Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system

Pharmaceutical Development and Technology

Volumn 15, Issue 5, 2010, Pages 469-483

  Singh, Sandeep Kumar ^a   Verma, Priya Ranjan Prasad ^a   Razdan, Balkishen ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Characterization; Lovastatin; Particle size distribution; Phase diagram; Self microemulsifying drug delivery system; Transmission electron microscopy

Indexed keywords

MEVINOLIN; WATER;

ABSORPTION; ANALYSIS OF VARIANCE; AQUEOUS SOLUTION; ARTICLE; CLUSTER ANALYSIS; CONTACT ANGLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; MULTIVARIATE ANALYSIS; PARTICLE SIZE; PRECIPITATION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL;

ANTICHOLESTEREMIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CLUSTER ANALYSIS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIFYING AGENTS; EMULSIONS; LOVASTATIN; MICROSCOPY, ELECTRON, TRANSMISSION; OILS; PHASE TRANSITION; PHYSICOCHEMICAL PHENOMENA; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; TIME FACTORS; X-RAY DIFFRACTION;

EID: 77954190608     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903286537     Document Type: Article

References (32)

1. Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classifcation: Te correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995;12:413-420.
2. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000;50:47-60.
3. Ahuja N, Katare OP, Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water soluble carriers. Eur J Pharm Biopharm 2007;65:26-38.
4. Robinson JR. Semi-solid formulations for oral drug delivery. Bull Tech Gattefosse 1996;89:11-13.
5. 10: Formulation development and bioavailability assessment. Int J Pharm 2001;21:233-246.
6. Aungst BJ. Novel formulations strategies for improving oral bioavailability of drugs with poor permeability or presystemic metabolism. J Pharm Sci 1993;82:979-987.
7. Shafq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of rami-pril nanoemulsion formulation. Eur J Pharm Biopharm 2007;66:227-243.
8. Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Delv Rev 1997;25:47-58.
9. Constantinides PP. Lipid microemulsion for improving drug dissolution and oral absorption: Physical and biopharmaceuti-cal aspects. Pharm Res 1995;12:1561-1572.
10. Pouton CW. Lipid formulations for oral administrations of drugs: Non-emulsifying, self-emulsifying and 'self-microemul-sifying' drug delivery systems. Eur J Pharm Sci 2000;11:S93-98.
11. Gershanik T, Benita S. Self dispersing lipid formulations for improving oral absorption of lipophillic drugs. Eur J Pharm Biopharm 2000;50:179-188.
12. Humberstone AJ, Charman WN. Lipid vehicles for the drug delivery of poorly water soluble drugs. Adv Drug Deliv Rev 1997;25:103-128.
13. O'Driscoll CM. Lipid based formulations for intestinal lymphatic delivery. Eur J Pharm Sci 2002;15:405-415.
14. Swenson ES, Mehta SC, Radebaugh GW. Targeting lymphatic transport and modifed systemic distribution of CI-976, a lipophillic lipid-regulator via a formulation approach. Int J Pharm 1994;108:85-93.
15. Grove M, Mullertz A, Nielsen JL, Pedersen GP. Bioavailability of seocalcitol II: Development and characterization of self-micro-emulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. Eur J Pharm Sci 2006;28:233-242.
16. Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of sim-vastatin in beagle dogs. Int J Pharm 2004;274:65-73.
17. Khoo SM, Humberstone AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lip-idic self-emulsifying formulations of halofantrine. Int J Pharm 1998;167:155-164.
18. Itoh K, Matsui S, Tozuka Y, Oguchi T, Yamamoto K. Improvement of physicochemical properties of N-4472 Part II: Characterization of N-4472 microemulsion and the enhanced oral absorption. Int J Pharm 2002;246:75-83.
19. Brenner GS, Ellison DK, Kaufman MJ. Analytical profles of drug substances and excipients. New York: Academic Press Inc; 1992;21:277-315.
20. Vrana A, Andrysek T. Te efect of particle size on bioavailability in cyclosporine preparations based on submicron dispersions. Biomed Papers 2001;145:9-15.
21. Singh SK, Verma PRP, Razdan BK. Development, and characterization of carvedilol loaded self-microemulsifying drug delivery system. Clin Res Reg Afairs 2009; 26:50-64.
22. Gershanik T, Benzeno S, Benita S. Interaction of the self-emulsifying lipid drug delivery system with mucosa of everted rat intestine as a function of surface charge and droplet size. Pharm Res 1998;15:863-869.
23. Taha EI, Samy AH, Kaseem AA, Khan MA. Response surface methodology for the development of self-nanoemulsifying drug delivery system (SNEDDS) of all-trans-retinol acetate. Pharm Dev Tech 2005;10:363-370.
24. Nazzal S, Khan M.A. Response surface methodology for the optimization of ubiquinone self-nanoemulsifed drug delivery system. AAPS PharmSciTech 2002;3:1-9.
25. Reiss HJ. Entropy-induced dispersion of bulk liquids. J Colloid Interface Sci 1975;53:61-70.
26. Iranloye TA, Pilpel N, Groves MJ. Some factors afecting the droplet size and charge of dilute oil-in-water emulsions prepared by self-emulsifcation. J Dispers Sci Technol 1983;4:109-121.
27. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35.
28. Sultananta W, Craig DQM, Newton JM. Te efects of ageing on the thermal behavior and mechanical properties of pharmaceutical glycerides. Int J Pharm 1994;111:51-62.
29. Damian F, Blaton N, Naesens L, Balzarini J, Kinget R, Augustijns P, Mooter VD. Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14. Eur J Pharm Sci 2000;10:311-322.
30. Barker SA, Yap SP, Yuen KH, McCoy CP, Murphy JR, Craig DQM. An investigation into the structure and bioavailabil-ity of α-tocopherol dispersions in Gelucire 44/14. J Contrl Rel 2003;91:477-488.
31. Francès C, Veiga MD, Espanol OM, Cadorniga R. Preparation, characterization and dissolution of ciprofoxacin/PEG 6000 binary systems. Int J Pharm 1991;77:193-198.
32. Guyot M, Fawaz F, Bildet J, Bonini F, Lagueny AM. Physicochemical characterization and dissolution of norfoxacin/cyclodextrin inclusions compounds and PEG solid dispersions. Int J Pharm 1995;123:53-63.