, Jaclyn K ^d   Jaggernath, Manjeetha ^d   Kang, Seung Gu ^e   Körner, Christian ^a,b   Chung, Amy W ^a   Schafer, Jamie L ^h   Evans, David T ^h,i   Alter, Galit ^a   Walker, Bruce D ^a   Goulder, Philip J ^d,j   Carrington, Mary ^a,k   Hartmann, Pia ^l   Pertel, Thomas ^m   Zhou, Ruhong ^e   Ndung’u, Thumbi ^a,d,n   Altfeld, Marcus ^a,b   more..

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e IBM T J WATSON RESEARCH CENTER   (United States)

^f MICROSOFT RESEARCH   (United States)

^g ACADEMIC MEDICAL CENTER   (Netherlands)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^j UNIVERSITY OF OXFORD   (United Kingdom)

^k FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^l UNIVERSITY OF COLOGNE   (Germany)

^m BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁿ MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; GAG PROTEIN; HLA C ANTIGEN; IMMUNOGLOBULIN G; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL3; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; EPITOPE; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELLULAR IMMUNITY; DEGRANULATION ASSAY; FLOW CYTOMETRY; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; NATURAL KILLER CELL; OBSERVATIONAL STUDY; PHASE 1 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; COHORT ANALYSIS; FEMALE; GENETIC VARIATION; GENETICS; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE EVASION; IMMUNOLOGY; MALE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOUTH AFRICA;

COHORT STUDIES; EPITOPES; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENETIC VARIATION; GENOTYPE; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HLA-C ANTIGENS; HUMANS; IMMUNE EVASION; KILLER CELLS, NATURAL; MALE; RECEPTORS, KIR2DL3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SEQUENCE ANALYSIS, RNA; SOUTH AFRICA;

EID: 84949473327     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001900     Document Type: Article

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