-
1
-
-
11144354339
-
Prevalence of age-related macular degeneration in the United States
-
Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004;122:564-572
-
(2004)
Arch Ophthalmol
, vol.122
, pp. 564-572
-
-
Friedman, D.S.1
O'Colmain, B.J.2
Munoz, B.3
-
2
-
-
0034800655
-
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
-
Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001;119:1417-1436 (Pubitemid 32963246)
-
(2001)
Archives of Ophthalmology
, vol.119
, Issue.10
, pp. 1417-1436
-
-
Kassoff, A.1
Kassoff, J.2
Buehler, J.3
Eglow, M.4
Kaufman, F.5
Mehu, M.6
Kieval, S.7
Mairs, M.8
Graig, B.9
Quattrocchi, A.10
Jones, D.11
Locatelli, J.12
Ruby, A.13
Capon Jr., A.14
Garretson, B.15
Hassan, T.16
Trese, M.T.17
Williams, G.A.18
Regan, V.19
Manatrey, P.20
Streasick, P.21
Szydlowski, L.22
McIver, F.23
Bridges, C.24
Stanley, C.25
Cumming, K.26
Lewis, B.27
Zajechowski, M.28
Margherio, R.R.29
Cox, M.S.30
Werner, J.C.31
Falk, R.32
Siedlak, P.33
Neubert, C.34
Klein, M.L.35
Stout, J.T.36
O'Malley, A.37
Lauer, A.K.38
Robertson, J.E.39
Wilson, D.J.40
Beardsley, C.41
Anderson, H.42
Wallace, P.43
Smith, G.44
Howard, S.45
Dreyer, R.F.46
Ma, C.47
Chenoweth, R.G.48
Zilis, J.D.49
Johnson, M.50
Rice, P.51
Daniel, H.52
Crider, H.53
Parker, S.54
Sherman, K.55
Martin, D.F.56
Aaberg Sr., T.M.57
Sternberg Jr., P.58
Curtis, L.T.59
Ju, B.60
Gilman, J.61
Myles, B.62
Strittman, S.63
Gentry, C.64
Yi, H.65
Capone Jr., A.66
Lambert, M.67
Meredith, T.68
Aaberg Jr., T.M.69
Saperstein, D.70
Lim, J.I.71
Stribling, B.72
Armiger, D.73
Swords, R.74
Orth, D.H.75
Flood, T.P.76
Civantos, J.77
Debustros, S.78
Packo, K.H.79
Merrill, P.T.80
Cohen, J.A.81
Figliulo, C.82
Morrison, C.83
Bryant, D.A.84
Doherty, D.85
McVicker, M.86
Drefcinski, T.87
Seddon, J.M.88
Pinnolis, M.K.89
Davis, N.90
Burton, I.91
Taitsel, T.92
Walsh, D.93
Dubois-Moran, J.94
Callahan, C.95
Evans, C.96
Snow, K.K.97
Jones-Devonish, D.A.98
Crouse, V.D.99
more..
-
4
-
-
0031940839
-
Vascular endothelial growth factor is essential for corpus luteum angiogenesis
-
Ferrara N, Chen H, Davis-Smyth T, et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med 1998;4:336-340
-
(1998)
Nat Med
, vol.4
, pp. 336-340
-
-
Ferrara, N.1
Chen, H.2
Davis-Smyth, T.3
-
5
-
-
0035110666
-
Control of hair growth and follicle size by VEGF-mediated angiogenesis
-
Yano K, Brown LF, Detmar M. Control of hair-growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest 2001;107:409-417 (Pubitemid 32167987)
-
(2001)
Journal of Clinical Investigation
, vol.107
, Issue.4
, pp. 409-417
-
-
Yano, K.1
Brown, L.F.2
Detmar, M.3
-
7
-
-
0036985699
-
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
-
Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol 2002;29:10-14
-
(2002)
Semin Oncol
, vol.29
, pp. 10-14
-
-
Ferrara, N.1
-
8
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
DOI 10.1016/S0092-8674(00)80108-7
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-364 (Pubitemid 26272076)
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
9
-
-
0024818355
-
Vascular endotherlial growth factor is a secreted angiogneic mitogen
-
Leung DW, Cachianes G, Kuang WJ, et al. Vascular endotherlial growth factor is a secreted angiogneic mitogen. Science 1989;246:1306-1309
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
-
10
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996;380:439-442
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
-
11
-
-
13144266696
-
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
-
Olofsson B, Korpelainen E, Pepper MS, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 1998;95:11709-11714
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11709-11714
-
-
Olofsson, B.1
Korpelainen, E.2
Pepper, M.S.3
-
12
-
-
0035126049
-
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
-
Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001;7:186-191
-
(2001)
Nat Med
, vol.7
, pp. 186-191
-
-
Stacker, S.A.1
Caesar, C.2
Baldwin, M.E.3
-
13
-
-
0029935043
-
Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation
-
Wells JA, Murthy R, Chibber R, et al. Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation. Br J Ophthalmol 1996;80:363-366 (Pubitemid 26113591)
-
(1996)
British Journal of Ophthalmology
, vol.80
, Issue.4
, pp. 363-366
-
-
Wells, J.A.1
Murthy, R.2
Chibber, R.3
Nunn, A.4
Molinatti, P.A.5
Kohner, E.M.6
Gregor, Z.J.7
-
14
-
-
0029831672
-
Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
-
Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest Ophthalmol Vis Sci 1996;37:1929-1934 (Pubitemid 26324159)
-
(1996)
Investigative Ophthalmology and Visual Science
, vol.37
, Issue.9
, pp. 1929-1934
-
-
Kvanta, A.1
Algvere, P.V.2
Berglin, L.3
Seregard, S.4
-
15
-
-
0031050126
-
Increased expression of angiogenic growth factors in age-related maculopathy
-
Kliffen M, Sharma HS, Mooy CM, et al. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol 1997;81:154-162 (Pubitemid 27092496)
-
(1997)
British Journal of Ophthalmology
, vol.81
, Issue.2
, pp. 154-162
-
-
Kliffen, M.1
Sharma, H.S.2
Mooy, C.M.3
Kerkvliet, S.4
De Jong, P.T.V.M.5
-
16
-
-
0032493654
-
165): Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
-
DOI 10.1074/jbc.273.32.20556
-
Ruckman J, Green LS, Beeson J, et al. 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J Biol Chem 1998;273:20556-20567 (Pubitemid 28377626)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.32
, pp. 20556-20567
-
-
Ruckman, J.1
Green, L.S.2
Beeson, J.3
Waugh, S.4
Gillette, W.L.5
Henninger, D.D.6
Claesson-Welsh, L.7
Janjic, N.8
-
17
-
-
0036959644
-
Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
-
DOI 10.1097/00006982-200204000-00002
-
Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002;22:143-152 (Pubitemid 36125089)
-
(2002)
Retina
, vol.22
, Issue.2
, pp. 143-152
-
-
Martin, D.F.1
Klein, M.2
Haller, J.3
Adamis, A.4
Gragoudas, E.5
Miller, J.6
Blumenkrantz, M.7
Goldberg, M.8
Yannuzzi, L.9
Henninger, D.10
Wiegand, L.B.11
Chen, L.-S.12
Drolet, D.W.13
Gill, S.C.14
Bill, J.15
Tomkinson, B.16
Bendele, R.A.17
O'Shaughnessy, D.18
Guyer, D.R.19
Patel, S.20
more..
-
18
-
-
11144239923
-
Pegaptanib for neovascular age-related macular degeneration
-
Demonstrated utility of pegaptanib in neovascular AMD
-
Gragoudas ES, Adamis AP, Cunningham ET Jr, et al. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004;351:2805-2816 •• Demonstrated utility of pegaptanib in neovascular AMD.
-
(2004)
N Engl J Med
, vol.351
, pp. 2805-2816
-
-
Gragoudas, E.S.1
Adamis, A.P.2
Cunningham Jr., E.T.3
-
19
-
-
0036129304
-
Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
-
Krzystolik MG, Afshari MA, Adamis AP, et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002;120:338-346
-
(2002)
Arch Ophthalmol
, vol.120
, pp. 338-346
-
-
Krzystolik, M.G.1
Afshari, M.A.2
Adamis, A.P.3
-
20
-
-
0026708632
-
The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
-
Kim KJ, Li B, Houck K, et al. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 1992;7:53-64
-
(1992)
Growth Factors
, vol.7
, pp. 53-64
-
-
Kim, K.J.1
Li, B.2
Houck, K.3
-
21
-
-
0033527584
-
Selection and analysis of an optimized Anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
-
DOI 10.1006/jmbi.1999.3192
-
Chen Y, Wiesmann C, Fuh G, et al. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol 1999;293:865-881 (Pubitemid 29527672)
-
(1999)
Journal of Molecular Biology
, vol.293
, Issue.4
, pp. 865-881
-
-
Chen, Y.1
Wiesmann, C.2
Fuh, G.3
Li, B.4
Christinger, H.W.5
McKay, P.6
De Vos, A.M.7
Lowman, H.B.8
-
22
-
-
20144368709
-
Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration
-
Rosenfeld PJ, Schwartz SD, Blumenkranz MS, et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology 2005;112:1048-1053
-
(2005)
Ophthalmology
, vol.112
, pp. 1048-1053
-
-
Rosenfeld, P.J.1
Schwartz, S.D.2
Blumenkranz, M.S.3
-
23
-
-
0032864292
-
Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
-
Mordenti J, Cuthbertson RA, Ferrara N, et al. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol 1999;27:536-544
-
(1999)
Toxicol Pathol
, vol.27
, pp. 536-544
-
-
Mordenti, J.1
Cuthbertson, R.A.2
Ferrara, N.3
-
24
-
-
0037406770
-
Human retinal molecular weight exclusion limit and estimate of species variation
-
DOI 10.1167/iovs.02-1027
-
Jackson TL, Antcliff RJ, Hillenkamp J, Marshall J. Human retinal molecular weight exclusion limit and estimate of species variation. Invest Ophthalmol Vis Sci 2003;44:2141-2146 (Pubitemid 36520310)
-
(2003)
Investigative Ophthalmology and Visual Science
, vol.44
, Issue.5
, pp. 2141-2146
-
-
Jackson, T.L.1
Antcliff, R.J.2
Hillenkamp, J.3
Marshall, J.4
-
25
-
-
13944266313
-
Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
-
Gaudreault J, Fei D, Rusit J, et al. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci 2005;46:726-733
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 726-733
-
-
Gaudreault, J.1
Fei, D.2
Rusit, J.3
-
26
-
-
33749445317
-
Ranibizumab for neovascular age-related macular degeneration
-
DOI 10.1056/NEJMoa054481
-
Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355:1419-1431 •• Demonstrated usefulness of ranibizumab in AMD with minimally classic or occult CNV. (Pubitemid 44511557)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.14
, pp. 1419-1431
-
-
Rosenfeld, P.J.1
Brown, D.M.2
Heier, J.S.3
Boyer, D.S.4
Kaiser, P.K.5
Chung, C.Y.6
Kim, R.Y.7
-
27
-
-
33749451356
-
Ranibizumab versus verteporfin for neovascular age-related macular degeneration
-
DOI 10.1056/NEJMoa062655
-
Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006;355:1432-1444 •• Demonstrated usefulness of ranibizumab in AMD with predominantly classic CNV. (Pubitemid 44511558)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.14
, pp. 1432-1444
-
-
Brown, D.M.1
Kaiser, P.K.2
Michels, M.3
Soubrane, G.4
Heier, J.S.5
Kim, R.Y.6
Sy, J.P.7
Schneider, S.8
-
29
-
-
38349172455
-
Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1
-
Explored alternative ranibizumab dosing regimen in neovascular AMD
-
Regillo CD, Brown DM, Abraham P, et al. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1. Am J Ophthalmol 2008;145:239-248 •• Explored alternative ranibizumab dosing regimen in neovascular AMD.
-
(2008)
Am J Ophthalmol
, vol.145
, pp. 239-248
-
-
Regillo, C.D.1
Brown, D.M.2
Abraham, P.3
-
30
-
-
20144372969
-
Systemic bevacisumab (Avastin) therapy for neovascular age-related macular degeneration: Twelve-week results of an uncontrolled open-label clinical study
-
Michels S, Rosenfeld PJ, Puliafito CA, et al. Systemic bevacisumab (Avastin) therapy for neovascular age-related macular degeneration: twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 2005;112:1035-1047
-
(2005)
Ophthalmology
, vol.112
, pp. 1035-1047
-
-
Michels, S.1
Rosenfeld, P.J.2
Puliafito, C.A.3
-
31
-
-
23044505200
-
Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin®) for neovascular age-related macular degeneration
-
Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin®) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005;36:331-335 •• Demonstrated treatment response of neovascular AMD to intravitreal bevacizumab. (Pubitemid 41073112)
-
(2005)
Ophthalmic Surgery Lasers and Imaging
, vol.36
, Issue.4
, pp. 331-335
-
-
Rosenfeld, P.J.1
Moshfeghi, A.A.2
Puliafito, C.A.3
-
32
-
-
0037235949
-
Engineered antibodies
-
DOI 10.1038/nm0103-129
-
Hudson PJ, Souriau C. Engineered antibodies. Nat Med 2003;9:129-134 (Pubitemid 36098274)
-
(2003)
Nature Medicine
, vol.9
, Issue.1
, pp. 129-134
-
-
Hudson, P.J.1
Souriau, C.2
-
33
-
-
35349022642
-
Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy
-
Sawada O, Kawamura H, Kakinoki M, et al. Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy. Arch Ophthalmol 2007;125(10):1363-1366
-
(2007)
Arch Ophthalmol
, vol.125
, Issue.10
, pp. 1363-1366
-
-
Sawada, O.1
Kawamura, H.2
Kakinoki, M.3
-
34
-
-
51649109046
-
Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
-
Krohne TU, Eter N, Holz FG, et al. Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans. Am J Ophthalmol 2008;146(4):508-512
-
(2008)
Am J Ophthalmol
, vol.146
, Issue.4
, pp. 508-512
-
-
Krohne, T.U.1
Eter, N.2
Holz, F.G.3
-
35
-
-
52949113486
-
Vitreous levels of bevacizumab and vascular endothelial growth factor-A in patients with choroidal neovascularization
-
Zhu Q, Ziemssen F, Henke-Fahle S, et al. Vitreous levels of bevacizumab and vascular endothelial growth factor-A in patients with choroidal neovascularization. Ophthalmology 1755;115(10):1750-1755
-
(1755)
Ophthalmology
, vol.115
, Issue.10
, pp. 1750-1755
-
-
Zhu, Q.1
Ziemssen, F.2
Henke-Fahle, S.3
-
36
-
-
42149145099
-
-
[ClinicalTrials.gov identifier: NCT00593450]. ClinicalTrials.gov. Available from: [Last accessed 17 Dec 2008]
-
Comparison of Age-Related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial. [ClinicalTrials.gov identifier: NCT00593450]. ClinicalTrials.gov. Available from: http://clinicaltrials.gov/ct2/show/ NCT00593450 [Last accessed 17 Dec 2008]
-
Comparison of Age-Related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial
-
-
-
37
-
-
7444261960
-
Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF trap) to inhibit vascular endothelial growth factor activity
-
Konner J, Dupont J. Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity. Clin Colorectal Cancer 2004;4:S81-5 (Pubitemid 39440148)
-
(2004)
Clinical Colorectal Cancer
, vol.4
, Issue.SUPPL. 2
-
-
Konner, J.1
Dupont, J.2
-
38
-
-
0037231664
-
Cytokine traps: Multi-component, high-affinity blockers of cytokine action
-
Economides AN, Carpenter LR, Rudge JS, et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nat Med 2003;9:47-52
-
(2003)
Nat Med
, vol.9
, pp. 47-52
-
-
Economides, A.N.1
Carpenter, L.R.2
Rudge, J.S.3
-
40
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich SJ, Fosnot J, Kuroki A, et al. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis 2003;9:210-216
-
(2003)
Mol Vis
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
Fosnot, J.2
Kuroki, A.3
-
41
-
-
41649115210
-
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
-
see comment
-
Kleinman ME, Yamada K, Takeda A, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.[see comment]. Nature 2008;452(7187):591-597
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
-
42
-
-
31444440290
-
Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
-
Shen J, Samul R, Silva RL, et al. Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 2006;13(3):225-234
-
(2006)
Gene Ther
, vol.13
, Issue.3
, pp. 225-234
-
-
Shen, J.1
Samul, R.2
Silva, R.L.3
-
43
-
-
67649632452
-
Small interfering RNA (CAND5) for the treatment of subfoveal choroidal neovascularization due to age-related macular degeneration
-
Brucker A. Small interfering RNA (CAND5) for the treatment of subfoveal choroidal neovascularization due to age-related macular degeneration. Combined Retina Society/Gonin Society Meeting; 2006 Oct 15-20; Cape Town
-
Combined Retina Society/Gonin Society Meeting; 2006 Oct 15-20; Cape Town
-
-
Brucker, A.1
-
47
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
DOI 10.1056/NEJMoa020461
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. [see comment]. N Engl J Med 2002;347(7):472-480 (Pubitemid 34879334)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.7
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.M.20
Joensuu, H.21
more..
-
48
-
-
45749098231
-
Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: A phase II study (STI571B1202)
-
DOI 10.1007/s10147-007-0746-y
-
Nishida T, Shirao K, Sawaki A, et al. Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202). Int J Clin Oncol 2008;13(3):244-251 (Pubitemid 351871892)
-
(2008)
International Journal of Clinical Oncology
, vol.13
, Issue.3
, pp. 244-251
-
-
Nishida, T.1
Shirao, K.2
Sawaki, A.3
Koseki, M.4
Okamura, T.5
Ohtsu, A.6
Sugiyama, T.7
Miyakawa, K.8
Hirota, S.9
-
49
-
-
34447260736
-
Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor
-
DOI 10.1007/s11912-007-0040-1
-
George S. Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. Curr Oncol Rep 2007;9(4):323-327 (Pubitemid 47045167)
-
(2007)
Current Oncology Reports
, vol.9
, Issue.4
, pp. 323-327
-
-
George, S.1
-
50
-
-
22144442836
-
Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice
-
Maier P, Unsoeld AS, Junnker B, et al. Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice. Graefes Arch Clin Exp Ophthalmol 2005;243(6):593-600
-
(2005)
Graefes Arch Clin Exp Ophthalmol
, vol.243
, Issue.6
, pp. 593-600
-
-
Maier, P.1
Unsoeld, A.S.2
Junnker, B.3
-
53
-
-
67649629310
-
A dual VEGFR/JAK2 kinase inhibitor suitable for topical delivery inhibits choroid neovascularization in mice
-
[abstract no. E-1469]. Available from: [Last accessed 17 Dec 2008]
-
Chen ZZ, Mak C, Renick J, et al. A dual VEGFR/JAK2 kinase inhibitor suitable for topical delivery inhibits choroid neovascularization in mice [abstract no. E-1469]. Invest Ophthalmol Vis Sci 2007;48(5). Available from: http://abstracts.iovs.org/cgi/content/abstract/48/5/1469 [Last accessed 17 Dec 2008]
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, Issue.5
-
-
Chen, Z.Z.1
Mak, C.2
Renick, J.3
-
54
-
-
67649614033
-
-
[ClinicalTrials.gov identifier: NCT00509548]. ClinicalTrials.gov. Available from: [Last accessed 17 Dec 2008]
-
Open-Label, Pilot Study of TG100801 in Patients With Choroidal Neovascularization Due to AMD [ClinicalTrials.gov identifier: NCT00509548]. ClinicalTrials.gov. Available from: http://clinicaltrials. gov/ct2/show/ NCT00509548 [Last accessed 17 Dec 2008]
-
Open-Label, Pilot Study of TG100801 in Patients with Choroidal Neovascularization Due to AMD
-
-
-
56
-
-
67649632360
-
AL-39324 is more potent and efficacious against ocular NV vs. other RTKi's
-
[abstract no. E-1747]. Available from: [Last accessed 17 Dec 2008]
-
Bingaman DP, Gu X, Landers RA, et al. AL-39324 is more potent and efficacious against ocular NV vs. other RTKi's [abstract no. E-1747]. Invest Ophthalmol Vis Sci 2007;48(5). Available from: http://abstracts.iovs.org/cgi/ content/abstract/48/5/1747 [Last accessed 17 Dec 2008]
-
Invest Ophthalmol Vis Sci
, vol.2007
, Issue.48
, pp. 5
-
-
Bingaman, D.P.1
Gu, X.2
Landers, R.A.3
-
57
-
-
0038299000
-
Sirolimus: Its discovery, biological properties, and mechanism of action
-
DOI 10.1016/S0041-1345(03)00211-2
-
Sehgal SN. Sirolimus: its discovery, biological properties, and mechanism of action. Transpl Proc 2003;35(3 Suppl):7S-14S (Pubitemid 36547910)
-
(2003)
Transplantation Proceedings
, vol.35
, Issue.3 SUPPL.
-
-
Sehgal, S.N.1
-
58
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8(2):128-135
-
(2002)
Nat Med
, vol.8
, Issue.2
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
-
59
-
-
67649632549
-
Sirolimus inhibits VEGF-induced microvascular hyperpermeability
-
[abstract no. E-1422]. Available from: [Last accessed 17 Dec 2008]
-
Kleinman DM, Kim DD, Nivaggioli T, et al. Sirolimus inhibits VEGF-induced microvascular hyperpermeability [abstract no. E-1422]. Invest Ophthalmol Vis Sci 2007;48(5). Available from: http://abstracts.iovs.org/cgi/content/abstract/ 48/5/1422 [Last accessed 17 Dec 2008]
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, Issue.5
-
-
Kleinman, D.M.1
Kim, D.D.2
Nivaggioli, T.3
-
60
-
-
25444435486
-
Systemic rapamycin inhibits retinal and choroidal neovascularization in mice
-
Dejneka NS, Kuroki AM, Fosnot J, et al. Systemic rapamycin inhibits retinal and choroidal neovascularization in mice. Mol Vis 2004;10:964-972
-
(2004)
Mol Vis
, vol.10
, pp. 964-972
-
-
Dejneka, N.S.1
Kuroki, A.M.2
Fosnot, J.3
-
62
-
-
33846606006
-
Four cases of sirolimus-associated interstitial pneumonitis: Identification of risk factors
-
Morath C, Schwenger V, Ksoll-Rudek D, et al. Four cases of sirolimus-associated interstitial pneumonitis: identification of risk factors. Transpl Proc 2007;39(1):99-102
-
(2007)
Transpl Proc
, vol.39
, Issue.1
, pp. 99-102
-
-
Morath, C.1
Schwenger, V.2
Ksoll-Rudek, D.3
-
63
-
-
34248327483
-
De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: Long-term outcomes and side effects
-
Toso C, Meeberg GA, Bigam DL, et al. De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects. Transplantation 2007;83(9):1162-1168
-
(2007)
Transplantation
, vol.83
, Issue.9
, pp. 1162-1168
-
-
Toso, C.1
Meeberg, G.A.2
Bigam, D.L.3
-
66
-
-
33947403618
-
An Optical Coherence Tomography-Guided, Variable Dosing Regimen with Intravitreal Ranibizumab (Lucentis) for Neovascular Age-related Macular Degeneration
-
DOI 10.1016/j.ajo.2007.01.028, PII S0002939407000682
-
Fung AE, Lalwani GA, Rosenfeld PJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol 2007;143:566-583 (Pubitemid 46452533)
-
(2007)
American Journal of Ophthalmology
, vol.143
, Issue.4
-
-
Fung, A.E.1
Lalwani, G.A.2
Rosenfeld, P.J.3
Dubovy, S.R.4
Michels, S.5
Feuer, W.J.6
Puliafito, C.A.7
Davis, J.L.8
Flynn Jr., H.W.9
Esquiabro, M.10
-
67
-
-
67649626269
-
-
http://www.retinatoday.com/Html%20Pages/0507/0507-cme.html [Last accessed 18/12/08] Explored alternative, OCT-guided ranibizumab dosing regimen in neovascular AMD
-
Lalwani G. All About PrONTO: Study Yielded Good Results in AMD With Treatment Guided by OCT. www.retinatoday.com. http://www.retinatoday.com/ Html%20Pages/0507/0507-cme.html [Last accessed 18/12/08] •• Explored alternative, OCT-guided ranibizumab dosing regimen in neovascular AMD.
-
All about PrONTO: Study Yielded Good Results in AMD with Treatment Guided by OCT
-
-
Lalwani, G.1
-
68
-
-
67649629671
-
-
Available from: Available from: http://www.modernmedicine.com/ modernmedicine/Modern+Medicine+Now/Intravitreal-ranibizumab-therapy-safe-well- tolerat/ArticleStandard/Article/detail/566351 [Last accessed 29 Dec 2008] Extension trial exploring utility of ranibizumab administered at clinician's discretion for neovascular AMD
-
Guttman C. Intravitreal ranibizumab therapy safe, well tolerated, study shows.Available from: www.modernmedicine.com. Available from: http://www.modernmedicine.com/modernmedicine/Modern+Medicine+Now/ Intravitreal-ranibizumab-therapy-safe-well-tolerat/ArticleStandard/Article/ detail/566351 [Last accessed 29 Dec 2008] •• Extension trial exploring utility of ranibizumab administered at clinician's discretion for neovascular AMD.
-
Intravitreal Ranibizumab Therapy Safe, Well Tolerated, Study Shows
-
-
Guttman, C.1
-
69
-
-
33749426139
-
The price of sight - Ranibizumab, bevacizumab, and the treatment of macular degeneration
-
DOI 10.1056/NEJMp068185
-
Steinbrook R. The price of sight - ranibizumab, bevacizumab, and the treatment of macular degeneration. N Engl J Med 2006;355(14):1409-1412 (Pubitemid 44511554)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.14
, pp. 1409-1412
-
-
Steinbrook, R.1
-
70
-
-
34548324016
-
Ranibizumab (Lucentis) versus bevacizumab (Avastin): Modelling cost effectiveness
-
DOI 10.1136/bjo.2007.116616
-
Raftery J, Clegg A, Jone J, et al. Ranibizumab (Lucentis) versus bevacizumab (Avastin): modeling cost effectiveness. Br J Ophthalmol 2007;91:1244-1246 (Pubitemid 47344908)
-
(2007)
British Journal of Ophthalmology
, vol.91
, Issue.9
, pp. 1244-1246
-
-
Raftery, J.1
Clegg, A.2
Jones, J.3
Seng, C.T.4
Lotery, A.5
-
71
-
-
56549093417
-
Computerized model of cost-utility analysis for treatment of age-related macular degeneration
-
Fletcher EC, Lade RJ, Adewoyin T, Chong NV. Computerized model of cost-utility analysis for treatment of age-related macular degeneration. Ophthalmology 2008;115:2192-2198
-
(2008)
Ophthalmology
, vol.115
, pp. 2192-2198
-
-
Fletcher, E.C.1
Lade, R.J.2
Adewoyin, T.3
Chong, N.V.4
-
72
-
-
38449106206
-
Genetic susceptibility to age-related macular degeneration: A paradigm for dissecting complex disease traits
-
Swaroop A, Branham KE, Chen W, Abecasis G. Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Hum Mol Genet 2007;16(Rev2):R174-82
-
(2007)
Hum Mol Genet
, vol.16
, Issue.2 REV
-
-
Swaroop, A.1
Branham, K.E.2
Chen, W.3
Abecasis, G.4
-
73
-
-
44349192752
-
CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration
-
Klein ML, Francis PJ, Rosner B, et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology 2008;115(6):1019-1025
-
(2008)
Ophthalmology
, vol.115
, Issue.6
, pp. 1019-1025
-
-
Klein, M.L.1
Francis, P.J.2
Rosner, B.3
|