-
2
-
-
0018287375
-
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells
-
Tucker, R. W., Pardee, A. B. & Fujiwara, K. Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell 17, 527-535 (1979).
-
(1979)
Cell
, vol.17
, pp. 527-535
-
-
Tucker, R.W.1
Pardee, A.B.2
Fujiwara, K.3
-
3
-
-
34250758641
-
HEF1-dependent Aurora A activation induces disassembly of the primary cilium
-
Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P. & Golemis, E. A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129, 1351-1363 (2007).
-
(2007)
Cell
, vol.129
, pp. 1351-1363
-
-
Pugacheva, E.N.1
Jablonski, S.A.2
Hartman, T.R.3
Henske, E.P.4
Golemis, E.A.5
-
4
-
-
79953331186
-
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry
-
Kim, S. et al. Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat. Cell Biol. 13, 351-360 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 351-360
-
-
Kim, S.1
-
5
-
-
84862507047
-
The ciliopathies: A transitional model into systems biology of human genetic disease
-
Davis, E. E. & Katsanis, N. The ciliopathies: a transitional model into systems biology of human genetic disease. Curr. Opin. Genet. Dev. 22, 290-303 (2012).
-
(2012)
Curr. Opin. Genet. Dev.
, vol.22
, pp. 290-303
-
-
Davis, E.E.1
Katsanis, N.2
-
6
-
-
79960629889
-
Centrosomes and cilia in human disease
-
Bettencourt-Dias, M., Hildebrandt, F., Pellman, D., Woods, G. & Godinho, S. A. Centrosomes and cilia in human disease. Trends Genet. 27, 307-315 (2011).
-
(2011)
Trends Genet.
, vol.27
, pp. 307-315
-
-
Bettencourt-Dias, M.1
Hildebrandt, F.2
Pellman, D.3
Woods, G.4
Godinho, S.A.5
-
8
-
-
84924850726
-
Loss of primary cilia occurs early in breast cancer development
-
Menzl, I. et al. Loss of primary cilia occurs early in breast cancer development. Cilia 3, 7 (2014).
-
(2014)
Cilia
, vol.3
, pp. 7
-
-
Menzl, I.1
-
9
-
-
85045859173
-
Cilia and cilia-associated proteins in cancer
-
Seeger-Nukpezah, T., Little, J. L., Serzhanova, V. & Golemis, E. A. Cilia and cilia-associated proteins in cancer. Drug Discov. Today Dis. Mech. 10, e135-e142 (2013).
-
(2013)
Drug Discov. Today Dis. Mech.
, vol.10
, pp. e135-e142
-
-
Seeger-Nukpezah, T.1
Little, J.L.2
Serzhanova, V.3
Golemis, E.A.4
-
10
-
-
77957325256
-
Primary cilia are decreased in breast cancer: Analysis of a collection of human breast cancer cell lines and tissues
-
Yuan, K. et al. Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J. Histochem. Cytochem. 58, 857-870 (2010).
-
(2010)
J. Histochem. Cytochem.
, vol.58
, pp. 857-870
-
-
Yuan, K.1
-
11
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
Neve, R. M. et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10, 515-527 (2006).
-
(2006)
Cancer Cell
, vol.10
, pp. 515-527
-
-
Neve, R.M.1
-
12
-
-
77951204905
-
Primary cilia regulate branching morphogenesis during mammary gland development
-
McDermott, K. M., Liu, B. Y., Tlsty, T. D. & Pazour, G. J. Primary cilia regulate branching morphogenesis during mammary gland development. Curr. Biol. 20, 731-737 (2010).
-
(2010)
Curr. Biol.
, vol.20
, pp. 731-737
-
-
McDermott, K.M.1
Liu, B.Y.2
Tlsty, T.D.3
Pazour, G.J.4
-
13
-
-
84899917293
-
Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells
-
Cappello, P. et al. Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells. Oncogene 33, 2375-2384 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 2375-2384
-
-
Cappello, P.1
-
14
-
-
84872373803
-
NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
-
Zhou, W. et al. NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell 23, 48-62 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 48-62
-
-
Zhou, W.1
-
15
-
-
5644280152
-
The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer
-
Hayward, D. G. et al. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 64, 7370-7376 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 7370-7376
-
-
Hayward, D.G.1
-
16
-
-
0034654399
-
The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
-
Pfleger, C. M. & Kirschner, M. W. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655-665 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 655-665
-
-
Pfleger, C.M.1
Kirschner, M.W.2
-
17
-
-
0037126610
-
APC/Cmediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
-
Hames, R. S., Wattam, S. L., Yamano, H., Bacchieri, R. & Fry, A. M. APC/Cmediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. EMBO J. 20, 7117-7127 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 7117-7127
-
-
Hames, R.S.1
Wattam, S.L.2
Yamano, H.3
Bacchieri, R.4
Fry, A.M.5
-
18
-
-
84872171489
-
Cell cycle regulation by the NEK family of protein kinases
-
Fry, A. M., O'Regan, L., Sabir, S. R. & Bayliss, R. Cell cycle regulation by the NEK family of protein kinases. J. Cell Sci. 125, 4423-4433 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4423-4433
-
-
Fry, A.M.1
O'regan, L.2
Sabir, S.R.3
Bayliss, R.4
-
19
-
-
0032578008
-
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
-
Fry, A. M. et al. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J. Cell Biol. 141, 1563-1574 (1998).
-
(1998)
J. Cell Biol.
, vol.141
, pp. 1563-1574
-
-
Fry, A.M.1
-
20
-
-
84861943636
-
Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition
-
Spalluto, C., Wilson, D. I. & Hearn, T. Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition. Eur. J. Cell Biol. 91, 675-686 (2012).
-
(2012)
Eur. J. Cell Biol.
, vol.91
, pp. 675-686
-
-
Spalluto, C.1
Wilson, D.I.2
Hearn, T.3
-
21
-
-
79958250238
-
Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis
-
Kobayashi, T., Tsang, W. Y., Li, J., Lane, W. & Dynlacht, B. D. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Cell 145, 914-925 (2011).
-
(2011)
Cell
, vol.145
, pp. 914-925
-
-
Kobayashi, T.1
Tsang, W.Y.2
Li, J.3
Lane, W.4
Dynlacht, B.D.5
-
22
-
-
84874652759
-
A genomic toolkit to investigate kinesin and myosin motor function in cells
-
Maliga, Z. et al. A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat. Cell Biol. 15, 325-334 (2013).
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 325-334
-
-
Maliga, Z.1
-
23
-
-
78649870675
-
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction
-
Mardin, B. R. et al. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat. Cell Biol. 12, 1166-1176 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1166-1176
-
-
Mardin, B.R.1
-
24
-
-
34547472737
-
Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle
-
Strnad, P. et al. Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. Dev. Cell 13, 203-213 (2007).
-
(2007)
Dev. Cell
, vol.13
, pp. 203-213
-
-
Strnad, P.1
-
25
-
-
67649838621
-
Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a
-
Jang, C. Y., Coppinger, J. A., Seki, A., Yates, J. R. 3rd & Fang, G. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J. Cell Sci. 122, 1334-1341 (2009).
-
(2009)
J. Cell Sci.
, vol.122
, pp. 1334-1341
-
-
Jang, C.Y.1
Coppinger, J.A.2
Seki, A.3
Yates, J.R.4
Fang, G.5
-
26
-
-
84862538643
-
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation
-
Hood, E. A., Kettenbach, A. N., Gerber, S. A. & Compton, D. A. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. Mol. Biol. Cell 23, 2264-2274 (2012).
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2264-2274
-
-
Hood, E.A.1
Kettenbach, A.N.2
Gerber, S.A.3
Compton, D.A.4
-
27
-
-
78951472328
-
PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity
-
Zhang, L. et al. PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity. J. Biol. Chem. 286, 3033-3046 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3033-3046
-
-
Zhang, L.1
-
28
-
-
84890792731
-
Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association
-
Ems-McClung, S. C. et al. Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association. Curr. Biol. 23, 2491-2499 (2013).
-
(2013)
Curr. Biol.
, vol.23
, pp. 2491-2499
-
-
Ems-McClung, S.C.1
-
29
-
-
40849094248
-
Regulation of the function of mammalian myosin and its conformational change
-
Ikebe, M. Regulation of the function of mammalian myosin and its conformational change. Biochem. Biophys. Res. Commun. 369, 157-164 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.369
, pp. 157-164
-
-
Ikebe, M.1
-
30
-
-
70350446761
-
Traffic control: Regulation of kinesin motors
-
Verhey, K. J. & Hammond, J. W. Traffic control: regulation of kinesin motors. Nat. Rev. Mol. Cell Biol. 10, 765-777 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 765-777
-
-
Verhey, K.J.1
Hammond, J.W.2
-
31
-
-
79953305554
-
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors
-
Li, A. et al. Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat. Cell Biol. 13, 402-411 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 402-411
-
-
Li, A.1
-
32
-
-
0030044330
-
MCF10AT: A model for the evolution of cancer from proliferative breast disease
-
Dawson, P. J., Wolman, S. R., Tait, L., Heppner, G. H. & Miller, F. R. MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am. J. Pathol. 148, 313-319 (1996).
-
(1996)
Am. J. Pathol.
, vol.148
, pp. 313-319
-
-
Dawson, P.J.1
Wolman, S.R.2
Tait, L.3
Heppner, G.H.4
Miller, F.R.5
-
33
-
-
0034686626
-
MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ
-
Miller, F. R., Santner, S. J., Tait, L. & Dawson, P. J. MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ. J. Natl Cancer Inst. 92, 1185-1186 (2000).
-
(2000)
J. Natl Cancer Inst.
, vol.92
, pp. 1185-1186
-
-
Miller, F.R.1
Santner, S.J.2
Tait, L.3
Dawson, P.J.4
-
34
-
-
0035129885
-
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells
-
Santner, S. J. et al. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res. Treat. 65, 101-110 (2001).
-
(2001)
Breast Cancer Res. Treat.
, vol.65
, pp. 101-110
-
-
Santner, S.J.1
-
35
-
-
0017645944
-
Two syngeneic cell lines from human breast tissue: The aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines
-
Hackett, A. J. et al. Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines. J. Natl Cancer Inst. 58, 1795-1806 (1977).
-
(1977)
J. Natl Cancer Inst.
, vol.58
, pp. 1795-1806
-
-
Hackett, A.J.1
-
36
-
-
84892876629
-
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly
-
Kobayashi, T., Kim, S., Lin, Y. C., Inoue, T. & Dynlacht, B. D. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204, 215-229 (2014).
-
(2014)
J. Cell Biol.
, vol.204
, pp. 215-229
-
-
Kobayashi, T.1
Kim, S.2
Lin, Y.C.3
Inoue, T.4
Dynlacht, B.D.5
-
37
-
-
80051733318
-
Cilia and cell cycle re-entry: More than a coincidence
-
Kim, S. & Tsiokas, L. Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle 10, 2683-2690 (2011).
-
(2011)
Cell Cycle
, vol.10
, pp. 2683-2690
-
-
Kim, S.1
Tsiokas, L.2
-
38
-
-
79956193249
-
Regulating the transition from centriole to basal body
-
Kobayashi, T. & Dynlacht, B. D. Regulating the transition from centriole to basal body. J. Cell Biol. 193, 435-444 (2011).
-
(2011)
J. Cell Biol.
, vol.193
, pp. 435-444
-
-
Kobayashi, T.1
Dynlacht, B.D.2
-
39
-
-
49449100251
-
Building it up and taking it down: The regulation of vertebrate ciliogenesis
-
Santos, N. & Reiter, J. F. Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev. Dyn. 237, 1972-1981 (2008).
-
(2008)
Dev. Dyn.
, vol.237
, pp. 1972-1981
-
-
Santos, N.1
Reiter, J.F.2
-
40
-
-
76649103368
-
The perennial organelle: Assembly and disassembly of the primary cilium
-
Seeley, E. S. & Nachury, M. V. The perennial organelle: assembly and disassembly of the primary cilium. J. Cell Sci. 123, 511-518 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 511-518
-
-
Seeley, E.S.1
Nachury, M.V.2
-
41
-
-
29244456404
-
Caught Nek-ing: Cilia and centrioles
-
Quarmby, L. M. & Mahjoub, M. R. Caught Nek-ing: cilia and centrioles. J. Cell Sci. 118, 5161-5169 (2005).
-
(2005)
J. Cell Sci.
, vol.118
, pp. 5161-5169
-
-
Quarmby, L.M.1
Mahjoub, M.R.2
-
42
-
-
22344446254
-
A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas
-
Bradley, B. A. & Quarmby, L. M. A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas. J. Cell Sci. 118, 3317-3326 (2005).
-
(2005)
J. Cell Sci.
, vol.118
, pp. 3317-3326
-
-
Bradley, B.A.1
Quarmby, L.M.2
-
43
-
-
33744729996
-
Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms
-
Wloga, D. et al. Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Mol. Biol. Cell 17, 2799-2810 (2006).
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 2799-2810
-
-
Wloga, D.1
-
44
-
-
77953658955
-
Regulation of cilia assembly, disassembly, and length by protein phosphorylation
-
Cao, M., Li, G. & Pan, J. Regulation of cilia assembly, disassembly, and length by protein phosphorylation. Methods Cell Biol. 94, 333-346 (2009).
-
(2009)
Methods Cell Biol.
, vol.94
, pp. 333-346
-
-
Cao, M.1
Li, G.2
Pan, J.3
-
45
-
-
63849291991
-
A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas
-
Piao, T. et al. A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas. Proc. Natl Acad. Sci. USA 106, 4713-4718 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4713-4718
-
-
Piao, T.1
-
46
-
-
0037089079
-
The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation
-
Mahjoub, M. R. et al. The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. J. Cell Sci. 115, 1759-1768 (2002).
-
(2002)
J. Cell Sci.
, vol.115
, pp. 1759-1768
-
-
Mahjoub, M.R.1
-
47
-
-
84923322310
-
The microtubule-depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation
-
Miyamoto, T. et al. The microtubule-depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation. Cell Rep. (2015). doi:10.1016/j.celrep.2015.01.003.
-
(2015)
Cell Rep.
-
-
Miyamoto, T.1
-
48
-
-
84889095194
-
The kinases LF4 and CNK2 control ciliary length by feedback regulation of assembly and disassembly rates
-
Hilton, L. K., Gunawardane, K., Kim, J. W., Schwarz, M. C. & Quarmby, L. M. The kinases LF4 and CNK2 control ciliary length by feedback regulation of assembly and disassembly rates. Curr. Biol. 23, 2208-2214 (2013).
-
(2013)
Curr. Biol.
, vol.23
, pp. 2208-2214
-
-
Hilton, L.K.1
Gunawardane, K.2
Kim, J.W.3
Schwarz, M.C.4
Quarmby, L.M.5
-
49
-
-
34250800642
-
Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization
-
Jeong, Y., Lee, J., Kim, K., Yoo, J. C. & Rhee, K. Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization. J. Cell Sci. 120, 2106-2116 (2007).
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2106-2116
-
-
Jeong, Y.1
Lee, J.2
Kim, K.3
Yoo, J.C.4
Rhee, K.5
-
50
-
-
38149118802
-
Beta-Catenin is a Nek2 substrate involved in centrosome separation
-
Bahmanyar, S. et al. beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22, 91-105 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 91-105
-
-
Bahmanyar, S.1
-
51
-
-
34547193780
-
Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis
-
Fu, G. et al. Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Cell Res. 17, 608-618 (2007).
-
(2007)
Cell Res.
, vol.17
, pp. 608-618
-
-
Fu, G.1
-
52
-
-
84904976128
-
Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): A perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition
-
Frett, B. et al. Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition. J. Med. Chem. 57, 5835-5844 (2014).
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5835-5844
-
-
Frett, B.1
|