Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 4, 2015, Pages 1856-1867

  Hussain, Tahir ^a   Yogavel, Manickam ^a   Sharma, Amit ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; BEDEROCIN; FUNGAL ENZYME; METHIONINE TRANSFER RNA LIGASE; REP 3123; TRANSFER RNA; UNCLASSIFIED DRUG; BENZOPYRAN DERIVATIVE; DIAMINE; PROTEIN SYNTHESIS INHIBITOR; THIOPHENE DERIVATIVE;

AMINO TERMINAL SEQUENCE; APICOPLAST; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; CONFOCAL MICROSCOPY; CYTOPLASM; DRUG TARGETING; EC50; ENZYME ACTIVE SITE; ENZYME INHIBITION ASSAY; ENZYME LOCALIZATION; ENZYME STRUCTURE; IC50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PARASITE DEVELOPMENT; PHYLOGENY; PLASMODIUM FALCIPARUM; PLASMODIUM FALCIPARUM 3D7; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TROPHOZOITE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; COMPUTER SIMULATION; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; ERYTHROCYTE; GENETICS; HUMAN; METABOLISM; PARASITOLOGY; SYNTHESIS;

ANIMALS; ANTIMALARIALS; BENZOPYRANS; COMPUTER SIMULATION; CYTOPLASM; DIAMINES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; HUMANS; METHIONINE-TRNA LIGASE; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PROTEIN SYNTHESIS INHIBITORS; THIOPHENES;

EID: 84949117076     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02220-13     Document Type: Article

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