An MRI study of cerebellar vermis morphology in patients with schizophrenia: Evidence in support of the cognitive dysmetria concept

Biological Psychiatry

Volumn 46, Issue 5, 1999, Pages 703-711

  Nopoulos, Peg C ^a   Ceilley, John W ^a   Gailis, Elizabeth A ^a   Andreasen, Nancy C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cerebellar vermis; Cerebellum; Cognition; Cognitive dysmetria; MRI; Schizophrenia

Indexed keywords

ARTICLE; CEREBELLUM; CEREBELLUM VERMIS; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FRONTAL LOBE; HEMISPHERE; HUMAN; MALE; MORPHOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADOLESCENT; ADULT; CEREBELLUM; COGNITION DISORDERS; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; SCHIZOPHRENIA;

EID: 0032814417     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00093-1     Document Type: Article

References (69)

1. Anand B., Malhotra C., Singh B., Dua A. Cerebellar projections to limbic system. J Neurophysiol. 22:1959;451-457.
2. Andreasen N.C. The Scale for the Assessment of Negative Symptoms (SANS). 1983;The University of Iowa, Iowa City, Iowa.
3. Andreasen N.C. The Scale for the Assessment of Positive Symptoms (SAPS). 1984;The University of Iowa, Iowa City, Iowa.
4. Andreasen N.C., Flaum M., Arndt S. The Comprehensive Assessment of Symptoms and History (CASH) an instrument for assessing psychopathology and diagnosis . Arch Gen Psychiatry. 49:1992;615-623.
5. Andreasen N, Flashman L, Flaum M, Arndt S, Swayze V.n. O'Leary D, et al (1994): Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272:1763-1769.
6. Andreasen N.C., Arndt S., Swayze V., Cizadlo T., Flaum M., O'Leary D., et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science. 266:1994;294-298.
7. Andreasen N.C., O'Leary D.S., Arndt S., Cizadlo T., Hurtig R., Rezai K., et al. Short-term and long-term verbal memory a positron emission tomography study . Proc Natl Acad Sci USA. 92:1995;5111-5115.
8. Andreasen N.C., O'Leary D.S., Cizadlo T., Arndt S., Rezai K., Watkins G.L., et al. PET studies of memory novel versus practiced free recall of word lists . NeuroImage. 2:1995;296-305.
9. Andreasen N.C., O'Leary D.S., Cizadlo T., Arndt S., Rezai K., Watkins G.L., et al. Remembering the past two facets of episodic memory explored with positron emission tomography . Am J Psychiatry. 152:1995;1576-1585.
10. Andreasen N.C., Swayze V., O'Leary D.S., Nopoulos P., Cizadlo T., Harris G., et al. Abnormalities in midline attentional circuitry in schizophrenia evidence from magnetic resonance and positron emission tomography . Eur Neuropsychopharmacol. 5:(Suppl):1995;37-41.
11. Andreasen N.C., O'Leary D.S., Arndt S., Cizadlo T., Hurtig R., Rezai K., et al. Neural substrates of facial recognition. J Neuropsychiatry Clin Neurosci. 8:1996;139-146.
12. Andreasen N.C., O'Leary D.S., Cizadlo T., Arndt S., Rezai K., Ponto L.L.B., et al. Schizophrenia and cognitive dysmetria a PET study of dysfunctional and prefrontal-thalamic-cerebellar circuitry . Proc Natl Acad Sci. 93:1996;9985-9990.
13. Andreasen N.C., Rajarethinam R., Cizadlo T., Arndt S., Swayze V.W. II, Flashman L.A., et al. Automatic atlas-based volume estimation of human brain regions from MR imaging. J Comput Assist Tomogr. 20:1996;98-106.
14. Andreasen N.C., O'Leary D.S., Flaum M., Nopoulos P., Watkins G.L., Ponto L.L.B., et al. "Hypofrontality" in schizophrenia distributed dysfunctional circuits in neuroleptic naive patients . Lancet. 349:1997;1730-1734.
15. Andreasen N.C., Paradiso S., O'Leary D.S. Cognitive dysmetria as an integrative theory of schizophrenia a dysfunction in cortical-cerebellar circuity? Schizophr Bull. 24:1998;203-218.
16. Arndt S., Swayze V., Cizadlo T., O'Leary D.S., Cohen G., Yuh W.T.C., et al. Evaluating and validating two methods for estimating brain structure volumes tesselation and simple pixel counting . NeuroImage. 1:1994;191-198.
17. Aylward E.H., Reiss A., Barta P., Tien A., Han W., Lee J., Pearlson G. Magnetic Resonance Imaging measurement of posterior fossa structures in schizophrenia. Am J Psychiatry. 151:1994;1448-1452.
18. Barkovich A.J., Kjow B.O., Norman D., Edwards M.S. Revised classification of posterior fossa cysts and cystlike malformations based on the results of multiplanar MR imaging. AJNR. 10:1989;977-988.
19. Berquin P.C., Giedd J.N., Jacobsen L.K., Hamburger S.D., Krain A.L., Rapoport J.L., Castellanos F.X. The cerebellum in attention-deficit/hyperactivity disorder a morphometric MRI study . Neurology. 50:1998;1087-1093.
20. Coffman J., Schwarzkopf S., Olson S., Nasrallah H. Midsagittal cerebral anatomy by magnetic resonance imaging the importance of slice position and thickness . Schizophren Res. 2:1989;287-294.
21. Collins D.L., Neelin P., Peters T.M., Evans A.C. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr. 18:1994;192-205.
22. Courchesne E., Yeung-Courchesne R., Press G.A., Hesselink J.R., Jernigan T. Hypoplasia of cerebellar vermal lobes VI and VII in autism. New Engl J Med. 318:1998;1349-1354.
23. Creutzfeldt O., Ojemann G., Lettich E. Neuronal activity in the human lateral temporal lobe I responses to speech . Exp Brain Res. 77:1989;451-475.
24. Creutzfeldt O., Ojemann G., Lettich E. Neuronal activity in the human lateral temporal lobe II responses to the subjects own voice . Exp Brain Res. 77:1989;476-489.
25. Dewan M., Pandurangi A., Lee S., Ramachandran T., Levy B., Boucher M., et al. Cerebellar morphology in chronic schizophrenic patients a controlled computed tomographic study . Psychiatry Res. 10:1983;97-103.
26. Dow R.S. Some novel concepts of cerebellar physiology. Mt Sinai J Med (NY). 41:1974;103-120.
27. Flaum M., Swayze V. 2nd, O'Leary D., Yugh W., Ehrhardt J., Arndt S., et al. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am J Psychiatry. 152:1995;704-714.
28. Geschwind N (1965): Disconnexion syndromes in animals and man. Brain 88:237-294, 585-564.
29. Harper J., Heath R. Anatomic connections of the fastigial nucleus to the rostral forebrain in the cat. Exp Neurol. 39:1973;285-292.
30. Heath R.G., Franklin D.E., Shraberg D. Gross pathology of the cerebellum in patients diagnosed and treated as functional psychiatric disorders. J Nerv Ment Dis. 167:1979;585-592.
31. Holcolmb H.H., Cascella N.G., Thaker G.K., Medoff D.R., Dannals R.F., Tamminga C.A. Functional sites of neuroleptic drug action in the human brain PET/FDG studies with and without haloperidol . Am J Psychiatry. 153:1996;41-48.
32. Jacobsen L.K., Giedd J.N., Berquin P.C., Krain A.L., Hamburger S.D., Kumra S., Rapoport J.L. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am J Psychiatry. 154:1997;1663-1669.
33. Johnson V.P., Swayze V.W. II, Sato Y., Andreasen N.C. Fetal alcohol syndrome craniofacial and central nervous system manifestations . Am J Med Genet. 61:1996;329-339.
34. Kollias S., Ball W. Jr, Prenger E. Cystic malformations of the posterior fossa differential diagnosis clarified through embryologic analysis . RadioGraphics. 13:1993;1211-1231.
35. Kwon J.S., Shenton M.E., Hirayasu Y., Salisbury D.F., Fischer I.A., Dickey C.C., et al. MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder. Am J Psychiatry. 155:1998;509-515.
36. Leiner H.C., Leiner A.L., Dow R.S. The human cerebro-cerebellar system its computing, cognitive, and language skills . Behav Brain Res. 44:1991;113-128.
37. Leiner H.C., Leiner A.L., Dow R.S. Cognitive and language functions of the human cerebellum. Trends Neurosci. 16:1993;444-447.
38. Leiner H., Leiner A., Dow R. Underestimated cerebellum. Hum Brain Mapp. 2:1995;244-245.
39. Lippman S., Manoochehr M., Baldwin H., Drasin G., Rice J., Alrajeh S. Cerebellar vermis dimensions on computerized tomographic scans of schizophrenic and bipolar patients. Am J Psychiatry. 139:1982;667-668.
40. Mathew R., Partain C. Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients. Am J Psychiatry. 142:1985;970-971.
41. Middleton F.A., Strick P.L. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science. 266:1994;458-461.
42. Middleton F.A., Strick P.L. Cerebellar output motor and cognitive channels . Trends Cognit Sci. 2:1998;338-347.
43. Miller D.D., Rezai K., Alliger R., Andreasen N.C. The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography . Biol Psychiatry. 41:1997;550-559.
44. Mostofsy S.H., Mazzocco M.M., Aakalu G., Warsofsky I.S., Denckla M.B., Reiss A.L. Decreased cerebellar posterior vermis size in fragile X syndrome correlations with neurocognitive performance . Neurology. 50:1998;546-551.
45. Nasrallah H.A., Jacoby C.G., McCalley-Whitters M. Cerebellar atrophy in schizophrenia and mania. Lancet. I:1981;1102.
46. Nasrallah H.A., McCalley-Whitters M., Jacoby C.G. Cortical atrophy in schizophrenia and mania a comparative CT study . J Clin Psychiatry. 43:1982;439-441.
47. Nasrallah H., Schwarzkopf S., Olson S., Coffman J. Perinatal brain injury and cerebellar vermal lobules I-X in schizophrenia. Biol Psychiatry. 29:1991;567-574.
48. Nopoulos P., Torres I., Flaum M., Andreasen N., Ehrhardt J., Yuh W. Brain morphology in first-episode schizophrenia. Am J Psychiatry. 152:1995;1721-1723.
49. Nopoulos P., Swayze V., Flaum M., Ehrhardt J., Yuh W.T.C., Andreasen N.C. Cavum Septi Pellucidi in normals and patients with schizophrenia as detected by MRI. Biol Psychiatry. 41:1997;1102-1108.
50. Nopoulos P.C., Flaum M., Andreasen N.C. Sex differences in brain morphology in schizophrenia. Am J Psychiatry. 154:1997;1648-1654.
51. Paradiso S., Andreasen N., O'Leary D., Arndt S., Robinson R. Cerebellar size and cognition correlations with IQ, verbal memory, and motor dexterity . Neuropsychiatry Neuropsychol Behav Neurol. 10:1997;1-8.
52. Renier D., Arnaud E., Cinalli G., Sebag G., Zerah M., Marchac D. Prognosis for mental function in Apert's syndrome. J Neurosurg. 85:1996;66-72.
53. Reyes M., Gordon A. Cerebellar vermis in schizophrenia. Lancet. 2:1981;700-701.
54. Rossi A., Stratta P., Mancini F., de Cataldo S., Casacchia M. Cerebellar vermal size in schizophrenia a male effect . Biol Psychiatry. 33:1993;354-357.
55. Sandyk R., Kay S.R., Merriam A.E. Atrophy of the cerebellar vermis relevance to the symptoms of schizophrenia . Int J Neurosci. 57:1991;205-212.
56. Schmahmann J. An emerging concept the cerebellar contribution to higher function . Arch Neurol. 48:1991;1178-1187.
57. Schmahmann J.D., Pandya D.N. Projections to the basis pontis from the superior temporal sulcus (STS) in the rhesus monkey. J Comp Neurol. 308:1991;224-248.
58. Schmahmann J.D., Pandya D.N. Prefrontal cortex projections to the basilar pons implications for the cerebellar congribution to higher function . Neurosci Lett. 199:1995;175-178.
59. Snider R., Maiti A. Septal afterdischarges and their modification by the cerebellum. Exp Neurol. 49:1975;529-539.
60. Snider R., Maiti A., Snider S. Cerebellar pathways to ventral midbrain and nigra. Exp Neurol. 53:1976;714-728.
61. Snider S., Snider R. Alterations in forebrain catecholamine metabolism produced by cerebellar lesions in the rat. J Neural Trans. 40:1977;115-128.
62. Sowell E.R., Jernigan T.L., Mattson S.N., Riley E.P., Sobel D.F., Jones K.L. Abnormal development of the cerebellar vermis in children prenatally exposed to alcohol size reduction in lobules I-V . Alcohol Clin Exp Res. 20:1996;31-34.
63. Swayze V.W., Johnson V.P., Hanson J.W., Piven J., Sato Y., Giedd J.N., et al. Magnetic resonance imaging of brain anomalies in fetal alcohol syndrome. Pediatrics. 99:1997;232-340.
64. Tibbo P., Nopoulos P., Arndt S., Andreasen N.C. Corpus callosum shape and size in male patients with schizophrenia. Biol Psychiatry. 44:1998;405-412.
65. Tran K.D., Smutzer G.S., Doty R.L., Arnold S.E. Reduced purkinje cell size in cerebellar vermis of elderly patients with schizophrenia. Am J Psychiatry. 155:1998;1288-1290.
66. Victor M., Adams R.D., Mancall E.L. A restricted form of cerebellar cortical degeneration occurring in alcoholic patients. Arch Neurol. 1:1959;579-688.
67. Volkow N., Levy A., Brodie J., Wolf A., Cancro R., Van Gelder P., et al. Low cerebellar metabolism in medicated patients with chronic schizophrenia. Am J Psychiatry. 149:1992;686-688.
68. Weinberger D., Torrey E., Wyatt R. Cerebellar atrophy in chronic schizophrenia. Lancet. 1:1979;718-719.
69. Weinberger D., Kleinmann J., Luchins D., Bigelow L., Wyatt R. Cerebellar pathology in schizophrenia a controlled postmortem study . Am J Psychiatry. 137:1980;359-361.