Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1

FEBS Letters

Volumn 586, Issue 16, 2012, Pages 2522-2528

  Yao, Xiu Qing ^a   Li, Xia Chun ^a   Zhang, Xiao Xue ^a   Yin, Yang Yang ^a   Liu, Bin ^a   Luo, Dan Ju ^a   Wang, Qun ^a   Wang, Jian Zhi ^a   Liu, Gong Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; Demethylation; Glycogen synthase kinase 3 ; Leucine carboxyl methyltransferase 1; Protein phosphatase methylesterase; Protein phosphatase 2A

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LEUCINE; LEUCINE 309; LEUCINE CARBOXYMETHYLTRANSFERASE 1; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN PHOSPHATASE METHYLESTERASE 1; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ALZHEIMER DISEASE; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; CELL LINE, TUMOR; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; LENTIVIRUS; LEUCINE; METHYLATION; PROTEIN O-METHYLTRANSFERASE; PROTEIN PHOSPHATASE 2;

EID: 84864289760     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.06.018     Document Type: Article

References (47)

1. P. Cohen The structure and regulation of protein phosphatases Annu. Rev. Biochem. 58 1989 453 508 (Pubitemid 19172978)
2. M. Gallego, and D.M. Virshup Potein serine/threonine phosphatases: life, death, and sleeping Curr. Opin. Cell Biol. 17 2005 197 202
3. J. Chen, B.L. Martin, and D.L. Brautigan Regulation of protein serine threonine phosphatase type-2A by tyrosine phosphorylation Science 257 1992 1261 1264
4. J. Chen, S. Parsons, and D.L. Brautigan Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts J. Biol. Chem. 269 1994 7957 7962 (Pubitemid 24200196)
5. Y. Xing, Z. Li, Y. Chen, J.B. Stock, P.D. Jeffrey, and Y. Shi Structural mechanism of demethylation and inactivation of protein phosphatase 2A Cell 33 2008 154 163 (Pubitemid 351442993)
6. J.Z. Wang, Q. Wu, A. Smith, I. Grundke-Iqbal, and K. Iqbal Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase FEBS Lett. 436 1998 28 34 (Pubitemid 28454601)
7. C.X. Gong, J.Z. Wang, K. Iqbal, and I. Grundke-Iqbal Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices Neurosci. Lett. 340 2003 107 110 (Pubitemid 36369286)
8. A. Hye, F. Kerr, N. Archer, C. Foy, M. Poppe, R. Brown, G. Hamilton, J. Powell, B. Anderton, and S. Lovestone Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease Neurosci. Lett. 373 1 2005 1 4 (Pubitemid 39536210)
9. K. Leroy, Z. Yilmaz, and J.P. Brion Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration Neuropathol. Appl. Neurobiol. 33 1 2007 43 55 (Pubitemid 46090309)
10. C.X. Gong, T.J. Singh, I. Grundke-Iqbal, and K. Iqbal Phosphoprotein phosphatase activities in Alzheimer disease brain J. Neurochem. 61 3 1993 921 927 (Pubitemid 23241228)
11. F. Liu, I. Grundke-Iqbal, K. Iqbal, and C.X. Gong Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation Eur. J. Neurosci. 22 2005 1942 1950 (Pubitemid 41579384)
12. S. Tsuji, S. Morinobu, K. Tanaka, K. Kawano, and S. Yamawaki Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression J. Neural. Transm. 110 2003 413 425 (Pubitemid 36428389)
13. Q.G. Ren, X.M. Liao, Z.F. Wang, Z.S. Qu, and J.Z. Wang The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation FEBS Lett. 580 2006 2503 2511
14. J.V. Louis, E. Martens, P. Borghgraef, C. Lambrecht, W. Sents, S. Longin, K. Zwaenepoel, R. Pijnenborg, I. Landrieu, G. Lippens, B. Ledermann, J. Götz, F. Van Leuven, J. Goris, and V. Janssens Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp 2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK-3beta Proc. Natl. Acad. Sci. U S A 108 17 2011 6957 6962
15. G.P. Liu, Y. Zhang, X.Q. Yao, C.E. Zhang, J. Fang, Q. Wang, and J.Z. Wang Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms Neurobiol. Aging. 29 9 2008 1348 1358 (Pubitemid 351970605)
16. C.L. Chen, C.F. Lin, C.W. Chiang, M.S. Jan, and Y.S. Lin Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis Mol. Pharmacol. 70 2 2006 510 517
17. X.Q. Yao, X.X. Zhang, Y.Y. Yin, B. Liu, D.J. Luo, D. Liu, N.N. Chen, Z.F. Ni, X. Wang, Q. Wang, J.Z. Wang, and G.P. Liu Glycogen synthase kinase-3 regulates tyrosine-307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src Biochem. J. 437 2 2011 335 344
18. S. Longin, K. Zwaenepoel, J.V. Louis, S. Dilworth, J. Goris, and V. Janssens Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit J. Biol. Chem. 282 37 2007 26971 26980 (Pubitemid 47501927)
19. P. Puustinen, M.R. Junttila, S. Vanhatupa, A.A. Sablina, M.E. Hector, K. Teittinen, O. Raheem, K. Ketola, S. Lin, J. Kast, H. Haapasalo, W.C. Hahn, and J. Westermarck PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma Cancer Res. 69 7 2009 2870 2877
20. B.K. Kaspar, B. Vissel, T. Bengoechea, S. Crone, L. Randolph-Moore, R. Muller, E.P. Brandon, D. Schaffer, I.M. Verma, K.F. Lee, S.F. Heinemann, and F.H. Gage Adeno-associated virus effectively mediates conditional gene modification in the brain Proc. Natl. Acad. Sci. U S A 99 4 2002 2320 2325 (Pubitemid 34169059)
21. M. Goedert Tau protein and neurofibrillary pathology of Alzheimer's disease Trends. Neurosci. 16 1993 460 465 (Pubitemid 23313524)
22. J.Q. Trojanowski, and V.M. Lee Phosphorylation of paried helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatase FASEB J. 9 1995 1570 1576 (Pubitemid 26012845)
23. A. Takashima GSK-3 is essential in the pathogenesis of Alzheimer's disease J. Alzheimers Dis. 9 2006 309 317 (Pubitemid 44253325)
24. J. Avila, and J. Díaz-Nido Tangling with hypothermia Nat. Med. 10 2004 460 461 (Pubitemid 38667901)
25. J.Z. Wang, C.X. Gong, T. Zaidi, I. Grundke-Iqbal, and K. Iqbal Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B J. Biol. Chem. 270 1995 4854 4860
26. M. Li, H. Guo, and Z. Damuni Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney Biochemistry 34 1995 1988 1996
27. X. Caylam, J. Goris, J. Hermann, P. Hendrix, R. Ozon, and W. Merlevede Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes Biochemistry 29 1990 658 667 (Pubitemid 20041946)
28. R.T. Dobrowsky, C. Kamibayashi, M.C. Mumby, and Y.A. Hannun Ceramide activates heterotrimeric protein phosphatase 2A J. Biol. Chem. 268 1993 15523 15530 (Pubitemid 23222045)
29. J. Lee, and J. Stock Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase J. Biol. Chem. 268 1993 19192 19195 (Pubitemid 23270686)
30. M. Li, and Z. Damuni Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase Biochem. Biophys. Res. Commun. 202 1994 1023 1030 (Pubitemid 24259315)
31. B. Favre, S. Zolnierowicz, P. Turowski, and B.A. Hemmings The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo J. Biol. Chem. 269 1994 16311 16317 (Pubitemid 24209328)
32. H. Xie, and S. Clarke An enzymatica activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A Biochem. Biophys. Res. Commun. 203 1994 1710 1715 (Pubitemid 24321561)
33. E. Sontag, A. Luangpirom, C. Hladik, I. Mudrak, E. Ogrisrd, S. Speciale, and C.L. White 3rd Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology J. Neuropathol. Exp. Neurol. 63 2004 287 301 (Pubitemid 38429026)
34. E. Sontag, C. Hladik, L. Montgomery, A. Luangpirom, I. Mudrak, E. Ogris, and C.L. White 3rd Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis J. Neuropathol. Exp. Neurol. 63 2004 1080 1091 (Pubitemid 39372592)
35. I. De Baere, R. Derua, V. Janssens, C. Van Hoof, E. Waelkens, W. Merlevede, and J. Goris Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human Homologue Biochemistry 38 1999 16539 16547
36. J. Lee, Y. Chen, T. Tolstykh, and J. Stock A specific protein carboxyl methesterase that demethylates phosphoprotein phosphatase 2A in bovine brain Proc. Natl. Acad. Sci. USA 93 1996 6043 6047 (Pubitemid 26190799)
37. H. Xie, and S. Clarke Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain J. Biol. Chem. 269 1994 1981 1984 (Pubitemid 24035403)
38. E. Sontag, V. Nunbhakdi-Craig, J.M. Sontag, R. Diaz-Arrastia, E. Ogris, S. Dayal, S.R. Lentz, E. Arning, and T. Bottiglieri Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation J. Neurosci. 27 11 2007 2751 2759 (Pubitemid 46438990)
39. H. Hombauer, D. Weismann, I. Mudrak, C. Stanzel, T. Fellner, D.H. Lackner, and E. Ogris Generation of active protein phosphatase 2A is coupled to holoenzyme assembly PLoS Biol. 5 6 2007 e155
40. E. Ogris, X. Du, K.C. Nelson, E.K. Mak, X.X. Yu, W.S. Lane, and D.C. Pallas A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A J. Biol. Chem. 274 20 1999 14382 14391
41. J.J. Pei, C.X. Gong, K. Iqbal, I. Grundke-Iqbal, Q.L. Wu, B. Winblad, and R.F. Cowburn Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains J. Neural. Transm. 105 1 1998 69 83 (Pubitemid 28132597)
42. V. Vogelsberg-Ragaglia, T. Schuck, J.Q. Trojanowski, and V.M. Lee PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus Exp. Neurol. 168 2 2001 402 412 (Pubitemid 32289776)
43. H. Tanimukai, I. Grundke-Iqbal, and K. Iqbal Upregulation of inhibitors of protein phosphatase-2A in Alzheimer's disease Am. J. Pathol. 166 2005 1761 1771 (Pubitemid 40734399)
44. R. Liu, X.W. Zhou, H. Tanila, C. Bjorkdahl, J.Z. Wang, Z.Z. Guan, Y. Cao, J.A. Gustafsson, B. Winblad, and J.J. Pei Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology J. Cell Mol. Med. 12 1 2008 241 257 (Pubitemid 351430466)
45. J.J. Pei, T. Tanaka, Y.C. Tung, E. Braak, K. Iqbal, and I. Grundke-Iqbal Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain J. Neuropathol. Exp. Neurol. 56 1997 70 78 (Pubitemid 127470328)
46. J.J. Pei, E. Braak, H. Braak, I. Grundke-Iqbal, K. Iqbal, B. Winblad, and R.F. Cowburn Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes J. Neuropathol. Exp. Neurol. 58 1999 1010 1019 (Pubitemid 29441929)
47. K. Leroy, A. Boutajangout, M. Authelet, J.R. Woodgett, B.H. Anderton, and J.P. Brion The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease Acta Neuropathol. 103 2 2002 91 99 (Pubitemid 36067485)