Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: A potential mechanism of hepatotoxicity

Chemico-Biological Interactions

Volumn 206, Issue 1, 2013, Pages 76-82

  Chen, Li ^a   Zhang, Feng ^a   Kong, Desong ^a   Zhu, Xiaojing ^a   Chen, Wenxing ^a   Wang, Aiyun ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Hepatotoxicity; Mitochondrial apoptosis; Platelet derived growth factor receptor p38; Saikosaponin D

Indexed keywords

CASPASE 3; CASPASE 9; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; SAIKOSAPONIN D; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOXICITY TESTING; UPREGULATION;

3-(4,5-DIMETHYLTHIAZOL-2-YL)-5-(3-CARBOXYMETHOXYPHENYL)-2-(4-SULFO-PHENYL)-2H-TETRAZOLIUM; APAP; DIMETHYLSULFOXIDE; DMEM; DMSO; DULBECCO'S MODIFIED EAGLE MEDIUM; FBS; FETAL BOVINE SERUM; HEPATOTOXICITY; MAPK; MITOCHONDRIAL APOPTOSIS; MITOCHONDRIAL TRANSMEMBRANE POTENTIAL; MITOGEN-ACTIVATED PROTEIN KINASE; MTP; MTS; N-ACETYL-P-AMINOPHENOL; P38; PDGF-ΒR; PLATELET-DERIVED GROWTH FACTOR-Β RECEPTOR; SAIKOSAPONIN D; SSD;

APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; OLEANOLIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP;

BUPLEURUM;

EID: 84883735547     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.08.006     Document Type: Article

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