The nima-like kinase nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry

Development (Cambridge)

Volumn 142, Issue 23, 2015, Pages 4068-4079

  Joseph Endicott, S ^a   Basu, Basudha ^a   Khokha, Mustafa ^a   Brueckner, Martina ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cilia; Congenital heart disease; Left right asymmetry; Nek2; Nucleoporin

Indexed keywords

GAMMA TUBULIN; HISTONE DEACETYLASE 6; NIMA RELATED KINASE 2; NUCLEOPORIN 98; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; DAND5 PROTEIN, HUMAN; HDAC6 PROTEIN, MOUSE; HISTONE DEACETYLASE; HOMEODOMAIN PROTEIN; NEK2 PROTEIN, HUMAN; NEK2A PROTEIN, XENOPUS; NEK2B PROTEIN, XENOPUS; NIMA RELATED KINASE; NUCLEOPORIN; NUP98 PROTEIN, XENOPUS; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PITX2; XENOPUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL ULTRASTRUCTURE; CENTRIOLE; CILIARY BODY EPITHELIUM; CILIARY MOTILITY; CILIOGENESIS; CONTROLLED STUDY; DAND5 GENE; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO AXIS; EMBRYO PATTERN FORMATION; GENE; GENE OVEREXPRESSION; GENE SILENCING; LEFT RIGHT ASYMMETRY; NONHUMAN; PHENOTYPE; PITX2 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; XENOPUS; ANIMAL; EUKARYOTIC FLAGELLUM; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MORPHOGENESIS; MOUSE; MUTATION; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; CENTRIOLES; CILIA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; NIMA-RELATED KINASES; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; XENOPUS; XENOPUS PROTEINS;

EID: 84949437322     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.126953     Document Type: Article

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