Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: Multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

Nanomedicine

Volumn 10, Issue 22, 2015, Pages 3373-3389

  Fagir, Wael ^a   Hathout, Rania M ^a   Sammour, Omaima A ^a   Elshafeey, Ahmed H ^b  

^a African Union Organization St Abbassia   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

hierarchical clustering; human volunteers; microemulsion; principal component; SMEDDS; spray drying

Indexed keywords

FINASTERIDE; GLIBENCLAMIDE; LEUCINE; MALTODEXTRIN; MEVINOLIN; EMULSION;

ADULT; ARTICLE; CLINICAL ARTICLE; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICROEMULSION; NANOEMULSION; NORMAL HUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; POWDER FLOW; PRIORITY JOURNAL; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; SINGLE DRUG DOSE; SPRAY DRYING; TABLET; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ADMINISTRATION AND DOSAGE; BIOAVAILABILITY; CHEMISTRY; DRUG STABILITY; EMULSION; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; SOLUBILITY;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FINASTERIDE; HEALTHY VOLUNTEERS; HUMANS; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84948428390     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.15.123     Document Type: Article

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