HIV Protective KIR3DL1/S1-HLA-B Genotypes Influence NK Cell-Mediated Inhibition of HIV Replication in Autologous CD4 Targets

PLoS Pathogens

Volumn 10, Issue 1, 2014, Pages

  Song, Rujun ^a,b   Lisovsky, Irene ^a,b   Lebouché, Bertrand ^b,c   Routy, Jean Pierre ^b,c,d   Bruneau, Julie ^e,f   Bernard, Nicole F ^a,b,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d ROYAL VICTORIA HOSPITAL   (Canada)

^e CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^f UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; HLA-B57 ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL1; KIR3DL1 PROTEIN, HUMAN;

ADULT; AGED; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL TRIAL; FEMALE; GENETICS; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MALE; MIDDLE AGED; MULTICENTER STUDY; NATURAL KILLER CELL; PATHOLOGY; PHYSIOLOGY; VIROLOGY; VIRUS REPLICATION;

ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENOTYPE; HIV INFECTIONS; HIV-1; HLA-B ANTIGENS; HUMANS; IMMUNITY, CELLULAR; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; RECEPTORS, KIR3DL1; VIRUS REPLICATION;

EID: 84893738301     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003867     Document Type: Article

References (30)

1. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, et al. (2003) Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med 198: 1069-1076.
2. Lanier LL, (2005) NK cell recognition. Annu Rev Immunol 23:225-74.: 225-274.
3. Bashirova AA, Thomas R, Carrington M, (2011) HLA/KIR restraint of HIV: surviving the fittest. Annu Rev Immunol 29: 295-317 10.1146/annurev-immunol-031210-101332 [doi].
4. Pando MJ, Gardiner CM, Gleimer M, McQueen KL, Parham P, (2003) The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at cell surfaces due to substitution at positions 86 in Ig domain 0 and 182 in Ig domain 1. J Immunol 171: 6640-6649.
5. Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, et al. (2011) Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol 186: 62-72 jimmunol.0903657 [pii]; 10.4049/jimmunol.0903657 [doi].
6. Yawata M, Yawata N, Draghi M, Little AM, Partheniou F, et al. (2006) Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J Exp Med 203: 633-645.
7. Martin MP, Qi Y, Gao X, Yamada E, Martin JN, et al. (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet 39: 733-740.
8. Wan AM, Ennis P, Parham P, Holmes N, (1986) The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes. J Immunol 137: 3671-3674.
9. Boulet S, Kleyman M, Kim JY, Kamya P, Sharafi S, et al. (2008) A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection. AIDS 22: 1487-1491.
10. Kamya P, Boulet S, Tsoukas CM, Routy JP, Thomas R, et al. (2011) Receptor-ligand requirements for increased NK cell poly-functional potential in *h/*y+B57 HIV-1 infected Slow progressors. J Virol JVI.02652-10 [pii]; 10.1128/JVI.02652-10 [doi].
11. Kim S, Sunwoo JB, Yang L, Choi T, Song YJ, et al. (2008) HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci U S A 105: 3053-3058 0712229105 [pii]; 10.1073/pnas.0712229105 [doi].
12. Gumperz JE, Litwin V, Phillips JH, Lanier LL, Parham P, (1995) The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med 181: 1133-1144.
13. Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song YJ, et al. (2005) Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436: 709-713 nature03847 [pii];10.1038/nature03847 [doi].
14. Anfossi N, Andre P, Guia S, Falk CS, Roetynck S, et al. (2006) Human NK cell education by inhibitory receptors for MHC class I. Immunity 25: 331-342.
15. Boulet S, Song R, Kamya P, Bruneau J, Shoukry NH, et al. (2010) HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells. J Immunol 184: 2057-2064 jimmunol.0902621 [pii];10.4049/jimmunol.0902621 [doi].
16. Martin MP, Gao X, Lee JH, Nelson GW, Detels R, et al. (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31: 429-434.
17. Qi Y, Martin MP, Gao X, Jacobson L, Goedert JJ, et al. (2006) KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections. PLoS Pathog 2: e79.
18. Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, et al. (2007) Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med 204: 3027-3036.
19. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, et al. (1995) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811-1815.
20. Oliva A, Kinter AL, Vaccarezza M, Rubbert A, Catanzaro A, et al. (1998) Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro. J Clin Invest 102: 223-231 10.1172/JCI2323 [doi].
21. Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D, (1998) HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391: 397-401.
22. Cohen GB, Gandhi RT, Davis DM, Mandelboim O, Chen BK, et al. (1999) The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10: 661-671.
23. Brodin P, Lakshmikanth T, Johansson S, Karre K, Hoglund P, (2009) The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. Blood 113: 2434-2441 blood-2008-05-156836 [pii];10.1182/blood-2008-05-156836 [doi].
24. Johansson S, Johansson M, Rosmaraki E, Vahlne G, Mehr R, et al. (2005) Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules. J Exp Med 201: 1145-1155 jem.20050167 [pii];10.1084/jem.20050167 [doi].
25. Fauriat C, Ivarsson MA, Ljunggren HG, Malmberg KJ, Michaelsson J, (2010) Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood 115: 1166-1174 blood-2009-09-245746 [pii];10.1182/blood-2009-09-245746 [doi].
26. Fadda L, O'Connor GM, Kumar S, Piechocka-Trocha A, Gardiner CM, et al. (2011) Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules. J Virol 85: 5970-5974 JVI.00412-11 [pii];10.1128/JVI.00412-11 [doi].
27. Vivian JP, Duncan RC, Berry R, O'Connor GM, Reid HH, et al. (2011) Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature 479: 401-405 nature10517 [pii];10.1038/nature10517 [doi].
28. Pelak K, Need AC, Fellay J, Shianna KV, Feng S, et al. (2011) Copy number variation of KIR genes influences HIV-1 control. PLoS Biol 9: e1001208 10.1371/journal.pbio.1001208 [doi]; PBIOLOGY-D-11-02515 [pii].
29. Boulet S, Sharafi S, Simic N, Bruneau J, Routy JP, et al. (2008) Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals. AIDS 22: 595-599.
30. Bounou S, Leclerc JE, Tremblay MJ, (2002) Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo. J Virol 76: 1004-1014.