Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Bellistri, Giusi Maria ^a   Casabianca, Anna ^c   Merlini, Esther ^a   Orlandi, Chiara ^c   Ferrario, Giulio ^b   Meroni, Luca ^b   Galli, Massimo ^b   Magnani, Mauro ^c   D'Arminio Monforte, Antonella ^a   Marchetti, Giulia ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENFUVIRTIDE; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEIN BCL 2; PROTEINASE INHIBITOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAT5 PROTEIN; VIRUS RNA; ANTIVIRUS AGENT;

ADULT; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; STROMA CELL; VIREMIA; BLOOD; BONE MARROW CELL; CYTOLOGY; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; STEM CELL;

ADULT; ANTIVIRAL AGENTS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; INTERLEUKIN-7; MALE; MIDDLE AGED; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-7; STAT5 TRANSCRIPTION FACTOR; STEM CELLS;

EID: 79251477552     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015663     Document Type: Article

References (41)

1. Napolitano L, Grant R, Deeks S, Schmidt D, De Rosa S, et al. (2001) Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature Medicine 7: 73-79.
2. Okamoto Y, Douek DC, McFarland RD, Koup RA (2002) Effects of exogenous interleukin-7 on human thymus function. Blood 99: 2851-2858.
3. Schluns KS, Kieper WC, Jameson SC, Lefrancois L (2000) Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 1: 426-432.
4. Tan J, Dudl E, LeRoy E, Murray R, Sprent J, et al. (2001) IL-7 is critical for homeostatic proliferation and survival of naive T cells. PNAS 98: 8732-8737.
5. Fry T, Mackall C (2002) Interleukin-7: from bench to clinic. Blood 99: 3892-3904.
6. Alpdogan O, van den Brink MR (2005) IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends Immunol 26: 56-64.
7. Bolotin E, Annett G, Parkman R, Weinberg K (1999) Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 23: 783-788.
8. Fry T, Connick E, Falloon J, Lederman M, Liewehr D, et al. (2001) A potential role for interleukin-7 in T-cell homeostasis. Blood 97: 2983-2990.
9. Colle JH, Moreau JL, Fontanet A, Lambotte O, Joussemet M, et al. (2006) Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-effects of antiretroviral therapy. J Acquir Immune Defic Syndr 42: 277-285.
10. Colle JH, Moreau JL, Fontanet A, Lambotte O, Delfraissy JF, et al. (2007) The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients. Aids 21: 101-103.
11. Rethi B, Fluur C, Atlas A, Krzyzowska M, Mowafi F, et al. (2005) Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. Aids 19: 2077-2086.
12. Dragsted UB, Mocroft A, Vella S, Viard JP, Hansen AB, et al. (2004) Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study. J Infect Dis 190: 148-155.
13. Nicastri E, Chiesi A, Angeletti C, Sarmati L, Palmisano L, et al. (2005) Clinical outcome after 4 years follow-up of HIV-seropositive subjects with incomplete virologic or immunologic response to HAART. J Med Virol 76: 153-160.
14. Grabar S, Le Moing V, Goujard C, Leport C, Kazatchkine M, et al. (2000) Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann Intern Med 133: 401-410.
15. Tan R, Westfall AO, Willig JH, Mugavero MJ, Saag MS, et al. (2008) Clinical outcome of HIV-infected antiretroviral-naive patients with discordant immunologic and virologic responses to highly active antiretroviral therapy. J Acquir Immune Defic Syndr 47: 553-558.
16. Bazdar DA, Kalinowska M, Sieg SF (2009) Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging. J Infect Dis 199: 1019-1028.
17. Camargo JF, Kulkarni H, Agan BK, Gaitan AA, Beachy LA, et al. (2009) Responsiveness of T cells to interleukin-7 is associated with higher CD4+ T cell counts in HIV-1-positive individuals with highly active antiretroviral therapyinduced viral load suppression. J Infect Dis 199: 1872-1882.
18. Isgro A, Leti W, De Santis W, Marziali M, Esposito A, et al. (2008) Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART. Clin Infect Dis 46: 1902-1910.
19. Badolato R (2008) Immunological nonresponse to highly active antiretroviral therapy in HIV-infected subjects: is the bone marrow impairment causing CD4 lymphopenia? Clin Infect Dis 46: 1911-1912.
20. MacPherson J, Fex C, Sanchez-Dardon J, Hawley-Foss N, Angel J (2001) Interleukin-7 receptor expression on CD8+ T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy. JAIDS 28: 454-457.
21. Sasson SC, Zaunders JJ, Zanetti G, King EM, Merlin KM, et al. (2006) Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis 193: 505-514.
22. Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, et al. (2004) Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21: 289-302.
23. Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, et al. (2005) Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals. J Immunol 174: 2900-2909.
24. Mercier F, Boulassel MR, Yassine-Diab B, Tremblay C, Bernard NF, et al. (2008) Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets. Clin Exp Immunol 152: 72-80.
25. Faller EM, McVey MJ, Kakal JA, MacPherson PA (2006) Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein. J Acquir Immune Defic Syndr 43: 257-269.
26. Weber R, Sabin CA, Friis-Moller N, Reiss P, El-Sadr WM, et al. (2006) Liverrelated deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med 166: 1632-1641.
27. Baker JV, Peng G, Rapkin J, Abrams DI, Silverberg MJ, et al. (2008) CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. Aids 22: 841-848.
28. Levy Y, Lacabaratz C, Weiss L, Viard JP, Goujard C, et al. (2009) Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 119: 997-1007.
29. Sereti I, Dunham RM, Spritzler J, Aga E, Proschan MA, et al. (2009) IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 113: 6304-6314.
30. Colle JH, Moreau JL, Fontanet A, Lambotte O, Joussemet M, et al. (2006) CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients-reversal by highly active anti-retroviral therapy (HAART). Clin Exp Immunol 143: 398-403.
31. Gazzola L, Tincati C, Bellistri GM, Monforte A, Marchetti G (2009) The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options. Clin Infect Dis 48: 328-337.
32. Moses A, Nelson J, Bagby GC, Jr. (1998) The influence of human immunodeficiency virus-1 on hematopoiesis. Blood 91: 1479-1495.
33. De Luca A, Teofili L, Antinori A, Iovino MS, Mencarini P, et al. (1993) Haemopoietic CD34+ progenitor cells are not infected by HIV-1 in vivo but show impaired clonogenesis. Br J Haematol 85: 20-24.
34. Bahner I, Kearns K, Coutinho S, Leonard EH, Kohn DB (1997) Infection of human marrow stroma by human immunodeficiency virus-1 (HIV-1) is both required and sufficient for HIV-1-induced hematopoietic suppression in vitro: demonstration by gene modification of primary human stroma. Blood 90: 1787-1798.
35. Isgro A, De Vita L, Mezzaroma I, Aiuti A, Aiuti F (1999) Recovery of haematopoietic abnormalities in HIV-1 infected patients treated with HAART. Aids 13: 2486-2488.
36. Douek DC (2003) Disrupting T-cell homeostasis: how HIV-1 infection causes disease. AIDS Rev 5: 172-177.
37. Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT () IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL- 7Ralpha in T cells. Blood 115: 3269-3277.
38. Kohler JJ, Tuttle DL, Coberley CR, Sleasman JW, Goodenow MM (2003) Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. J Leukoc Biol 73: 407-416.
39. Bovolenta C, Camorali L, Lorini AL, Ghezzi S, Vicenzi E, et al. (1999) Constitutive activation of STATs upon in vivo human immunodeficiency virus infection. Blood 94: 4202-4209.
40. Neuhaus T, Stier S, Totzke G, Gruenewald E, Fronhoffs S, et al. (2003) Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation. Cell Prolif 36: 75-86.
41. Schmittgen TD, Zakrajsek BA (2000) Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J Biochem Biophys Methods 46: 69-81.