Metabolic engineering of Escherichia coli to improve recombinant protein production

Applied Microbiology and Biotechnology

Volumn 99, Issue 24, 2015, Pages 10367-10377

  Liu, Min ^a,b   Feng, Xinjun ^a   Ding, Yamei ^c   Zhao, Guang ^a   Liu, Huizhou ^a   Xian, Mo ^a  

^a QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF OCEANOLOGY   (China)

Author keywords

Carbon flux regulation; Growth retardation; Metabolic engineering; Recombinant protein production; Stress factors; Workhorse selection

Indexed keywords

CELL ENGINEERING; CELLS; CYTOLOGY; DETERIORATION; ESCHERICHIA COLI; METABOLIC ENGINEERING; METABOLISM; PHYSIOLOGY; PROTEINS;

CARBON FLUXES; GROWTH RETARDATION; RECOMBINANT PROTEIN PRODUCTIONS; STRESS FACTORS; WORKHORSE SELECTION;

RECOMBINANT PROTEINS;

ACETIC ACID; CARBON; RECOMBINANT PROTEIN; UNTRANSLATED RNA;

ACADEMIC RESEARCH; CARBON FLUX; GLUCOSE; METABOLISM; METABOLITE; MICROBIAL ACTIVITY; PHYSIOLOGICAL RESPONSE; PROTEIN;

BACTERIAL CELL; CARBON SOURCE; CELL GROWTH; ESCHERICHIA COLI; GLUCOSE TRANSPORT; GROWTH INHIBITION; METABOLIC ENGINEERING; NONHUMAN; REGULATORY MECHANISM; REVIEW; ENERGY METABOLISM; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROCEDURES;

ESCHERICHIA COLI;

CARBON; ENERGY METABOLISM; ESCHERICHIA COLI; METABOLIC ENGINEERING; RECOMBINANT PROTEINS;

EID: 84948380433     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6955-9     Document Type: Review

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