Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

Future Microbiology

Volumn 10, Issue 12, 2015, Pages 1953-1968

  Bhargava, Nidhi ^a   Singh, Sukhvinder P ^b   Sharma, Anupam ^c   Sharma, Prince ^a   Capalash, Neena ^a  

^a PANJAB UNIVERSITY   (India)

^b NSW DEPARTMENT OF PRIMARY INDUSTRIES   (Australia)

^c PANJAB UNIVERSITY   (India)

Author keywords

Acinetobacter baumannii; biofilm; catalase; flavonoids; Glycyrrhiza glabra; motility; quorum sensing inhibition; superoxide dismutase

Indexed keywords

FLAVONOID; GLYCYRIN; GLYZARIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GLYCYRRHIZA GLABRA; MICROBIAL ATTENUATION; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING; CHEMISTRY; DRUG EFFECTS; GLYCYRRHIZA; ISOLATION AND PURIFICATION; PHYSIOLOGY; VIRULENCE;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; FLAVONOIDS; GLYCYRRHIZA; QUORUM SENSING; VIRULENCE;

EID: 84948422093     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.15.107     Document Type: Article

References (54)

1. Rit K, Saha R. Multidrug-resistant Acinetobacter infection and their susceptibility patterns in a tertiary care hospital. Niger Med. J. 53(3), 126-128 (2012).
2. McConnell MJ, Actis L, Pachón J et al. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. FEMS Microbiol. Rev. 37(2), 130-155 (2013).
3. Lagana P, Melcarne L, Delia S. Acinetobacter baumannii and endocartitis, rare complication but important clinical relevance. Int. J. Cardiol. 187, 678-679 (2015).
4. Durante-Mangoni E, Zarrilli R. Global spread of drug-resistant Acinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance. Future Microbiol. 6(4), 407-422 (2011).
5. Niu C, Clemmer KM, Bonomo RA et al. Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii. J. Bacteriol. 190, 3386-3392 (2008).
6. Clemmer KM, Bonomo RA, Rather PN. Genetic analysis of surface motility in Acinetobacter baumannii. Microbiolgy 157(9), 2534-2544 (2011).
7. Bhargava N, Sharma P, Capalash N. Pyocyanin stimulates quorum sensingmediated tolerance to oxidative stress and increases persister cells population in Acinetobacter baumannii. Infect. Immun. 8, 3417-3425 (2014).
8. Tay SB, Yew WS. Development of quorumbased anti-virulence therapeutics targeting gram-negative bacterial pathogens. Int. J. Mol. Sci. 14(8), 16570-16599 (2013).
9. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 109(Suppl. 1), 69-75 (2001).
10. Stapleton PD, Taylor PW. Methicillin resistance in Staphylococcus aureus: mechanisms and modulation. Sci. Prog. 85, 57-72 (2002).
11. Truchado P, Giménez-Bastida JA, Larrosa M et al. Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones. J. Agric. Food Chem. 12(36), 8885-8894 (2012).
12. Yuan ZC, Edlind MP, Liu P et al. The plant signal salicylic acid shuts down expression of the vir regulon and activates quormonequenching genes in Agrobacterium. Proc. Natl Acad. Sci. USA 104(28), 11790-11795 (2007).
13. Girennavar B, Cepeda ML, Soni KA et al. Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. Int. J. Food Microbiol. 125(2), 204-208 (2008).
14. Sarabhai S, Sharma P, Capalash N. Ellagic acid derivatives from Terminalia chebula Retz. downregulate the expression of quorum sensing genes to attenuate Pseudomonas aeruginosa PAO1 virulence. PLoS ONE 8(1), e53441 (2013).
15. Prajapati SM, Patel BR. Phytopharmacological perspective of Yashtimadhu (Glycyrrhiza glabra LINN.)-a review. Int. J. Pharm. Biol. Arch. 4(5), 833-841 (2013).
16. Fukai T, Marumo A, Kaitou K, Kanda T et al. Antimicrobial activity of licorice flavonoids against methicillin-resistant Staphylococcus aureus. Fitoterapia 73(6), 536-539 (2002).
17. Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J. Ethnopharmacol. 125, 218-223 (2009).
18. Fuqua C, Winans SC. Conserved cis-acting promoter elements are required for densitydependent transcription of Agrobacterium tumefaciens conjugal transfer genes. J. Bacteriol. 78, 435-440 (1996).
19. Performance Standards for Antimicrobial Susceptibility Testing; 20th Informational Supplement M100-S20. Clinical and Laboratory Standards Institute. PA, USA (2012).
20. Manchanda V, Sanchaita S, Singh N. Multidrug resistant Acinetobacter. J. Glob. Infect. Dis. 2, 291-304 (2010).
21. Adonizio A, Kong KF, Mathee K. Inhibition of quorum sensing controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts. Antimicrob. Agents Chemother. 52, 198-203 (2008).
22. Rudrappa T, Bais HP. Curcumin, a known phenolic from Curcuma longa attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J. Agric. Food Chem. 56(6), 1955-62 (2008).
23. Miller JH. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, NY, USA, 352-355 (1972).
24. Zhou M, Jiang M, Ying X et al. Identification and comparison of anti-inflammatory ingredients from different organs of Lotus nelumbo by UPLC/Q-TOF and PCA coupled with a NF-B reporter gene assay. PLoS ONE doi:10.1371/journal.pone.0081971 (2013) (Epub ahead of print).
25. Favre-Bonté S, Köhler T, Van Delden C. Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin. J. Antimicrob. Chemother. 52(4), 598-604 (2003).
26. Semmler AB, Whitchurch CB, Mattick JS. A re-examination of twitching motility in Pseudomonas aeruginosa. Microbiolgy 145(10), 2863-2873 (1999).
27. You JL, Xue XL, Cao LX et al. Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66. Appl. Microbiol. Biotechnol. 76, 1137-1144 (2007).
28. Zeng Z, Qian L, Cao L et al. Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl. Microbiol. Biotechnol. 79, 119-126 (2008).
29. Hentzer M, Eberl L, Nielsen J et al. Quorum sensing: a novel target for the treatment of biofilm infections. BioDrugs. 17, 241-250 (2003).
30. Hassett DJ, Ma J-F, Elkins JG et al. Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes mediates biofilm susceptibility to hydrogen peroxide. Mol. Microbiol. 34, 1082-1093 (1999).
31. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 21, 130-132 (1984).
32. Shaw PD, Ping G, Daly S L et al. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography. Proc. Natl Acad. Sci. USA. 94, 6036-6041 (1997).
33. Makemson J, Eberhard A, Mathee K. Simple electrospray mass spectrometry detection of acylhomoserine lactones. Luminescence 21, 1-6 (2006).
34. Nazzaro F, Fratianni F, Coppola R. Quorum sensing and phytochemicals. Int. J. Mol. Sci.14(6), 12607-12619 (2013).
35. Bjarnsholt T, Jensen P, Rasmussen TB et al. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology 151, 3873-3880 (2005).
36. Zahin M, Hasan S, Aqil F et al. Screening of certain medicinal plants from India for their anti-quorum sensing activity. Indian J. Exp. Biol. 48, 1219-1224 (2010).
37. Nagaraj SRM, Lingaraj SM, Balaraju Y et al. MTA1 induced angiogenesis, migration and tumor growth is inhibited by Glycyrrhiza glabra. IOSR J. Pharm. 4, 34-43 (2012).
38. Ali EM. Phytochemical composition, antifungal, antiaflatoxigenic, antioxidant, and anticancer activities of Glycyrrhiza glabra L. and Matricaria chamomilla L.essential oils. J. Med. Plants Res. 7(29), 2197-2207 (2013).
39. Long DR, Mead J, Hendricks JM et al. 18-glycyrrhetinic acid inhibits methicillinresistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob. Agents Chemother. 57, 1241-247 (2013).
40. Vasavi HS, Arun AB, Rekha PD. Antiquorum sensing activity of Psidium guajava L. flavonoids against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1. Microbiol. Immunol. 58(5), 286-293 (2014).
41. Luo L, Wu L, Xiao Y et al. Enhancing pili assembly and biofilm formation in Acinetobacter baumannii ATCC19606 using non-native acyl-homoserine lactones. BMC Microbiol. 15, 62 (2015).
42. Klausen M, Heydorn A, Ragas P et al. Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants. Mol. Microbiol. 48(6), 1511-1524 (2003).
43. Wood TK, Barrios AFG, Herzberg M, Lee J. Motility influences biofilm architecture in Escherichia coli. Appl. Microbiol. Biotechnol. 72, 361-367 (2006).
44. Lynch M, Kuramitsu H. Expression and role of superoxide dismutases (SOD) in pathogenic bacteria. Microbes Infect. 2, 1245-1255 (2000).
45. Heindorf M, Kadari M, Heider C et al. Impact of Acinetobacter baumannii superoxide dismutase on motility, virulence, oxidative stress resistance and susceptibility to antibiotics. PLoS ONE doi:10.1371/journal. pone.0101033 (2104) (Epub ahead of print).
46. Maeda T, Garciá-Contreras R, Pu M et al. Quorum quenching quandary: resistance to antivirulence compounds. ISME J. 6, 493-501 (2012).
47. Chen F, Gao Y, Chen X et al. Degrading signal molecules to block quorum sensingdependent infection. Int. J. Mol. Sci. 14, 17477-17500 (2013).
48. Hong Kar-Wai, Chong-Lek Koh, Choon-Kook Sam et al. Quorum quenching revisited-from signal decays to signalling confusion. Sensors (Basel) 12(4), 4661-4696 (2012).
49. Schramm VL, Gutierrez JA, Cordovano G et al. Transition state analogues in quorum sensing and SAM recycling. Nucleic Acids Symp. Ser. 52, 75-76 (2008).
50. Hoang TT, Schweizer HP. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (fabi): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis. J. Bacteriol. 181, 5489-5497 (1999).
51. Vandeputte OM, Kiendrebeogo M, Rasamiravaka T et al. The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. Microbiology 157, 2120-2132 (2011).
52. Jakobsen TH, van Gennip M, Phipps RK et al. Ajoene, a sulphur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob. Agents Chemother. 56, 5, 2314-25 (2012).
53. Dent LL, Marshall DR, Pratap S et al. Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital. BMC Infect. Dis. 10, 196-202 (2011).
54. KNApSAcK database. http://kanaya.naist.jp/KNApSAcK/