-
1
-
-
1842266562
-
HIV viral load markers in clinical practice
-
Saag MS, Holodniy M, Kuritzkes DR, et al. HIV viral load markers in clinical practice. Nat Med. 1996;2:625-629.
-
(1996)
Nat Med
, vol.2
, pp. 625-629
-
-
Saag, M.S.1
Holodniy, M.2
Kuritzkes, D.R.3
-
2
-
-
0030868897
-
Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
-
Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997;277:112-116.
-
(1997)
Science
, vol.277
, pp. 112-116
-
-
Autran, B.1
Carcelain, G.2
Li, T.S.3
-
3
-
-
13144306121
-
Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents
-
Pakker NG, Roos MT, van Leeuwen, et al. Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:318-326.
-
(1997)
J Acquir Immune Defic Syndr Hum Retrovirol
, vol.16
, pp. 318-326
-
-
Pakker, N.G.1
Roos, M.T.2
Van Leeuwen3
-
4
-
-
33847414203
-
Ten years of highly active antiretroviral therapy for HIV infection
-
Chen LF, Hoy J, Lewin SR. Ten years of highly active antiretroviral therapy for HIV infection. Med J Aust. 2007;186:146-151.
-
(2007)
Med J Aust
, vol.186
, pp. 146-151
-
-
Chen, L.F.1
Hoy, J.2
Lewin, S.R.3
-
5
-
-
33646052566
-
Immunological recovery and antiretroviral therapy in HIV-1 infection
-
Battegay M, Nuesch R, Hirschel B, et al. Immunological recovery and antiretroviral therapy in HIV-1 infection. Lancet Infect Dis. 2006;6: 280-287.
-
(2006)
Lancet Infect Dis
, vol.6
, pp. 280-287
-
-
Battegay, M.1
Nuesch, R.2
Hirschel, B.3
-
6
-
-
22544453346
-
Characteristics, determinants, and clinical relevance of CD4 T cell recovery to,500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy
-
Kaufmann GR, Furrer H, Ledergerber B, et al. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to,500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy. Clin Infect Dis. 2005;41:361-372.
-
(2005)
Clin Infect Dis
, vol.41
, pp. 361-372
-
-
Kaufmann, G.R.1
Furrer, H.2
Ledergerber, B.3
-
7
-
-
0035871818
-
Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: Evidence from the EuroSIDA study
-
Viard JP, Mocroft A, Chiesi A, et al. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis. 2001;183:1290-1294.
-
(2001)
J Infect Dis
, vol.183
, pp. 1290-1294
-
-
Viard, J.P.1
Mocroft, A.2
Chiesi, A.3
-
8
-
-
24644443695
-
Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy
-
Rockstroh JK, Mocroft A, Soriano V, et al. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005;192:992-1002.
-
(2005)
J Infect Dis
, vol.192
, pp. 992-1002
-
-
Rockstroh, J.K.1
Mocroft, A.2
Soriano, V.3
-
9
-
-
0026509890
-
In vitro toxicity of 3#-azido-3#-deoxythymidine, carbovir and 2#,3#-didehydro-2#,3#-dideoxythymidine to human and murine haematopoietic progenitor cells
-
Du DL, Volpe DA, Grieshaber CK, et al. In vitro toxicity of 3#-azido-3#-deoxythymidine, carbovir and 2#,3#-didehydro-2#,3#-dideoxythymidine to human and murine haematopoietic progenitor cells, Br J Haematol. 1992;80:437-445
-
(1992)
Br J Haematol
, vol.80
, pp. 437-445
-
-
Du, D.L.1
Volpe, D.A.2
Grieshaber, C.K.3
-
10
-
-
27944511495
-
Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir
-
Karrer U, Ledergerber B, Furrer H, et al. Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir. AIDS. 2005;19:1987-1994.
-
(2005)
AIDS
, vol.19
, pp. 1987-1994
-
-
Karrer, U.1
Ledergerber, B.2
Furrer, H.3
-
11
-
-
38549149823
-
Immune activation and inflammation in HIV-1 infection: Causes and consequences
-
Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol. 2008;214:231-241.
-
(2008)
J Pathol
, vol.214
, pp. 231-241
-
-
Appay, V.1
Sauce, D.2
-
12
-
-
34147110822
-
Accelerated immune senescence and HIV-1 infection
-
Appay V, Almeida JR, Sauce D, et al. Accelerated immune senescence and HIV-1 infection. Exp Gerontol. 2007;42:432-437.
-
(2007)
Exp Gerontol
, vol.42
, pp. 432-437
-
-
Appay, V.1
Almeida, J.R.2
Sauce, D.3
-
13
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
Keir ME, Butte MJ, Freeman GJ, et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008;26:677-704.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
-
14
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439:682-687.
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
-
15
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443:350-354.
-
(2006)
Nature
, vol.443
, pp. 350-354
-
-
Day, C.L.1
Kaufmann, D.E.2
Kiepiela, P.3
-
16
-
-
33749009709
-
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
-
Trautmann L, Janbazian L, Chomont N, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med. 2006;12:1198-1202.
-
(2006)
Nat Med
, vol.12
, pp. 1198-1202
-
-
Trautmann, L.1
Janbazian, L.2
Chomont, N.3
-
17
-
-
33749324118
-
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade
-
Freeman GJ, Wherry EJ, Ahmed R, et al. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med. 2006;203: 2223-2227.
-
(2006)
J Exp Med
, vol.203
, pp. 2223-2227
-
-
Freeman, G.J.1
Wherry, E.J.2
Ahmed, R.3
-
18
-
-
34548637484
-
Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
-
D'Souza M, Fontenot AP, Mack DG, et al. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol. 2007;179:1979-1987.
-
(2007)
J Immunol
, vol.179
, pp. 1979-1987
-
-
D'Souza, M.1
Fontenot, A.P.2
MacK, D.G.3
-
19
-
-
34249711903
-
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors
-
Zhang JY, Zhang Z, Wang X, et al. PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood. 2007;109:4671-4678.
-
(2007)
Blood
, vol.109
, pp. 4671-4678
-
-
Zhang, J.Y.1
Zhang, Z.2
Wang, X.3
-
20
-
-
58149218516
-
The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells
-
Kober J, Leitner J, Klauser C, et al. The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur J Immunol. 2008;38:2678-2688.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2678-2688
-
-
Kober, J.1
Leitner, J.2
Klauser, C.3
-
21
-
-
33646559596
-
No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation
-
Pfistershammer K, Klauser C, Pickl WF, et al. No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur J Immunol. 2006;36:1104-1113.
-
(2006)
Eur J Immunol
, vol.36
, pp. 1104-1113
-
-
Pfistershammer, K.1
Klauser, C.2
Pickl, W.F.3
-
22
-
-
69249135880
-
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction
-
Leitner J, Klauser C, Pickl WF, et al. B7-H3 is a potent inhibitor of human T-cell activation: no evidence for B7-H3 and TREML2 interaction. Eur J Immunol. 2009;39:1754-1764.
-
(2009)
Eur J Immunol
, vol.39
, pp. 1754-1764
-
-
Leitner, J.1
Klauser, C.2
Pickl, W.F.3
-
23
-
-
33847401888
-
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: An update on implications for chronic infections and tumor evasion
-
Blank C, Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother. 2007;56:739-745.
-
(2007)
Cancer Immunol Immunother
, vol.56
, pp. 739-745
-
-
Blank, C.1
MacKensen, A.2
-
24
-
-
33845532053
-
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
-
Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371.
-
(2006)
Nat Med
, vol.12
, pp. 1365-1371
-
-
Brenchley, J.M.1
Price, D.A.2
Schacker, T.W.3
-
25
-
-
38949134533
-
Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
-
Gori A, Tincati C, Rizzardini G, et al. Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis. J Clin Microbiol. 2008;46: 757-758.
-
(2008)
J Clin Microbiol
, vol.46
, pp. 757-758
-
-
Gori, A.1
Tincati, C.2
Rizzardini, G.3
-
26
-
-
0037012044
-
Age associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells
-
Dennett NS, Barcia RN, McLeod JD. Age associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells. Exp Gerontol. 2002;37:271-283.
-
(2002)
Exp Gerontol
, vol.37
, pp. 271-283
-
-
Dennett, N.S.1
Barcia, R.N.2
McLeod, J.D.3
-
27
-
-
42549131481
-
Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4+ Cell counts and HIV RNA levels during follow-up
-
Lundgren JD, Babiker A, El-Sadr W, et al. Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up. J Infect Dis. 2008;197:1145-1155.
-
(2008)
J Infect Dis
, vol.197
, pp. 1145-1155
-
-
Lundgren, J.D.1
Babiker, A.2
El-Sadr, W.3
-
28
-
-
55249101754
-
HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies
-
Monforte A, Abrams D, Pradier C, et al. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies. AIDS. 2008;22:2143-2153.
-
(2008)
AIDS
, vol.22
, pp. 2143-2153
-
-
Monforte, A.1
Abrams, D.2
Pradier, C.3
-
29
-
-
0031562690
-
Activation-induced expression of human programmed death-1 gene in T-lymphocytes
-
Vibhakar R, Juan G, Traganos F, et al. Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp Cell Res. 1997; 232:25-28.
-
(1997)
Exp Cell Res
, vol.232
, pp. 25-28
-
-
Vibhakar, R.1
Juan, G.2
Traganos, F.3
-
30
-
-
33750691709
-
PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
-
Urbani S, Amadei B, Tola D, et al. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol. 2006;80:11398-11403.
-
(2006)
J Virol
, vol.80
, pp. 11398-11403
-
-
Urbani, S.1
Amadei, B.2
Tola, D.3
-
31
-
-
0038701685
-
T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
-
Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187:1534-1543.
-
(2003)
J Infect Dis
, vol.187
, pp. 1534-1543
-
-
Hunt, P.W.1
Martin, J.N.2
Sinclair, E.3
-
32
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001;2:261-268.
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
-
33
-
-
0034927194
-
PD-1: An inhibitory immunoreceptor involved in peripheral tolerance
-
Nishimura H, Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 2001;22:265-268.
-
(2001)
Trends Immunol
, vol.22
, pp. 265-268
-
-
Nishimura, H.1
Honjo, T.2
-
34
-
-
0042376265
-
Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
-
Carter LL, Carreno BM. Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation. Immunol Res. 2003;28:49-59.
-
(2003)
Immunol Res
, vol.28
, pp. 49-59
-
-
Carter, L.L.1
Carreno, B.M.2
-
35
-
-
54449088740
-
Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
-
Blackburn SD, Shin H, Freeman GJ, et al. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc Natl Acad Sci USA. 2008;105:15016-15021.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15016-15021
-
-
Blackburn, S.D.1
Shin, H.2
Freeman, G.J.3
-
36
-
-
55749102699
-
Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
-
Lichterfeld M, Mou D, Cung TD, et al. Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood. 2008; 112:3679-3687.
-
(2008)
Blood
, vol.112
, pp. 3679-3687
-
-
Lichterfeld, M.1
Mou, D.2
Cung, T.D.3
-
37
-
-
44649188658
-
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
-
1937, e1921-e1922
-
Nakamoto N, Kaplan DE, Coleclough J, et al. Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology. 2008;134:1927-1937, 1937 e1921-e1922.
-
(2008)
Gastroenterology
, vol.134
, pp. 1927-1937
-
-
Nakamoto, N.1
Kaplan, D.E.2
Coleclough, J.3
-
38
-
-
39849088117
-
Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
-
Urbani S, Amadei B, Tola D, et al. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment. J Hepatol. 2008;48:548-558.
-
(2008)
J Hepatol
, vol.48
, pp. 548-558
-
-
Urbani, S.1
Amadei, B.2
Tola, D.3
-
39
-
-
33744994084
-
Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade
-
Yao S, Chen L. Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade. Trends Mol Med. 2006;12:244-246.
-
(2006)
Trends Mol Med
, vol.12
, pp. 244-246
-
-
Yao, S.1
Chen, L.2
-
40
-
-
58149339765
-
B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection
-
Wang X, Zhang Z, Zhang S, et al. B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection. Eur J Immunol. 2008;38:3226-3236.
-
(2008)
Eur J Immunol
, vol.38
, pp. 3226-3236
-
-
Wang, X.1
Zhang, Z.2
Zhang, S.3
-
41
-
-
34249979761
-
Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients
-
Rosignoli G, Cranage A, Burton C, et al. Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients. AIDS. 2007;21:1379-1381.
-
(2007)
AIDS
, vol.21
, pp. 1379-1381
-
-
Rosignoli, G.1
Cranage, A.2
Burton, C.3
-
43
-
-
56049087551
-
Anti-tumor immunotherapy by blockade of the PD-1/PD-L1 pathway with recombinant human PD-1-IgV
-
Zhang C, Wu S, Xue X, et al. Anti-tumor immunotherapy by blockade of the PD-1/PD-L1 pathway with recombinant human PD-1-IgV. Cytotherapy. 2008;10:711-719.
-
(2008)
Cytotherapy
, vol.10
, pp. 711-719
-
-
Zhang, C.1
Wu, S.2
Xue, X.3
-
44
-
-
34247532726
-
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
-
Nomi T, Sho M, Akahori T, et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res. 2007;13:2151-2157.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2151-2157
-
-
Nomi, T.1
Sho, M.2
Akahori, T.3
-
45
-
-
34848900497
-
Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
-
Wong RM, Scotland RR, Lau RL, et al. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol. 2007;19:1223-1234.
-
(2007)
Int Immunol
, vol.19
, pp. 1223-1234
-
-
Wong, R.M.1
Scotland, R.R.2
Lau, R.L.3
-
46
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005;65:1089-1096.
-
(2005)
Cancer Res
, vol.65
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
|