-
1
-
-
26244432388
-
Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
-
Baigent C, Keech A, Kearney P, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005; 366: 1267-1278.
-
(2005)
Lancet
, vol.366
, pp. 1267-1278
-
-
Baigent, C.1
Keech, A.2
Kearney, P.3
-
2
-
-
78449281377
-
Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
-
Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010; 376: 1670-1681.
-
(2010)
Lancet
, vol.376
, pp. 1670-1681
-
-
Baigent, C.1
Blackwell, L.2
Emberson, J.3
-
3
-
-
79960539641
-
ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committees. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). ESC/EAS guidelines for the management of dyslipidaemias
-
Reiner Z, Catapano AL, De Backer G, et al. ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committees. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2011; 32: 1769-1818.
-
(2011)
Eur Heart J
, vol.32
, pp. 1769-1818
-
-
Reiner, Z.1
Catapano, A.L.2
De Backer, G.3
-
4
-
-
84862119222
-
European guidelines on cardiovascular disease prevention in clinical practice (version 2012)
-
Peck J, De Backer G, Gohlke H, et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012). Eur Heart J. 2012; 33: 1635-1701.
-
(2012)
Eur Heart J
, vol.33
, pp. 1635-1701
-
-
Peck, J.1
De Backer, G.2
Gohlke, H.3
-
6
-
-
84905189482
-
Very low levels of atherogenic lipoproteins and the risk for cardiovascular events. A meta-analysis of statin trials
-
Boekholdt SM, Hovingh GK, Mora S, et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events. A meta-analysis of statin trials. J Am Coll Cardiol. 2014; 64: 485-494.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 485-494
-
-
Boekholdt, S.M.1
Hovingh, G.K.2
Mora, S.3
-
7
-
-
84937529439
-
The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk: A new paradigm supported by more evidence
-
Robinson JG, Stone NJ. The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk: a new paradigm supported by more evidence. Eur Heart J. 2015;36:2110-2118.
-
(2015)
Eur Heart J
, vol.36
, pp. 2110-2118
-
-
Robinson, J.G.1
Stone, N.J.2
-
9
-
-
84931411520
-
Ezetimibe added to statin therapy after acute coronary syndromes
-
Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015; 372: 2387-2397.
-
(2015)
N Engl J Med
, vol.372
, pp. 2387-2397
-
-
Cannon, C.P.1
Blazing, M.A.2
Giugliano, R.P.3
-
10
-
-
84871260146
-
Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: A Mendelian randomization analysis
-
Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012; 60: 2631-2639.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 2631-2639
-
-
Ference, B.A.1
Yoo, W.2
Alesh, I.3
-
11
-
-
84928026823
-
Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: A 2x2 factorial Mendelian randomization study
-
Ference BA, Majeed F, Penumetcha R, et al. Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2x2 factorial Mendelian randomization study. J Am Coll Cardiol. 2015; 65: 1552-1561.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1552-1561
-
-
Ference, B.A.1
Majeed, F.2
Penumetcha, R.3
-
12
-
-
84931260952
-
IMPROVE-IT and genetics reaffirm the causal role of LDL in cardiovascular disease
-
Catapano AL, Ference BA. IMPROVE-IT and genetics reaffirm the causal role of LDL in cardiovascular disease. Atherosclerosis. 2015; 241: 498-501.
-
(2015)
Atherosclerosis
, vol.241
, pp. 498-501
-
-
Catapano, A.L.1
Ference, B.A.2
-
13
-
-
84927742065
-
Statin-associated muscle symptoms: Impact on statin therapy - European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management
-
Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015; 36: 1012-1022.
-
(2015)
Eur Heart J
, vol.36
, pp. 1012-1022
-
-
Stroes, E.S.1
Thompson, P.D.2
Corsini, A.3
-
14
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003; 34: 154-156.
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
15
-
-
13944265645
-
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
-
Cohen J, Pertsemlidis A, Korowski IK, et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet. 2005; 37: 161-165.
-
(2005)
Nat Genet
, vol.37
, pp. 161-165
-
-
Cohen, J.1
Pertsemlidis, A.2
Korowski, I.K.3
-
16
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen JC, Boerwinkle E, Mosley TH Jr, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006; 354: 1264-1272.
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, T.H.3
-
17
-
-
77953309816
-
PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
-
Benn M, Nordestgaard BG, Grande P, et al. PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. J Am Coll Cardiol. 2010; 55: 2833-2842.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2833-2842
-
-
Benn, M.1
Nordestgaard, B.G.2
Grande, P.3
-
18
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov. 2012; 11: 367-383.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
19
-
-
84897889156
-
PCSK9: A key modulator of cardiovascular health
-
Seidah NG, Awan Z, Chrétien M, et al. PCSK9: a key modulator of cardiovascular health. Circ Res. 2014; 114: 1022-1036.
-
(2014)
Circ Res
, vol.114
, pp. 1022-1036
-
-
Seidah, N.G.1
Awan, Z.2
Chrétien, M.3
-
21
-
-
84904964617
-
PCSK9 inhibition for the treatment of hypercholesterolemia: Promises and emerging challenges
-
Norata GD, Tibolla G, Catapano AL. PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges. Vascul Pharmacol. 2014; 62: 103-111.
-
(2014)
Vascul Pharmacol
, vol.62
, pp. 103-111
-
-
Norata, G.D.1
Tibolla, G.2
Catapano, A.L.3
-
22
-
-
84885447918
-
Targeting the proprotein convertase subtilisin/kexin type 9 (PCSK9) for the treatment of dyslipidemia and atherosclerosis
-
Urban D, Pöss J, Böhm M, et al. Targeting the proprotein convertase subtilisin/kexin type 9 (PCSK9) for the treatment of dyslipidemia and atherosclerosis. J Am Coll Cardiol. 2013; 62: 1401-1408.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 1401-1408
-
-
Urban, D.1
Pöss, J.2
Böhm, M.3
-
23
-
-
84895075938
-
PCSK9: From discovery to therapeutic applications
-
Farnier M. PCSK9: from discovery to therapeutic applications. Arch Cardiovasc Dis. 2014; 107: 58-66.
-
(2014)
Arch Cardiovasc Dis
, vol.107
, pp. 58-66
-
-
Farnier, M.1
-
24
-
-
84918820589
-
PCSK9 inhibition in LDL cholesterol reduction: Genetics and therapeutic implications of very low plasma lipoprotein levels
-
Marais AD, Kim JB, Wasserman SM, et al. PCSK9 inhibition in LDL cholesterol reduction: genetics and therapeutic implications of very low plasma lipoprotein levels. Pharmacol Ther. 2015; 145: 58-66.
-
(2015)
Pharmacol Ther
, vol.145
, pp. 58-66
-
-
Marais, A.D.1
Kim, J.B.2
Wasserman, S.M.3
-
26
-
-
69549101648
-
Targeting PCSK9 for the treatment of hypercholesterolemia
-
Hedrick JA. Targeting PCSK9 for the treatment of hypercholesterolemia. Curr Opin Invest Drugs. 2009; 10: 938-946.
-
(2009)
Curr Opin Invest Drugs
, vol.10
, pp. 938-946
-
-
Hedrick, J.A.1
-
27
-
-
84871362850
-
PCSK9 inhibition and LDL cholesterol lowering: The biology of an attractive therapeutic target and critical review of the latest clinical trials
-
Rhainds D, Arsenault BJ, Tardif J-C. PCSK9 inhibition and LDL cholesterol lowering: the biology of an attractive therapeutic target and critical review of the latest clinical trials. Clin Lipid. 2012; 7: 621-640.
-
(2012)
Clin Lipid
, vol.7
, pp. 621-640
-
-
Rhainds, D.1
Arsenault, B.J.2
Tardif, J.-C.3
-
28
-
-
61449444418
-
PCSK9 as a therapeutic target of dyslipidemia
-
Seidah NG. PCSK9 as a therapeutic target of dyslipidemia. Expert Opin Ther Targets. 2009; 13: 19-28.
-
(2009)
Expert Opin Ther Targets
, vol.13
, pp. 19-28
-
-
Seidah, N.G.1
-
29
-
-
84873927641
-
Anti-PCSK9 therapies for the treatment of hypercholesterolemia
-
Hooper AJ, Burnett JR. Anti-PCSK9 therapies for the treatment of hypercholesterolemia. Expert Opin Biol Ther. 2013; 13: 429-435.
-
(2013)
Expert Opin Biol Ther
, vol.13
, pp. 429-435
-
-
Hooper, A.J.1
Burnett, J.R.2
-
30
-
-
84880095092
-
PCSK9 inhibitors
-
Farnier M. PCSK9 inhibitors. Curr Opin Lipidol. 2013; 24: 251-258.
-
(2013)
Curr Opin Lipidol
, vol.24
, pp. 251-258
-
-
Farnier, M.1
-
31
-
-
84925351969
-
Lipid lowering with PCSK9 inhibitors
-
Dadu RT, Ballantyne CM. Lipid lowering with PCSK9 inhibitors. Nat Rev Cardiol. 2014; 11: 563-575.
-
(2014)
Nat Rev Cardiol
, vol.11
, pp. 563-575
-
-
Dadu, R.T.1
Ballantyne, C.M.2
-
32
-
-
84948564221
-
-
Praluent (alirocumab) injection. The Endocrinologic and Metabolic Drugs Advisory Committee Meeting; Jun 9; [cited 2015 Aug 10]
-
Praluent (alirocumab) injection. FDA document-BLA 125559. FDA Center for Drug Evaluation and Research. The Endocrinologic and Metabolic Drugs Advisory Committee Meeting; 2015. Jun 9; [cited 2015 Aug 10]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM449865.pdf.
-
(2015)
FDA Document - BLA 125559. FDA Center for Drug Evaluation and Research
-
-
-
33
-
-
84948582449
-
-
cited 2015 Aug 10
-
Praluent prescribing information. [cited 2015 Aug 10]. Available from: www.regeneron.com/Praluent/Praluent-fpi.pdf.
-
Praluent Prescribing Information
-
-
-
34
-
-
84899541245
-
Alirocumab for hyperlipidemia: Physiology of PCSK9 inhibition, pharmacodynamics and phase i and II clinical trial results of a PCSK9 monoclonal antibody
-
Roth EM, Diller P. Alirocumab for hyperlipidemia: physiology of PCSK9 inhibition, pharmacodynamics and phase I and II clinical trial results of a PCSK9 monoclonal antibody. Future Cardiol. 2014; 10: 183-199.
-
(2014)
Future Cardiol
, vol.10
, pp. 183-199
-
-
Roth, E.M.1
Diller, P.2
-
35
-
-
84858638369
-
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
-
Stein EA, Mellis S, Yancopoulos GD, et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med. 2012; 366: 1108-1118.
-
(2012)
N Engl J Med
, vol.366
, pp. 1108-1118
-
-
Stein, E.A.1
Mellis, S.2
Yancopoulos, G.D.3
-
36
-
-
84911411495
-
A randomized study of the relative pharmacokinetics, pharmacodynamics, and safety of alirocumab, a fully human monoclonal antibody to PCSK9, after single subcutaneous administration at three different injection sites in healthy subjects
-
Lunven C, Paehler T, Poitiers F, et al. A randomized study of the relative pharmacokinetics, pharmacodynamics, and safety of alirocumab, a fully human monoclonal antibody to PCSK9, after single subcutaneous administration at three different injection sites in healthy subjects. Cardiovasc Ther. 2014; 32: 297-301.
-
(2014)
Cardiovasc Ther
, vol.32
, pp. 297-301
-
-
Lunven, C.1
Paehler, T.2
Poitiers, F.3
-
37
-
-
0014450553
-
Metabolism of immunoglobulins
-
Waldmann TA, Strober W. Metabolism of immunoglobulins. Prog Allergy. 1969; 13: 1-110.
-
(1969)
Prog Allergy
, vol.13
, pp. 1-110
-
-
Waldmann, T.A.1
Strober, W.2
-
38
-
-
84862219022
-
Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
-
McKenney JM, Koren MJ, Kereiakes DJ, et al. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol. 2012; 59: 2344-2353.
-
(2012)
J Am Coll Cardiol
, vol.59
, pp. 2344-2353
-
-
McKenney, J.M.1
Koren, M.J.2
Kereiakes, D.J.3
-
39
-
-
84863494422
-
Effect of a monoclonal antibody to PCSK9, REG727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
-
Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REG727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet. 2012; 380: 29-36.
-
(2012)
Lancet
, vol.380
, pp. 29-36
-
-
Stein, E.A.1
Gipe, D.2
Bergeron, J.3
-
40
-
-
84868689211
-
Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
-
Roth EM, McKenney JM, Hanotin C, et al. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. 2012; 367: 1891-1900.
-
(2012)
N Engl J Med
, vol.367
, pp. 1891-1900
-
-
Roth, E.M.1
McKenney, J.M.2
Hanotin, C.3
-
41
-
-
84908363070
-
Effect of Alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials)
-
Gaudet D, Kereiakes DJ, McKenney JM, et al. Effect of Alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials). Am J Cardiol. 2014; 114: 711-715.
-
(2014)
Am J Cardiol
, vol.114
, pp. 711-715
-
-
Gaudet, D.1
Kereiakes, D.J.2
McKenney, J.M.3
-
42
-
-
84926191670
-
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
-
Robinson JG, Farnier M, Krempf M, et al. for the ODYSSEY LONG TERM investigators. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015; 372: 1489-1499.
-
(2015)
N Engl J Med
, vol.372
, pp. 1489-1499
-
-
Robinson, J.G.1
Farnier, M.2
Krempf, M.3
-
43
-
-
84983160332
-
ODYSSEY FH i and FH II: 78-week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolemia
-
Sept 1. pii:ehv370. [Epub ahead of print]
-
Kastelein JJP, Ginsberg HN, Langslet G, et al. ODYSSEY FH I and FH II: 78-week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolemia. Eur Heart J. 2015 Sept 1. pii:ehv370. [Epub ahead of print]
-
(2015)
Eur Heart J
-
-
Kastelein, J.J.P.1
Ginsberg, H.N.2
Langslet, G.3
-
45
-
-
84930179904
-
Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO i study
-
Kereiakes DJ, Robinson JG, Cannon CP, et al. Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: the ODYSSEY COMBO I study. Am Heart J. 2015; 169: 906-915.
-
(2015)
Am Heart J
, vol.169
, pp. 906-915
-
-
Kereiakes, D.J.1
Robinson, J.G.2
Cannon, C.P.3
-
46
-
-
84948580958
-
Efficacy and safety of alirocumab 150 mg and 300 mg every four weeks in patients with uncontrolled hypercholesterolemia: The ODYSSEY CHOICE i and CHOICE II studies
-
Mar 17; San Diego CA; abstract 1107-105
-
Stroes E, Guyton J, Farnier M, et al. Efficacy and safety of alirocumab 150 mg and 300 mg every four weeks in patients with uncontrolled hypercholesterolemia: the ODYSSEY CHOICE I and CHOICE II studies. Presented at the American College of Cardiology Sessions; 2015 Mar 17; San Diego CA; abstract 1107-105.
-
(2015)
Presented at the American College of Cardiology Sessions
-
-
Stroes, E.1
Guyton, J.2
Farnier, M.3
-
47
-
-
84948566741
-
Efficacy and safety of alirocumab 150 mg every 4 weeks in patients with hypercholesterolemia not on statin therapy: The ODYSSEY CHOICE II study
-
Jun; Amsterdam, NL
-
Stroes E, Guyton JR, Farnier M, et al. for the ODYSSEY CHOICE II investigators. Efficacy and safety of alirocumab 150 mg every 4 weeks in patients with hypercholesterolemia not on statin therapy: the ODYSSEY CHOICE II study. Presented at the ISA meeting at the late breaker session; 2015 Jun; Amsterdam, NL.
-
(2015)
Presented at the ISA Meeting at the Late Breaker Session
-
-
Stroes, E.1
Guyton, J.R.2
Farnier, M.3
-
48
-
-
84929322473
-
Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: The ODYSSEY COMBO II randomized controlled trial
-
Cannon CP, Cariou B, Blom D, et al. Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial. Eur Heart J. 2015; 36: 1186-1194.
-
(2015)
Eur Heart J
, vol.36
, pp. 1186-1194
-
-
Cannon, C.P.1
Cariou, B.2
Blom, D.3
-
49
-
-
84947965019
-
Efficacy and safety of alirocumab versus ezetimibe in statin-intolerant patients, with a statin- re-challenge arm: The ODYSSEY ALTERNATIVE randomized trial
-
Moriarty PM, Thompson PD, Cannon CP, et al. Efficacy and safety of alirocumab versus ezetimibe in statin-intolerant patients, with a statin- re-challenge arm: the ODYSSEY ALTERNATIVE randomized trial. J Clin Lipidol. 2015. DOI: 10.1016/j.jacl.2015.08.006.
-
(2015)
J Clin Lipidol
-
-
Moriarty, P.M.1
Thompson, P.D.2
Cannon, C.P.3
-
50
-
-
84906323762
-
Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24 week, double-blind, randomized phase 3 trial
-
Roth EM, Taskinen M-R, Ginsberg HN, et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized phase 3 trial. Int J Cardiol. 2014; 176: 55-61.
-
(2014)
Int J Cardiol
, vol.176
, pp. 55-61
-
-
Roth, E.M.1
Taskinen, M.-R.2
Ginsberg, H.N.3
-
51
-
-
84939207026
-
Alirocumab as add-on to atorvastatin versus other lipid treatment strategies: ODYSSEY OPTIONS i randomized trial
-
Bays H, Gaudet D, Weiss R, et al. Alirocumab as add-on to atorvastatin versus other lipid treatment strategies: ODYSSEY OPTIONS I randomized trial. J Clin Endocrinol Metab. 2015; 100: 3140-3148.
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 3140-3148
-
-
Bays, H.1
Gaudet, D.2
Weiss, R.3
-
52
-
-
84948572821
-
Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: The ODYSSEY OPTIONS II randomized trial
-
Forthcoming
-
Farnier M, Jones P, Severance R, et al. Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: the ODYSSEY OPTIONS II randomized trial. Atherosclerosis. Forthcoming 2015.
-
(2015)
Atherosclerosis
-
-
Farnier, M.1
Jones, P.2
Severance, R.3
-
53
-
-
84908322310
-
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY outcomes trial
-
Schwartz GG, Bessac L, Berdan LG, et al. Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. Am Heart J. 2014; 168: 682-689.
-
(2014)
Am Heart J
, vol.168
, pp. 682-689
-
-
Schwartz, G.G.1
Bessac, L.2
Berdan, L.G.3
-
54
-
-
84926206074
-
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
-
Sabatine MS, Giugliano RP, Wiviott SD, et al. for the open-label study of long-term evaluation against LDL-cholesterol (OSLER) investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015; 372: 1500-1509.
-
(2015)
N Engl J Med
, vol.372
, pp. 1500-1509
-
-
Sabatine, M.S.1
Giugliano, R.P.2
Wiviott, S.D.3
-
55
-
-
84903754236
-
Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: Design and rationale of the ODYSSEY FH studies
-
Kastelein JJP, Robinson JG, Farnier M, et al. Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies. Cardiovasc Drugs Ther. 2014; 28: 281-289.
-
(2014)
Cardiovasc Drugs Ther
, vol.28
, pp. 281-289
-
-
Kastelein, J.J.P.1
Robinson, J.G.2
Farnier, M.3
-
56
-
-
84948567554
-
Efficacy and safety of the PCSK9 monoclonal antibody alirocumab vs placebo in 1254 patients with heterozygous familial hypercholesterolemia (HeFH): Analyses up to 78 weeks from four ODYSSEY trials
-
Sept; London, UK; abstract
-
Kastelein JJP, Farnier M, Hovingh GK, et al. Efficacy and safety of the PCSK9 monoclonal antibody alirocumab vs placebo in 1254 patients with heterozygous familial hypercholesterolemia (HeFH): analyses up to 78 weeks from four ODYSSEY trials. Presented at European Society of Cardiology Sessions; 2014 Sept; London, UK; abstract.
-
(2014)
Presented at European Society of Cardiology Sessions
-
-
Kastelein, J.J.P.1
Farnier, M.2
Hovingh, G.K.3
-
57
-
-
84948580064
-
Characterization of autosomal dominant hypercholesterolemia caused by PCSK9 gain of function mutations and its specific treatment with alirocumab, a PCSK9 monoclonal antibody
-
Sept 15. pii:CIRCGENETICS.115.001129. [Epub ahead of print]
-
Hopkins PN, Defesche J, Fouchier SW, et al. Characterization of autosomal dominant hypercholesterolemia caused by PCSK9 gain of function mutations and its specific treatment with alirocumab, a PCSK9 monoclonal antibody. Circ Cardiovasc Genet. 2015 Sept 15. pii:CIRCGENETICS.115.001129. [Epub ahead of print]
-
(2015)
Circ Cardiovasc Genet
-
-
Hopkins, P.N.1
Defesche, J.2
Fouchier, S.W.3
-
58
-
-
84961288617
-
Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab
-
Lambert G, Chatelais M, Petrides F, et al. Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab. J Am Coll Cardiol. 2014; 64: 2299-2300.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 2299-2300
-
-
Lambert, G.1
Chatelais, M.2
Petrides, F.3
-
59
-
-
84921459685
-
Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA part B): A randomised, double-blind, placebo-controlled trial
-
Raal FJ, Honarpour N, Blom DK, et al. for the TESLA investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA part B): a randomised, double-blind, placebo-controlled trial. Lancet. 2015; 385: 341-350.
-
(2015)
Lancet
, vol.385
, pp. 341-350
-
-
Raal, F.J.1
Honarpour, N.2
Blom, D.K.3
-
60
-
-
84923845326
-
Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trials
-
Moriarty PM, Jacobson TA, Bruckert E, et al. Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trials. J Clin Lipidol. 2014; 8: 554-561.
-
(2014)
J Clin Lipidol
, vol.8
, pp. 554-561
-
-
Moriarty, P.M.1
Jacobson, T.A.2
Bruckert, E.3
-
61
-
-
84911807189
-
Efficacy and safety of alirocumab as add-on therapy in high-cardiovascular-risk patients with hypercholesterolemia not adequately controlled with atorvastatin (20 or 40 mg) or rosuvastatin (10 or 20 mg): Design and rationale of the ODYSSEY OPTIONS studies
-
Robinson JG, Colhoun HM, Bays HE, et al. Efficacy and safety of alirocumab as add-on therapy in high-cardiovascular-risk patients with hypercholesterolemia not adequately controlled with atorvastatin (20 or 40 mg) or rosuvastatin (10 or 20 mg): design and rationale of the ODYSSEY OPTIONS studies. Clin Cardiol. 2014; 37: 597-604.
-
(2014)
Clin Cardiol
, vol.37
, pp. 597-604
-
-
Robinson, J.G.1
Colhoun, H.M.2
Bays, H.E.3
-
62
-
-
84907525325
-
Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
-
Kühnast S, van der Hoorn JWA, Pieterman EJ, et al. Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. J Lipid Res. 2014; 55: 2103-2112.
-
(2014)
J Lipid Res
, vol.55
, pp. 2103-2112
-
-
Kühnast, S.1
Van Der Hoorn, J.W.A.2
Pieterman, E.J.3
-
63
-
-
84948587680
-
Adverse events in patients with low-density lipoprotein cholesterol levels < 25 or < 15 mg/dL on at least two consecutive visits in fourteen randomized, controlled, clinical trials of alirocumab
-
Mar 17; San Diego, CA; abstract 1164M-05
-
Robinson J, Farnier M, Chaudhari U, et al. Adverse events in patients with low-density lipoprotein cholesterol levels < 25 or < 15 mg/dL on at least two consecutive visits in fourteen randomized, controlled, clinical trials of alirocumab. Presented at American College of Cardiology Sessions; 2015 Mar 17; San Diego, CA; abstract 1164M-05.
-
(2015)
Presented at American College of Cardiology Sessions
-
-
Robinson, J.1
Farnier, M.2
Chaudhari, U.3
-
64
-
-
84906239708
-
Lipids and cardiovascular disease 1. LDL-cholesterol: Controversies and future therapeutic directions
-
Ridker PM. Lipids and cardiovascular disease 1. LDL-cholesterol: controversies and future therapeutic directions. Lancet. 2014; 384: 607-617.
-
(2014)
Lancet
, vol.384
, pp. 607-617
-
-
Ridker, P.M.1
-
65
-
-
84861849012
-
Persistent lipid abnormalies in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada
-
Gitt AK, Drexel H, Feely J, et al. on behalf of the DYSIS investigators. Persistent lipid abnormalies in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada. Eur J Prev Cardiol. 2012; 19: 221-230.
-
(2012)
Eur J Prev Cardiol
, vol.19
, pp. 221-230
-
-
Gitt, A.K.1
Drexel, H.2
Feely, J.3
-
66
-
-
84920894208
-
Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes
-
Gencer B, Auer R, Nanchen D, et al. Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes. Atherosclerosis. 2015; 239: 118-124.
-
(2015)
Atherosclerosis
, vol.239
, pp. 118-124
-
-
Gencer, B.1
Auer, R.2
Nanchen, D.3
-
67
-
-
84929493809
-
Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor
-
Romagnuolo R, Scipione CA, Boffa MB, et al. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. J Biol Chem. 2015; 290: 11649-11662.
-
(2015)
J Biol Chem
, vol.290
, pp. 11649-11662
-
-
Romagnuolo, R.1
Scipione, C.A.2
Boffa, M.B.3
-
68
-
-
79953760698
-
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue
-
Roubtsova A, Munkonda MN, Awan Z, et al. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arterioscler Thromb Vasc Biol. 2011; 31: 785-791.
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 785-791
-
-
Roubtsova, A.1
Munkonda, M.N.2
Awan, Z.3
-
69
-
-
84905101303
-
Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglycerides-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms
-
Rashid S, Tavori H, Brown PE, et al. Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglycerides-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms. Circulation. 2014; 130: 431-441.
-
(2014)
Circulation
, vol.130
, pp. 431-441
-
-
Rashid, S.1
Tavori, H.2
Brown, P.E.3
-
70
-
-
84875055214
-
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells
-
Levy E, Ouadda ABD, Spahis S, et al. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis. 2013; 227: 297-306.
-
(2013)
Atherosclerosis
, vol.227
, pp. 297-306
-
-
Levy, E.1
Ouadda, A.B.D.2
Spahis, S.3
-
71
-
-
84876801739
-
The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the PCSK9 pathway
-
Catapano AL, Papadopoulos N. The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis. 2013; 228: 18-28.
-
(2013)
Atherosclerosis
, vol.228
, pp. 18-28
-
-
Catapano, A.L.1
Papadopoulos, N.2
-
72
-
-
84900802536
-
The use of statins in people at risk of developing diabetes mellitus: Evidence and guidance for clinical practice
-
Sattar NA, Ginsberg H, Ray K, et al. The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice. Atherosclerosis Suppl. 2014; 15: 1-15.
-
(2014)
Atherosclerosis Suppl
, vol.15
, pp. 1-15
-
-
Sattar, N.A.1
Ginsberg, H.2
Ray, K.3
-
73
-
-
77649274263
-
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
-
Mbikay M, Sirois F, Mayne J, et al. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Lett. 2010; 584: 701-706.
-
(2010)
FEBS Lett
, vol.584
, pp. 701-706
-
-
Mbikay, M.1
Sirois, F.2
Mayne, J.3
-
74
-
-
84938748581
-
The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis
-
Bonnefond A, Yengo L, Le May C, et al. The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia. 2015; 58: 2051-2055.
-
(2015)
Diabetologia
, vol.58
, pp. 2051-2055
-
-
Bonnefond, A.1
Yengo, L.2
Le May, C.3
-
75
-
-
84922398205
-
Preserved adrenal function in fully PCSK9-deficient subject
-
Cariou B, Benoit I, Le May C. Preserved adrenal function in fully PCSK9-deficient subject. Int J Cardiol. 2014; 176: 499-500.
-
(2014)
Int J Cardiol
, vol.176
, pp. 499-500
-
-
Cariou, B.1
Benoit, I.2
Le May, C.3
-
76
-
-
67651160910
-
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression
-
Labonte P, Begley S, Guevin C, et al. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology. 2009; 50: 17-24.
-
(2009)
Hepatology
, vol.50
, pp. 17-24
-
-
Labonte, P.1
Begley, S.2
Guevin, C.3
-
77
-
-
49649128629
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver generation
-
Zaid A, Roubtsova A, Essalmani R, et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver generation. Hepatology. 2008; 48: 646-654.
-
(2008)
Hepatology
, vol.48
, pp. 646-654
-
-
Zaid, A.1
Roubtsova, A.2
Essalmani, R.3
-
78
-
-
84890461947
-
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease
-
Nordestgaard BG, Chapman MJ, Humphries SE, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease. Eur Heart J. 2013; 34: 3478-3490.
-
(2013)
Eur Heart J
, vol.34
, pp. 3478-3490
-
-
Nordestgaard, B.G.1
Chapman, M.J.2
Humphries, S.E.3
-
79
-
-
84893873856
-
Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: A study of a cohort of 14,000 mutation carriers
-
Besseling J, Kindt I, Hof M, et al. Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers. Atherosclerosis. 2014; 233: 219-223.
-
(2014)
Atherosclerosis
, vol.233
, pp. 219-223
-
-
Besseling, J.1
Kindt, I.2
Hof, M.3
-
80
-
-
77049105368
-
Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: A large cross-sectional study in the Netherlands
-
Pijlman AH, Huijgen R, Verhagen SN, et al. Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands. Atherosclerosis. 2010; 209: 184-194.
-
(2010)
Atherosclerosis
, vol.209
, pp. 184-194
-
-
Pijlman, A.H.1
Huijgen, R.2
Verhagen, S.N.3
-
81
-
-
84931028781
-
Mortality among patients with familial hypercholesterolemia: A registry-based study in Norway, 1992-2010
-
Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010. J Am Heart Assoc. 2014; 3: e001236. DOI:10.1161/JAHA.114.001236
-
(2014)
J Am Heart Assoc
, vol.3
, pp. e001236
-
-
Mundal, L.1
Sarancic, M.2
Ose, L.3
|