A grape seed procyanidin extract ameliorates fructose-induced hypertriglyceridemia in rats via enhanced fecal bile acid and cholesterol excretion and inhibition of hepatic lipogenesis

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Downing, Laura E ^a   Heidker, Rebecca M ^a   Caiozzi, Gianella C ^a,b   Wong, Brian S ^a   Rodriguez, Kelvin ^a   Del Rey, Fernando ^a   Ricketts, Marie Louise ^a  

^a UNIVERSITY OF NEVADA   (United States)

^b Hospital de Urgencia Asistencia Pública Doctor Alejandro del Rio   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; BILE ACID; CHOLESTEROL; PROCYANIDIN; STEAROYL COENZYME A DESATURASE 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; BIFLAVONOID; CATECHIN; FRUCTOSE; GRAPE SEED EXTRACT; PROANTHOCYANIDIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; ESTERIFICATION; GENE EXPRESSION REGULATION; HYPERTRIGLYCERIDEMIA; LIPID STORAGE; LIPOGENESIS; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIET; DRUG EFFECTS; FECES; GENETICS; LIVER; METABOLISM; ORGAN SIZE; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; BIFLAVONOIDS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; BODY WEIGHT; CATECHIN; CHOLESTEROL; DIET; FECES; FRUCTOSE; GENE EXPRESSION REGULATION; GRAPE SEED EXTRACT; HYPERTRIGLYCERIDEMIA; HYPOLIPIDEMIC AGENTS; LIPOGENESIS; LIVER; MALE; ORGAN SIZE; PROANTHOCYANIDINS; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 84948983793     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140267     Document Type: Article

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