The allergy epidemics: 1870-2010

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 1, 2015, Pages 3-13

  Platts Mills, Thomas A E ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

asthma; Hay fever; hygiene; indoor environment; lifestyle; peanut

Indexed keywords

ALLERGIC DISEASE; ANAPHYLAXIS; ASTHMA; BREATHING PATTERN; CHILD; CLINICAL EVALUATION; COCCINELLIDAE; ENVIRONMENTAL CHANGE; EPIDEMIC; FOOD ALLERGY; HUMAN; LIFESTYLE MODIFICATION; PEDIATRICS; PERSONAL HYGIENE; PHYSICAL ACTIVITY; POLLEN ALLERGY; PREVALENCE; PRIORITY JOURNAL; RED MEAT; REVIEW; RISK FACTOR; AFRICA; ANIMAL; EUROPE; HISTORY; HYGIENE; HYGIENE HYPOTHESIS; HYPERSENSITIVITY; LIFESTYLE; UNITED STATES;

AFRICA; ANIMALS; CHILD; EPIDEMICS; EUROPE; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; HYGIENE; HYGIENE HYPOTHESIS; HYPERSENSITIVITY; LIFE STYLE; UNITED STATES;

EID: 84949117787     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.03.048     Document Type: Review

References (118)

1. K. Bergmann, and J. Ring History of allergy in antiquity History of allergy 2014 Karger Unionville (CT)
2. C.H. Blackley Experiments and researches on the causes of nature of catarrhus aestivas 1873 Balliere London
3. M. Wyman Autumnal catarrh (hay fever) 1872 Huro & Houghton Cambridge (MA)
4. T. Platts-Mills Local production of IgG, IgA and IgE antibodies to pollen allergen in patients with hay fever [PhD thesis] 1983 London University London (UK) 163
5. G. Mitman Hay fever holiday: health, leisure, and place in gilded-age America Bull Hist Med 77 2003 600 635
6. W. Dunbar The present state of knowledge of hay fever J Hyg (Lond) 13 1913 105 148
7. L. Noon Prophylactic innoculation for hay fever Lancet i 1911 1572
8. A. Briggs The making of modern England 1783-1867: the age of improvement 1959 Routledge New York (NY) 314
9. E. deWaal The hare with amber eyes 2010 Picador, Farrr, Straus and Giroux New York (NY)
10. P. Johnson, and D.G. Marsh 'Isoallergens' from rye grass pollen Nature 206 1965 935 937
11. R. Davies Grass pollen counts: London 1961-1980 Clin Allergy 12 1982 511 512
12. T. King, and P. Norman Isolation studies of allergens from ragweed pollen Biochemistry 1 1962 709
13. S.B. Johnson The ghost map 2006 Riverhead Books London (UK)
14. A. Reynolds, and A. Hazen The water-supply of Chicago: its source and sanitary aspects Public Health Pap Rep 19 1893 146 151
15. S. Hempel John Snow Lancet 381 2013 1269 1270
16. C. Millard Destiny of the republic. A tale of madness, medicine, and the murder of a president 2011 Doubleday New York (NY)
17. 4000 Acres that breed sneezes, target in City's hay fever war. New York Times. June 3, 1949.
18. M. Walzer, and B.B. Siegel The effectiveness of the ragweed eradication campaigns in New York City; a 9-year study; 1946-1954 J Allergy 27 1956 113 126
19. A. Frankland, and R. Augustin Prophylaxis of summer hay fever and asthma: controlled trial comparing crude grass pollen extracts with isolated main component Lancet 266 1954 1055 1057
20. O. Swineford Jr. Asthma and hay fever 1971 Charles C Thomas Springfield (IL)
21. J.M. Smith, M.E. Disney, J.D. Williams, and Z.A. Goels Clinical significance of skin reactions to mite extracts in children with asthma BMJ 2 1969 723 726
22. C.W. Clarke, and P.M. Aldons The nature of asthma in Brisbane Clin Allergy 9 1979 147 152
23. T. Miyamoto, S.G. Johansson, K. Ito, and Y. Horiuchi Atopic allergy in Japanese subjects: studies primarily with radioallergosorbent test J Allergy Clin Immunol 53 1974 9 19
24. T.A.E. Platts-Mills, E.B. Mitchell, E.R. Tovey, M.D. Chapman, and S.R. Wilkins Airborne allergen exposure, allergen avoidance and bronchial hyperreactivity A.B. Kay, K.F. Austen, L.M. Lichtenstein, Asthma: physiology, immunopharmacology and treatment, Third International Symposium 1984 Academic Press London 297 314
25. T.A. Platts-Mills, E.R. Tovey, E.B. Mitchell, H. Moszoro, P. Nock, and S.R. Wilkins Reduction of bronchial hyperreactivity during prolonged allergen avoidance Lancet 2 1982 675 678
26. E.R. Tovey, M.D. Chapman, C.W. Wells, and T.A. Platts-Mills The distribution of dust mite allergen in the houses of patients with asthma Am Rev Respir Dis 124 1981 630 635
27. T. Haahtela, H. Lindholm, F. Bjorksten, K. Koskenvuo, and L.A. Laitinen Prevalence of asthma in Finnish young men BMJ 301 1990 266 268
28. L. Braback, A. Hjern, and F. Rasmussen Trends in asthma, allergic rhinitis and eczema among Swedish conscripts from farming and non-farming environments. A nationwide study over three decades Clin Exp Allergy 34 2004 38 43
29. E.A. Erwin, E. Ronmark, K. Wickens, M.S. Perzanowski, D. Barry, B. Lundback, and et al. Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence J Allergy Clin Immunol 119 2007 359 365
30. E. Ronmark, A. Bjerg, M. Perzanowski, T. Platts-Mills, and B. Lundback Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden J Allergy Clin Immunol 124 2009 357 363 e1-15
31. A. Hulett, and R. Dockhorn House dust, mite (D. farinae) and cockroach allergy in a Midwestern population Ann Allergy Asthma Immunol 43 1979 160 165
32. L.E. Gelber, L.H. Seltzer, J.K. Bouzoukis, S.M. Pollart, M.D. Chapman, and T.A. Platts-Mills Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital Am Rev Respir Dis 147 1993 573 578
33. D.L. Rosenstreich, P. Eggleston, M. Kattan, D. Baker, R.G. Slavin, P. Gergen, and et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma N Engl J Med 336 1997 1356 1363
34. H. Anderson, R. Gupta, D. Strachan, and E. Limb 50 years of asthma: UK trends from 1955 to 2004 Thorax 62 2007 85 90
35. D.D. Crater, S. Heise, M. Perzanowski, R. Herbert, C.G. Morse, T.C. Hulsey, and et al. Asthma hospitalization trends in Charleston, South Carolina, 1956 to 1997: twenty-fold increase among black children during a 30-year period Pediatrics 108 2001 E97
36. E. Mitchell International trends in hospital admission rates for asthma Arch Dis Child 60 1985 376 378
37. R.E.C. Altounyan Changes in histamine and atropine responsiveness as a guide to diagnosis and evaluation of therapy in obstructive airways disease J. Pepys, A.W. Frankland, Disodium chromoglycate in allergic airways disease 1970 Butterworth London (UK)
38. K. Kerrebijn Endogenous factors in childhood CNSLD: methodological aspects in population studies 1970 Royal Van Gorcum Assen (The Netherlands) 38 48
39. D. Cockcroft, R. Ruffin, J. Dolovich, and F. Hargreave Allergen-induced increase in non-allergic bronchial reactivity Allergy 7 1977 503 513
40. S. Shaheen, R. Newson, S. Ring, M. Rose-Zerilli, J. Holloway, and A. Henderson Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma J Allergy Clin Immunol 126 2010 1141 1148.e7
41. J.K. Peat, E. Tovey, C.M. Mellis, S.R. Leeder, and A.J. Woolcock Importance of house dust mite and Alternaria allergens in childhood asthma: an epidemiological study in two climatic regions of Australia Clin Exp Allergy 23 1993 812 820
42. J.K. Peat, and J. Li Reversing the trend: reducing the prevalence of asthma J Allergy Clin Immunol 103 1999 1 10
43. D.P. Strachan Hay fever, hygiene, and household size BMJ 299 1989 1259 1260
44. M.S. Perzanowski, L.W. Ng'ang'a, M.C. Carter, J. Odhiambo, P. Ngari, J.W. Vaughan, and et al. Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya J Pediatr 140 2002 582 588
45. S. Scrivener, H. Yemaneberhan, M. Zebenigus, D. Tilahun, S. Girma, S. Ali, and et al. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study Lancet 358 2001 1493 1499
46. W. Stevens, E. Addo-Yobo, J. Roper, A. Woodcock, H. James, T. Platts-Mills, and et al. Differences in both prevalence and titre of specific immunoglobulin E among children with asthma in affluent and poor communities within a large town in Ghana Clin Exp Allergy 41 2011 1587 1594
47. P. Endara, M. Vaca, T.A. Platts-Mills, L. Workman, M.E. Chico, M.L. Barreto, and et al. Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis Clin Exp Allergy 45 2015 438 447
48. M.J. Ege, M. Mayer, A.C. Normand, J. Genuneit, W.O. Cookson, C. Braun-Fahrlander, and et al. Exposure to environmental microorganisms and childhood asthma N Engl J Med 364 2011 701 709
49. W. Eder, M.J. Ege, and E. von Mutius The asthma epidemic N Engl J Med 355 2006 2226 2235
50. B. Hesselmar, N. Aberg, B. Aberg, B. Eriksson, and B. Bjorksten Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 29 1999 611 617
51. T. Platts-Mills, J. Vaughan, S. Squillace, J. Woodfolk, and R. Sporik Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study Lancet 357 2001 752 756
52. G. Wegienka, C.C. Johnson, S. Havstad, D.R. Ownby, C. Nicholas, and E.M. Zoratti Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years Clin Exp Allergy 41 2011 979 986
53. K.E. Fujimura, C.C. Johnson, D.R. Ownby, M.J. Cox, E.L. Brodie, S.L. Havstad, and et al. Man's best friend? The effect of pet ownership on house dust microbial communities J Allergy Clin Immunol 126 2010 410 412 e1-3
54. M. Soto-Quiros, L. Avila, T.A. Platts-Mills, J.F. Hunt, D.D. Erdman, H. Carper, and et al. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus J Allergy Clin Immunol 129 2012 1499 1505.e5
55. D. Strachan Family size, infection and atopy: the first decade of the "hygiene hypothesis" Thorax 55 suppl 1 2000 S2 S10
56. H. Bisgaard, M.N. Hermansen, F. Buchvald, L. Loland, L.B. Halkjaer, K. Bonnelykke, and et al. Childhood asthma after bacterial colonization of the airway in neonates N Engl J Med 357 2007 1487 1495
57. A.P. Stallings, S.P. Commins, and T.A. Platts-Mills Asthma and neonatal airway colonization N Engl J Med 358 2008 423 424 author reply 424-5
58. N. Scichilone, T. Kapsali, S. Permutt, and A. Togias Deep inspiration-induced bronchiprotection is stronger than bronchodilation Am J Respir Crit Care Med 162 2000 910 916
59. J. Fredberg, D. Inouye, S. Mijailovich, and J. Butler Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm Am J Respir Crit Care Med 159 1999 959 967
60. J.J. Fredberg Airway smooth muscle in asthma: flirting with disaster Eur Respir J 12 1998 1252 1256
61. G. Skloot, S. Permutt, and A. Togias Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration J Clin Invest 96 1995 2393 2403
62. J. Nadel, and D. Tierney Effect of a previous deep inspiration on airway resistance in man J Appl Physiol 16 1961 717 719
63. J.E. Fish, M.G. Ankin, J.F. Kelly, and V.I. Peterman Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects J Appl Physiol 50 1981 1079 1086
64. W.T. Hark, W.M. Thompson, T.E. McLaughlin, L.M. Wheatley, and T.A. Platts-Mills Spontaneous sigh rates during sedentary activity: watching television vs reading Ann Allergy Asthma Immunol 94 2005 247 250
65. National Institutes of Health; National Heart, Lung, and Blood Institute: National Asthma Education Prevention Program Expert panel report 3: guidelines for the diagnosis and management of asthma 2007 National Institutes of Health Bethesda (MD) NIH publication no. 07-4051
66. R. Shaaban, B. Leynaert, D. Soussan, J. Anto, S. Chinn, R. de Marco, and et al. Physical activity and bronchial hyperresponsiveness: European Community Respiratory Health Survey II Thorax 62 2006 403 410
67. L. Hoskin-Parr, A. Teyhan, A. Blocker, and A. Henderson Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: a dose-dependent relationship Pediatr Allergy Immunol 24 2013 762 771
68. P. Cullinan, J. Harris, P. Mills, S. Moffat, C. White, J. Figg, and et al. Early prescriptions of antibiotics and the risk of allergic disease in adults: a cohort study Thorax 59 2004 11 15
69. D. Diaz-Sanchez, M. Garcia, M. Wang, M. Jyrala, and A. Saxon Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa J Allergy Clin Immunol 104 1999 1183 1188
70. A. Ghio, C. Smith, and M. Madden Diesel exhaust particles and airway inflammation Curr Opin Pulm Med 18 2012 144 150
71. E. von Mutius, F. Martinez, C. Fritzsch, T. Nicolai, G. Roell, and H. Thiemann Prevalence of asthma and atopy in two areas of West and East Germany Am J Respir Crit Care Med 149 1994 358 364
72. A. Sherriff, A. Maitra, A.R. Ness, C. Mattocks, C. Riddoch, J.J. Reilly, and et al. Association of duration of television viewing in early childhood with the subsequent development of asthma Thorax 64 2009 321 325
73. L. Epstein, J. Roemmich, J. Robinson, R. Pauluch, D. Winiewica, J. Fuerch, and et al. A randomized trial of the effects of reducing television viewing and computer use on body mass index in young children Arch Pediatr Adolesc Med 162 2008 239 245
74. L. Cottrell, W.A. Neal, C. Ice, M.K. Perez, and G. Piedimonte Metabolic abnormalities in children with asthma Am J Respir Crit Care Med 183 2010 441 448
75. R. Granell, A. Henderson, D. Evans, G. Smith, A. Ness, S. Lewis, and et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study PLoS Med 11 2014 e1001669
76. Y.M. Shim, A. Burnette, S. Lucas, R.C. Herring, J. Weltman, J.T. Patrie, and et al. Physical deconditioning as a cause of breathlessness among obese adolescents with a diagnosis of asthma PLoS One 8 2013 e61022
77. 2-enriched atmospheres Ann Allergy Asthma Immunol 88 2002 279 282
78. S. Shaheen, R. Newson, S. Ring, M. Rose-Zerilli, J. Holloway, and A. Henderson Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma J Allergy Clin Immunol 126 2010 1141
79. M.S. Perzanowski, R.L. Miller, D. Tang, D. Ali, R.S. Garfinkel, G.L. Chew, and et al. Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort Thorax 65 2010 118 123
80. A. Varner, W. Busse, and R.J. Lemanske Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma Ann Allergy Asthma Immunol 81 1998 347 351
81. T. Shirakawa, T. Enomoto, S. Shimazu, and J.M. Hopkin The inverse association between tuberculin responses and atopic disorder Science 275 1997 77 79
82. M. Linehan, U. Nurmatov, T. Frank, R. Niven, D. Baxter, and A. Sheikh Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis J Allergy Clin Immunol 133 2014 688 695
83. C. Gruber, S. Lau, A. Dannemann, C. Sommerfeld, U. Wahn, and R. Aalberse Down-regulation of IgE and IgG4 antibodies to tetanus toxoid and diphtheria toxoid by covaccination with cellular Bordetella pertussis vaccine J Immunol 167 2001 2411 2417
84. C. Ausiello, F. Urbani, A. la Sala, R. Lande, and A. Cassone Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines Infect Immun 65 1997 2168 2174
85. J. Rowe, S.T. Yerkovich, P. Richmond, D. Suriyaarachchi, E. Fisher, L. Feddema, and et al. Th2-associated local reactions to the acellular diphtheria-tetanus-pertussis vaccine in 4- to 6-year-old children Infect Immun 73 2005 8130 8135
86. S. Bunyavanich, S.L. Rifas-Shiman, T.A. Platts-Mills, L. Workman, J.E. Sordillo, M.W. Gillman, and et al. Peanut allergy prevalence among school-age children in a US cohort not selected for any disease J Allergy Clin Immunol 134 2014 753 755
87. S. Sicherer, A. Munoz-Furlong, J. Godbold, and H. Sampson US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up J Allergy Clin Immunol 125 2010 1322 1326
88. G. Du Toit, G. Roberts, P. Sayre, M. Plaut, H. Bahnson, H. Mitchell, and et al. Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study J Allergy Clin Immunol 131 2013 135 143
89. G. Du Toit, G. Roberts, P. Sayre, H. Bahnson, S. Radulovic, A. Santos, and et al. Randomized trial of peanut consumption in infants at risk for peanut allergy N Engl J Med 372 2015 803 813
90. S. Bunyavanich, S. Rifas-Shiman, T.A. Platts-Mills, L. Workman, J.E. Sordillo, C.J. Camargo, and et al. Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children J Allergy Clin Immunol 133 2014 1373 1382
91. S. Sicherer, R. Wood, D. Stablein, R. Lindblad, A. Burk, A. Liu, and et al. Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants J Allergy Clin Immunol 126 2010 1191 1197
92. G. Lack, D. Fox, K. Northstone, and J. Golding Factors associated with the development of peanut allergy in childhood N Engl J Med 348 2003 977 985
93. T. Yokooji, S. Kurihara, T. Murakami, Y. Chinuki, H. Takahashi, and E. Morita Characterization of causative allergens for wheat-dependent exercise-induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap Allergol Int 64 2013 435 445
94. H. Brough, A. Simpson, K. Makinson, J. Hankinson, S. Brown, A. Douiri, and et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations J Allergy Clin Immunol 134 2014 867 875
95. G. Du Toit, Y. Katz, P. Sasieni, D. Mesher, S. Maleki, H. Fisher, and et al. Early consumption of peanuts in infancy is association with a low prevalence of peanut allergy J Allergy Clin Immunol 122 2008 984 991
96. A. de Benedetto, A. Kubo, and L. Beck Skin barrier disruption: a requirement for allergen sensitization? J Invest Dermatol 132 2012 949 963
97. J. Savage, E. Matsui, R. Wood, and C. Keet Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization J Allergy Clin Immunol 130 2012 453 460
98. J. Yarbrough, J. Armstrong, M. Blumberg, A. Phillips, E. McGahee, and W. Dolen Allergic rhinoconjunctivitis caused by Harmonia axyridis (Asian lady beetle, Japanese lady beetle, or lady bug) J Allergy Clin Immunol 104 1999 704 705
99. T. Nakazawa, S.M. Satinover, L. Naccara, L. Goddard, B.P. Dragulev, E. Peters, and et al. Asian ladybugs (Harmonia axyridis): a new seasonal indoor allergen J Allergy Clin Immunol 119 2007 421 427
100. J. Steinke, T. Platts-Mills, and S. Commins The alpha-gal story: lessons learned from connecting the dots J Allergy Clin Immunol 135 2015 589 597
101. S. Commins, H. James, E. Kelly, S. Pochan, L. Workman, M. Perzanowski, and et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose J Allergy Clin Immunol 127 2011 1286 1293
102. S.A. Van Nunen, K.S. O'Connor, L.R. Clarke, R.X. Boyle, and S.L. Fernando An association between tick bite reactions and red meat allergy in humans Med J Aust 190 2009 510 511
103. S.P. Commins, H. James, W. Stevens, S. Pochan, M. Land, C. King, and et al. Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1, 3-galactose J Allergy Clin Immunol 134 2014 108 115
104. C. Hamsten, T. Tran, M. Starkhammar, A. Brauner, S.P. Commins, T.A. Platts-Mills, and et al. Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups J Allergy Clin Immunol 132 2013 1431 1434
105. J. Fischer, J. Hebsaker, P. Caponetto, T.A. Platts-Mills, and T. Biedermann Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis J Allergy Clin Immunol 133 2014 755 759.e1
106. A. Tripathi, S.P. Commins, P. Heymann, and T.A. Platts-Mills Delayed anaphylaxis to red meat masquerading as idiopathic anaphylaxis J Allergy Clin Immunol Pract 2 2014 259 265
107. C.D. Paddock, and M.J. Yabsley Ecological havoc, the rise of white-tailed deer, and the emergence of Amblyomma americanum-associated zoonoses in the United States Curr Top Microbiol Immunol 315 2007 289 324
108. K.B. Weiss, P.J. Gergen, and D.K. Wagener Breathing better or wheezing worse? The changing epidemiology of asthma morbidity and mortality Annu Rev Public Health 14 1993 491 513
109. G. Hagy, and G. Settipane Bronchial asthma, allergic rhinitis, and allergy skin tests among college students J Allergy 44 1969 323 332
110. R. Nathan, E. Meltzer, J. Selner, and W. Storms Prevalence of allergic rhinitis in the United States J Allergy Clin Immunol 99 suppl 2 1997 S808 S814
111. S. Johnston, P. Pattemore, G. Sanderson, S. Smith, M. Campbell, L. Josephs, and et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis Am J Respir Crit Care Med 154 1996 654 660
112. G.P. Rakes, E. Arruda, J.M. Ingram, G.E. Hoover, J.C. Zambrano, F.G. Hayden, and et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses Am J Respir Crit Care Med 159 1999 785 790
113. P.W. Heymann, H.T. Carper, D.D. Murphy, T.A. Platts-Mills, J. Patrie, A.P. McLaughlin, and et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing J Allergy Clin Immunol 114 2004 239 247
114. J. Gern How rhinovirus infections cause exacerbations of asthma Clin Exp Allergy 45 2015 32 42
115. W.W. Busse, W.J. Morgan, P.J. Gergen, H.E. Mitchell, J.E. Gern, A.H. Liu, and et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children N Engl J Med 364 2011 1005 1015
116. R. Smith, and B. Lourie Slow death by rubber duck: how the toxic chemistry of everyday life affects our health 2010 Counterpoint Press Berkeley (CA)
117. T.A. Platts-Mills, J.A. Woodfolk, M.D. Chapman, and P.W. Heymann Changing concepts of allergic disease: the attempt to keep up with real changes in lifestyles J Allergy Clin Immunol 98 suppl 1996 S297 S306
118. S.R. Lucas, and T.A. Platts-Mills Physical activity and exercise in asthma: relevance to etiology and treatment J Allergy Clin Immunol 115 2005 928 934