-
1
-
-
0442276554
-
The glamour and gloom of glycogen synthase kinase-3
-
Jope RS, Johnson GV (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29, 95-102.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 95-102
-
-
Jope, R.S.1
Johnson, G.V.2
-
2
-
-
0344245499
-
Expression analysis of glycogen synthase kinase-3 in human tissues
-
Lau KF, Miller CC, Anderton BH, Shaw PC (1999) Expression analysis of glycogen synthase kinase-3 in human tissues. J Pept Res 54, 85-91.
-
(1999)
J Pept Res
, vol.54
, pp. 85-91
-
-
Lau, K.F.1
Miller, C.C.2
Anderton, B.H.3
Shaw, P.C.4
-
3
-
-
0028675873
-
Alzheimer's disease-like phosphorylation of the microtubule-Associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
-
Lovestone S, Reynolds CH, Latimer D, Davis DR, Anderton BH, Gallo JM, Hanger D, Mulot S, Marquardt B, Stabel S, et al. (1994) Alzheimer's disease-like phosphorylation of the microtubule-Associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 4, 1077-1086.
-
(1994)
Curr Biol
, vol.4
, pp. 1077-1086
-
-
Lovestone, S.1
Reynolds, C.H.2
Latimer, D.3
Davis, D.R.4
Anderton, B.H.5
Gallo, J.M.6
Hanger, D.7
Mulot, S.8
Marquardt, B.9
Stabel, S.10
-
4
-
-
36949040819
-
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-Aggregation
-
Liu F, Li B, Tung EJ, Grundke-Iqbal I, Iqbal K, Gong CX (2007) Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-Aggregation. Eur J Neurosci 26, 3429-3436.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 3429-3436
-
-
Liu, F.1
Li, B.2
Tung, E.J.3
Grundke-Iqbal, I.4
Iqbal, K.5
Gong, C.X.6
-
5
-
-
0032566623
-
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
-
Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K (1998) Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. FEBS Lett 436, 28-34.
-
(1998)
FEBS Lett
, vol.436
, pp. 28-34
-
-
Wang, J.Z.1
Wu, Q.2
Smith, A.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
6
-
-
0032850599
-
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
-
Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (1999) Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 58, 1010-1019.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 1010-1019
-
-
Pei, J.J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
7
-
-
33846129434
-
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
-
Leroy K, Yilmaz Z, Brion JP (2007) Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol 33, 43-55.
-
(2007)
Neuropathol Appl Neurobiol
, vol.33
, pp. 43-55
-
-
Leroy, K.1
Yilmaz, Z.2
Brion, J.P.3
-
8
-
-
84901417472
-
GSK-3beta, a pivotal kinase in Alzheimer disease
-
Llorens-Martin M, Jurado J, Hernandez F, Avila J (2014) GSK-3beta, a pivotal kinase in Alzheimer disease. Front Mol Neurosci 7, 46.
-
(2014)
Front Mol Neurosci
, vol.7
, pp. 46
-
-
Llorens-Martin, M.1
Jurado, J.2
Hernandez, F.3
Avila, J.4
-
9
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA(1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
10
-
-
12944250922
-
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
-
Fang X, Yu SX, Lu Y, Bast RC Jr, Woodgett JR, Mills GB (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A 97, 11960-11965.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11960-11965
-
-
Fang, X.1
Yu, S.X.2
Lu, Y.3
Bast, R.C.4
Woodgett, J.R.5
Mills, G.B.6
-
11
-
-
0037434790
-
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
-
Etienne-Manneville S, Hall A (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756.
-
(2003)
Nature
, vol.421
, pp. 753-756
-
-
Etienne-Manneville, S.1
Hall, A.2
-
12
-
-
0344406228
-
Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines
-
Lee CW, Lau KF, Miller CC, Shaw PC (2003) Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines. Neuroreport 14, 257-260.
-
(2003)
Neuroreport
, vol.14
, pp. 257-260
-
-
Lee, C.W.1
Lau, K.F.2
Miller, C.C.3
Shaw, P.C.4
-
13
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations
-
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations. EMBO J 23, 2586-2596.
-
(2004)
EMBO J
, vol.23
, pp. 2586-2596
-
-
Baki, L.1
Shioi, J.2
Wen, P.3
Shao, Z.4
Schwarzman, A.5
Gama-Sosa, M.6
Neve, R.7
Robakis, N.K.8
-
14
-
-
0036273020
-
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
-
Martinez A, Castro A, Dorronsoro I, AlonsoM(2002) Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev 22, 373-384.
-
(2002)
Med Res Rev
, vol.22
, pp. 373-384
-
-
Martinez, A.1
Castro, A.2
Dorronsoro, I.3
Alonso, M.4
-
15
-
-
3042634127
-
Anovel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons
-
Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, deboer S, Beffert U, Brady ST (2004)Anovel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J 23, 2235-2245.
-
(2004)
EMBO J
, vol.23
, pp. 2235-2245
-
-
Morfini, G.1
Szebenyi, G.2
Brown, H.3
Pant, H.C.4
Pigino, G.5
Deboer, S.6
Beffert, U.7
Brady, S.T.8
-
16
-
-
20444464441
-
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells
-
Lee YI, Seo M, Kim Y, Kim SY, Kang UG, Kim YS, Juhnn YS (2005) Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells. J Biol Chem 280, 22044-22052.
-
(2005)
J Biol Chem
, vol.280
, pp. 22044-22052
-
-
Lee, Y.I.1
Seo, M.2
Kim, Y.3
Kim, S.Y.4
Kang, U.G.5
Kim, Y.S.6
Juhnn, Y.S.7
-
17
-
-
0027515127
-
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signalling
-
Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signalling. Biochem J 296(Pt 1), 15-19.
-
(1993)
Biochem J.
, vol.296
, pp. 15-19
-
-
Sutherland, C.1
Leighton, I.A.2
Cohen, P.3
-
18
-
-
61649127812
-
From promiscuity to precision: Protein phosphatases get a makeover
-
Virshup DM, Shenolikar S (2009) From promiscuity to precision: Protein phosphatases get a makeover. Mol Cell 33, 537-545.
-
(2009)
Mol Cell
, vol.33
, pp. 537-545
-
-
Virshup, D.M.1
Shenolikar, S.2
-
19
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
20
-
-
0027214404
-
Phosphoprotein phosphatase activities in Alzheimer disease brain
-
Gong CX, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61, 921-927.
-
(1993)
J Neurochem
, vol.61
, pp. 921-927
-
-
Gong, C.X.1
Singh, T.J.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
21
-
-
0026786471
-
Regulation of protein serine-Dhreonine phosphatase type-2A by tyrosine phosphorylation
-
Chen J, Martin BL, Brautigan DL (1992) Regulation of protein serine-Dhreonine phosphatase type-2A by tyrosine phosphorylation. Science 257, 1261-1264.
-
(1992)
Science
, vol.257
, pp. 1261-1264
-
-
Chen, J.1
Martin, B.L.2
Brautigan, D.L.3
-
22
-
-
0030821233
-
Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen
-
Ogris E, Gibson DM, Pallas DC (1997) Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15, 911-917.
-
(1997)
Oncogene
, vol.15
, pp. 911-917
-
-
Ogris, E.1
Gibson, D.M.2
Pallas, D.C.3
-
23
-
-
39949083195
-
PP2A holoenzyme assembly. in cauda venenum (the sting is in the tail)
-
Janssens V, Longin S, Goris J (2008) PP2A holoenzyme assembly: In cauda venenum (the sting is in the tail). Trends Biochem Sci 33, 113-121.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 113-121
-
-
Janssens, V.1
Longin, S.2
Goris, J.3
-
24
-
-
34848843828
-
Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit
-
Longin S, Zwaenepoel K, Louis JV, Dilworth S, Goris J, Janssens V (2007) Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem 282, 26971-26980.
-
(2007)
J Biol Chem
, vol.282
, pp. 26971-26980
-
-
Longin, S.1
Zwaenepoel, K.2
Louis, J.V.3
Dilworth, S.4
Goris, J.5
Janssens, V.6
-
25
-
-
0029952559
-
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
-
Lee J, Chen Y, Tolstykh T, Stock J (1996) A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci U S A 93, 6043-6047.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6043-6047
-
-
Lee, J.1
Chen, Y.2
Tolstykh, T.3
Stock, J.4
-
26
-
-
0033553570
-
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
-
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (1999) A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J Biol Chem 274, 14382-14391.
-
(1999)
J Biol Chem
, vol.274
, pp. 14382-14391
-
-
Ogris, E.1
Du, X.2
Nelson, K.C.3
Mak, E.K.4
Yu, X.X.5
Lane, W.S.6
Pallas, D.C.7
-
27
-
-
49349110718
-
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
-
Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ (2008) Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiol Dis 31, 386-394.
-
(2008)
Neurobiol Dis
, vol.31
, pp. 386-394
-
-
Zhou, X.W.1
Gustafsson, J.A.2
Tanila, H.3
Bjorkdahl, C.4
Liu, R.5
Winblad, B.6
Pei, J.J.7
-
28
-
-
33947328858
-
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
-
Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T (2007) Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 27, 2751-2759.
-
(2007)
J Neurosci
, vol.27
, pp. 2751-2759
-
-
Sontag, E.1
Nunbhakdi-Craig, V.2
Sontag, J.M.3
Diaz-Arrastia, R.4
Ogris, E.5
Dayal, S.6
Lentz, S.R.7
Arning, E.8
Bottiglieri, T.9
-
29
-
-
84920479139
-
Cross talk between PI3K-AKT-GSK-3beta and PP2A pathways determines tau hyperphosphorylation
-
Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F (2015) Cross talk between PI3K-AKT-GSK-3beta and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging 36, 188-200.
-
(2015)
Neurobiol Aging
, vol.36
, pp. 188-200
-
-
Wang, Y.1
Yang, R.2
Gu, J.3
Yin, X.4
Jin, N.5
Xie, S.6
Chang, H.7
Qian, W.8
Shi, J.9
Iqbal, K.10
Gong, C.X.11
Cheng, C.12
Liu, F.13
-
30
-
-
67849111942
-
Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage
-
Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage. J Alzheimers Dis 17, 531-539.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 531-539
-
-
Liang, Z.1
Liu, F.2
Iqbal, K.3
Grundke-Iqbal, I.4
Gong, C.X.5
-
31
-
-
0030602070
-
Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics
-
Gong CX, Shaikh S, Grundke-Iqbal I, Iqbal K (1996) Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics. Brain Res 741, 95-102.
-
(1996)
Brain Res
, vol.741
, pp. 95-102
-
-
Gong, C.X.1
Shaikh, S.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
32
-
-
0025998844
-
Classification of protein-serine/threonine phosphatases: Identification and quantitation in cell extracts
-
Cohen P (1991) Classification of protein-serine/threonine phosphatases: Identification and quantitation in cell extracts. Methods Enzymol 201, 389-398.
-
(1991)
Methods Enzymol
, vol.201
, pp. 389-398
-
-
Cohen, P.1
-
33
-
-
78449292337
-
Regulation of GSK3 isoforms by phosphatases PP1 and PP2A
-
Hernandez F, Langa E, Cuadros R, Avila J, Villanueva N (2010) Regulation of GSK3 isoforms by phosphatases PP1 and PP2A. Mol Cell Biochem 344, 211-215.
-
(2010)
Mol Cell Biochem
, vol.344
, pp. 211-215
-
-
Hernandez, F.1
Langa, E.2
Cuadros, R.3
Avila, J.4
Villanueva, N.5
-
34
-
-
84897401611
-
Protein phosphatase 2A dysfunction in Alzheimer's disease
-
Sontag JM, Sontag E (2014) Protein phosphatase 2A dysfunction in Alzheimer's disease. Front Mol Neurosci 7, 16.
-
(2014)
Front Mol Neurosci
, vol.7
, pp. 16
-
-
Sontag, J.M.1
Sontag, E.2
-
35
-
-
1842510667
-
Altered expression levels of the protein phosphatase 2A abalphac enzyme are associated with Alzheimer disease pathology
-
Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL, 3rd (2004) Altered expression levels of the protein phosphatase 2A abalphac enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 63, 287-301.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 287-301
-
-
Sontag, E.1
Luangpirom, A.2
Hladik, C.3
Mudrak, I.4
Ogris, E.5
Speciale, S.6
White, C.L.7
-
36
-
-
5644293035
-
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
-
Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL, 3rd (2004) Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63, 1080-1091.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 1080-1091
-
-
Sontag, E.1
Hladik, C.2
Montgomery, L.3
Luangpirom, A.4
Mudrak, I.5
Ogris, E.6
White, C.L.7
-
37
-
-
84860354271
-
The protein phosphatase PP2A/Balpha binds to the microtubule-Associated proteins tau and MAP2 at a motif also recognized by the kinase Fyn: Implications for tauopathies
-
Sontag JM, Nunbhakdi-Craig V, White CL, 3rd, Halpain S, Sontag E (2012) The protein phosphatase PP2A/Balpha binds to the microtubule-Associated proteins tau and MAP2 at a motif also recognized by the kinase Fyn: Implications for tauopathies. J Biol Chem 287, 14984-14993.
-
(2012)
J Biol Chem
, vol.287
, pp. 14984-14993
-
-
Sontag, J.M.1
Nunbhakdi-Craig, V.2
White, C.L.3
Halpain, S.4
Sontag, E.5
-
38
-
-
84884537540
-
Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells
-
Sontag JM, Nunbhakdi-CraigV, Sontag E (2013) Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells. J Biol Chem 288, 27396-27405.
-
(2013)
J Biol Chem
, vol.288
, pp. 27396-27405
-
-
Sontag, J.M.1
Nunbhakdi-Craig, V.2
Sontag, E.3
-
39
-
-
19544362550
-
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
-
Tanimukai H, Grundke-Iqbal I, Iqbal K (2005) Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am J Pathol 166, 1761-1771.
-
(2005)
Am J Pathol
, vol.166
, pp. 1761-1771
-
-
Tanimukai, H.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
40
-
-
44849144122
-
I1PP2A affects tau phosphorylation via association with the catalytic sub unit of protein phosphatase 2A
-
Chen S, Li B, Grundke-Iqbal I, IqbalK(2008) I1PP2A affects tau phosphorylation via association with the catalytic sub unit of protein phosphatase 2A. J Biol Chem 283, 10513-10521.
-
(2008)
J Biol Chem
, vol.283
, pp. 10513-10521
-
-
Chen, S.1
Li, B.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
41
-
-
84907495395
-
Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau
-
Arif M, Wei J, Zhang Q, Liu F, Basurto-Islas G, Grundke-Iqbal I, Iqbal K (2014) Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. J Biol Chem 289, 27677-27691.
-
(2014)
J Biol Chem
, vol.289
, pp. 27677-27691
-
-
Arif, M.1
Wei, J.2
Zhang, Q.3
Liu, F.4
Basurto-Islas, G.5
Grundke-Iqbal, I.6
Iqbal, K.7
-
42
-
-
84925368990
-
Inhibition of protein phosphatase-2A (PP2A) by I1PP2A leads to hyperphosphorylation of tau, neurodegeneration, and cognitive impairment in rats
-
Wang X, Blanchard J, Tung YC, Grundke-Iqbal I, Iqbal K (2015) Inhibition of protein phosphatase-2A (PP2A) by I1PP2A leads to hyperphosphorylation of tau, neurodegeneration, and cognitive impairment in rats. J Alzheimers Dis 45, 423-435.
-
(2015)
J Alzheimers Dis
, vol.45
, pp. 423-435
-
-
Wang, X.1
Blanchard, J.2
Tung, Y.C.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
43
-
-
18744411780
-
Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A
-
Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings BA, Gotz J (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci 16, 2039-2048.
-
(2002)
Eur J Neurosci
, vol.16
, pp. 2039-2048
-
-
Schmidt, K.1
Kins, S.2
Schild, A.3
Nitsch, R.M.4
Hemmings, B.A.5
Gotz, J.6
-
44
-
-
1042298807
-
Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice
-
Martens E, Stevens I, Janssens V, Vermeesch J, Gotz J, Goris J, Van Hoof C (2004) Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. J Mol Biol 336, 971-986.
-
(2004)
J Mol Biol
, vol.336
, pp. 971-986
-
-
Martens, E.1
Stevens, I.2
Janssens, V.3
Vermeesch, J.4
Gotz, J.5
Goris, J.6
Van Hoof, C.7
-
45
-
-
0027279893
-
Structure and expression of a 72-kda regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing
-
Hendrix P, Mayer-Jackel RE, Cron P, Goris J, Hofsteenge J, Merlevede W, Hemmings BA (1993) Structure and expression of a 72-kda regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. J Biol Chem 268, 15267-15276.
-
(1993)
J Biol Chem
, vol.268
, pp. 15267-15276
-
-
Hendrix, P.1
Mayer-Jackel, R.E.2
Cron, P.3
Goris, J.4
Hofsteenge, J.5
Merlevede, W.6
Hemmings, B.A.7
-
46
-
-
79955566269
-
Mice lacking phosphatase PP2A subunit PR61/b'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta
-
Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Gotz J, Van Leuven F, Goris J, Janssens V (2011) Mice lacking phosphatase PP2A subunit PR61/b'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A 108, 6957-6962.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 6957-6962
-
-
Louis, J.V.1
Martens, E.2
Borghgraef, P.3
Lambrecht, C.4
Sents, W.5
Longin, S.6
Zwaenepoel, K.7
Pijnenborg, R.8
Landrieu, I.9
Lippens, G.10
Ledermann, B.11
Gotz, J.12
Van Leuven, F.13
Goris, J.14
Janssens, V.15
-
47
-
-
79959736543
-
Glycogen synthase kinase-3beta regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
-
Yao XQ, Zhang XX, YinYY, Liu B, Luo DJ, Liu D, Chen NN, Ni ZF, Wang X, Wang Q, Wang JZ, Liu GP (2011) Glycogen synthase kinase-3beta regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochem J 437, 335-344.
-
(2011)
Biochem J
, vol.437
, pp. 335-344
-
-
Yao, X.Q.1
Zhang, X.X.2
Yin, Y.Y.3
Liu, B.4
Luo, D.J.5
Liu, D.6
Chen, N.N.7
Ni, Z.F.8
Wang, X.9
Wang, Q.10
Wang, J.Z.11
Liu, G.P.12
-
48
-
-
84864289760
-
Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1
-
Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP (2012) Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1. FEBS Lett 586, 2522-2528.
-
(2012)
FEBS Lett
, vol.586
, pp. 2522-2528
-
-
Yao, X.Q.1
Li, X.C.2
Zhang, X.X.3
Yin, Y.Y.4
Liu, B.5
Luo, D.J.6
Wang, Q.7
Wang, J.Z.8
Liu, G.P.9
|