-
1
-
-
34548050436
-
CD8 T cell dysfunction during chronic viral infection
-
Shin, H. & Wherry, E.J. CD8 T cell dysfunction during chronic viral infection. Curr. Opin. Immunol. 19, 408-415 (2007).
-
(2007)
Curr. Opin. Immunol
, vol.19
, pp. 408-415
-
-
Shin, H.1
Wherry, E.J.2
-
2
-
-
67649660551
-
Redefining chronic viral infection
-
Virgin, H.W., Wherry, E.J. & Ahmed, R. Redefining chronic viral infection. Cell 138, 30-50 (2009).
-
(2009)
Cell
, vol.138
, pp. 30-50
-
-
Virgin, H.W.1
Wherry, E.J.2
Ahmed, R.3
-
3
-
-
79956077563
-
T cell exhaustion
-
Wherry, E.J. T cell exhaustion. Nat. Immunol. 12, 492-499 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 492-499
-
-
Wherry, E.J.1
-
4
-
-
35349014587
-
Molecular signature of CD8+ T cell exhaustion during chronic viral infection
-
Wherry, E.J. et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27, 670-684 (2007).
-
(2007)
Immunity
, vol.27
, pp. 670-684
-
-
Wherry, E.J.1
-
5
-
-
17644444485
-
Analysis of successful immune responses in persons infected with hepatitis C virus
-
Lechner, F. et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191, 1499-1512 (2000).
-
(2000)
J. Exp. Med
, vol.191
, pp. 1499-1512
-
-
Lechner, F.1
-
6
-
-
84912111808
-
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8+ T cells during chronic infection
-
Staron, M.M. et al. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8+ T cells during chronic infection. Immunity 41, 802-814 (2014).
-
(2014)
Immunity
, vol.41
, pp. 802-814
-
-
Staron, M.M.1
-
7
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber, D. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.1
-
8
-
-
34848852256
-
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
-
Mueller, S. et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl. Acad. Sci. USA 104, 15430-15435 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 15430-15435
-
-
Mueller, S.1
-
9
-
-
79957925314
-
Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients
-
Baitsch, L. et al. Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients. J. Clin. Invest. 121, 2350-2360 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2350-2360
-
-
Baitsch, L.1
-
10
-
-
79960906880
-
Role of PD-1 in regulating T-cell immunity
-
Jin, H.T., Ahmed, R. & Okazaki, T. Role of PD-1 in regulating T-cell immunity. Curr. Top. Microbiol. Immunol. 350, 17-37 (2011).
-
(2011)
Curr. Top. Microbiol. Immunol
, vol.350
, pp. 17-37
-
-
Jin, H.T.1
Ahmed, R.2
Okazaki, T.3
-
11
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
Sakuishi, K. et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207, 2187-2194 (2010).
-
(2010)
J. Exp. Med
, vol.207
, pp. 2187-2194
-
-
Sakuishi, K.1
-
12
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S.L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
13
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day, C.L. et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350-354 (2006).
-
(2006)
Nature
, vol.443
, pp. 350-354
-
-
Day, C.L.1
-
14
-
-
68249152608
-
Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
-
Tinoco, R., Alcalde, V., Yang, Y., Sauer, K. & Zuniga, E.I. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 31, 145-157 (2009).
-
(2009)
Immunity
, vol.31
, pp. 145-157
-
-
Tinoco, R.1
Alcalde, V.2
Yang, Y.3
Sauer, K.4
Zuniga, E.I.5
-
15
-
-
33750530611
-
Resolution of a chronic viral infection after interleukin-10 receptor blockade
-
Ejrnaes, M. et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 203, 2461-2472 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2461-2472
-
-
Ejrnaes, M.1
-
16
-
-
33750499311
-
Interleukin-10 determines viral clearance or persistence in vivo
-
Brooks, D.G. et al. Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 12, 1301-1309 (2006).
-
(2006)
Nat. Med
, vol.12
, pp. 1301-1309
-
-
Brooks, D.G.1
-
17
-
-
79955102870
-
The role of IL-10 in immune regulation during M. Tuberculosis infection
-
Redford, P.S., Murray, P.J. & O'Garra, A. The role of IL-10 in immune regulation during M. tuberculosis infection. Mucosal Immunol. 4, 261-270 (2011).
-
(2011)
Mucosal Immunol
, vol.4
, pp. 261-270
-
-
Redford, P.S.1
Murray, P.J.2
O'Garra, A.3
-
18
-
-
77953293751
-
Prostaglandin e synthases: Understanding their pathophysiological roles through mouse genetic models
-
Hara, S. et al. Prostaglandin E synthases: understanding their pathophysiological roles through mouse genetic models. Biochimie 92, 651-659 (2010).
-
(2010)
Biochimie
, vol.92
, pp. 651-659
-
-
Hara, S.1
-
19
-
-
0036499224
-
Prostaglandins as modulators of immunity
-
Harris, S.G., Padilla, J., Koumas, L., Ray, D. & Phipps, R.P. Prostaglandins as modulators of immunity. Trends Immunol. 23, 144-150 (2002).
-
(2002)
Trends Immunol
, vol.23
, pp. 144-150
-
-
Harris, S.G.1
Padilla, J.2
Koumas, L.3
Ray, D.4
Phipps, R.P.5
-
20
-
-
84855361145
-
Regulation of immune responses by prostaglandin e2
-
Kalinski, P. Regulation of immune responses by prostaglandin e2. J. Immunol. 188, 21-28 (2012).
-
(2012)
J. Immunol
, vol.188
, pp. 21-28
-
-
Kalinski, P.1
-
21
-
-
0027336336
-
Prostaglandin E2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells
-
Linnemeyer, P.A. & Pollack, S.B. Prostaglandin E2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells. J. Immunol. 150, 3747-3754 (1993).
-
(1993)
J. Immunol
, vol.150
, pp. 3747-3754
-
-
Linnemeyer, P.A.1
Pollack, S.B.2
-
22
-
-
84863727431
-
Prostaglandin E2 and T cells: Friends or foes?
-
Sreeramkumar, V., Fresno, M. & Cuesta, N. Prostaglandin E2 and T cells: friends or foes? Immunol. Cell Biol. 90, 579-586 (2012).
-
(2012)
Immunol. Cell Biol
, vol.90
, pp. 579-586
-
-
Sreeramkumar, V.1
Fresno, M.2
Cuesta, N.3
-
23
-
-
0028109394
-
Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
-
Strassmann, G., Patil-Koota, V., Finkelman, F., Fong, M. & Kambayashi, T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med. 180, 2365-2370 (1994).
-
(1994)
J. Exp. Med
, vol.180
, pp. 2365-2370
-
-
Strassmann, G.1
Patil-Koota, V.2
Finkelman, F.3
Fong, M.4
Kambayashi, T.5
-
24
-
-
0031283083
-
Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines
-
Demeure, C.E., Yang, L.P., Desjardins, C., Raynauld, P. & Delespesse, G. Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines. Eur. J. Immunol. 27, 3526-3531 (1997).
-
(1997)
Eur. J. Immunol
, vol.27
, pp. 3526-3531
-
-
Demeure, C.E.1
Yang, L.P.2
Desjardins, C.3
Raynauld, P.4
Delespesse, G.5
-
25
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich, D.I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174 (2009).
-
(2009)
Nat. Rev. Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
26
-
-
19944381855
-
Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
-
Rahmouni, S. et al. Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice. Biochem. J. 384, 469-476 (2004).
-
(2004)
Biochem. J.
, vol.384
, pp. 469-476
-
-
Rahmouni, S.1
-
27
-
-
84870230232
-
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
-
Paley, M.A. et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220-1225 (2012).
-
(2012)
Science
, vol.338
, pp. 1220-1225
-
-
Paley, M.A.1
-
28
-
-
57849168934
-
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
-
Blackburn, S.D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29-37 (2009).
-
(2009)
Nat. Immunol
, vol.10
, pp. 29-37
-
-
Blackburn, S.D.1
-
29
-
-
54449088740
-
Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
-
Blackburn, S.D., Shin, H., Freeman, G.J. & Wherry, E.J. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc. Natl. Acad. Sci. USA 105, 15016-15021 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15016-15021
-
-
Blackburn, S.D.1
Shin, H.2
Freeman, G.J.3
Wherry, E.J.4
-
30
-
-
0025193381
-
Forskolin and prostaglandin E2 regulate the generation of human cytolytic T lymphocytes
-
Khan, M.M., Tran, A.C. & Keaney, K.M. Forskolin and prostaglandin E2 regulate the generation of human cytolytic T lymphocytes. Immunopharmacology 19, 151-161 (1990).
-
(1990)
Immunopharmacology
, vol.19
, pp. 151-161
-
-
Khan, M.M.1
Tran, A.C.2
Keaney, K.M.3
-
31
-
-
81555228400
-
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
-
Obermajer, N., Muthuswamy, R., Lesnock, J., Edwards, R.P. & Kalinski, P. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood 118, 5498-5505 (2011).
-
(2011)
Blood
, vol.118
, pp. 5498-5505
-
-
Obermajer, N.1
Muthuswamy, R.2
Lesnock, J.3
Edwards, R.P.4
Kalinski, P.5
-
32
-
-
80052059246
-
An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: Downregulated immune activation and improved T cell-dependent vaccine responses
-
Pettersen, F.O. et al. An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses. J. Virol. 85, 6557-6566 (2011).
-
(2011)
J. Virol
, vol.85
, pp. 6557-6566
-
-
Pettersen, F.O.1
-
33
-
-
79953764331
-
Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes
-
Su, Y., Jackson, E.K. & Gorelik, E. Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunol. Immunother. 60, 111-122 (2011).
-
(2011)
Cancer Immunol. Immunother
, vol.60
, pp. 111-122
-
-
Su, Y.1
Jackson, E.K.2
Gorelik, E.3
-
34
-
-
84859907018
-
Modulation of T cell immune functions by the prostaglandin E(2)-cAMP pathway in chronic inflammatory states
-
Brudvik, K.W. & Taskén, K. Modulation of T cell immune functions by the prostaglandin E(2)-cAMP pathway in chronic inflammatory states. Br. J. Pharmacol. 166, 411-419 (2012).
-
(2012)
Br. J. Pharmacol
, vol.166
, pp. 411-419
-
-
Brudvik, K.W.1
Taskén, K.2
-
35
-
-
0035910759
-
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
-
Vang, T. et al. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J. Exp. Med. 193, 497-507 (2001).
-
(2001)
J. Exp. Med
, vol.193
, pp. 497-507
-
-
Vang, T.1
-
36
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz, J.M., Parry, R.V., Nichols, K.E., June, C.H. & Riley, J.L. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J. Immunol. 173, 945-954 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
37
-
-
77957059176
-
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
-
Jin, H.-T. et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 107, 14733-14738 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14733-14738
-
-
Jin, H.-T.1
-
38
-
-
0032416085
-
Viral immune evasion due to persistence of activated T cells without effector function
-
Zajac, A.J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205-2213 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 2205-2213
-
-
Zajac, A.J.1
-
39
-
-
0037383592
-
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
-
Wherry, E.J., Blattman, J.N., Murali-Krishna, K., van der Most, R. & Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911-4927 (2003).
-
(2003)
J. Virol
, vol.77
, pp. 4911-4927
-
-
Wherry, E.J.1
Blattman, J.N.2
Murali-Krishna, K.3
Van Der Most, R.4
Ahmed, R.5
-
40
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet, P. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738 (1999).
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
-
41
-
-
33845472476
-
Caspase inhibitors: Viral, cellular and chemical
-
Callus, B.A. & Vaux, D.L. Caspase inhibitors: viral, cellular and chemical. Cell Death Differ. 14, 73-78 (2007).
-
(2007)
Cell Death Differ
, vol.14
, pp. 73-78
-
-
Callus, B.A.1
Vaux, D.L.2
-
42
-
-
0032762607
-
Additive effects of IL-2 and protein kinase A type i antagonist on function of T cells from HIV-infected patients on HAART
-
Aandahl, E.M. et al. Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART. AIDS 13, F109-F114 (1999).
-
(1999)
AIDS
, vol.13
, pp. F109-F114
-
-
Aandahl, E.M.1
-
43
-
-
0031748984
-
Protein kinase A type i antagonist restores immune responses of T cells from HIV-infected patients
-
Aandahl, E.M. et al. Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients. FASEB J. 12, 855-862 (1998).
-
(1998)
FASEB J.
, vol.12
, pp. 855-862
-
-
Aandahl, E.M.1
-
44
-
-
33646710893
-
Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
-
Kvale, D. et al. Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment. AIDS 20, 813-820 (2006).
-
(2006)
AIDS
, vol.20
, pp. 813-820
-
-
Kvale, D.1
-
45
-
-
2142819981
-
Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy
-
Johansson, C.C. et al. Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy. AIDS 18, 951-952 (2004).
-
(2004)
AIDS
, vol.18
, pp. 951-952
-
-
Johansson, C.C.1
-
46
-
-
84860467522
-
Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials
-
Algra, A.M. & Rothwell, P.M. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 13, 518-527 (2012).
-
(2012)
Lancet Oncol
, vol.13
, pp. 518-527
-
-
Algra, A.M.1
Rothwell, P.M.2
-
47
-
-
0037421985
-
A randomized trial of aspirin to prevent colorectal adenomas
-
Baron, J.A. et al. A randomized trial of aspirin to prevent colorectal adenomas. N. Engl. J. Med. 348, 891-899 (2003).
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 891-899
-
-
Baron, J.A.1
-
48
-
-
33748641378
-
Role of Bim in regulating CD8+ T-cell responses during chronic viral infection
-
Grayson, J.M., Weant, A.E., Holbrook, B.C. & Hildeman, D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J. Virol. 80, 8627-8638 (2006).
-
(2006)
J. Virol
, vol.80
, pp. 8627-8638
-
-
Grayson, J.M.1
Weant, A.E.2
Holbrook, B.C.3
Hildeman, D.4
-
49
-
-
43049112084
-
Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
-
Lopes, A.R. et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835-1845 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 1835-1845
-
-
Lopes, A.R.1
-
50
-
-
2442682766
-
The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells
-
Zhang, L. & Insel, P.A. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J. Biol. Chem. 279, 20858-20865 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 20858-20865
-
-
Zhang, L.1
Insel, P.A.2
-
51
-
-
42949157936
-
Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells
-
Zhang, L. et al. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J. Biol. Chem. 283, 4304-4313 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 4304-4313
-
-
Zhang, L.1
-
52
-
-
78650886200
-
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim
-
Moujalled, D. et al. Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. EMBO Rep. 12, 77-83 (2011).
-
(2011)
EMBO Rep
, vol.12
, pp. 77-83
-
-
Moujalled, D.1
-
53
-
-
80052992261
-
Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells
-
Zambon, A.C., Wilderman, A., Ho, A. & Insel, P.A. Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J. Biol. Chem. 286, 33260-33267 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 33260-33267
-
-
Zambon, A.C.1
Wilderman, A.2
Ho, A.3
Insel, P.A.4
-
54
-
-
84878585947
-
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
-
West, E.E. et al. PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J. Clin. Invest. 123, 2604-2615 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 2604-2615
-
-
West, E.E.1
-
55
-
-
34250787647
-
Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections
-
Bachmann, M.F., Wolint, P., Walton, S., Schwarz, K. & Oxenius, A. Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Eur. J. Immunol. 37, 1502-1512 (2007).
-
(2007)
Eur. J. Immunol
, vol.37
, pp. 1502-1512
-
-
Bachmann, M.F.1
Wolint, P.2
Walton, S.3
Schwarz, K.4
Oxenius, A.5
-
56
-
-
0038025292
-
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
-
Blattman, J.N. et al. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat. Med. 9, 540-547 (2003).
-
(2003)
Nat. Med
, vol.9
, pp. 540-547
-
-
Blattman, J.N.1
-
57
-
-
0032906087
-
Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
-
Kennedy, C.R. et al. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat. Med. 5, 217-220 (1999).
-
(1999)
Nat. Med
, vol.5
, pp. 217-220
-
-
Kennedy, C.R.1
-
58
-
-
10644241480
-
Generation of a conditional allele of the mouse prostaglandin EP4 receptor
-
Schneider, A. et al. Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis 40, 7-14 (2004).
-
(2004)
Genesis
, vol.40
, pp. 7-14
-
-
Schneider, A.1
-
59
-
-
0043261465
-
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin e synthase
-
Trebino, C.E. et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. USA 100, 9044-9049 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9044-9049
-
-
Trebino, C.E.1
-
60
-
-
0033542458
-
Modelling T-cell memory by genetic marking of memory T cells in vivo
-
Jacob, J. & Baltimore, D. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399, 593-597 (1999).
-
(1999)
Nature
, vol.399
, pp. 593-597
-
-
Jacob, J.1
Baltimore, D.2
-
61
-
-
34548027000
-
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
-
Joshi, N.S. et al. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281-295 (2007).
-
(2007)
Immunity
, vol.27
, pp. 281-295
-
-
Joshi, N.S.1
-
62
-
-
0021225388
-
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
-
Ahmed, R., Salmi, A., Butler, L.D., Chiller, J.M. & Oldstone, M.B. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521-540 (1984).
-
(1984)
J. Exp. Med
, vol.160
, pp. 521-540
-
-
Ahmed, R.1
Salmi, A.2
Butler, L.D.3
Chiller, J.M.4
Oldstone, M.B.5
-
63
-
-
1642415940
-
Maintenance loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
-
Fuller, M.J., Khanolkar, A., Tebo, A.E. & Zajac, A.J. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J. Immunol. 172, 4204-4214 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 4204-4214
-
-
Fuller, M.J.1
Khanolkar, A.2
Tebo, A.E.3
Zajac, A.J.4
|