Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 936, Issue , 2013, Pages 25-32

  Rago, Brian ^a   Fu, Cexiong ^a  

^a PFIZER INC   (United States)

Author keywords

Atherosclerosis; Cluster analysis; Eicosanoid; Lipid biomarkers; UPLC MS MS

Indexed keywords

ATHEROSCLEROSIS; EICOSANOID; INFLAMMATORY SIGNALING; LIMIT OF QUANTITATIONS; LIPID BIOMARKERS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; UPLC-MS/MS;

BIOMARKERS; CHROMATOGRAPHY; CLUSTER ANALYSIS; CYTOLOGY; DIAGNOSIS; DISEASES;

ENDOTHELIAL CELLS;

11(12) EPOXY 5Z,8Z,14Z EICOSATRIENOIC ACID; 11,12 DIIHYDROXY 5Z,8Z,14Z EICOSATRIENOIC ACID; 12 HYDROXY 5Z,8Z,10E,14Z EICOSATETRAENOIC ACID; 12S HYDROXY 5Z,8Z,10E,14Z EICOSATETRAENOIC 5,6,8,9,11,12,14,15 D8 ACID; 13 HYDROXY 9Z,11E OCTADECADIENOIC ACID; 14,15 DIHYDROXY 5Z,8Z,11Z EICOSATRIENOIC 16,16,17,17,18,18,19,19,20,20,20 D11 ACID; 14,15 DIHYDROXY 5Z,8Z,11Z EICOSATRIENOIC ACID; 15 HYDROXY 5Z,8Z,11Z,13E EICOSATETRAENOIC ACID; 5S,12R DIHYDROXY 6Z,8E,10E,14Z EICOSATETRAENOIC ACID; 8 HYDROXY 5Z,9E,11Z,14Z EICOSATETRAENOIC ACID; 8(9) EPOXY 5Z,11Z,14Z EICOSATRIENOIC ACID; 8,9 DIHYDROXY 5Z,11Z,14Z EICOSATRIENOIC ACID; 9 HYDROXY 10E,12Z OCTADECADIENOIC ACID; 9 HYDROXY 5Z,7E,11Z,14Z EICOSATETRAENOIC ACID; BIOLOGICAL MARKER; ICOSANOID; LINOLEIC ACID; LIPID; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; POLYUNSATURATED FATTY ACID; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FREEZE THAWING; HUMAN; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84882933465     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.08.001     Document Type: Article

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