Nucleoporin Nup188 is required for chromosome alignment in mitosis

Cancer Science

Volumn 104, Issue 7, 2013, Pages 871-879

  Itoh, Go ^a   Sugino, Shiro ^a   Ikeda, Masanori ^a   Mizuguchi, Mayumi ^a   Kanno, Shin Ichiro ^a   Amin, Mohammed A ^a   Iemura, Kenji ^a   Yasui, Akira ^a   Hirota, Toru ^b   Tanaka, Kozo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPORIN; NUCLEOPORIN NUP188; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; BINDING ASSAY; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CENTROMERE; CENTROSOME; CHROMOSOMAL PARAMETERS; CHROMOSOME; CHROMOSOME ALIGNMENT; CHROMOSOME SEGREGATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MEMBRANE TRANSPORT; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS INDEX; MITOSIS INHIBITION; NUCLEAR PORE COMPLEX; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CENTROSOME; CHROMOSOME SEGREGATION; HELA CELLS; HUMANS; KINETOCHORES; METAPHASE; MICROTUBULES; MITOSIS; NUCLEAR PORE COMPLEX PROTEINS; SPINDLE APPARATUS;

EID: 84880714422     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12159     Document Type: Article

References (33)

1. Holland AJ, Cleveland DW. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep 2012; 13: 501-14.
2. Tanaka K, Hirota T. Chromosome segregation machinery and cancer. Cancer Sci 2009; 100: 1158-65.
3. Tanaka K. Regulatory mechanisms of kinetochore-microtubule interaction in mitosis. Cell Mol Life Sci 2013; 70: 559-79.
4. Brohawn SG, Partridge JR, Whittle JR, Schwartz TU. The nuclear pore complex has entered the atomic age. Structure 2009; 17: 1156-68.
5. Guttinger S, Laurell E, Kutay U. Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol 2009; 10: 178-91.
6. Chatel G, Fahrenkrog B. Nucleoporins: leaving the nuclear pore complex for a successful mitosis. Cell Signal 2011; 23: 1555-62.
7. Wozniak R, Burke B, Doye V. Nuclear transport and the mitotic apparatus: an evolving relationship. Cell Mol Life Sci 2010; 67: 2215-30.
8. Zuccolo M, Alves A, Galy V et al. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J 2007; 26: 1853-64.
9. Mishra RK, Chakraborty P, Arnaoutov A, Fontoura BM, Dasso M. The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores. Nat Cell Biol 2010; 12: 164-9.
10. Platani M, Santarella-Mellwig R, Posch M, Walczak R, Swedlow JR, Mattaj IW. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell 2009; 20: 5260-75.
11. Wong RW, Blobel G, Coutavas E. Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci U S A 2006; 103: 19783-7.
12. Hashizume C, Nakano H, Yoshida K, Wong RW. Characterization of the role of the tumor marker Nup88 in mitosis. Mol Cancer 2010; 9: 119.
13. Blower MD, Nachury M, Heald R, Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 2005; 121: 223-34.
14. Xu S, Powers MA. Nuclear pore proteins and cancer. Semin Cell Dev Biol 2009; 20: 620-30.
15. Nakamura T, Largaespada DA, Lee MP et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 1996; 12: 154-8.
16. Borrow J, Shearman AM, Stanton VP Jr et al. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet 1996; 12: 159-67.
17. von Lindern M, Fornerod M, van Baal S et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol 1992; 12: 1687-97.
18. Cooper CS, Park M, Blair DG et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 1984; 311: 29-33.
19. Gould VE, Martinez N, Orucevic A, Schneider J, Alonso A. A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. Am J Pathol 2000; 157: 1605-13.
20. Gould VE, Orucevic A, Zentgraf H, Gattuso P, Martinez N, Alonso A. Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis. Hum Pathol 2002; 33: 536-44.
21. Martinez N, Alonso A, Moragues MD, Ponton J, Schneider J. The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Cancer Res 1999; 59: 5408-11.
22. Dawlaty MM, Malureanu L, Jeganathan KB et al. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell 2008; 133: 103-15.
23. Theerthagiri G, Eisenhardt N, Schwarz H, Antonin W. The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. J Cell Biol 2010; 189: 1129-42.
24. Nowak NJ, Sait SN, Zeidan A et al. Recurrent deletion of 9q34 in adult normal karyotype precursor B-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 2010; 199: 15-20.
25. Nakajima M, Kumada K, Hatakeyama K, Noda T, Peters JM, Hirota T. The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci 2007; 120: 4188-96.
26. Itoh G, Kanno S, Uchida KS et al. CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J 2011; 30: 130-44.
27. Radulescu AE, Cleveland DW. NuMA after 30 years: the matrix revisited. Trends Cell Biol 2010; 20: 214-22.
28. Haren L, Gnadt N, Wright M, Merdes A. NuMA is required for proper spindle assembly and chromosome alignment in prometaphase. BMC Res Notes 2009; 2: 64.
29. Dephoure N, Zhou C, Villen J et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 2008; 105: 10762-7.
30. Malik R, Lenobel R, Santamaria A, Ries A, Nigg EA, Korner R. Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 2009; 8: 4553-63.
31. Silk AD, Holland AJ, Cleveland DW. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 2009; 184: 677-90.
32. Merdes A, Ramyar K, Vechio JD, Cleveland DW. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 1996; 87: 447-58.
33. Kapoor TM, Lampson MA, Hergert P et al. Chromosomes can congress to the metaphase plate before biorientation. Science 2006; 311: 388-91.