The cerebellum: Synaptic changes and fear conditioning

Neuroscientist

Volumn 11, Issue 3, 2005, Pages 217-227

  Sacchetti, Benedetto ^a   Scelfo, Bibiana ^a   Strata, Piergiorgio ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Cerebellar vermis; Fear conditioning; Learning and memory; LTP LTD; Parallel fiber; Purkinje cell

Indexed keywords

AUTONOMIC NERVOUS SYSTEM; BEHAVIOR; BRAIN REGION; CEREBELLUM; CEREBELLUM VERMIS; EMOTION; FEAR; HUMAN; MEMORY; MEMORY DISORDER; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; REVIEW; SYNAPTIC EFFICACY; SYNAPTIC POTENTIAL;

ANIMALS; CEREBELLUM; CONDITIONING (PSYCHOLOGY); EXCITATORY POSTSYNAPTIC POTENTIALS; FEAR; HUMANS; NEURAL NETWORKS (COMPUTER); SYNAPSES;

EID: 18844435658     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858405276428     Document Type: Review

References (62)

1. Albus JS. 1971. A theory of cerebellar function. Math Biosci 10:25-61.
2. Andersen BB, Korbo L, Pakkenberg B. 1992. A quantitative study of the human cerebellum with unbiased stereological techniques. J Comp Neurol 326:549-60.
3. Attwell PJ, Cooke SF, Yeo CH. 2002. Cerebellar function in consolidation of a motor memory. Neuron 34:1011-20.
4. Berntson GG, Torello MW. 1982. The paleocerebellum and the integration of behavioral function. Physiol Psychol 10:2-12.
5. Berthier NE, Moore JW. 1986. Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Exp Brain Res 63:341-50.
6. Bures J, Bermudez-Rattoni F, Yamamoto T. 1998. Conditioned taste aversion: memory of a special kind. Oxford (UK): Oxford University Press.
7. Carulli D, Buffo A, Strata P 2004. Reparative mechanisms in the cerebellar cortex. Prog Neurobiol 72:373-98.
8. Dahhaoui M, Caston J, Auvray N, Reber A. 1990. Role of the cerebellum in an avoidance conditioning task in the rat. Physiol Behav 47:1175-80.
9. Dahhaoui M, Stelz T, Caston J. 1992. Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat. J Comp Physiol 171:657-64.
10. Dow RS. 1942. The evolution and anatomy of the cerebellum. Biol Rev 17:179-220.
11. Dow RS, Moruzzi G. 1958. The physiology and pathology of the cerebellum. Minneapolis: University of Minnesota Press.
12. Guillaumin S, Dahhaoui M, Caston J. 1991. Cerebellum and memory: an experimental study in the rat using a passive avoidance conditioning test. Physiol Behav 49:507-11.
13. Heath RG, Rouchell, AM, Goethe JW. 1981. Cerebellar stimulation in treating intractable behavior disorders. Curr Psychiatr Ther 20:329-36.
14. Hitchcock J, Davis M. 1986. Lesions of the amygdale, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm. Behav Neurosci 100:11-22.
15. Ito M. 1984. The cerebellum and neural control. New York: Raven.
16. Ito M. 2001. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81:1143-95.
17. Kim JJ, Thompson RF. 1997. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci 20:177-81.
18. Leaton R. 2003. Fear and the cerebellum. Mol Psychiatry 8:461-2.
19. Leaton RN, Supple WF. 1986. Cerebellar vermis: essential for long-term habituation of the acoustic startle response. Science 232:513-15.
20. LeDoux JE. 2000. Emotion circuits in the brain. Annu Rev Neurosci 23:155-84.
21. Lev-Ram V, Wong ST, Storm DR, Tsien RG. 2002. A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proc Natl Acad Sci U S A 99:8389-93.
22. Lopiano L, de'Sperati C, Montarolo PG. 1990. Long-term habituation of the acoustic startle response: role of the cerebellar vermis. Neuroscience 35:79-84.
23. Maren S. 2001. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24:897-931.
24. Maren S, Holt WG. 2004. Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impairs the acquisition of conditional freezing to an auditory conditional stimulus. Behav Neurosci 118:97-110.
25. Marr D. 1969. A theory of cerebellar cortex. J Physiol 202:437-70.
26. Maschke M, Schugens M, Kindsvater K, Drepper J, Kolb FP, Diener HC, and others. 2002. Fear conditioned changes of heart rate in patients with medial cerebellar lesions. J Neurol Neurosurg Psychiatry 72:116-18.
27. McGaugh JL. 2000. Memory - a century of consolidation. Science 287:248-51.
28. McGaugh JL. 2004. The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 27:1-28.
29. McKernan MG, Shinnick-Gallagher P. 1997. Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 390:607-11.
30. Morando L, Cesa R, Rasetti R, Harvey R, Strata P. 2001. Role of glutamate delta-2 receptors in activity-dependent competition between heterologous afferent fibers. Proc Natl Acad Sci U S A 98:9954-9.
31. Nashold BS Jr, Wilson WP, Slaughter DG. 1969. Sensations evoked by stimulation in the midbrain of man. J Neurosurg 30:14-24.
32. Riedel G, Micheau J, Lam AG, Roloff EL, Martin SJ, Bridge H, and others. 1999. Reversible neural inactivation reveals hippocampal participation in several memory processes. Nat Neurosci 2:898-905.
33. Rogan MT, Staubli UV, LeDoux JE. 1997. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390:604-7.
34. Saab CY, Willis WD. 2003. The cerebellum: organization, functions and its role in nociception. Brain Res Rev 42:85-95.
35. Sacchetti B, Baldi E, Lorenzini CA, Bucherelli C. 2002. Cerebellar role in fear-conditioning consolidation. Proc Natl Acad Sci U S A 99:8406-11.
36. Sacchetti B, Baldi E, Lorenzini CA, Bucherelli C. 2003. Role of the neocortex in consolidation of fear conditioning memories in rats. Exp Brain Res 152:323-8.
37. Sacchetti B, Lorenzini CA, Baldi E, Bucherelli C, Roberto M, Tassoni G, Brunelli M. 2001. Long-lasting hippocampal potentiation and contextual memory consolidation. Eur J Neurosci 13:2291-8.
38. Sacchetti B, Lorenzini CA, Baldi E, Bucherelli C, Roberto M, Tassoni G, Brunelli M. 2002. Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat. Eur J Neurosci 15:143-50.
39. Sacchetti B, Lorenzini CA, Baldi E, Tassoni G, Bucherelli C. 1999. Auditory thalamus, dorsal hippocampus, basolateral amygdala, and perirhinal cortex role in the consolidation of conditioned freezing to context and to acoustic conditioned stimulus in the rat. J Neurosci 19:9570-8.
40. Sacchetti B, Scelfo B, Tempia F, Strata P. 2004. Long-term synaptic changes induced in the cerebellar cortex by fear conditioning. Neuron 42:973-82.
41. Salin P, Malenka RC, Nicoll RA. 1996. Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron 16:797-803.
42. Schmahmann JD, Sherman JC. 1998. The cerebellar cognitive affective syndrome. Brain 121:561-79.
43. Schreurs BG, Tomsic D, Gusev P, Alkon DL. 1997. Dendritic excitability microzones and occluded long-term depression after classical conditioning of the rabbit's nictitating membrane response. J Neurophysiol 77:86-92.
44. Schreurs BG, Tomsic D, Gusev PA, Alkon DL, Shi T. 1998. Intracellular correlates of acquisition and long-term memory of classical conditioning in Purkinje cell dendrites in slices of rabbit cerebellar lobule HVI. J Neurosci 18:5498-507.
45. Sears LL, Steinmetz JE. 1990. Acquisition of classically conditioned-related activity in the hippocampus is affected by lesions of the cerebellar interpositus nucleus. Behav Neurosci 104:681-92.
46. Sebastiani L, La Noce A, Paton JFR, Ghelarducci B. 1992. Influence of the cerebellar posterior vermis on the acquisition of the classically conditioned bradycardic response in the rabbit. Exp Brain Res 88:193-8.
47. Shadmehr R, Holcomb HH 1997. Neural correlates of motor memory consolidation. Science 277:821-5.
48. Snider RS. 1950. Recent contribution to the anatomy and physiology of the cerebellum. Arch Neurol Psychiatry 64:196-219.
49. Snider RS, Maiti A. 1976. Cerebellar contributions to the Papez circuit. J Neurosci Res 2:133-46.
50. Snider RS, Stowell A. 1944. Receiving areas of the tactile auditory and visual systems in the cerebellum. J Neurophysiol 7:331-58.
51. Strata P, Rossi F. 1998. Plasticity of the olivocerebellar pathway. Trends Neurosci 21:407-13.
52. Sultan F, Braitenberg V. 1993. Shapes and sizes of different mammalian cerebella. A study in quantitative comparative neuroanatomy. J Hirnforsch 34:79-92.
53. Supple WF, Cranney J, Leaton RN. 1988. Effects of lesions of the cerebellar vermis on VMH lesion-induced hyperdefensiveness, spontaneous mouse killing, and freezing in rats. Physiol Behav 42:145-53.
54. Supple WF, Kapp BS. 1993. The anterior cerebellar vermis: essential involvement in classically conditioned bradycardia in the rabbit. J Neurosci 13:3705-11.
55. Supple WF, Leaton RN. 1990. Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats. Behav Neurosci 104:934-47.
56. Supple WF, Leaton RN, Fanselow MS. 1987. Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats. Physiol Behav 39:579-86.
57. Supple WF, Sebastiani L, Kapp BS. 1993. Purkinje cell responses in the anterior cerebellar vermis during Pavlovian fear conditioning in the rabbit. Neuroreport 4:975-8.
58. Takatsuki K, Kawahara S, Kotani S, Fukunaga S, Mori H, Mishina M, Kirino Y. 2003. The hippocampus plays an important role in eye-blink conditioning with a short trace interval in glutamate receptor subunit delta 2 mutant mice. J Neurosci 23:17-22.
59. Thach WT. 1998. What is the role of the cerebellum in motor learning and cognition? Trends Cogn Sci 2:331-7.
60. Thompson RF. 1990. Neural mechanisms of classical conditioning in mammals. Philos Trans R Soc Lond B Biol Sci 329:161-70.
61. Yoshida M, Okamura I, Uematsu K. 2004. Involvement of the cerebellum in classical fear conditioning in goldfish. Behav Brain Res 153:143-8.
62. Yuzaki M. 2003. The delta2 glutamate receptor: 10 years later. Neurosci Res 46:11-22.