Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling

Chemico-Biological Interactions

Volumn 223, Issue , 2014, Pages 80-86

  Liu, Aiming ^a,b   Tanaka, Naoki ^b   Sun, Lu ^b,e   Guo, Bin ^c   Kim, Jung Hwan ^b,f   Krausz, Kristopher W ^b   Fang, Zhongze ^b,g   Jiang, Changtao ^b,h   Yang, Julin ^d   Gonzalez, Frank J ^b  

^a NINGBO UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HUNAN NORMAL UNIVERSITY   (China)

^d Ningbo College of Health Sciences   (China)

^e SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^f Gyeongsang National University   (South Korea)

^g TIANJIN MEDICAL UNIVERSITY   (China)

^h PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Acetaminophen; Hepatotoxicity; NF B; Saikosaponin d; STAT3

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIM PROTEIN; CYTOCHROME P450 2E1; CYTOCHROME P450 3A11; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; SAIKOSAPONIN D; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; ANALGESIC AGENT; ANTIPYRETIC AGENT; CYTOKINE; HERBACEOUS AGENT; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN; STAT3 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAX GENE; BCL XL GENE; BIM GENE; BUPLEURUM FALCATUM; CCL2 GENE; CONTROLLED STUDY; DOWN REGULATION; DRUG DETOXIFICATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; FGA GENE; FGB GENE; FGG GENE; GENE; GENE EXPRESSION; IL6 GENE; INTRACELLULAR SIGNALING; LIVER HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SOCS3 GENE; TOXIC HEPATITIS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BUPLEURUM; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; DRUG INACTIVATION; GENETICS; HUMAN; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; SIGNAL TRANSDUCTION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIPYRETICS; BUPLEURUM; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOKINES; DOWN-REGULATION; DRUGS, CHINESE HERBAL; HUMANS; INACTIVATION, METABOLIC; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; OLEANOLIC ACID; OXIDATIVE STRESS; PLANTS, MEDICINAL; PPAR ALPHA; RNA, MESSENGER; SAPONINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84907927347     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.09.012     Document Type: Article

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