Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Mobraten, Kaia ^a   Haug, Trude M ^b   Kleiveland, Charlotte R ^a,c   Lea, Tor ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c Østfold Hospital Trust Fredrikstad   (Norway)

Author keywords

GPR120 Caco 2 cells; Polyunsaturated fatty acids (PUFAs)

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR 120; I KAPPA B KINASE ALPHA; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAF PROTEIN; ANTIINFLAMMATORY AGENT; G PROTEIN COUPLED RECEPTOR; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; O3FAR1 PROTEIN, HUMAN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; UNSATURATED FATTY ACID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; PROTEIN BINDING; SIGNAL TRANSDUCTION; CALCIUM SIGNALING; CELL STRAIN CACO 2; CYTOSOL; INFLAMMATION; KINETICS; METABOLISM; PATHOLOGY; CACO 2 CELL LINE;

ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; CACO-2 CELLS; CALCIUM SIGNALING; CYTOSOL; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; KINETICS; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84880092164     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-101     Document Type: Article

References (35)

1. Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J: Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003, 278: 25481-25489. 10.1074/jbc.M301403200
2. Nilsson NE, Kotarsky K, Owman C, Olde B: Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun. 2003, 303: 1047-1052. 10.1016/S0006-291X(03)00488-1
3. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem. 2003, 278: 11303-11311. 10.1074/jbc.M211495200
4. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 2003, 422: 173-176. 10.1038/nature01478
5. Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B: A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun. 2003, 301: 406-410. 10.1016/S0006-291X(02)03064-4
6. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G: Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. nature medicine. 2005, 11: 90-94. 10.1038/nm1168
7. Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V: GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. 2007, 56: 1087-1094. 10.2337/db06-1532
8. Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H: The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 2005, 1: 245-258. 10.1016/j.cmet.2005.03.007
9. Edfalk S, Steneberg P, Edlund H: Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008, 57: 2280-2287. 10.2337/db08-0307
10. Tanaka T, Katsuma S, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G: Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol. 2008, 377: 523-527. 10.1007/s00210-007-0200-8
11. Oh DY, Talukdar S, Bae EJ, Imamura T, Moringa H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM: GPR120 is an Omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010, 142: 687-698. 10.1016/j.cell.2010.07.041
12. Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J, de Madariaga MA, Domingo JC: Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. J Leukoc Biol. 2008, 84: 1172-1182. 10.1189/jlb.1007688
13. Kong W, Yen JH, Vassiliou E, Adhikary S, Toscano MG, Ganea D: Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family. Lipids Health Dis. 2010, 9: 12- 10.1186/1476-511X-9-12
14. Vilaseca J, Salas A, Guarner F, Rodriguez R, Martinez M, Malagelada JR: Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Gut. 1990, 31: 539-544. 10.1136/gut.31.5.539
15. Nieto N, Torres MI, Rios A, Gil A: Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. J Nutr. 2002, 132: 11-19.
16. Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JX: Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A. 2006, 103: 11276-11281. 10.1073/pnas.0601280103
17. Shoda R, Matsueda K, Yamato S, Umeda N: Therapeutic efficacy of N-3 polyunsaturated fatty acid in experimental Crohn's disease. J Gastroenterol. 1995, 30 (Suppl 8): 98-101.
18. Yuceyar H, Ozutemiz O, Huseyinov A, Saruc M, Alkanat M, Bor S, Coker I, Batur Y: Is administration of n-3 fatty acids by mucosal enema protective against trinitrobenzene-induced colitis in rats?. Prostaglandins Leukot Essent Fatty Acids. 1999, 61: 339-345. 10.1054/plef.1999.0111
19. Andoh A, Tsujikawa T, Ishizuka I, Araki Y, Sasaki M, Koyama S, Fujiyama Y: N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. Int J Mol Med. 2003, 12: 721-725.
20. Cabre E, Manosa M, Gassull MA: Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Br J Nutr. 2012, 107 (Suppl 2): S240-252.
21. Ramakers JD, Mensink RP, Schaart G, Plat J: Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells. Lipids. 2007, 42: 687-698. 10.1007/s11745-007-3071-3
22. Marion-Letellier R, Butler M, Dechelotte P, Playford RJ, Ghosh S: Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells-potential for dietary modulation of peroxisome proliferator-activated receptor gamma in intestinal inflammation. Am J Clin Nutr. 2008, 87: 939-948.
23. Im DS: Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. Prog Lipid Res. 2012, 51: 232-237. 10.1016/j.plipres.2012.02.003
24. Osborn O, Olefsky JM: The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012, 18: 363-374. 10.1038/nm.2627
25. Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G: Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008, 377: 515-522. 10.1007/s00210-007-0250-y
26. Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, Hirasawa A, Tsujimoto G: Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J Biol Chem. 2005, 280: 19507-19515. 10.1074/jbc.M412385200
27. Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol. 2001, 1: 135-145. 10.1038/35100529
28. Al-Sadi R, Ye D, Said HM, Ma TY: IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am J Pathol. 2010, 177: 2310-2322. 10.2353/ajpath.2010.100371
29. Hara T, Hirasawa A, Sun Q, Sadakane K, Itsubo C, Iga T, Adachi T, Koshimizu TA, Hashimoto T, Asakawa Y, Tsujimoto G: Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009, 380: 247-255. 10.1007/s00210-009-0425-9
30. Soto-Guzman A, Robledo T, Lopez-Perez M, Salazar EP: Oleic acid induces ERK1/2 activation and AP-1 DNA binding activity through a mechanism involving Src kinase and EGFR transactivation in breast cancer cells. Mol Cell Endocrinol. 2008, 294: 81-91. 10.1016/j.mce.2008.08.003
31. Vacaresse N, Lajoie-Mazenc I, Auge N, Suc I, Frisach MF, Salvayre R, Negre-Salvayre A: Activation of epithelial growth factor receptor pathway by unsaturated fatty acids. Circ Res. 1999, 85: 892-899. 10.1161/01.RES.85.10.892
32. Adachi T, Tanaka T, Takemoto K, Koshimizu TA, Hirasawa A, Tsujimoto G: Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin. Biochem Biophys Res Commun. 2006, 340: 332-337. 10.1016/j.bbrc.2005.11.162
33. Shah BP, Liu P, Yu T, Hansen DR, Gilbertson TA: TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. Am J Physiol Cell Physiol. 2012, 302: C210-219. 10.1152/ajpcell.00209.2011
34. Simopoulos AP: The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002, 56: 365-379. 10.1016/S0753-3322(02)00253-6
35. Shoda R, Matsueda K, Yamato S, Umeda N: Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am J Clin Nutr. 1996, 63: 741-745.