-
1
-
-
78650096816
-
Importance of disrupted intestinal barrier in inflammatory bowel diseases
-
S.Y. Salim, and J.D. Soderholm Importance of disrupted intestinal barrier in inflammatory bowel diseases Inflamm. Bowel Dis. 17 2011 362 381
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 362-381
-
-
Salim, S.Y.1
Soderholm, J.D.2
-
3
-
-
41149092188
-
The 10 remaining mysteries of inflammatory bowel disease
-
J.F. Colombel, A.J. Watson, and M.F. Neurath The 10 remaining mysteries of inflammatory bowel disease Gut 57 2008 429 433
-
(2008)
Gut
, vol.57
, pp. 429-433
-
-
Colombel, J.F.1
Watson, A.J.2
Neurath, M.F.3
-
4
-
-
84862834603
-
Tight junctions on the move: Molecular mechanisms for epithelial barrier regulation
-
L. Shen Tight junctions on the move: molecular mechanisms for epithelial barrier regulation Ann. N. Y. Acad. Sci. 1258 2012 9 18
-
(2012)
Ann. N. Y. Acad. Sci.
, vol.1258
, pp. 9-18
-
-
Shen, L.1
-
5
-
-
57349107080
-
Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function
-
J.B. Ewaschuk, H. Diaz, L. Meddings, and et al. Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function Am. J. Physiol. Gastrointest. Liver Physiol. 295 2008 G1025 G1034
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.295
, pp. G1025-G1034
-
-
Ewaschuk, J.B.1
Diaz, H.2
Meddings, L.3
-
6
-
-
34447281675
-
Molecular basis of epithelial barrier regulation: From basic mechanisms to clinical application
-
J.R. Turner Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application Am. J. Pathol. 169 2006 1901 1909
-
(2006)
Am. J. Pathol.
, vol.169
, pp. 1901-1909
-
-
Turner, J.R.1
-
7
-
-
0031943571
-
Regulation of the movement of solutes across tight junctions
-
J. Madara Regulation of the movement of solutes across tight junctions Annu. Rev. Physiol. 60 1998 143 159
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 143-159
-
-
Madara, J.1
-
8
-
-
70350509805
-
Intestinal mucosal barrier function in health and disease
-
J.R. Turner Intestinal mucosal barrier function in health and disease Nat. Rev. Immunol. 9 2009 799 809
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 799-809
-
-
Turner, J.R.1
-
9
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? the change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
S. Brand Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease Gut 58 2009 1152 1167
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
10
-
-
55149112367
-
The interleukin-23 axis in intestinal inflammation
-
P.P. Ahern, A. Izcue, K.J. Maloy, and et al. The interleukin-23 axis in intestinal inflammation Immunol. Rev. 226 2008 147 159
-
(2008)
Immunol. Rev.
, vol.226
, pp. 147-159
-
-
Ahern, P.P.1
Izcue, A.2
Maloy, K.J.3
-
11
-
-
78650505681
-
KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-gamma production
-
J.A. Goettel, H.M. Scott Algood, D. Olivares-Villagomez, and et al. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-gamma production Gastroenterology 140 2011 265 274
-
(2011)
Gastroenterology
, vol.140
, pp. 265-274
-
-
Goettel, J.A.1
Scott Algood, H.M.2
Olivares-Villagomez, D.3
-
12
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
R. Kuhn, J. Lohler, D. Rennick, and et al. Interleukin-10-deficient mice develop chronic enterocolitis Cell 75 1993 263 274
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
-
13
-
-
84858195802
-
New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa
-
A.C. Gomes-Santos, T.G. Moreira, A.B. Castro-Junior, and et al. New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa Clin. Dev. Immunol. 2012 2012 560817
-
(2012)
Clin. Dev. Immunol.
, vol.2012
, pp. 560817
-
-
Gomes-Santos, A.C.1
Moreira, T.G.2
Castro-Junior, A.B.3
-
14
-
-
84858217865
-
Placebo-controlled trial of oral laquinimod for multiple sclerosis
-
G. Comi, D. Jeffery, L. Kappos, and et al. Placebo-controlled trial of oral laquinimod for multiple sclerosis N. Engl. J. Med. 366 2012 1000 1009
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1000-1009
-
-
Comi, G.1
Jeffery, D.2
Kappos, L.3
-
15
-
-
4744340401
-
Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
-
J.S. Yang, L.Y. Xu, B.G. Xiao, and et al. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats J. Neuroimmunol. 156 2004 3 9
-
(2004)
J. Neuroimmunol.
, vol.156
, pp. 3-9
-
-
Yang, J.S.1
Xu, L.Y.2
Xiao, B.G.3
-
16
-
-
84896289833
-
Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells
-
E.V. Lourenço, M. Wong, and B.H. Hahn Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells Arthritis Rheum 66 2014 674 685
-
(2014)
Arthritis Rheum
, vol.66
, pp. 674-685
-
-
Lourenço, E.V.1
Wong, M.2
Hahn, B.H.3
-
17
-
-
7244248661
-
Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
-
D.E. Elliott, T. Setiawan, A. Metwali, and et al. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice Eur. J. Immunol. 34 2004 2690 2698
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 2690-2698
-
-
Elliott, D.E.1
Setiawan, T.2
Metwali, A.3
-
18
-
-
34547775237
-
Maturation of the mucosal immune system underlies colitis susceptibility in interleukin-10-deficient (IL-10 -/-) mice
-
M.R. Etling, S. Davies, M. Campbell, and et al. Maturation of the mucosal immune system underlies colitis susceptibility in interleukin-10-deficient (IL-10 -/-) mice J. Leukoc. Biol. 82 2007 311 319
-
(2007)
J. Leukoc. Biol.
, vol.82
, pp. 311-319
-
-
Etling, M.R.1
Davies, S.2
Campbell, M.3
-
19
-
-
0041845066
-
Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10 -/- mice
-
U.P. Singh, S. Singh, D.D. Taub, and et al. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10 -/- mice J. Immunol. 171 2003 1401 1406
-
(2003)
J. Immunol.
, vol.171
, pp. 1401-1406
-
-
Singh, U.P.1
Singh, S.2
Taub, D.D.3
-
20
-
-
58249085436
-
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
-
M.C. Arrieta, K. Madsen, J. Doyle, and et al. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse Gut 58 2009 41 48
-
(2009)
Gut
, vol.58
, pp. 41-48
-
-
Arrieta, M.C.1
Madsen, K.2
Doyle, J.3
-
21
-
-
84877970588
-
Bifidobacteria may be beneficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusion injury
-
H. Wang, W. Zhang, L. Zuo, and et al. Bifidobacteria may be beneficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusion injury Br. J. Nutr. 109 2013 1990 1998
-
(2013)
Br. J. Nutr.
, vol.109
, pp. 1990-1998
-
-
Wang, H.1
Zhang, W.2
Zuo, L.3
-
22
-
-
26444577545
-
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
-
D.R. Clayburgh, T.A. Barrett, Y. Tang, and et al. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo J. Clin. Invest. 115 2005 2702 2715
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2702-2715
-
-
Clayburgh, D.R.1
Barrett, T.A.2
Tang, Y.3
-
23
-
-
79960919901
-
Control of TH17 cells occurs in the small intestine
-
E. Esplugues, S. Huber, N. Gagliani, and et al. Control of TH17 cells occurs in the small intestine Nature 475 2011 514 518
-
(2011)
Nature
, vol.475
, pp. 514-518
-
-
Esplugues, E.1
Huber, S.2
Gagliani, N.3
-
24
-
-
84874588590
-
Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-kappaB pathway in lung cancer cells
-
S.Z. Ke, X.Y. Ni, Y.H. Zhang, and et al. Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-kappaB pathway in lung cancer cells Int. J. Oncol. 42 4 2013 1289 1296
-
(2013)
Int. J. Oncol.
, vol.42
, Issue.4
, pp. 1289-1296
-
-
Ke, S.Z.1
Ni, X.Y.2
Zhang, Y.H.3
-
25
-
-
84892958092
-
Beneficial effects of camellia oil (Camellia oleifera Abel.) on ketoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF
-
Y.T. Cheng, S.L. Wu, C.Y. Ho, and et al. Beneficial effects of camellia oil (Camellia oleifera Abel.) on ketoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF J. Agric. Food Chem. 62 3 2014 642 650
-
(2014)
J. Agric. Food Chem.
, vol.62
, Issue.3
, pp. 642-650
-
-
Cheng, Y.T.1
Wu, S.L.2
Ho, C.Y.3
-
26
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
D. Yen, J. Cheung, H. Scheerens, and et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 J. Clin. Invest. 116 2006 1310 1316
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
27
-
-
84862873626
-
TNF-alpha-induced intestinal epithelial cell shedding: Implications for intestinal barrier function
-
A.J. Watson, and K.R. Hughes TNF-alpha-induced intestinal epithelial cell shedding: implications for intestinal barrier function Ann. N. Y. Acad. Sci. 1258 2012 1 8
-
(2012)
Ann. N. Y. Acad. Sci.
, vol.1258
, pp. 1-8
-
-
Watson, A.J.1
Hughes, K.R.2
-
28
-
-
0000418018
-
Tumor necrosis factor-alpha (TNF-α) regulates the epithelial barrier in the human intestinal cell line HT-29/B6
-
H. Schmitz, M. Fromm, C.J. Bentzel, and et al. Tumor necrosis factor-alpha (TNF-α) regulates the epithelial barrier in the human intestinal cell line HT-29/B6 J. Cell Sci. 112 1999 137 146
-
(1999)
J. Cell Sci.
, vol.112
, pp. 137-146
-
-
Schmitz, H.1
Fromm, M.2
Bentzel, C.J.3
-
29
-
-
33947631511
-
IL-1beta causes an increase in intestinal epithelial tight junction permeability
-
R.M. Al-Sadi, and T.Y. Ma IL-1beta causes an increase in intestinal epithelial tight junction permeability J. Immunol. 178 2007 4641 4649
-
(2007)
J. Immunol.
, vol.178
, pp. 4641-4649
-
-
Al-Sadi, R.M.1
Ma, T.Y.2
-
31
-
-
0034128634
-
Claudins regulate the intestinal barrier in response to immune mediators
-
T. Kinugasa, T. Sakaguchi, X. Gu, and et al. Claudins regulate the intestinal barrier in response to immune mediators Gastroenterology 118 2000 1001 1011
-
(2000)
Gastroenterology
, vol.118
, pp. 1001-1011
-
-
Kinugasa, T.1
Sakaguchi, T.2
Gu, X.3
-
32
-
-
84865863065
-
Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
-
W. Brück, R. Pförtner, T. Pham, and et al. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination Acta Neuropathol. 124 2012 411 424
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 411-424
-
-
Brück, W.1
Pförtner, R.2
Pham, T.3
-
33
-
-
78149291807
-
IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
-
R. Al-Sadi, D. Ye, H.M. Said, and et al. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway Am. J. Pathol. 177 2010 2310 2322
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 2310-2322
-
-
Al-Sadi, R.1
Ye, D.2
Said, H.M.3
-
34
-
-
13444312010
-
Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice
-
A. Saadane, J. Soltys, and M. Berger Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice J. Allergy Clin. Immunol. 115 2005 405 411
-
(2005)
J. Allergy Clin. Immunol.
, vol.115
, pp. 405-411
-
-
Saadane, A.1
Soltys, J.2
Berger, M.3
-
35
-
-
84873695281
-
NF-κB: Roles and regulation in different CD4 + T-cell subsets
-
H. Oh, and S. Ghosh NF-κB: roles and regulation in different CD4 + T-cell subsets Immunol. Rev. 252 2013 41 51
-
(2013)
Immunol. Rev.
, vol.252
, pp. 41-51
-
-
Oh, H.1
Ghosh, S.2
-
36
-
-
84876042951
-
Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis
-
V. Jolivel, F. Luessi, J. Masri, and et al. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis Brain 136 2013 1048 1066
-
(2013)
Brain
, vol.136
, pp. 1048-1066
-
-
Jolivel, V.1
Luessi, F.2
Masri, J.3
-
37
-
-
0032711223
-
Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
-
M.A. Aronica, A.L. Mora, D.B. Mitchell, and et al. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo J. Immunol. 163 1999 5116 5124
-
(1999)
J. Immunol.
, vol.163
, pp. 5116-5124
-
-
Aronica, M.A.1
Mora, A.L.2
Mitchell, D.B.3
-
38
-
-
80055116357
-
The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis
-
Q. Ruan, V. Kameswaran, Y. Zhang, and et al. The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis J. Exp. Med. 208 2011 2321 2333
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2321-2333
-
-
Ruan, Q.1
Kameswaran, V.2
Zhang, Y.3
-
39
-
-
0027264083
-
Nuclear factor kappa B, a mediator of lipopolysaccharide effects
-
J.M. Muller, H.W. Ziegler-Heitbrock, and P.A. Baeuerle Nuclear factor kappa B, a mediator of lipopolysaccharide effects Immunobiology 187 1993 233 256
-
(1993)
Immunobiology
, vol.187
, pp. 233-256
-
-
Muller, J.M.1
Ziegler-Heitbrock, H.W.2
Baeuerle, P.A.3
-
40
-
-
13244277880
-
Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing
-
S. Maeda, L.C. Hsu, H. Liu, and et al. Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing Science 307 2005 734 738
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
Hsu, L.C.2
Liu, H.3
-
42
-
-
4444366271
-
Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease
-
S. Ardizzone, G. Maconi, G.M. Sampietro, and et al. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease Gastroenterology 127 2004 730 740
-
(2004)
Gastroenterology
, vol.127
, pp. 730-740
-
-
Ardizzone, S.1
Maconi, G.2
Sampietro, G.M.3
-
43
-
-
77951218761
-
Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: In-vitro high-throughput gene expression study
-
M. Gurevich, T. Gritzman, R. Orbach, and et al. Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study J. Neuroimmunol. 221 2010 87 94
-
(2010)
J. Neuroimmunol.
, vol.221
, pp. 87-94
-
-
Gurevich, M.1
Gritzman, T.2
Orbach, R.3
-
45
-
-
84940121888
-
Laquinimod for Crohn's disease investigators. A phase II study of laquinimod in Crohn's disease
-
G. D'Haens, W.J. Sandborn, J.F. Colombel, and et al. Laquinimod for Crohn's disease investigators. A phase II study of laquinimod in Crohn's disease Gut 64 2015 1227 1235
-
(2015)
Gut
, vol.64
, pp. 1227-1235
-
-
D'Haens, G.1
Sandborn, W.J.2
Colombel, J.F.3
|