The alpha-gal story: Lessons learned from connecting the dots

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 3, 2015, Pages 589-596

  Steinke, John W ^a   Platts Mills, Thomas A E ^a   Commins, Scott P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Anaphylaxis; delayed reaction to red meat; galactosealpha 1 3 galactose

Indexed keywords

CARBOHYDRATE; CETUXIMAB; GALACTOSYLGALACTOSE; IMMUNOGLOBULIN E ANTIBODY; ALLERGEN; ANTINEOPLASTIC AGENT; DISACCHARIDE; EPITOPE; GALACTOSYL-(1-3)GALACTOSE; IMMUNOGLOBULIN E; MONOCLONAL ANTIBODY;

ANAPHYLAXIS; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; CARBOHYDRATE ANALYSIS; DISEASE COURSE; DRUG HYPERSENSITIVITY; FOOD ALLERGY; HUMAN; IMMUNE RESPONSE; INGESTION; PRIORITY JOURNAL; RED MEAT; REVIEW; T LYMPHOCYTE; TICK BITE; ANIMAL; BLOOD; BOVINAE; CHEMICALLY INDUCED; FOOD HYPERSENSITIVITY; HYPERSENSITIVITY, DELAYED; IMMUNOLOGY; MEAT; PATHOLOGY; PATHOPHYSIOLOGY; SWINE; TICK BITES;

ALLERGENS; ANAPHYLAXIS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; CATTLE; DISACCHARIDES; EPITOPES; FOOD HYPERSENSITIVITY; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN E; MEAT; SWINE; T-LYMPHOCYTES; TICK BITES;

EID: 84924365591     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.12.1947     Document Type: Review

References (46)

1. C.H. Chung, B. Mirakhur, E. Chan, Q.T. Le, J. Berlin, and M. Morse Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose N Engl J Med 358 2008 1109 1117
2. B.H. O'Neil, R. Allen, D.R. Spigel, T.E. Stinchcombe, D.T. Moore, and J.D. Berlin High incidence of cetuximab-related infusion reactions in Tennessee and North Carolina and the association with atopic history J Clin Oncol 25 2007 3644 3648
3. S. Maier, C.H. Chung, M. Morse, T. Platts-Mills, L. Townes, and P. Mukhopadhyay A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions Cancer Med 4 2015 36 42
4. E.A. Erwin, N.J. Custis, S.M. Satinover, M.S. Perzanowski, J.A. Woodfolk, and J. Crane Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phase J Allergy Clin Immunol 115 2005 1029 1035
5. K. Landsteiner The specificity of serological reactions 1936 Charles C Thomas Baltimore (MD)
6. J. Milland, and M.S. Sandrin ABO blood group and related antigens, natural antibodies and transplantation Tissue Antigens 68 2006 459 466
7. C. Koike, M. Uddin, D.E. Wildman, E.A. Gray, M. Trucco, and T.E. Starzl Functionally important glycosyltransferase gain and loss during catarrhine primate emergence Proc Natl Acad Sci U S A 104 2007 559 564
8. B.A. Macher, and U. Galili The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance Biochim Biophys Acta 1780 2008 75 88
9. U. Galili, E.A. Rachmilewitz, A. Peleg, and I. Flechner A unique natural human IgG antibody with anti-alpha-galactosyl specificity J Exp Med 160 1984 1519 1531
10. R. Hurtado-Guerrero, and G.J. Davies Recent structural and mechanistic insights into post-translational enzymatic glycosylation Curr Opin Chem Biol 16 2012 479 487
11. J. Qian, T. Liu, L. Yang, A. Daus, R. Crowley, and Q. Zhou Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion Anal Biochem 364 2007 8 18
12. D. Ayoub, W. Jabs, A. Resemann, W. Evers, C. Evans, and L. Main Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques mAbs 5 2013 699 710
13. U. Galili The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy Immunol Cell Biol 83 2005 674 686
14. S.P. Commins, S.M. Satinover, J. Hosen, J. Mozena, L. Borish, and B.D. Lewis Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose J Allergy Clin Immunol 123 2009 426 433
15. A. Thall, and U. Galili Distribution of Gal alpha 1-3Gal beta 1-4GlcNAc residues on secreted mammalian glycoproteins (thyroglobulin, fibrinogen, and immunoglobulin G) as measured by a sensitive solid-phase radioimmunoassay Biochemistry 29 1990 3959 3965
16. J.L. Kennedy, A.P. Stallings, T.A. Platts-Mills, W.M. Oliveira, L. Workman, and H.R. James Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children Pediatrics 131 2013 e1545 e1552
17. D. Apostolovic, T. Tran, C. Hamsten, M. Starkhammar, T. Cirkovic Velickovic, and M. van Hage Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose containing allergens Allergy 69 2014 1308 1315
18. S.A. Van Nunen, K.S. O'Connor, L.R. Clarke, R.X. Boyle, and S.L. Fernando An association between tick bite reactions and red meat allergy in humans Med J Aust 190 2009 510 511
19. S.P. Commins, H.R. James, L.A. Kelly, S.L. Pochan, L.J. Workman, and M.S. Perzanowski The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose J Allergy Clin Immunol 127 2011 1286 1293.e6
20. C. Hamsten, T.A. Tran, M. Starkhammar, A. Brauner, S.P. Commins, and T.A. Platts-Mills Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups J Allergy Clin Immunol 132 2013 1431 1434
21. C. Hamsten, M. Starkhammar, T.A. Tran, M. Johansson, U. Bengtsson, and G. Ahlen Identification of galactose-alpha-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy Allergy 68 2013 549 552
22. G. Burke, S.K. Wikel, A. Spielman, S.R. Telford, K. McKay, and P.J. Krause Hypersensitivity to ticks and Lyme disease risk Emerg Infect Dis 11 2005 36 41
23. K.A. Fagerstone, and W.H. Clay Overview of USDA animal damage control efforts to manage overabundant deer Wildlife Soc Bull 25 1997 413 417
24. S.D. Cote, T.P. Rooney, J. Tremblay, C. Dussault, and D.M. Waller Ecological impacts of deer overabundance Annu Rev Ecol Evol Systematics 35 2004 113 147
25. L.E. Gelber, L.H. Seltzer, J.K. Bouzoukis, S.M. Pollart, M.D. Chapman, and T.A. Platts-Mills Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital Am Rev Respir Dis 147 1993 573 578
26. M.R. Sears, J.M. Greene, A.R. Willan, E.M. Wiecek, D.R. Taylor, and E.M. Flannery A longitudinal, population-based, cohort study of childhood asthma followed to adulthood N Engl J Med 349 2003 1414 1422
27. E.A. Erwin, E. Ronmark, K. Wickens, M.S. Perzanowski, D. Barry, and B. Lundback Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence J Allergy Clin Immunol 119 2007 359 365
28. S.P. Commins, L.A. Kelly, E. Ronmark, H.R. James, S.L. Pochan, and E.J. Peters Galactose-alpha-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma Am J Respir Crit Care Med 185 2012 723 730
29. M.S. Perzanowski, E. Ronmark, B. Nold, B. Lundback, and T.A. Platts-Mills Relevance of allergens from cats and dogs to asthma in the northernmost province of Sweden: schools as a major site of exposure J Allergy Clin Immunol 103 1999 1018 1024
30. K. Arkestal, E. Sibanda, C. Thors, M. Troye-Blomberg, T. Mduluza, and R. Valenta Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-alpha 1,3-galactose J Allergy Clin Immunol 127 2011 1024 1028
31. R.C. Aalberse, and R. van Ree Cross-reactive carbohydrate determinants Monogr Allergy 32 1996 78 83
32. R. van Ree, M. Cabanes-Macheteau, J. Akkerdaas, J.P. Milazzo, C. Loutelier-Bourhis, and C. Rayon Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens J Biol Chem 275 2000 11451 11458
33. I. Mittermann, M. Zidarn, M. Silar, Z. Markovic-Housley, W. Aberer, and P. Korosec Recombinant allergen-based IgE testing to distinguish bee and wasp allergy J Allergy Clin Immunol 125 2010 1300 1307.e3
34. A. Mari IgE to cross-reactive carbohydrate determinants: analysis of the distribution and appraisal of the in vivo and in vitro reactivity Int Arch Allergy Immunol 129 2002 286 295
35. S.P. Commins, H.R. James, W. Stevens, S.L. Pochan, M.H. Land, and C. King Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose J Allergy Clin Immunol 134 2014 108 115.e11
36. B. Gonen, P. O'Donnell, T.J. Post, T.J. Quinn, and E.S. Schulman Very low density lipoproteins (VLDL) trigger the release of histamine from human basophils Biochim Biophys Acta 917 1987 418 424
37. E.S. Schulman, T.J. Quinn, T.J. Post, P. O'Donnell, A. Rodriguez, and B. Gonen Low density lipoprotein (LDL) inhibits histamine release from human mast cells Biochem Biophys Res Commun 148 1987 553 559
38. M. Morisset, C. Richard, C. Astier, S. Jacquenet, A. Croizier, and E. Beaudouin Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose Allergy 67 2012 699 704
39. J. Fischer, J. Hebsaker, P. Caponetto, T.A. Platts-Mills, and T. Biedermann Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis J Allergy Clin Immunol 134 2014 755 759.e1
40. M. Vicario, C. Blanchard, K.F. Stringer, M.H. Collins, M.K. Mingler, and A. Ahrens Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis Gut 59 2010 12 20
41. R.E. Snow, R. Djukanovic, and F.K. Stevenson Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events Immunology 98 1999 646 651
42. E. Pratt, A.M. Collins, W.A. Sewell, and R.J. Harvey Antigen selection in IgE antibodies from individuals with chronic rhinosinusitis with nasal polyps Am J Rhinol Allergy 24 2010 416 421
43. B.A. Cobb, Q. Wang, A.O. Tzianabos, and D.L. Kasper Polysaccharide processing and presentation by the MHCII pathway Cell 117 2004 677 687
44. D.B. Moody Immunology: how a T cell sees sugar Nature 448 2007 36 37
45. Y. Wang, K.J. Jackson, Z. Chen, B.A. Gaeta, P.M. Siba, and W. Pomat IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection Scand J Immunol 73 2011 496 504
46. J. Kleine-Tebbe, A. Heinatz, I. Graser, H. Dautel, G.N. Hansen, and S. Kespohl Bites of the European pigeon tick (Argas reflexus): risk of IgE-mediated sensitizations and anaphylactic reactions J Allergy Clin Immunol 117 2006 190 195