Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity

Environmental Toxicology and Pharmacology

Volumn 41, Issue , 2016, Pages 8-13

  Zhang, Feng ^a   Chen, Li ^a   Jin, Huanhuan ^a   Shao, Jiangjuan ^a   Wu, Li ^a   Lu, Yin ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Bid; Extrinsic apoptosis; Fas; Hepatotoxicity; Saikosaponin D

Indexed keywords

CASPASE 3; CYTOCHROME C; DEATH RECEPTOR; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE B; SAIKOSAPONIN D; STAT3 PROTEIN; BID PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASPASE 8; FAS PROTEIN, HUMAN; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME RELEASE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TOXIC HEPATITIS; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BUPLEURUM; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; TOXICITY;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BUPLEURUM; CASPASE 8; CELL LINE; CHEMICAL AND DRUG INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOCHONDRIA; OLEANOLIC ACID; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84948769852     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2015.11.005     Document Type: Article

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