Involvement of cerebellum in emotional behavior

Physiological Research

Volumn 60, Issue SUPPL.1, 2011, Pages

  Strata, P ^a   Scelfo, B ^a   Sacchetti, B ^a,b  

^a National Institute of Neuroscience Italy   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Cerebellum; Fear conditioning; Learning and memory; LTP LTD; Purkinje cell

Indexed keywords

ANIMAL; ANIMAL BEHAVIOR; CEREBELLUM; EMOTION; FEAR; HUMAN; LEARNING; NERVE CELL PLASTICITY; NERVE TRACT; PHYSIOLOGY; RECALL; REVIEW; SYNAPTIC TRANSMISSION;

ANIMALS; BEHAVIOR, ANIMAL; CEREBELLUM; EMOTIONS; FEAR; HUMANS; LEARNING; MENTAL RECALL; NEURAL PATHWAYS; NEURONAL PLASTICITY; SYNAPTIC TRANSMISSION;

EID: 84856593486     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (79)

1. ALBUS JS. A theory of cerebellar function. Math Biosci 10: 25-61, 1971.
2. ATTWELL PJ, COOKE SF, YEO CH. Cerebellar function in consolidation of a motor memory. Neuron 34: 1011-1020, 2002.
3. BAST T, ZHANG WN, FELDON J. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Exp Brain Res 139: 39-52, 2001.
4. BERNTSON GG, TORELLO MW. The paleocerebellum and the integration of behavioural function. Physiol Psychol 10: 2-12, 1982.
5. BERTHIER NE, MOORE JW. Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Exp Brain Res 63: 341-350, 1986.
6. BLISS TV, LØMO T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331-356, 1973.
7. BLITZ DM, REGEHR WG. Timing and specificity of feed-forward inhibition within the LGN. Neuron 45: 917-928, 2005.
8. CAREW TJ, WALTERS ET, KANDEL ER. Associative learning in Aplysia: cellular correlates supporting a conditioned fear hypothesis. Science 211: 501-504, 1981.
9. CLUGNET MC, LEDOUX JE. Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci 10: 2818-2824, 1990.
10. CONQUET F, BASHIR ZI, DAVIES CH, DANIEL H, FERRAGUTI F, BORDI F, FRANZ-BACON K, REGGIANI A, MATARESE V, CONDÉ F, COLLINGRIDGE GL, CRÉPEL F. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372: 237-243, 1994.
11. CUDMORE RH, TURRIGIANO GG. Long-term potentiation of intrinsic excitability in LV visual cortical neurons. J Neurophysiol 92: 341-348, 2004.
12. DAMASIO AR, GRABOWSKI TJ, BECHARA A, DAMASIO H, PONTO LL, PARVIZI J, HICHWA RD. Subcortical and cortical brain activity during the feeling of self-generated emotions. Nat Neurosci 3: 1049-1056, 2000.
13. DE ZEEUW CI, SIMPSON JI, HOOGENRAAD CC, GALJART N, KOEKKOEK SK, RUIGROK TJ. Microcircuitry and function of the inferior olive. Trends Neurosci 21: 391-400, 1998.
14. DOW RS, MORUZZI G. The Physiology and Pathology of the Cerebellum. University of Minnesota Press, Minneapolis, 1958.
15. ECCLES JC, ITO M, SZENTÀGOTHAI. The Cerebellum as a Neuronal Machine. Springer, Berlin, 1967a
16. ECCLES JC, SASAKI K, STRATA P. A comparison of the inhibitory actions of Golgi cells and of basket cells. Exp Brain Res 3: 81-94, 1967b.
17. FANSELOW MS, KIM JJ, YIPP J, DE OCA B. Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav Neurosci 108: 235-240, 1994.
18. FISCHER H, ANDERSSON JL, FURMARK T, FREDRIKSON M. Fear conditioning and brain activity: a positron emission tomography study in humans. Behav Neurosci 114: 671-680, 2000.
19. FLOURENS P. Recherches Expérimentales sur les Propriétés et les Fonctions du Système Nerveux dans les Animaux Vertébrés. Crevot, Paris, 1824. English translation in CLARKE E, O'MALLEY C: The Human Brain and Spinal Cord, University of California Press, Berkeley and Los Angeles, pp 657-661, 1968.
20. FUNABIKI K, MISHINA M, HIRANO T. Retarded vestibular compensation in mutant mice deficient in delta 2 glutamate receptor subunit. Neuroreport 7: 189-192, 1995.
21. GLICKSTEIN M, STRATA P, VOOGD J. Cerebellum: history. Neuroscience 162: 549-559, 2009.
22. GOOSSENS J, DANIEL H, RANCILLAC A, VAN DER STEEN J, OBERDICK J, CRÉPEL F, DE ZEEUW CI, FRENS MA. Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affecting Purkinje cell excitability in alert mice. J Neurosci 21: 5813-5823, 2001.
23. GOULD TJ, STEINMETZ JE. Changes in rabbit cerebellar cortical and interpositus nucleus activity during acquisition, extinction, and backward classical eyelid conditioning. Neurobiol Learn Mem 65: 17-34, 1996.
24. HIRANO T, KASONO K, ARAKI K, MISHINA M. Suppression of LTD in cultured Purkinje cells deficient in the glutamate receptor delta 2 subunit. Neuroreport 6: 524-526, 1995.
25. HOLMES G. The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 4: 461-535, 1917.
26. ITO M. The Cerebellum and Neural Control. Raven Press, New York, 1984.
27. ITO M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81: 1143-1195, 2001.
28. IVANOVA SF, BURES J. Conditioned taste aversion is disrupted by prolonged retrograde effects of intracerebral injection of tetrodotoxin in rats. Behav Neurosci 104: 948-954, 1990.
29. KIM JJ, FANSELOW MS. Modality-specific retrograde amnesia of fear. Science 256: 675-677, 1992.
30. LANG EJ, PARÉ D. Similar inhibitory processes dominate the responses of cat lateral amygdaloid projection neurons to their various afferents. J Neurophysiol 77: 341-352, 1997.
31. LEDOUX JE. Emotion, memory and the brain. Sci Am 270: 50-57, 1994.
32. LEDOUX JE. Emotion circuits in the brain. Annu Rev Neurosci 23: 155-184, 2000.
33. LEV-RAM V, WONG ST, STORM DR, TSIEN RY. A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proc Natl Acad Sci USA 99: 8389-8393, 2002.
34. LEVY WB, STEWARD O. Synapses as associative memory elements in the hippocampal formation. Brain Res 175: 233-245, 1979.
35. LI XF, ARMONY JL, LEDOUX JE. GABAA and GABAB receptors differentially regulate synaptic transmission in the auditory thalamo-amygdala pathway: an in vivo microiontophoretic study and a model. Synapse 24: 115-124, 1996.
36. LUCIANI L. Il Cervelletto: Nuovi Studi di Fisiologia Normale e Patologica. Le Monnier, Firenze, 1891.
37. MARDER E, ABBOTT LF, TURRIGIANO GG, LIU Z, GOLOWASCH J. Memory from the dynamics of intrinsic membrane currents. Proc Natl Acad Sci USA 93: 13481-13486, 1996.
38. MAREN S. Synaptic transmission and plasticity in the amygdala. An emerging physiology of fear conditioning circuits. Mol Neurobiol 13: 1-22, 1996.
39. MAREN S. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24: 897-931, 2001.
40. MARR D. A theory of cerebellar function. J Physiol 202: 437-470, 1969.
41. MASCHKE M, SCHUGENS M, KINDSVATER K, DREPPER J, KOLB FP, DIENER HC, DAUM I, TIMMANN D. Fear conditioned changes of heart rate in patients with medial cerebellar lesions. J Neurol Neurosurg Psychiatry 72:116-118, 2002.
42. MATSUDA S, MIKAWA S, HIRAI H. Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein. J Neurochem 73: 1765-1768, 1999.
43. MITTMANN W, KOCH U, HAUSSER M. Feed-forward inhibition shapes the spike output of cerebellar Purkinje cells. J Physiol 563: 369-378, 2005.
44. MIYATA M, FINCH EA, KHIROUG L, HASHIMOTO K, HAYASAKA S, ODA SI, INOUYE M, TAKAGISHI Y, AUGUSTINE GJ, KANO M. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28: 233-244, 2000.
45. MORUZZI G. Sur les rapports entre le paléocervelet et le réflexes vasomoteurs. Ann Physiol 14: 605-612, 1938.
46. ODA Y, KAWASAKI K, MORITA M, KORN H, MATSUI H. Inhibitory long-term potentiation underlies auditory conditioning of goldfish escape behaviour. Nature 394: 182-185, 1998.
47. PLOGHAUS A, TRACEY I, GATI JS, CLARE S, MENON RS, MATTHEWS PM, RAWLINS JN. Dissociating pain from its anticipation in the human brain. Science 284: 1979-1981, 1999.
48. PLOGHAUS A, TRACEY I, CLARE S, GATI JS, RAWLINS JN, MATTHEWS PM. Learning about pain: the neural substrate of the prediction error for aversive events. Proc Natl Acad Sci USA 97: 9281-9286, 2000.
49. PLOGHAUS A, BECERRA L, BORRAS C, BORSOOK D. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci 7: 197-200, 2003.
50. POUILLE F, SCANZIANI M. Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science 293: 1159-1163, 2001.
51. ROLANDO L. Saggio sopra le vera struttura del cervello dell'uomo e degli animali e sopra le funzioni del sistema nervoso. Sassari: Stamperia da S.S.R.M., 1809.
52. ROLANDO L. Expériences sur les fonctions du système nerveux. J de Physiol expér 3: 95-113, 1823.
53. SAAB CY, WILLIS WD. The cerebellum: organization, functions and its role in nociception. Brain Res Brain Res Rev 42: 85-95, 2003.
54. SAAR D, BARKAI E. Long-term modifications in intrinsic neuronal properties and rule learning in rats. Eur J Neurosci 17: 2727-2734, 2003.
55. SACCHETTI B, BALDI E, LORENZINI CA, BUCHERELLI C. Cerebellar role in fear-conditioning consolidation. Proc Natl Acad Sci USA 99: 8406-8411, 2002.
56. SACCHETTI B, SCELFO B, TEMPIA F, STRATA P. Long-term synaptic changes induced in the cerebellar cortex by fear conditioning. Neuron 42: 973-982, 2004.
57. SACCHETTI B, SCELFO B, STRATA P. The cerebellum: synaptic changes and fear conditioning. Neuroscientist 11: 217-227, 2005.
58. SACCHETTI B, SCELFO B, STRATA P. Cerebellum and emotional behavior. Neuroscience 162: 756-762, 2009.
59. SCELFO B, SACCHETTI B, STRATA P. Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex. Proc Natl Acad Sci USA 105: 769-774, 2008.
60. SCHMAHMANN JD, SHERMAN JC. The cerebellar cognitive affective syndrome. Brain 121: 561-579, 1998.
61. SCHMAHMANN JD, MACMORE J, VANGEL M. Cerebellar stroke without motor deficit: clinical evidence for motor and non-motor domains within the human cerebellum. Neuroscience 162: 852-861, 2009.
62. SCHREURS BG, ALKON DL. Rabbit cerebellar slice analysis of long-term depression and its role in classical conditioning. Brain Res 631: 235-240, 1993.
63. SCHREURS BG, TOMSIC D, GUSEV PA, ALKON DL. Dendritic excitability microzones and occluded long-term depression after classical conditioning of the rabbit's nictitating membrane response. J Neurophysiol 77: 86-92, 1997.
64. SCHREURS BG, GUSEV PA, TOMSIC D, ALKON DL, SHI T. Intracellular correlates of acquisition and long-term memory of classical conditioning in Purkinje cell dendrites in slices of rabbit cerebellar lobule HVI. J Neurosci 18: 5498-5507, 1998.
65. SINGER T, SEYMOUR B, O'DOHERTY J, KAUBE H, DOLAN RJ, FRITH CD. Empathy for pain involves the affective but not sensory components of pain. Science 303: 1157-1162, 2004.
66. SNIDER RS. Recent contribution to the anatomy and physiology of the cerebellum. Arch Neurol Psychiatry 64: 196-219, 1950.
67. SNIDER RS, MAITI A. Cerebellar contributions to the Papez circuit. J Neurosci Res 2: 133-146, 1976.
68. SNIDER RS, STOWELL A. Receiving areas of the tactile auditory and visual systems in the cerebellum. J Neurophysiol 7: 331-358, 1944.
69. STRATA P. David Marr's theory of cerebellar learning: 40 years later. J Physiol 587: 5519-5520, 2009.
70. STRICK PL, DUM RP, FIEZ JA. Cerebellum and nonmotor function. Annu Rev Neurosci 32: 413-434, 2009.
71. SUPPLE WF Jr, LEATON RN, FANSELOW MS. Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats. Physiol Behav 39: 579-586, 1987.
72. SUPPLE WF, LEATON RN. Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats. Behav Neurosci 104: 934-947, 1990.
73. THOMPSON RF. The neurobiology of learning and memory. Science 233: 941-947, 1986.
74. THOMPSON RF. Neural mechanisms of classical conditioning in mammals. Philos Trans R Soc Lond B Biol Sci 2: 331-337, 1990.
75. THOMPSON LT, MOYER JR Jr, DISTERHOFT JF. Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation. J Neurophysiol 76: 1836-1849, 1996.
76. TURNER BM, PARADISO S, MARVEL CL, PIERSON R, BOLES PONTO LL, HICHWA RD, ROBINSON RG. The cerebellum and emotional experience. Neuropsychologia 45: 1331-1341, 2007.
77. WILTGEN BJ, SANDERS MJ, FERGUSON C, HOMANICS GE, FANSELOW MS. Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor. Learn Mem 12: 327-333, 2005.
78. ZHU L, SCELFO B, TEMPIA F, SACCHETTI B, STRATA P. Membrane excitability and fear conditioning in cerebellar Purkinje cell. Neuroscience 140: 801-810, 2006.
79. ZHU L, SCELFO B, HARTELL NA, STRATA P, SACCHETTI B. The effects of fear conditioning on cerebellar LTP and LTD. Eur J Neurosci 26: 219-227, 2007.