Using principal component analysis in studying the transdermal delivery of a lipophilic drug from soft nano-colloidal carriers to develop a quantitative composition effect permeability relationship

Pharmaceutical Development and Technology

Volumn 19, Issue 5, 2014, Pages 598-604

  Hathout, Rania M ^a,b  

^a African Union Organization St Abbassia   (Egypt)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Drug permeation; Eigen; Microemulsions; Multivariate; Principal component

Indexed keywords

NANOCARRIER; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; INFRARED SPECTROSCOPY; LIPOPHILICITY; MICROEMULSION; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGRESSION ANALYSIS; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; COLLOIDS; DRUG CARRIERS; EMULSIONS; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SKIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SWINE; TESTOSTERONE;

EID: 84899873647     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2013.813544     Document Type: Article

References (33)

1. Changez M, Varshney M. Aerosol-OT microemulsions as transdermal carriers of tetracaine hydrochloride. Drug Dev Ind Pharm 2000; 26:507-512.
2. Hathout RM, ElShafeey AH. Development and characterization of colloidal soft nano-carriers for transdermal delivery and bioavailability enhancement of an angiotensin II receptor blocker. Eur J Pharm Biopharm 2012;82:230-240.
3. Hathout RM, Woodman TJ. Applications of NMR in the characterization of pharmaceutical microemulsions. J Control Release 2012; 161:62-72.
4. Hathout RM, Woodman TJ, Mansour S, et al. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci 2010;40:188-196.
5. McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft matter 2012;8:1719-1729.
6. Moss GP, Shah AJ, Adams RG, et al. The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers. Eur J Pharm Sci 2012;45:116-127.
7. Pratiwi D, Fawcett JP, Gordon KC, Rades T. Quantitative analysis of polymorphic mixtures of ranitidine hydrochloride by Raman spectroscopy and principal components analysis. Eur J Pharm Biopharm 2002;54:337-341.
8. Gad HA, El-Ahmady SH, bou-Shoer MI, Al-Azizi MM. Application of chemometrics in authentication of herbal medicines: a review. Phytochem Anal 2013;1:1-24.
9. Martins S, Tho I, Souto E, et al. Multivariate design for the evaluation of lipid and surfactant composition effect for optimisation of lipid nanoparticles. Eur J Pharm Sci 2012;45:613-623.
10. Singh SK, Verma PR, Razdan B. Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system. Pharm Dev Technol 2010;15:469-483.
11. Hathout RM, Mansour S, Mortada ND, et al. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm 2010;7:1266-1273.
12. Hathout RM, Mansour S, Geneidi AS, Mortada ND. Visualization, dermatopharmacokinetic analysis and monitoring the conformational effects of a microemulsion formulation in the skin stratum corneum. J Colloid Interface Sci 2011;354:124-130.
13. Klang V, Schwarz JC, Lenobel B, et al. In vitro vs. in vivo tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. Eur J Pharm Biopharm 2012;80:604-614.
14. Chen H, Chang X, Weng T, et al. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release 2004;98: 427-436.
15. Garti N, Clement V, Fanun M, Leser ME. Some characteristics of sugar ester nonionic microemulsions in view of possible food applications. J Agric Food Chem 2000;48:3945-3956.
16. Bommannan D, Potts RO, Guy RH. Examination of stratumcorneum barrier function invivo by infrared-spectroscopy. J Invest Dermatol 1990;95:403-408.
17. Jadoul A, Bouwstra J, Preat V. Effects of iontophoresis and electroporation on the stratum corneum - review of the biophysical studies. Adv Drug Deliv Rev 1999;35:89-105.
18. Mendelsohn R, Flach CR, Moore DJ. Determination of molecular conformation and permeation in skin via IR spectroscopy, microscopy, and imaging. Biochim Biophys Acta - Biomembranes 2006; 1758:923-933.
19. Karande P, Jain A, Ergun K, et al. Design principles of chemical penetration enhancers for transdermal drug delivery. Proc Natl Acad Sci USA 2005;102:4688-4693.
20. Potts RO, Golden GM, Francoeur ML, et al. Mechanism and enhancement of solute transport across the stratum-corneum. J Control Release 1991;15:249-260.
21. Singh SK, Verma PR, Razdan B. Glibenclamide-loaded selfnanoemulsifying drug delivery system: development and characterization. Drug Dev Ind Pharm 2010;36:933-945.
22. Friend DR. In vitro skin permeation techniques. J Control Release 1992;18:235-248.
23. Sekkat N, Kalia YN, Guy RH. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. Pharm Res 2004;21:1390-1397.
24. Stone M. Cross-validatory choice and assessment of statistical predictions. J R Stat Soc Series B Stat Methodol 1974;36:111-147.
25. Naik A, Pechtold LARM, Potts RO, Guy RH. Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans. J Control Release 1995;37:299-306.
26. Araya H, Tomita M, Hayashi M. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm 2005;305: 61-74.
27. Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skin's barrier function. Pharm Sci Technolo Today 2000;3: 318-326.
28. Leichtnam ML, Rolland H, Wuthrich P, Guy RH. Enhancement of transdermal testosterone delivery by supersaturation. J Pharm Sci 2006;95:2373-2379.
29. Rhee YS, Huh JY, Park CW, et al. Effects of vehicles and enhancers on transdermal delivery of clebopride. Arch Pharm Res 2007;30: 1155-1161.
30. Trommer H, Neubert RHH. Overcoming the stratum corneum: the modulation of skin penetration - a review. Skin Pharmacol Physiol 2006;19:106-121.
31. Zulfakar MH, Abdelouahab N, Heard CM. Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil. Inflamm Res 2010;59:23-30.
32. Rossi RJ. Describing populations. In: Rossi RJ, ed. Applied statistics for the health science. Hoboken (NJ): John Wiley and Sons, Inc.; 2010:22-75.
33. Wold S, Johansson E, Cocchi M. PLS-Partial square analysis. In: Kubinyi H, ed. 3D QSAR in drug design: Volume 1: Theory methods and applications. Dordrecht: Kluwer Academic Publishers. The Netherlands; 2000:523-550.