The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

Diabetologia

Volumn 58, Issue 9, 2015, Pages 2051-2055

  Bonnefond, Amélie ^a,b,c   Yengo, Loïc ^a,b,c   Le May, Cédric ^d   Fumeron, Fréderic ^e,f   Marre, Michel ^e,f,g   Balkau, Beverley ^h   Charpentier, Guillaume ⁱ   Franc, Sylvia ⁱ   Froguel, Philippe ^a,b,c,j   Cariou, Bertrand ^d,k  

^a France IPL F 59000 Lille France   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c UNIV LILLE   (France)

^d L INSTITUT DU THORAX   (France)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g BICHAT HOSPITAL   (France)

^h LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

ⁱ CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^j HAMMERSMITH HOSPITAL   (United Kingdom)

^k UNIVERSITÉ DE NANTES   (France)

more..

Author keywords

Apolipoprotein B; Cholesterol; LDL; Low frequency genetic variant; PCSK9; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9; PROTEIN PRECURSOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CHOLESTEROL; GLUCOSE BLOOD LEVEL; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

ADULT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INCIDENCE; INSULIN BLOOD LEVEL; LIPID HOMEOSTASIS; LIPOPROTEIN BLOOD LEVEL; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; AGE; ANTAGONISTS AND INHIBITORS; BLOOD; BODY MASS; FRANCE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENETICS; HOMEOSTASIS; LONGITUDINAL STUDY; METABOLISM; REGRESSION ANALYSIS; RISK FACTOR; SEX DIFFERENCE;

ADULT; AGE FACTORS; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; FEMALE; FRANCE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; HOMEOSTASIS; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROPROTEIN CONVERTASES; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RISK FACTORS; SERINE ENDOPEPTIDASES; SEX FACTORS;

EID: 84938748581     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3659-8     Document Type: Article

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