Down-regulation of a signaling mediator in association with lowered plasma arachidonic acid levels in individuals with autism spectrum disorders

Neuroscience Letters

Volumn 610, Issue , 2016, Pages 223-228

  Yui, Kunio ^a   Imataka, George ^b   Kawasaki, Yohei ^c   Yamada, Hiroshi ^c  

^a Ashiya University   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Arachidonic acid; Autism spectrum disorder; Competitive interaction; Eicosapentaenoic acid; Signaling mediators

Indexed keywords

5 HYDROPEROXY 6,8,11,14 ICOSATETRAENOIC ACID; ADRENIC ACID; ARACHIDONIC ACID; CERULOPLASMIN; SUPEROXIDE DISMUTASE; TRANSFERRIN; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID;

ADOLESCENT; ADULT; ARTICLE; AUTISM; BEHAVIOR DISORDER; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DOWN REGULATION; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; MALE; METABOLITE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCORING SYSTEM; SIGNAL TRANSDUCTION; BLOOD; CASE CONTROL STUDY; DIET; EATING; METABOLISM;

ADOLESCENT; ARACHIDONIC ACID; AUTISM SPECTRUM DISORDER; CASE-CONTROL STUDIES; CERULOPLASMIN; CHILD; DIET; DOCOSAHEXAENOIC ACIDS; DOWN-REGULATION; EATING; EICOSAPENTAENOIC ACID; FEMALE; HUMANS; MALE; SUPEROXIDE DISMUTASE; TRANSFERRIN;

EID: 84948784109     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.11.006     Document Type: Article

References (55)

1. Wong C., Crawford D.A. Lipid signaling in the pathology of autism spectrum disorders. Comprehensive Guide to Autism 2014, 1259-1283. Springer Publishing, New York (USA). V.B. Patel, V.R. Preedy, C.R. Martin (Eds.).
2. 2+ channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization. Biochim. Biophys. 2014, 1841:1210-1216.
3. Tamiji J., Crawford D.A. The neurobiology of lipid metabolism in autism spectrum disorders. Neurosignals 2010, 18:98-112.
4. Hawcroft G., Loadman P.M., Belluzzi A., Hull M.A. Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells. Neoplasia 2010, 618-627.
5. Gharami K., Das M., Das S. Essential role of docosahexaenoic acid towards development of a smarter brain. Neurochem. Int. 2015, S0197-0186(15) 30041-3. 10.1016/j.neuint.2015.08.014.
6. Vancassel S., Durand G., Barthélémy C., Lejeune B., Martineau J., Guilloteau D., Andrès C., Chalon S. Plasma fatty acid levels in autistic children. Prostaglandins Leukot. Essent. Fatty Acids 2001, 65:1-7.
7. El-Ansary A.K., Bacha A.G., Al-Ayahdi L.Y. Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Dis. 2011, http://www.ncbi.nlm.nihgov/pmc/articles/PMC3107801/.
8. Brigandi S.A., Shao H., Qian S.Y., Shen Y., Wu B.L. Kang: Autistic children exhibit decreased levels of essential fatty acids in red blood cells. Int. J. Mol. Sci. 2015, 16:10061-10076.
9. Luxwolda R.S., Smit E.N., Velzing-Aarts F.V., Dijck-Brouwer D.A., Muskiet F.A. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. Prostaglandins Leukot. Essent. Fatty Acids 2011, 8:171-178.
10. Taha A.Y., Cheon Y., Faurot K.F., Macintosh B., Majchrzak-Hong S.F., Mann J.D., Hibbeln J.R., Ringel A., Ramsden C.E. Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins Leukot. Essent. Fatty Acids 2014, 90:151-157.
11. Obajimi O., Black K.D., MacDonald D.J., Boyle R.M., Glen I., Ross B.M. Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. Pharmacol. Res. 2005, 52:183-191.
12. Morbtaten K., Haug T.M., Kleiveland C.R., Lea T. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signaling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis. 2013, 12:101.
13. Calder C.P. Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie 2009, 91:791-795.
14. Sidhu A., Miller P.J., Hollenbach A.D. FOXO1 stimulates ceruloplasmin promoter activity in human hepatoma cells treated with IL-6. Biochem. Biophys. Res. Commun. 2011, 404:963-967.
15. Tsang C.K., Liu Y., Thoma J., Zhang Y., Zheng X.F. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance. Nat. Commun. 2014, 5:3446.
16. Jian J., Yang Q., Huang X. Src regulates Tyr (20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. J. Biol. Chem. 2011, 286:35708-35715.
17. Barbariga M., Curnis F., Spitaleri A., Andolfo A., Zucchell C., Lazzaro M., Magnani G., Musco G., Corti A., Alessio M. Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signaling. J. Biol. Chem. 2014, 289:3736-3748.
18. Ayton S., Zhang M., Roberts B.R., Lam L.Q., Lind M., McLean C., Bush A.I., Frugier T., Crack P.J., Duce J.A. Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron. Free Radic. Biol. Med. 2014, 69:331-337.
19. Sokov A.V., Golenkina E.A., Kostevich V.A., Vasilyev V.B. G.F. Sud'ina: interaction of ceruloplasmin and 5-lipoxygenase. Biochemistry (Mosc.) 2010, 75:1464-1469.
20. Lee K.H., Yun S.J., Nam K.N., Gho Y.S., Lee E.H. Activation of microglial cells by ceruloplasmin. Brain Res. 2007, 1171:1-8.
21. Pacht E.R., DeMichele S.J., Nelson J.L., Hart J., Wennberg A.K., Gadek J.E. Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. Crit. Care Med. 2003, 31:491-500.
22. Fukai T. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal. 2011, 15:1583-1606.
23. Du J., Li X., Lin C., He X. Protective effects of arachidonic acid against paraquat-induced pulmonary injury. Inflammation 2015, 38:1458-1463.
24. Cardoso H.D., dos Santos E.F., de Santana D.F., Gonçalves-Pimentel C., Angelim M.K., Isaac A.R., Lagranha C.J., Guedes R.C., Beltrão E.I., Morya E., Rodrigues M.C., Andrade-da-Costa B.L. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochim. Biophys. Acta 2014, 840:1902-1912.
25. Kasibhatla S., Jessen K.A., Maliartchouk S., Wang J.Y., English N.M., Drewe J., Qiu L., Archer S.P., Ponce A.E., Sirisoma N., Jiang S., Zhang H.Z., Cai S.X., Gehlsen K.R., Green D.R., Tseng B. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:12095-12100.
26. Schonfeld E., Yasharel I., Yavin E., Brand A. Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. Neurochem. Res. 2007, 2:1673-1684.
27. Meguid N.A., Dardir A.A., Abdel-Raouf E.R., Hashish A. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Biol. Trace Elem. Res. 2011, 143:58-65.
28. Parellada M., Moreno C., Mac-Dowell K., Leza L.C., Giraldez M., Bailón C., Castro C., Miranda-Azpiazu P., Fraguas D., Arango C. Plasma antioxidant capacity is reduced in Asperger syndrome. J. Psychiatr. Res. 2012, 46:394-401.
29. Chauhan A., Chauhan V., Brown W.T., Cohen L. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin-the antioxidant proteins. Life Sci. 2004, 75:2539-2549.
30. Hata A.N., Breyer R.M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 2004, 103:147-166.
31. Rutter M., Le Couteur A., Lord C. ADI-R Autism Diagnostic Interview Revised Manual 2003, Western Psychological Services, Los Angeles.
32. Wechsler D. Wechsler Intelligence Scale for Children-Revised Manual. The Psychological Corporation 1974, New York, NY.
33. Wechsler D. Wechsler Adult Intelligence Scale-Revised Manual. The Psychological Corporation 1981, San Antonio, TX.
34. Koyama T., Kamio Y., Inada N., Kurita H. Sex differences in WISC-III profiles of children with high-functioning pervasive developmental disorders. J. Autism Dev. Disord. 2009, 39:135-141.
35. Ministry of Health, Labour and Welfare, and Ministry of Agriculture, Forestry and Fishers, Japanese Food Guide. Ministry of Health, Labour and Welfare, and Ministry of Agriculture, Forestry and Fishers, Tokyo, 2012.
36. Okuda M., Sasaki S., Bando N., Hashimoto M., Kunitsugu I., Sugiyama S., Terao J., Hobara T. Carotenoid, tocopherol, and fatty acid biomarkers and dietary intake estimated by using a brief self-administered diet history questionnaire for older Japanese children and adolescents. Nutr. Sci. Vitaminol. 2009, 5:231-241.
37. Hollander E., Chaplin W., Soorya L., Wasserman S., Novotny S., Rusoff J., Feirsen N., Pepa L., Anagnostou E. Divalproex sodium vs. placebo for the treatment of irritability in children and adolescents with autism spectrum disorders. Neuropsychopharmacology 2009, 35:990-998.
38. Karabekiroglu K., Aman M.G. Validity of the aberrant behavior checklist in a clinical sample of toddlers. Child Psychiatry Hum. Dev. 2009, 40:99-110.
39. Hamazaki H., Itomura M., Hamazaki T., Sawazaki S. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. Nutrition 2006, 22:534-536.
40. Singh K., Connors S.L., Macklin E.A., Smith K.D., Fahey J.W., Talalay P., Zimmerman A.W. Sulforaphane treatment of autism disorder (ASD). Pro.c Natl. Acad. Sci. U. S. A. 2014, 111:15550-15555.
41. Chiang H.M., Tsai L.Y., Cheung Y.K., Brown A., Li H.A. A meta-analysis of differences in IQ profiles between individuals with Asperger's disorder and high-functioning autism. J. Autism Dev. Disord. 2014, 44(2014):1577-1596.
42. Halladay A.K., Bishop S., Constantino J.N., Daniels A.M., Koenig K., Palmer K., Messinger D., Pelphrey K., Sanders S.J., Singer A.T., Taylor J.L., Szatmari P. Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority. Mol. Autism 2015, 6:36. 10.1186/s13229-015-0019-y.
43. Bryson S.E., Bradley E.A., Thompson A., Wainwright A. Prevalence of autism among adolescents with intellectual disabilities. Can. J. Psychiatry 2008, 53:449-459.
44. Werling D.M., Geschwind D.H. Sex differences in autism spectrum disorders. Curr. Opin. Neurol. 2013, 26:146-153.
45. Sublette M.E., Bosetti F., DeMar J.C., Ma K., Bell J.M., Fagin-Jones S., Russ M.J., Rapoport S.I. Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. Bipolar Disord. 2007, 9:759-765.
46. Bednar M.M., Gross C.E., Balazy M.K., Belosludtsev Y., Colella D.T., Falck J.R., Balazy M. 16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes. Biochem. Pharmacol. 2000, 60:447-455.
47. Kopf P.G., Zhang D.X., Gauthier K.M., Nithipatikom K., Yi X.Y., Falck J.R., Campbell W.B. Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors. Hypertension 2010, 55:547-554.
48. Seegmiller A.C. Abnormal unsaturated fatty acid metabolism in cystic fibrosis: biochemical mechanisms and clinical implications. Int. J. Mol. Sci. 2014, 15:16083-16099.
49. LinderborgG.Kaur K.M., Miller E., Meikle P.J., Larsen A.E., Weir J.M., Nuora A., Barlow C.K., Kallio H.P., Cameron-Smith D., Sinclair A.J. Postprandial metabolism of docosapentaenoic acid (DPA, 22:5n-3) and eicosapentaenoic acid (EPA, 20:5n-3) in humans. Prostaglandins. Leukot. Essent. Fatty Acids 2013, 88:313-319.
50. Squitti R., Ghidoni R., Siott M., Ventriglia M., Benussi L., Paterlini A., Magri M., Binetti G., Cassetta E., Caprara D., Vernieri F., Rossini P.M. P Pasqualetti: value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease. Ann. Neurol. 2014, 75:574-580.
51. El-Ansary A.K., Bacha A.G., Al-Ayahdi L.Y. Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia. Lipids Health Dis. 2011, 10:62. 10.1186/1476-511X-10-62.
52. Karr J.E., Alexander J.E., Winningham R.G. Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review. Nutr. Neurosci. 2011, 14:216-225.
53. Adel S., Kakularam K.R., Horn T., Reddanna P., Kuhn H., Heydeck D. Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens. Arch. Biochem. Biophys. 2015, 565:17-24.
54. Chen J.H., Perry C.J., Tsui Y.C., Staron M.M., Parish I.A., Dominguez C.X., Rosenberg D.W., Kaech S.M. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat. Med. 2015, 21:327-334.
55. Rago B., Fu C. Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2013, 936:25-32.