Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats

Journal of Alzheimer's Disease

Volumn 45, Issue 2, 2015, Pages 423-435

  Wang, Xiaochuan ^a   Blanchard, Julie ^a   Tung, Yunn Chyn ^a   Grundke Iqbal, Inge ^a   Iqbal, Khalid ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Inhibitor I of PP2A (I1PP2A; neurofibrillary degeneration; protein phosphatase 2A (PP2A); tau hyperphosphorylation

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; PHOSPHOPROTEIN PHOSPHATASE 2A; SYNAPSIN I; TAU PROTEIN; ANP32A PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; SIGNAL PEPTIDE; SYNAPSIN;

ADENO ASSOCIATED VIRUS 1; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; COGNITIVE DEFECT; CONTROLLED STUDY; EXPERIMENTAL BEHAVIORAL TEST; EXPLORATORY BEHAVIOR; IMMUNOHISTOCHEMISTRY; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REFERENCE MEMORY; 3T3 CELL LINE; ANIMAL; BRAIN; COGNITION DISORDERS; DEPENDOPARVOVIRUS; DISEASE MODEL; GENETICS; MAZE TEST; METABOLISM; MOUSE; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLE; NEUROLOGIC EXAMINATION; NEWBORN; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; COGNITION DISORDERS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAZE LEARNING; MICE; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; NEUROLOGIC EXAMINATION; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR; SYNAPSINS; TAU PROTEINS;

EID: 84925368990     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142403     Document Type: Article

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