Drug delivery's quest for polymers: Where are the frontiers? Dedicated to Robert Gurny on the occasion of his 70th birthday.

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 97, Issue , 2015, Pages 293-303

  Merkle, Hans P ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Biological response modifiers; Biopolymers; Cationic polymers; Multifunctional polymeric carriers; Polymer therapeutics; Polymer drug conjugates; Stimuli sensitive polymers; Supramolecular polymers; Tissue engineering; Translational medicine

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; BIOPOLYMER; CHITOSAN; EXCIPIENT; NUCLEIC ACID; POLYESTER; POLYGLUTAMIC ACID; POLYMER; SILK FIBROIN; CELL PENETRATING PEPTIDE; DNA; DRUG CARRIER; MACROGOL DERIVATIVE;

APPLIED RESEARCH; DRUG DELIVERY SYSTEM; HUMAN; NONHUMAN; OBSERVATIONAL STUDY; REGENERATIVE MEDICINE; REVIEW; TISSUE ENGINEERING; TREND STUDY; CHEMISTRY;

CELL-PENETRATING PEPTIDES; CHITOSAN; DNA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID; POLYMERS;

EID: 84948400504     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.038     Document Type: Review

References (88)

1. J. Folkman, and D.M. Long The use of silicone rubber as a carrier for prolonged drug therapy J. Surg. Res. 4 1964 139 142
2. K. Kataoka, A. Harada, and Y. Nagasaki Block copolymer micelles for drug delivery: design, characterization and biological significance Adv. Drug Deliv. Rev. 47 2001 113 131
3. J. Panyam, and V. Labhasetwar Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv. Drug Deliv. Rev. 55 2003 329 347
4. Y. Qiu, and K. Park Environment-sensitive hydrogels for drug delivery Adv. Drug Deliv. Rev. 53 2001 321 339
5. I. Brigger, C. Dubernet, and P. Couvreur Nanoparticles in cancer therapy and diagnosis Adv. Drug Deliv. Rev. 54 2002 631 651
6. A.S. Hoffman Hydrogels for biomedical applications Adv. Drug Deliv. Rev. 54 2002 3 12
7. M.J. Roberts, M.D. Bentley, and J.M. Harris Chemistry for peptide and protein PEGylation Adv. Drug Deliv. Rev. 54 2002 459 476
8. S. Svenson, and D.A. Tomalia Commentary - dendrimers in biomedical applications - reflections on the field Adv. Drug Deliv. Rev. 57 2005 2106 2129
9. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv. Drug Deliv. Rev. 48 2001 139 157
10. D. Schmaljohann Thermo- and pH-responsive polymers in drug delivery Adv. Drug Deliv. Rev. 58 2006 1655 1670
11. L. Brannon-Peppas, and J.O. Blanchette Nanoparticle and targeted systems for cancer therapy Adv. Drug Deliv. Rev. 56 2004 1649 1659
12. B. Jeong, S.W. Kim, and Y.H. Bae Thermosensitive sol-gel reversible hydrogels Adv. Drug Deliv. Rev. 54 2002 37 51
13. J.M. Anderson, and M.S. Shive Biodegradation and biocompatibility of PLA and PLGA microspheres Adv. Drug Deliv. Rev. 28 1997 5 24
14. H. Otsuka, Y. Nagasaki, and K. Kataoka PEGylated nanoparticles for biological and pharmaceutical applications Adv. Drug Deliv. Rev. 55 2003 403 419
15. W.E. Hennink, and C.F. van Nostrum Novel crosslinking methods to design hydrogels Adv. Drug Deliv. Rev. 54 2002 13 36
16. V.P. Torchilin Multifunctional nanocarriers Adv. Drug Deliv. Rev. 58 2006 1532 1555
17. J. Sudimack, and R.J. Lee Targeted drug delivery via the folate receptor Adv. Drug Deliv. Rev. 41 2000 147 162
18. W.R. Gombotz, and S.F. Wee Protein release from alginate matrices Adv. Drug Deliv. Rev. 31 1998 267 285
19. A. Rosler, G.W.M. Vandermeulen, and H.A. Klok Advanced drug delivery devices via self-assembly of amphiphilic block copolymers Adv. Drug Deliv. Rev. 53 2001 95 108
20. J. Kreuter Nanoparticulate systems for brain delivery of drugs Adv. Drug Deliv. Rev. 47 2001 65 81
21. M.E. Brewster, and T. Loftsson Cyclodextrins as pharmaceutical solubilizers Adv. Drug Deliv. Rev. 59 2007 645 666
22. A.S. Hoffman The origins and evolution of "controlled" drug delivery systems J. Control. Release 132 2008 153 163
23. M. Madan, A. Bajaj, S. Lewis, N. Udupa, and J.A. Baig In situ forming polymeric drug delivery systems Indian J. Pharm. Sci. 71 2009 242 251
24. Y.C. Kim, J.H. Park, and M.R. Prausnitz Microneedles for drug and vaccine delivery Adv. Drug Deliv. Rev. 64 2012 1547 1568
25. J. Kreuter Nanoparticles - a historical perspective Int. J. Pharm. 331 2007 1 10
26. S. Madduri, and B. Gander Growth factor delivery systems and repair strategies for damaged peripheral nerves J. Control. Release 161 2012 274 282
27. R. Duncan, and M.J. Vicent Polymer therapeutics-prospects for 21st century: the end of the beginning Adv. Drug Deliv. Rev. 65 2013 60 70
28. A. Abuchowski, J.R. McCoy, N.C. Palczuk, T. Vanes, and F.F. Davis Effect of covalent attachment of polyethylene-glycol on immunogenicity and circulating life of bovine liver catalase J. Biol. Chem. 252 1977 3582 3586
29. F.F. Davis Commentary - the origin of pegnology Adv. Drug Deliv. Rev. 54 2002 457 458
30. A. Jain, and S.K. Jain PEGylation: an approach for drug delivery. A review Crit. Rev. Ther. Drug 25 2008 403 447
31. G. Pasut, and F.M. Veronese State of the art in PEGylation: the great versatility achieved after forty years of research J. Control. Release 161 2012 461 472
32. D. Pfister, and M. Morbidelli Process for protein PEGylation J. Control. Release 180 2014 134 149
33. A. Chanan-Khan, J. Szebeni, S. Savay, L. Liebes, N.M. Rafique, C.R. Alving, and F.M. Muggia Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions Ann. Oncol. 14 2003 1430 1437
34. S.M. Moghimi, A.C. Hunter, C.M. Dadswell, S. Savay, C.R. Alving, and J. Szebeni Causative factors behind poloxamer 188 (pluronic F68, Flocor (TM))-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels BBA-Mol. Basis Dis. 1689 2004 103 113
35. I. Hamad, and S.M. Moghimi Critical issues in site-specific targeting of solid tumours: the carrier, the tumour barriers and the bioavailable drug Expert Opin. Drug Del. 5 2008 205 219
36. M.R. Buchmeiser Precision polymers Macromol. Chem. Phys. 215 2014 1934 1935
37. http://en.wikipedia.org/wiki/Quality-by-Design.
38. B. Pitard, H. Pollard, O. Agbulut, O. Lambert, J.T. Vilquin, Y. Cherel, J. Abadie, J.L. Samuel, J.L. Rigaud, S. Menoret, I. Anegon, and D. Escande A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles Hum. Gene Ther. 13 2002 1767 1775
39. A.V. Kabanov Polymer genomics: an insight into pharmacology and toxicology of nanomedicines Adv. Drug Deliv. Rev. 58 2006 1597 1621
40. E.V. Batrakova, and A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J. Control. Release 130 2008 98 106
41. J.P. Jain, W.Y. Ayen, and N. Kumar Self assembling polymers as polymersomes for drug delivery Curr. Pharm. Des. 17 2011 65 79
42. S. Jilek, E. Walter, H.P. Merkle, and B. Corthesy Modulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres J. Allergy Clin. Immun. 114 2004 943 950
43. V. Luginbuehl, E. Zoidis, L. Meinel, B. von Rechenberg, B. Gander, and H.P. Merkle Impact of IGF-I release kinetics on bone healing: a preliminary study in sheep Eur. J. Pharm. Biopharm. 85 2013 99 106
44. F.A. Sharp, D. Ruane, B. Claass, E. Creagh, J. Harris, P. Malyala, M. Singh, D.T. O'Hagan, V. Petrilli, J. Tschopp, L.A.J. O'Neill, and E.C. Lavelle Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome Proc. Natl. Acad. Sci. USA 106 2009 870 875
45. M.L. De Temmerman, J. Rejman, J. Demeester, D.J. Irvine, B. Gander, and S.C. De Smedt Particulate vaccines: on the quest for optimal delivery and immune response Drug Discov. Today 16 2011 569 582
46. B. Ballarin-Gonzalez, and K.A. Howard Polycation-based nanoparticle delivery of RNAi therapeutics: adverse effects and solutions Adv. Drug Deliv. Rev. 64 2012 1717 1729
47. K. Regnstrom, E.G.E. Ragnarsson, M. Fryknas, M. Koping-Hoggard, and P. Artursson Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery Pharm. Res. 23 2006 475 482
48. H. Hatakeyama, E. Ito, M. Yamamoto, H. Akita, Y. Hayashi, K. Kajimoto, N. Kaji, Y. Baba, and H. Harashima A DNA microarray-based analysis of the host response to a nonviral gene carrier: a strategy for improving the immune response Mol. Ther. 19 2011 1487 1498
49. R.L. Kanasty, K.A. Whitehead, A.J. Vegas, and D.G. Anderson Action and reaction: the biological response to siRNA and its delivery vehicles Mol. Ther. 20 2012 513 524
50. A.M. Hafner, B. Corthesy, and H.P. Merkle Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant Adv. Drug Deliv. Rev. 64 2013 1386 1399
51. V.P. Torchilin Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers Adv. Drug Deliv. Rev. 60 2008 548 558
52. T. Aida, E.W. Meijer, and S.I. Stupp Functional supramolecular polymers Science 335 2012 813 817
53. R. Ravichandran, M. Griffith, and J. Phopase Applications of self-assembling peptide scaffolds in regenerative medicine: the way to the clinic J. Mater. Chem. B 2 2014 8466 8478
54. M. Yolamanova, C. Meier, A.K. Shaytan, V. Vas, C.W. Bertoncini, F. Arnold, O. Zirafi, S.M. Usmani, J.A. Muller, D. Sauter, C. Goffinet, D. Palesch, P. Walther, N.R. Roan, H. Geiger, O. Lunov, T. Simmet, J. Bohne, H. Schrezenmeier, K. Schwarz, L. Standker, W.G. Forssmann, X. Salvatella, P.G. Khalatur, A.R. Khokhlov, T.P.J. Knowles, T. Weil, F. Kirchhoff, and J. Munch Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses Nat. Nanotechnol. 8 2013 130 136
55. C. Meier, T. Weil, F. Kirchhoff, and J. Muench Peptide nanofibrils as enhancers of retroviral gene transfer Wires Nanomed. Nanobiotechnol. 6 2014 438 451
56. D. Desmaele, R. Gref, and P. Couvreur Squalenoylation: a generic platform for nanoparticular drug delivery J. Control. Release 161 2012 609 618
57. E. Lepeltier, C. Bourgaux, V. Rosilio, J.H. Poupaert, F. Meneau, F. Zouhiri, S. Lepetre-Mouelhi, D. Desmaele, and P. Couvreur Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles Langmuir 29 2013 14795 14803
58. J. Kost, and R. Langer Responsive polymeric delivery systems Adv. Drug Deliv. Rev. 6 1991 19 50
59. R.A. Siegel Stimuli sensitive polymers and self regulated drug delivery systems: a very partial review J. Control. Release 2014 10.1016/j.jconrel.2014.06.035
60. D.S.T. Hsieh, R. Langer, and J. Folkman Magnetic modulation of release of macromolecules from polymers Proc. Natl. Acad. Sci. Biol. 78 1981 1863 1867
61. L. Uebersax, H.P. Merkle, and L. Meinel Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems Tissue Eng. Pt. B - Rev. 15 2009 263 289
62. E. Wenk, A.R. Murphy, D.L. Kaplan, L. Meinel, H.P. Merkle, and L. Uebersax The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration Biomaterials 31 2010 1403 1413
63. J.C.M. van Hest, and D.A. Tirrell Protein-based materials, toward a new level of structural control Chem. Commun. 2001 1897 1904
64. S.A. Maskarinec, and D.A. Tirrell Protein engineering approaches to biomaterials design Curr. Opin. Biotechnol. 16 2005 422 426
65. R. Price, A. Poursaid, and H. Ghandehari Controlled release from recombinant polymers J. Control. Release 190 2014 304 313
66. P. Baldrick The safety of chitosan as a pharmaceutical excipient Regul. Toxicol. Pharmacol. 56 2010 290 299
67. M. Barz, R. Luxenhofer, R. Zentel, and M.J. Vicent Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure-property relationships to better defined therapeutics Polym. Chem. 2 2011 1900 1918
68. I. Bajaj, and R. Singhal Poly (glutamic acid) - an emerging biopolymer of commercial interest Bioresour. Technol. 102 2011 5551 5561
69. E.M. Pritchard, and D.L. Kaplan Silk fibroin biomaterials for controlled release drug delivery Expert Opin. Drug Del. 8 2011 797 811
70. L. Meinel, and D.L. Kaplan Silk constructs for delivery of musculoskeletal therapeutics Adv. Drug Deliv. Rev. 64 2012 1111 1122
71. E. Wenk, H.P. Merkle, and L. Meinel Silk fibroin as a vehicle for drug delivery applications J. Control. Release 150 2011 128 141
72. L. Meinel, S. Hofmann, V. Karageorgiou, C. Kirker-Head, J. McCool, G. Gronowicz, L. Zichner, R. Langer, G. Vunjak-Novakovic, and D.L. Kaplan The inflammatory responses to silk films in vitro and in vivo Biomaterials 26 2005 147 155
73. Y. Wang, D.D. Rudym, A. Walsh, L. Abrahamsen, H.-J. Kim, H.S. Kim, C. Kirker-Head, and D.L. Kaplan In vivo degradation of three-dimensional silk fibroin scaffolds Biomaterials 29 2008 3415 3428
74. L. Uebersax, T. Apfel, K.M.R. Nuss, R. Vogt, H.Y. Kim, L. Meinel, D.L. Kaplan, J.A. Auer, H.P. Merkle, and B. von Rechenberg Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep Eur. J. Pharm. Biopharm. 85 2013 107 118
75. E.M. Pritchard, P.B. Dennis, F. Omenetto, R.R. Naik, and D.L. Kaplan Review physical and chemical aspects of stabilization of compounds in silk Biopolymers 97 2012 479 498
76. A.J. Meinel, Cell instructive silk fibroin scaffolds for tissue engineering, PhD thesis, ETH Zürich No. 19217, 2010, pp. 81-110 < http://dx.doi.org/10.3929/ethz-a-006325663 >.
77. J. Zhang, E. Pritchard, X. Hu, T. Valentin, B. Panilaitis, F.G. Omenetto, and D.L. Kaplan Stabilization of vaccines and antibiotics in silk and eliminating the cold chain Proc. Natl. Acad. Sci. USA 109 2012 11981 11986
78. T. Trimaille, R. Gurny, and M. Moeller Poly(hexyl-substituted lactides): novel injectable hydrophobic drug delivery systems J. Biomed. Mater. Res. A 80A 2007 55 65
79. L.R. Asmus, R. Gurny, and M. Moller Solutions as solutions - synthesis and use of a liquid polyester excipient to dissolve lipophilic drugs and formulate sustained-release parenterals Eur. J. Pharm. Biopharm. 79 2011 584 591
80. L.R. Asmus, R. Gurny, and M. Moller Solutions for lipophilic drugs: a biodegradable polymer acting as solvent, matrix, and carrier to solve drug delivery issues Int. J. Artificial Organs 34 2011 238 242
81. L.R. Asmus, B. Kaufmann, L. Melander, T. Weiss, G. Schwach, R. Gurny, and M. Moller Single processing step toward injectable sustained-release formulations of Triptorelin based on a novel degradable semi-solid polymer Eur. J. Pharm. Biopharm. 81 2012 591 599
82. L.R. Asmus, J.C. Tille, B. Kaufmann, L. Melander, T. Weiss, K. Vessman, W. Koechling, G. Schwach, R. Gurny, and M. Moller In vivo biocompatibility, sustained-release and stability of triptorelin formulations based on a liquid, degradable polymer J. Control. Release 165 2013 199 206
83. K. Mondon, M. Zeisser-Labouebe, R. Gurny, and M. Moller Novel cyclosporin A formulations using MPEG-hexyl-substituted polylactide micelles: a suitability study Eur. J. Pharm. Biopharm. 77 2011 56 65
84. C. Di Tommaso, J.L. Bourges, F. Valamanesh, G. Trubitsyn, A. Torriglia, J.C. Jeanny, F. Behar-Cohen, R. Gurny, and M. Moller Novel micelle carriers for cyclosporin A topical ocular delivery: in vivo cornea penetration, ocular distribution and efficacy studies Eur. J. Pharm. Biopharm. 81 2012 257 264
85. C. Di Tommaso, F. Valamanesh, F. Miller, P. Furrer, M. Rodriguez-Aller, F. Behar-Cohen, R. Gurny, and M. Moller A novel cyclosporin A aqueous formulation for dry eye treatment: in vitro and in vivo evaluation Invest. Ophth. Vis. Sci. 53 2012 2292 2299
86. J.Y. Cherng, T.Y. Hou, M.F. Shih, H. Talsma, and W.E. Hennink Polyurethane-based drug delivery systems Int. J. Pharm. 450 2013 145 162
87. S. Wohlfart, S. Gelperina, and J. Kreuter Transport of drugs across the blood-brain barrier by nanoparticles J. Control. Release 161 2012 264 273
88. S. Kim, J.H. Kim, O. Jeon, I.C. Kwon, and K. Park Engineered polymers for advanced drug delivery Eur. J. Pharm. Biopharm. 71 2009 420 430