메뉴 건너뛰기




Volumn 241, Issue 2, 2015, Pages 498-501

IMPROVE-IT and genetics reaffirm the causal role of LDL in Cardiovascular Disease

Author keywords

[No Author keywords available]

Indexed keywords

EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMBRANE PROTEIN; NPC1L1 PROTEIN, HUMAN;

EID: 84931260952     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.06.008     Document Type: Note
Times cited : (29)

References (16)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005, 366:1267-1278. Cholesterol Treatment Trialists' (CTT) Collaborators.
    • (2005) Lancet , vol.366 , pp. 1267-1278
  • 2
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010, 376:1670-1681. Cholesterol Treatment Trialists' (CTT) Collaboration.
    • (2010) Lancet , vol.376 , pp. 1670-1681
  • 3
    • 84864753387 scopus 로고    scopus 로고
    • Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials
    • Morrone D., Weintraub W.S., Toth P.P., et al. Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials. Atherosclerosis 2012, 223:251-261.
    • (2012) Atherosclerosis , vol.223 , pp. 251-261
    • Morrone, D.1    Weintraub, W.S.2    Toth, P.P.3
  • 5
    • 41649107358 scopus 로고    scopus 로고
    • Enhance investigators: simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein J.J., Akdim F., Stroes E.S., et al. Enhance investigators: simvastatin with or without ezetimibe in familial hypercholesterolemia. N.Engl. J. Med. 2008, 358:1431-1443.
    • (2008) N.Engl. J. Med. , vol.358 , pp. 1431-1443
    • Kastelein, J.J.1    Akdim, F.2    Stroes, E.S.3
  • 6
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor A.T., Villines T.C., Stanek E.J., et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N.Engl. J. Med. 2009, 361:2113-2122.
    • (2009) N.Engl. J. Med. , vol.361 , pp. 2113-2122
    • Taylor, A.T.1    Villines, T.C.2    Stanek, E.J.3
  • 7
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Willer C.J., Schmidt E.M., Sengupta S., et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 2013, 45:1274-1283. Global Lipids Genetics Consortium.
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
    • Willer, C.J.1    Schmidt, E.M.2    Sengupta, S.3
  • 8
    • 40849083720 scopus 로고    scopus 로고
    • Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
    • Lawlor D.A., Harbord R.M., Sterne J.A., Timpson N. Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med. 2008, 27:1133-1163.
    • (2008) Stat. Med. , vol.27 , pp. 1133-1163
    • Lawlor, D.A.1    Harbord, R.M.2    Sterne, J.A.3    Timpson, N.4
  • 9
    • 32444441330 scopus 로고    scopus 로고
    • Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
    • Cohen J.C., Pertsemlidis A., Fahmi S., et al. Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:1810-1815.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 1810-1815
    • Cohen, J.C.1    Pertsemlidis, A.2    Fahmi, S.3
  • 10
    • 77951069483 scopus 로고    scopus 로고
    • Prospective study of pravastatin in the elderly at risk (PROSPER) investigators. Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly
    • Polisecki E.1, Peter I., Simon J.S., et al. Prospective study of pravastatin in the elderly at risk (PROSPER) investigators. Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly. J.Lipid Res. 2010, 51:1201-1207.
    • (2010) J.Lipid Res. , vol.51 , pp. 1201-1207
    • Polisecki, E.1.1    Peter, I.2    Simon, J.S.3
  • 11
    • 84871969762 scopus 로고    scopus 로고
    • Large-scale association analysis identifies new risk loci for coronary artery disease
    • Deloukas P., Kanoni S., Willenborg C., et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 2013, 45:25-33. CARDIoGRAMplusC4D Consortium.
    • (2013) Nat. Genet. , vol.45 , pp. 25-33
    • Deloukas, P.1    Kanoni, S.2    Willenborg, C.3
  • 12
    • 84915819121 scopus 로고    scopus 로고
    • Inactivating mutations in NPC1L1 and protection from coronary heart disease
    • Inactivating mutations in NPC1L1 and protection from coronary heart disease. N.Engl. J. Med. 2014, 371:2072-2082. Myocardial Infarction Genetics Consortium Investigators.
    • (2014) N.Engl. J. Med. , vol.371 , pp. 2072-2082
  • 13
    • 84871260146 scopus 로고    scopus 로고
    • Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis
    • Ference B.A., Yoo W., Alesh I., et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J.Am. Coll. Cardiol. 2012, 60:2631-2639.
    • (2012) J.Am. Coll. Cardiol. , vol.60 , pp. 2631-2639
    • Ference, B.A.1    Yoo, W.2    Alesh, I.3
  • 14
    • 84928026823 scopus 로고    scopus 로고
    • Effect of naturally randomvallocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 x 2 factorial Mendelian randomization study
    • Ference B.A., Majeed F., Penumetcha R., Flack J.M., Brook R.D. Effect of naturally randomvallocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 x 2 factorial Mendelian randomization study. J.Am. Coll. Cardiol. 2015, 65:1552-1561.
    • (2015) J.Am. Coll. Cardiol. , vol.65 , pp. 1552-1561
    • Ference, B.A.1    Majeed, F.2    Penumetcha, R.3    Flack, J.M.4    Brook, R.D.5
  • 16
    • 84920566229 scopus 로고    scopus 로고
    • HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
    • S0140-6736
    • Swerdlow D.I., Preiss D., Kuchenbaecker K.B., et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet 2014, (14):61183-61191. S0140-6736.
    • (2014) Lancet , Issue.14 , pp. 61183-61191
    • Swerdlow, D.I.1    Preiss, D.2    Kuchenbaecker, K.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.