Flux to acetate and lactate excretions in industrial fermentations: Physiological and biochemical implications

Journal of Industrial Microbiology and Biotechnology

Volumn 31, Issue 7, 2004, Pages 295-300

  El Mansi, Mansi ^a  

^a EDINBURGH NAPIER UNIVERSITY   (United Kingdom)

Author keywords

Acetate excretion; Acetate kinase; Coenzyme A; Fluoroacetate resistance; Phosphotransacetylase

Indexed keywords

2 OXOGLUTARIC ACID; ACETATE KINASE; CARBON DIOXIDE; COENZYME A; LACTATE DEHYDROGENASE; LACTIC ACID; OXOGLUTARATE DEHYDROGENASE; PHOSPHATE ACETYLTRANSFERASE;

ARTICLE; BACTERIAL STRAIN; BATCH FERMENTATION; BIOMASS FERMENTATION; CARBON DIOXIDE EXCRETION; CELL DENSITY; CELL MUTANT; CITRIC ACID CYCLE; CONTINUOUS FERMENTATION; ENZYME ACTIVE SITE; ENZYME METABOLISM; ESCHERICHIA COLI; FED BATCH FERMENTATION; MICROBIAL BIOMASS; MICROBIAL GROWTH; NONHUMAN; OXIDATION REDUCTION REACTION; SITE DIRECTED MUTAGENESIS;

ACETATE KINASE; ACETATES; CITRIC ACID; COENZYME A; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUCONATES; GLUCOSE; ISOCITRATES; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETOGLUTARIC ACIDS; LACTIC ACID; OXIDATION-REDUCTION; PHOSPHATE ACETYLTRANSFERASE; PYRUVATES; PYRUVIC ACID;

ESCHERICHIA COLI;

EID: 4544373143     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-004-0149-2     Document Type: Article

References (22)

1. Aristidou AA, San K-Y, Bennett GN (1994) Modification of central pathways in Escherichia coli to reduce acetate accumulation by heterologous expression of the Bacillus subtilis acetolactate synthase gene. Biotechnol Bioeng 44:944-951
2. Bauer K, Bassat AB, Dawson M, De La Puente VT, Neway JO (1990) Improved expression of human interleukin-2 in high-cell-density cultures of Escherichia coli K-12 by a phosphotransacetylase mutant. Appl Environ Microbiol 56:1296-1302
3. Chin AM, Feldheim DA, Saier MH Jr (1987) Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium. J Bacteriol 169:897-899
4. Contiero J, Beaty C, Kumari S, DeSanti CL, Strohl WR, Wolfe A (2000) Effect of mutations in acetate metabolism on high-cell-density growth of Escherichia coli. J Ind Microbiol Biotechnol 24:421-430
5. Cortay JC, Neger D, Scarabel M, Ramseier TM, Vertak NB, Reizer J, Saier MH Jr, Cozzone AJ (1994) In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling the glyoxylate shunt enzymes synthesis. J Biol Chem 269:14885-14891
6. Diaz-Ricci JC, Tsu M, Bailey JE (1992) Influence of expression of the pet operon on intracellular metabolic fluxes of Escherichia coli. Biotechnol Bioeng 39:59-65
7. Dobzansky TH (1973) Nothing in biology makes sense except in the light of evolution. Am Biol Teach 35:125-128
8. El-Mansi EMT (1997) Diversion of carbon flux from central metabolism to product formation. Soc Gen Microbiol Symp 145:17
9. El-Mansi EMT (1998) Control of metabolic interconversion of isocitrate dehydrogenase between the catalytically active and inactive forms in Escherichia coli. FEMS Microbiol Lett 166:333-339
10. El-Mansi EMT, Holms WH (1989) Control of carbon flux to acetate excretion during growth of Escherichia coli in batch and continuous cultures. J Gen Microbiol 135:2875-2883
11. Gottschal JC, Morris JG (1981) The induction of acetone and butanol production in cultures of Clostridium acetobutylicum by elevated concentration of acetate and butyrate. FEMS Microbiol Lett 12:38-89
12. Han K, Lim HC, Hong J (1992) Acetic acid formation in Escherichia coli fermentation. Biotechnol Bioeng 39:663-671
13. Holms WH (1986) The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass and excretion to acetate. Curr Top Cell Regul 28:59-105
14. Kleman GL, Strol WR (1994) Acetate metabolism by Escherichia coli in high cell density fermentation. Appl Environ Microbiol 60:3952-3958
15. Luli GW, Strohl WR (1990) Comparison of growth, acetate production and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations. Appl Environ Microbiol 56:1004-1011
16. Postoma PW, Lengeler JW, Jacobson GR (1993) Phosphoenolpyruvate: carbohydrate phosphotransferase systems in bacteria. Microbiol Rev 57:543-594
17. San K-Y, Bennett GN, Berrios-Rivera SJ, Vadali RV, Yang Y-T, Horton E, Rudolph FB, Sariyar B, Blackwood K (2002) Metabolic engineering through cofactor manipulation and its effect on metabolic flux redistribution in Escherichia coli. Methods Eng 4:182-192
18. Varma A, Palson BO (1994) Stoichiometric flux balance models quantitatively predict growth and metabolic by-product excretion in wild-type Escherichia coli W3110. Appl Environ Microbiol 60:3724-3731
19. Xu B, Jahic M, Enfors S-O (1999) Modeling of overflow metabolism in batch and fed-batch cultures of Escherichia coli Biotechnol Prog 15:81-90
20. Yang S, Enfors S-O (1996) Process conditions affecting proteolysis of recombinant proteins in Escherichia coli. Biotechnol Lett 18:7-12
21. Yang Y-T, Aristidou AA, San K-Y, Bennett GN (1999) Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase. Methods Eng 1:26-34
22. Yee L, Blanch HW (1992) Recombinant protein expression in high cell density fed-batch culture of Escherichia coli. Biotechnology 10:1550-1556