메뉴 건너뛰기




Volumn 1, Issue 4, 2012, Pages 318-334

Anti-angiogenic treatment for exudative age-related macular degeneration: New strategies are underway

Author keywords

Anti angiogenesis; Combination treatment; Endothelium; Exudative age related macular degeneration; Gene therapy; Photodynamic therapy; Tyrosine kinase inhibitors; Vascular endothelial growth factor

Indexed keywords

ADENOVIRUS VECTOR; AFLIBERCEPT; AGANIRSEN; ANGIOGENESIS INHIBITOR; ARC 1905; BEVACIZUMAB; COMBRETASTATIN A4 PHOSPHATE; DEXAMETHASONE; E 10030; ERLOTINIB; PAZOPANIB; PEGAPTANIB; PERCEIVA; PF 04523655; PIGMENT EPITHELIUM DERIVED FACTOR; PLACEBO; POT 4; RANIBIZUMAB; RAPAMYCIN; SIRNA 027; SORAFENIB; SUNITINIB; TARGEGEN; TG 100801; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; VATALANIB; VERTEPORFIN; VOLOCIXIMAB;

EID: 84948094339     PISSN: 22115528     EISSN: 22115536     Source Type: Journal    
DOI: 10.2174/2211552811201040318     Document Type: Article
Times cited : (7)

References (114)
  • 1
    • 0026681119 scopus 로고
    • Prevalence of age-related maculopathy. The Beaver Dam Eye Study
    • Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 1992; 99: 933-43.
    • (1992) Ophthalmology , vol.99 , pp. 933-943
    • Klein, R.1    Klein, B.E.2    Linton, K.L.3
  • 2
    • 33745195463 scopus 로고    scopus 로고
    • Age-related macular degeneration: An emerging challenge for eye care and public health professionals in the Asia Pacific region
    • Au Eong KG. Age-related macular degeneration: an emerging challenge for eye care and public health professionals in the Asia Pacific region. Ann Acad Med 2006; 35: 133-5.
    • (2006) Ann Acad Med , vol.35 , pp. 133-135
    • Au, E.K.G.1
  • 3
    • 79958262185 scopus 로고    scopus 로고
    • Optimising the management of choroidal neovascularisation in Asian patients: Consensus on treatment recommendations for anti-VEGF therapy
    • Koh A, Lim TH, Au Eong KG, et al. Optimising the management of choroidal neovascularisation in Asian patients: consensus on treatment recommendations for anti-VEGF therapy. Singapore Med J 2011; 52: 232-40.
    • (2011) Singapore Med J , vol.52 , pp. 232-240
    • Koh, A.1    Lim, T.H.2    Au, E.K.G.3
  • 4
    • 80053622693 scopus 로고    scopus 로고
    • Polypoidal choroidal vasculopathy, diagnosis and management
    • Coppens G, Spielberg L, Leys A. Polypoidal choroidal vasculopathy, diagnosis and management. Bull Soc Belge Ophtalmol 2011; (317): 39-44.
    • (2011) Bull Soc Belge Ophtalmol , Issue.317 , pp. 39-44
    • Coppens, G.1    Spielberg, L.2    Leys, A.3
  • 5
    • 77951932130 scopus 로고    scopus 로고
    • Mediators of ocular angiogenesis
    • Qazi Y, Maddula S, Ambati BK. Mediators of ocular angiogenesis. J Genet 2009; 88: 495-515.
    • (2009) J Genet , vol.88 , pp. 495-515
    • Qazi, Y.1    Maddula, S.2    Ambati, B.K.3
  • 7
    • 21244451958 scopus 로고    scopus 로고
    • The retinal pigment epithelium in visual function
    • Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005; 85: 845-81.
    • (2005) Physiol Rev , vol.85 , pp. 845-881
    • Strauss, O.1
  • 8
    • 4043074205 scopus 로고    scopus 로고
    • Neuroprotective and antiangiogenic actions of PEDF in the eye: Molecular targets and therapeutic potential
    • Barnstable CJ, Tombran-Tink J. Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res 2004; 23: 561-77.
    • (2004) Prog Retin Eye Res , vol.23 , pp. 561-577
    • Barnstable, C.J.1    Tombran-Tink, J.2
  • 9
    • 80052214839 scopus 로고    scopus 로고
    • Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors
    • Seddon JM, Reynolds R, Yu Y, Daly MJ, Rosner B. Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. Ophthalmology 2011; 118: 2203-11.
    • (2011) Ophthalmology , vol.118 , pp. 2203-2211
    • Seddon, J.M.1    Reynolds, R.2    Yu, Y.3    Daly, M.J.4    Rosner, B.5
  • 10
    • 0019218713 scopus 로고
    • Membrane assembly in retinal photoreceptors I. Freeze-fracture analysis of cytoplasmic vesicles in relationship to disc assembly
    • Besharse JC, Pfenninger KH. Membrane assembly in retinal photoreceptors I. Freeze-fracture analysis of cytoplasmic vesicles in relationship to disc assembly. J Cell Biol 1980; 87: 451-63.
    • (1980) J Cell Biol , vol.87 , pp. 451-463
    • Besharse, J.C.1    Pfenninger, K.H.2
  • 11
    • 7144261729 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovascularization: Clinical and angiographic examples
    • Schmidt-Erfurth U, Miller J, Sickenberg M, et al. Photodynamic therapy of subfoveal choroidal neovascularization: clinical and angiographic examples. Graefes Arch Clin Exp Ophthalmol 1998; 236: 365-74.
    • (1998) Graefes Arch Clin Exp Ophthalmol , vol.236 , pp. 365-374
    • Schmidt-Erfurth, U.1    Miller, J.2    Sickenberg, M.3
  • 12
    • 0033520641 scopus 로고    scopus 로고
    • Histopathology of age-related macular degeneration
    • Green WR. Histopathology of age-related macular degeneration. Mol Vis 1999; 5: 27.
    • (1999) Mol Vis , vol.5 , pp. 27
    • Green, W.R.1
  • 13
    • 0024461206 scopus 로고
    • Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
    • Connolly DT, Heuvelman DM, Nelson R, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 1989; 84: 1470-8.
    • (1989) J Clin Invest , vol.84 , pp. 1470-1478
    • Connolly, D.T.1    Heuvelman, D.M.2    Nelson, R.3
  • 14
    • 0035555091 scopus 로고    scopus 로고
    • Photodynamic therapy of age-related macular degeneration
    • van den Bergh H. Photodynamic therapy of age-related macular degeneration: History and principles. Semin Ophthalmol 2001; 16: 181-200.
    • (2001) History and Principles. Semin Ophthalmol , vol.16 , pp. 181-200
    • van den Bergh, H.1
  • 15
    • 79960342630 scopus 로고    scopus 로고
    • Update on geographic atrophy in age-related macular degeneration
    • Biarnes M, Mones J, Alonso J, Arias L. Update on geographic atrophy in age-related macular degeneration. Optom Vis Sci 2011; 88: 881-9.
    • (2011) Optom Vis Sci , vol.88 , pp. 881-889
    • Biarnes, M.1    Mones, J.2    Alonso, J.3    Arias, L.4
  • 17
    • 0035173448 scopus 로고    scopus 로고
    • Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
    • Ohno-Matsui K, Morita I, Tombran-Tink J, et al. Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol 2001; 189: 323-33.
    • (2001) J Cell Physiol , vol.189 , pp. 323-333
    • Ohno-Matsui, K.1    Morita, I.2    Tombran-Tink, J.3
  • 18
    • 0025837828 scopus 로고
    • Laser photocoagulation of subfoveal neovascular lesions in agerelated macular degeneration. Results of a randomized clinical trial
    • Macular Photocoagulation Study Group
    • Laser photocoagulation of subfoveal neovascular lesions in agerelated macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Arch Ophthalmol 1991; 109: 1220-31.
    • (1991) Arch Ophthalmol , vol.109 , pp. 1220-1231
  • 19
    • 0342632445 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials--TAP report
    • Treatment of agerelated macular degeneration with photodynamic therapy (TAP) Study Group
    • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of agerelated macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol 1999; 117: 1329-45.
    • (1999) Arch Ophthalmol , vol.117 , pp. 1329-1345
  • 20
    • 0035124965 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: Two-year results of 2 randomized clinical trials-tap report 2
    • Bressler NM. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2. Arch Ophthalmol 2001; 119: 198-207.
    • (2001) Arch Ophthalmol , vol.119 , pp. 198-207
    • Bressler, N.M.1
  • 21
    • 33747635327 scopus 로고    scopus 로고
    • Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: 5-year results of two randomized clinical trials with an open-label extension: TAP report no. 8
    • Kaiser PK. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: 5-year results of two randomized clinical trials with an open-label extension: TAP report no. 8. Graefes Arch Clin Exp Ophthalmol 2006; 244: 1132-42.
    • (2006) Graefes Arch Clin Exp Ophthalmol , vol.244 , pp. 1132-1142
    • Kaiser, P.K.1
  • 22
    • 0036145056 scopus 로고    scopus 로고
    • Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2
    • Bressler NM. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2. Am J Ophthalmol 2002; 133: 168-9.
    • (2002) Am J Ophthalmol , vol.133 , pp. 168-169
    • Bressler, N.M.1
  • 24
    • 0037993973 scopus 로고    scopus 로고
    • Immediate indocyanine green angiography and optical coherence tomography evaluation after photodynamic therapy for subfoveal choroidal neovascularization
    • Costa RA, Farah ME, Cardillo JA, Calucci D, Williams GA. Immediate indocyanine green angiography and optical coherence tomography evaluation after photodynamic therapy for subfoveal choroidal neovascularization. Retina 2003; 23: 159-65.
    • (2003) Retina , vol.23 , pp. 159-165
    • Costa, R.A.1    Farah, M.E.2    Cardillo, J.A.3    Calucci, D.4    Williams, G.A.5
  • 25
    • 84859498670 scopus 로고
    • Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea
    • Weiss A, van den Bergh H, Griffioen AW, Nowak-Sliwinska P. Angiogenesis inhibition for the improvement of photodynamic therapy: the revival of a promising idea. BBA Rev Cancer 2012; 1826: 53-70.
    • (1826) BBA Rev Cancer , vol.2012 , pp. 53-70
    • Weiss, A.1    van den Bergh, H.2    Griffioen, A.W.3    Nowak-Sliwinska, P.4
  • 26
    • 0038265923 scopus 로고    scopus 로고
    • Role of cytokines in photodynamic therapy-induced local and systemic inflammation
    • Gollnick SO, Evans SS, Baumann H, et al. Role of cytokines in photodynamic therapy-induced local and systemic inflammation. Br J Cancer 2003; 88: 1772-9.
    • (2003) Br J Cancer , vol.88 , pp. 1772-1779
    • Gollnick, S.O.1    Evans, S.S.2    Baumann, H.3
  • 27
    • 28344432744 scopus 로고    scopus 로고
    • Time course and morphology of vascular effects associated with photodynamic therapy
    • Schmidt-Erfurth U, Niemeyer M, Geitzenauer W, Michels S. Time course and morphology of vascular effects associated with photodynamic therapy. Ophthalmology 2005; 112: 2061-9.
    • (2005) Ophthalmology , vol.112 , pp. 2061-2069
    • Schmidt-Erfurth, U.1    Niemeyer, M.2    Geitzenauer, W.3    Michels, S.4
  • 29
    • 26244459463 scopus 로고    scopus 로고
    • Low-dose photodynamic therapy increases endothelial cell proliferation and VEGF expression in nude mice brain
    • Zhang X, Jiang F, Zhang ZG, et al. Low-dose photodynamic therapy increases endothelial cell proliferation and VEGF expression in nude mice brain. Lasers Med Sci 2005; 20: 74-9.
    • (2005) Lasers Med Sci , vol.20 , pp. 74-79
    • Zhang, X.1    Jiang, F.2    Zhang, Z.G.3
  • 30
    • 0141430051 scopus 로고    scopus 로고
    • Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor
    • Schmidt-Erfurth U, Schlotzer-Schrehard U, Cursiefen C, Michels S, Beckendorf A, Naumann GO. Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 2003; 44: 4473-80.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 4473-4480
    • Schmidt-Erfurth, U.1    Schlotzer-Schrehard, U.2    Cursiefen, C.3    Michels, S.4    Beckendorf, A.5    Naumann, G.O.6
  • 32
    • 17144408416 scopus 로고    scopus 로고
    • Expression of VEGF and angiopoietins in subfoveal membranes from patients with age-related macular degeneration
    • Hera R, Keramidas M, Peoc'h M, Mouillon M, Romanet JP, Feige JJ. Expression of VEGF and angiopoietins in subfoveal membranes from patients with age-related macular degeneration. Am J Ophthalmol 2005; 139: 589-96.
    • (2005) Am J Ophthalmol , vol.139 , pp. 589-596
    • Hera, R.1    Keramidas, M.2    Peoc'h, M.3    Mouillon, M.4    Romanet, J.P.5    Feige, J.J.6
  • 33
    • 0142122287 scopus 로고    scopus 로고
    • Retinal and choroidal angiogenesis: Pathophysiology and strategies for inhibition
    • Das A, McGuire PG. Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition. Prog Retin Eye Res 2003; 22: 721-48.
    • (2003) Prog Retin Eye Res , vol.22 , pp. 721-748
    • Das, A.1    McGuire, P.G.2
  • 34
    • 33747891752 scopus 로고    scopus 로고
    • Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    • Chakravarthy U, Adamis AP, Cunningham ET, Jr., et al. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 2006; 113: 1508 e1-25.
    • (2006) Ophthalmology , vol.113 , Issue.1508
    • Chakravarthy, U.1    Adamis, A.P.2    Cunningham Jr., E.T.3
  • 35
    • 78649858371 scopus 로고    scopus 로고
    • Pegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration: The LEVEL study
    • doi:10.1136/bjo.2009.174946
    • Friberg TR, Tolantino M. Pegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration: the LEVEL study. Br J Ophthalmol 2010; doi:10.1136/bjo.2009.174946.
    • (2010) Br J Ophthalmol
    • Friberg, T.R.1    Tolantino, M.2
  • 36
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-31.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 37
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-44.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 38
    • 38349172455 scopus 로고    scopus 로고
    • Randomized, doublemasked, sham-controlled trial of ranibizumab for neovascular agerelated macular degeneration: PIER Study year 1
    • Regillo CD, Brown DM, Abraham P, et al. Randomized, doublemasked, sham-controlled trial of ranibizumab for neovascular agerelated macular degeneration: PIER Study year 1. Am J Ophthalmol 2008; 145: 239-48.
    • (2008) Am J Ophthalmol , vol.145 , pp. 239-248
    • Regillo, C.D.1    Brown, D.M.2    Abraham, P.3
  • 40
    • 67149101784 scopus 로고    scopus 로고
    • A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: Year 2 of the PrONTO Study
    • Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Ophthalmol 2009; 148: 43-58 e1.
    • (2009) Am J Ophthalmol , vol.148
    • Lalwani, G.A.1    Rosenfeld, P.J.2    Fung, A.E.3
  • 41
    • 79851497820 scopus 로고    scopus 로고
    • The role of bevacizumab in colorectal cancer: Understanding its benefits and limitations
    • Mulder K, Scarfe A, Chua N, Spratlin J. The role of bevacizumab in colorectal cancer: understanding its benefits and limitations. Expert Opin Biol Ther 2011; 11: 405-13.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 405-413
    • Mulder, K.1    Scarfe, A.2    Chua, N.3    Spratlin, J.4
  • 43
    • 80755126037 scopus 로고    scopus 로고
    • Therapeutic efficacy of bevacizumab for age-related macular degeneration: What are the implications of CATT for routine management?
    • Ziemssen F, Sobolewska B. Therapeutic efficacy of bevacizumab for age-related macular degeneration: what are the implications of CATT for routine management? Drugs Aging 2011; 28: 853-65.
    • (2011) Drugs Aging , vol.28 , pp. 853-865
    • Ziemssen, F.1    Sobolewska, B.2
  • 44
    • 70349330817 scopus 로고    scopus 로고
    • VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration
    • Dixon JA, Oliver SC, Olson JL, Mandava N. VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration. Expert Opin Invest Drugs 2009; 18: 1573-80.
    • (2009) Expert Opin Invest Drugs , vol.18 , pp. 1573-1580
    • Dixon, J.A.1    Oliver, S.C.2    Olson, J.L.3    Mandava, N.4
  • 45
    • 33747874091 scopus 로고    scopus 로고
    • A phase I trial of an IVadministered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
    • Nguyen QD, Shah SM, Hafiz G, et al. A phase I trial of an IVadministered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 2006; 113: 1522 e1-e14.
    • (2006) Ophthalmology , vol.113 , Issue.1522
    • Nguyen, Q.D.1    Shah, S.M.2    Hafiz, G.3
  • 46
    • 34547101121 scopus 로고    scopus 로고
    • Results of a phase I, doseescalation, safety, tolerability, and bioactivity study of intravitreal VEGF trap in patients with neovascular age-related macular degeneration: The CLEAR-IT I study
    • Nguyen QD, Hariprasad S, Shah SM. Results of a phase I, doseescalation, safety, tolerability, and bioactivity study of intravitreal VEGF trap in patients with neovascular age-related macular degeneration: the CLEAR-IT I study. Retina Society/Club Jules Gonin Annual Meeting 2006;
    • (2006) Retina Society/Club Jules Gonin Annual Meeting
    • Nguyen, Q.D.1    Hariprasad, S.2    Shah, S.M.3
  • 47
    • 79957990661 scopus 로고    scopus 로고
    • The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing
    • Heier JS, Boyer D, Nguyen QD, et al. The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. Ophthalmology 2011; 118: 1098-106.
    • (2011) Ophthalmology , vol.118 , pp. 1098-1106
    • Heier, J.S.1    Boyer, D.2    Nguyen, Q.D.3
  • 48
    • 84952991713 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT00509795.
  • 49
    • 84952991251 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT00637377.
  • 50
    • 84952995087 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://newsroom.regeneron.com/releasedetail.cfm?ReleaseID=629800.
  • 51
    • 10744228532 scopus 로고    scopus 로고
    • Polypoidal choroidal vasculopathy: Incidence, demographic features, and clinical characteristics
    • Sho K, Takahashi K, Yamada H, et al. Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics. Arch Ophthalmol 2003; 121: 1392-6.
    • (2003) Arch Ophthalmol , vol.121 , pp. 1392-1396
    • Sho, K.1    Takahashi, K.2    Yamada, H.3
  • 52
    • 2642566913 scopus 로고    scopus 로고
    • Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy
    • Matsuoka M, Ogata N, Otsuji T, Nishimura T, Takahashi K, Matsumura M. Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy. Br J Ophthalmol 2004; 88: 809-15.
    • (2004) Br J Ophthalmol , vol.88 , pp. 809-815
    • Matsuoka, M.1    Ogata, N.2    Otsuji, T.3    Nishimura, T.4    Takahashi, K.5    Matsumura, M.6
  • 54
    • 78049486726 scopus 로고    scopus 로고
    • Improvement of angiographic findings of polypoidal choroidal vasculopathy after intravitreal injection of ranibizumab monthly for 3 months
    • Hikichi T, Ohtsuka H, Higuchi M, et al. Improvement of angiographic findings of polypoidal choroidal vasculopathy after intravitreal injection of ranibizumab monthly for 3 months. Am J Ophthalmol 2010; 150: 674-82 e1.
    • (2010) Am J Ophthalmol , vol.150
    • Hikichi, T.1    Ohtsuka, H.2    Higuchi, M.3
  • 55
    • 34250774583 scopus 로고    scopus 로고
    • Indocyanine green angiography: Guided photodynamic therapy for polypoidal choroidal vasculopathy
    • Otani A, Sasahara M, Yodoi Y, et al. Indocyanine green angiography: guided photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol 2007; 144: 7-14.
    • (2007) Am J Ophthalmol , vol.144 , pp. 7-14
    • Otani, A.1    Sasahara, M.2    Yodoi, Y.3
  • 57
    • 3442875289 scopus 로고    scopus 로고
    • Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: One-year results of a prospective case series
    • Chan WM, Lam DS, Lai TY, et al. Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series. Ophthalmology 2004; 111: 1576-84.
    • (2004) Ophthalmology , vol.111 , pp. 1576-1584
    • Chan, W.M.1    Lam, D.S.2    Lai, T.Y.3
  • 58
    • 37349061329 scopus 로고    scopus 로고
    • One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    • Gomi F, Ohji M, Sayanagi K, et al. One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients. Ophthalmology 2008; 115: 141-6.
    • (2008) Ophthalmology , vol.115 , pp. 141-146
    • Gomi, F.1    Ohji, M.2    Sayanagi, K.3
  • 59
    • 68249113677 scopus 로고    scopus 로고
    • Two-year visual outcomes after photodynamic therapy in age-related macular degeneration patients with or without polypoidal choroidal vasculopathy lesions
    • Tsuchiya D, Yamamoto T, Kawasaki R, Yamashita H. Two-year visual outcomes after photodynamic therapy in age-related macular degeneration patients with or without polypoidal choroidal vasculopathy lesions. Retina 2009; 29: 960-5.
    • (2009) Retina , vol.29 , pp. 960-965
    • Tsuchiya, D.1    Yamamoto, T.2    Kawasaki, R.3    Yamashita, H.4
  • 60
    • 43249107809 scopus 로고    scopus 로고
    • Long-term results of photodynamic therapy of polypoidal choroidal vasculopathy
    • Akaza E, Mori R, Yuzawa M. Long-term results of photodynamic therapy of polypoidal choroidal vasculopathy. Retina 2008; 28: 717-22.
    • (2008) Retina , vol.28 , pp. 717-722
    • Akaza, E.1    Mori, R.2    Yuzawa, M.3
  • 61
    • 43049176776 scopus 로고    scopus 로고
    • Ranibizumab combined with verteporfin photodynamic therapy in neovascular agerelated macular degeneration (FOCUS): Year 2 results
    • Antoszyk AN, Tuomi L, Chung CY, Singh A. Ranibizumab combined with verteporfin photodynamic therapy in neovascular agerelated macular degeneration (FOCUS): year 2 results. Am J Ophthalmol 2008; 145: 862-74.
    • (2008) Am J Ophthalmol , vol.145 , pp. 862-874
    • Antoszyk, A.N.1    Tuomi, L.2    Chung, C.Y.3    Singh, A.4
  • 62
    • 57149115612 scopus 로고    scopus 로고
    • Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularisation due to age-related macular degeneration
    • Schmidt-Erfurth U, Wolf S. Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularisation due to age-related macular degeneration. Br J Ophthalmol 2008; 92: 1628-35.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1628-1635
    • Schmidt-Erfurth, U.1    Wolf, S.2
  • 64
    • 77954668887 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Current strategies and future prospects
    • Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 2010; 60: 222-43.
    • (2010) CA Cancer J Clin , vol.60 , pp. 222-243
    • Cook, K.M.1    Figg, W.D.2
  • 65
    • 79957592445 scopus 로고    scopus 로고
    • Review of combination therapies for neovascular age-related macular degeneration
    • Couch SM, Bakri SJ. Review of combination therapies for neovascular age-related macular degeneration. Semin Ophthalmol 2011; 26: 114-20.
    • (2011) Semin Ophthalmol , vol.26 , pp. 114-120
    • Couch, S.M.1    Bakri, S.J.2
  • 66
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005; 308: 419-21.
    • (2005) Science , vol.308 , pp. 419-421
    • Haines, J.L.1    Hauser, M.A.2    Schmidt, S.3
  • 67
    • 61449112923 scopus 로고    scopus 로고
    • Photodynamic therapy with intravitreal application of triamcinolone acetonide in age-related macular degeneration: Functional results in 54 patients
    • Frimpong-Boateng A, Bunse A, Rufer F, Roider J. Photodynamic therapy with intravitreal application of triamcinolone acetonide in age-related macular degeneration: functional results in 54 patients. Acta Ophthalmol 2009; 87: 183-7.
    • (2009) Acta Ophthalmol , vol.87 , pp. 183-187
    • Frimpong-Boateng, A.1    Bunse, A.2    Rufer, F.3    Roider, J.4
  • 68
    • 82055186248 scopus 로고    scopus 로고
    • The RADICAL Trial: Exploring Combination Therapies
    • Hudson HL. The RADICAL Trial: Exploring Combination Therapies. Retina Today 2008; 1: 59-62.
    • (2008) Retina Today , vol.1 , pp. 59-62
    • Hudson, H.L.1
  • 69
    • 68049127818 scopus 로고    scopus 로고
    • Triple therapy for age-related macular degeneration
    • Augustin A. Triple therapy for age-related macular degeneration. Retina 2009; 29: S8-11.
    • (2009) Retina , vol.29
    • Augustin, A.1
  • 70
    • 66749143189 scopus 로고    scopus 로고
    • Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone
    • Yip PP, Woo CF, Tang HH, Ho CK. Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone. Br J Ophthalmol 2009; 93: 754-8.
    • (2009) Br J Ophthalmol , vol.93 , pp. 754-758
    • Yip, P.P.1    Woo, C.F.2    Tang, H.H.3    Ho, C.K.4
  • 71
    • 66349105686 scopus 로고    scopus 로고
    • Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degeneration
    • Bakri SJ, Couch SM, McCannel CA, Edwards AO. Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degeneration. Retina 2009; 29: 573-8.
    • (2009) Retina , vol.29 , pp. 573-578
    • Bakri, S.J.1    Couch, S.M.2    McCannel, C.A.3    Edwards, A.O.4
  • 72
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo N, Mailhos C, Ju M, et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 2006; 168: 2036-53.
    • (2006) Am J Pathol , vol.168 , pp. 2036-2053
    • Jo, N.1    Mailhos, C.2    Ju, M.3
  • 73
    • 77949494504 scopus 로고    scopus 로고
    • Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
    • Helfrich I, Scheffrahn I, Bartling S, et al. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J Exp Med 2010; 207: 491-503.
    • (2010) J Exp Med , vol.207 , pp. 491-503
    • Helfrich, I.1    Scheffrahn, I.2    Bartling, S.3
  • 74
    • 84952994166 scopus 로고    scopus 로고
    • Available from: Reference: Available from
    • Available from: Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT00569140.
  • 75
    • 84952995891 scopus 로고    scopus 로고
    • Available from
    • Available from: http://clinicaltrials.gov/ct2/show/NCT01089517.
  • 76
    • 41149178633 scopus 로고    scopus 로고
    • Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema
    • Doukas J, Mahesh S, Umeda N, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol 2008; 216: 29-37.
    • (2008) J Cell Physiol , vol.216 , pp. 29-37
    • Doukas, J.1    Mahesh, S.2    Umeda, N.3
  • 77
    • 84856779834 scopus 로고    scopus 로고
    • Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion
    • Nowak-Sliwinska P, Weiss A, van Beijnum JR, et al. Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion. J Cell Mol Med 2012; 16: 1553-62.
    • (2012) J Cell Mol Med , vol.16 , pp. 1553-1562
    • Nowak-Sliwinska, P.1    Weiss, A.2    van Beijnum, J.R.3
  • 78
    • 67649622340 scopus 로고    scopus 로고
    • VEGF inhibitors for the treatment of neovascular age-related macular degeneration
    • Barakat MR, Kaiser PK. VEGF inhibitors for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs 2009; 18: 637-46.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 637-646
    • Barakat, M.R.1    Kaiser, P.K.2
  • 79
    • 84952991762 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT01134055.
  • 80
    • 84952994859 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT00138632.
  • 81
    • 79955663810 scopus 로고    scopus 로고
    • Anti-VEGF compounds in the treatment of neovascular age related macular degeneration
    • Campa C, Harding SP. Anti-VEGF compounds in the treatment of neovascular age related macular degeneration. Curr Drug Targets 2011; 12: 173-81.
    • (2011) Curr Drug Targets , vol.12 , pp. 173-181
    • Campa, C.1    Harding, S.P.2
  • 82
    • 8544222783 scopus 로고    scopus 로고
    • Development of gene-specific double-stranded RNA drugs
    • Barik S. Development of gene-specific double-stranded RNA drugs. Ann Med 2004; 36: 540-51.
    • (2004) Ann Med , vol.36 , pp. 540-551
    • Barik, S.1
  • 83
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNAinterference-based therapeutics
    • Castanotto D, Rossi JJ. The promises and pitfalls of RNAinterference-based therapeutics. Nature 2009; 457: 426-33.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 84
    • 77953909544 scopus 로고    scopus 로고
    • RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027
    • Kaiser PK, Symons RC, Shah SM, et al. RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. Am J Ophthalmol 2010; 150: 33-9 e2.
    • (2010) Am J Ophthalmol , vol.150
    • Kaiser, P.K.1    Symons, R.C.2    Shah, S.M.3
  • 85
    • 84952992559 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://www.clinicaltrials.gov/ct2/show/NCT00713518.
  • 86
    • 84952992780 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://www.clinicaltrials.gov/ct2/show/NCT00709527.
  • 87
    • 84952993314 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://clinicaltrials.gov/ct2/show/NCT00473928.
  • 88
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006; 6: 729-34.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 89
    • 84952995924 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://www.clinicaltrials.gov/ct2/show/NCT00766337.
  • 91
    • 48349112269 scopus 로고    scopus 로고
    • Repeat administration of proteins to the eye with a single intraocular injection of an adenovirus vector
    • McVey D, Hamilton MM, Hsu C, King CR, Brough DE, Wei LL. Repeat administration of proteins to the eye with a single intraocular injection of an adenovirus vector. Mol Ther 2008; 16: 1444-9.
    • (2008) Mol Ther , vol.16 , pp. 1444-1449
    • McVey, D.1    Hamilton, M.M.2    Hsu, C.3    King, C.R.4    Brough, D.E.5    Wei, L.L.6
  • 92
    • 0029834562 scopus 로고    scopus 로고
    • Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
    • Guo ZS, Wang LH, Eisensmith RC, Woo SL. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther 1996; 3: 802-10.
    • (1996) Gene Ther , vol.3 , pp. 802-810
    • Guo, Z.S.1    Wang, L.H.2    Eisensmith, R.C.3    Woo, S.L.4
  • 93
    • 32944481724 scopus 로고    scopus 로고
    • Adenoviral vectordelivered pigment epithelium-derived factor for neovascular agerelated macular degeneration: Results of a phase I clinical trial
    • Campochiaro PA, Nguyen QD, Shah SM, et al. Adenoviral vectordelivered pigment epithelium-derived factor for neovascular agerelated macular degeneration: results of a phase I clinical trial. Hum Gene Ther 2006; 17: 167-76.
    • (2006) Hum Gene Ther , vol.17 , pp. 167-176
    • Campochiaro, P.A.1    Nguyen, Q.D.2    Shah, S.M.3
  • 94
    • 79551622680 scopus 로고    scopus 로고
    • Preclinical safety evaluation of AAV2-sFLT01-a gene therapy for age-related macular degeneration
    • Maclachlan TK, Lukason M, Collins M, et al. Preclinical safety evaluation of AAV2-sFLT01-a gene therapy for age-related macular degeneration. Mol Ther 2011; 19: 326-34.
    • (2011) Mol Ther , vol.19 , pp. 326-334
    • Maclachlan, T.K.1    Lukason, M.2    Collins, M.3
  • 95
    • 84952993574 scopus 로고    scopus 로고
    • Available from
    • Available from: http://clinicaltrials.gov/ct2/show/NCT01024998.
  • 96
    • 84952993862 scopus 로고    scopus 로고
    • Available from
    • Available from: http://clinicaltrials.gov/ct2/show/NCT01301443.
  • 97
    • 77950976702 scopus 로고    scopus 로고
    • Disrupting established tumor blood vessels: An emerging therapeutic strategy for cancer
    • McKeage MJ, Baguley BC. Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. Cancer 2010; 116: 1859-71.
    • (2010) Cancer , vol.116 , pp. 1859-1871
    • McKeage, M.J.1    Baguley, B.C.2
  • 98
    • 0042343848 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization
    • Nambu H, Nambu R, Melia M, Campochiaro PA. Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization. Invest Ophthalmol Vis Sci 2003; 44: 3650-5.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3650-3655
    • Nambu, H.1    Nambu, R.2    Melia, M.3    Campochiaro, P.A.4
  • 99
    • 67650705517 scopus 로고    scopus 로고
    • Emerging pharmacologic therapies for wet age-related macular degeneration
    • Ni Z, Hui P. Emerging pharmacologic therapies for wet age-related macular degeneration. Ophthalmologica 2009; 223: 401-10.
    • (2009) Ophthalmologica , vol.223 , pp. 401-410
    • Ni, Z.1    Hui, P.2
  • 100
    • 84952992280 scopus 로고    scopus 로고
    • Reference: Available from
    • Reference: Available from: http://www.globenewswire.com/newsroom/news.html?d=240145.
  • 101
    • 26444583909 scopus 로고    scopus 로고
    • Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis)
    • Umeda S, Suzuki MT, Okamoto H, et al. Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis). FASEB J 2005; 19: 1683-5.
    • (2005) FASEB J , vol.19 , pp. 1683-1685
    • Umeda, S.1    Suzuki, M.T.2    Okamoto, H.3
  • 102
    • 84952991652 scopus 로고    scopus 로고
    • Available from
    • Available from: http://clinicaltrials.gov/ct2/show/NCT00782093.
  • 103
    • 0041355277 scopus 로고    scopus 로고
    • Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis
    • Jiang ZY, He Z, King BL, et al. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 2003; 278: 31964-71.
    • (2003) J Biol Chem , vol.278 , pp. 31964-31971
    • Jiang, Z.Y.1    He, Z.2    King, B.L.3
  • 105
    • 0031616132 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • White MF. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog Horm Res 1998; 53: 119-38.
    • (1998) Recent Prog Horm Res , vol.53 , pp. 119-138
    • White, M.F.1
  • 106
    • 65649108417 scopus 로고    scopus 로고
    • Potent in vivo antiangiogenic effects of GS-101 (5'-TATCCGGAGGGCTCGCCATGCTGCT-3'), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1
    • Al-Mahmood S, Colin S, Farhat N, Thorin E, Steverlynck C, Chemtob S. Potent in vivo antiangiogenic effects of GS-101 (5'-TATCCGGAGGGCTCGCCATGCTGCT-3'), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1. J Pharmacol Exp Ther 2009; 329: 496-504.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 496-504
    • Al-Mahmood, S.1    Colin, S.2    Farhat, N.3    Thorin, E.4    Steverlynck, C.5    Chemtob, S.6
  • 107
    • 84860625079 scopus 로고    scopus 로고
    • Anti-angiogenic activity of Aganirsen in non-human primate and rodent models of retinal neovascular disease following topical administration
    • Cloutier F, Lawrence M, Goody R, et al. Anti-angiogenic activity of Aganirsen in non-human primate and rodent models of retinal neovascular disease following topical administration. Invest Ophthalmol Vis Sci 2012; 53: 1195-203.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 1195-1203
    • Cloutier, F.1    Lawrence, M.2    Goody, R.3
  • 108
    • 84856777866 scopus 로고    scopus 로고
    • Angiogenesis inhibition by the maleimide-based small molecule GNX-686
    • Nowak-Sliwinska P, Storto M, Cataudella T, et al Angiogenesis inhibition by the maleimide-based small molecule GNX-686. Microvas Res 2012; 83: 105-10.
    • (2012) Microvas Res , vol.83 , pp. 105-110
    • Nowak-Sliwinska, P.1    Storto, M.2    Cataudella, T.3
  • 109
    • 33644872951 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants
    • Sieving PA, Caruso RC, Tao W, et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A 2006; 103: 3896-901.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3896-3901
    • Sieving, P.A.1    Caruso, R.C.2    Tao, W.3
  • 110
    • 67349119829 scopus 로고    scopus 로고
    • Intravenous transferrin, RGD peptide and dualtargeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
    • Singh SR, Grossniklaus HE, Kang SJ, Edelhauser HF, Ambati BK, Kompella UB. Intravenous transferrin, RGD peptide and dualtargeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV. Gene Ther 2009; 16: 645-59.
    • (2009) Gene Ther , vol.16 , pp. 645-659
    • Singh, S.R.1    Grossniklaus, H.E.2    Kang, S.J.3    Edelhauser, H.F.4    Ambati, B.K.5    Kompella, U.B.6
  • 111
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007; 7: 475-85.
    • (2007) Nat Rev Cancer , vol.7 , pp. 475-485
    • Verheul, H.M.1    Pinedo, H.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.