Nerolidol exhibits antinociceptive and anti-inflammatory activity: Involvement of the GABAergic system and proinflammatory cytokines

Fundamental and Clinical Pharmacology

Volumn 30, Issue 1, 2016, Pages 14-22

  Fonsêca, Diogo V ^a   Salgado, Paula R R ^a   de Carvalho, Fabíola L ^a   Salvadori, Mirian Graciela S S ^a   Penha, Antônia Rosângela S ^a   Leite, Fagner C ^a   Borges, Clóvis José S ^a   Piuvezam, Marcia R ^a   Pordeus, Liana Clébia de Morais ^a   Sousa, Damião P ^a   Almeida, Reinaldo N ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Anti inflammatory; Antinociception; Nerolidol; Sesquiterpene

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; DEXAMETHASONE; DIAZEPAM; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MORPHINE; MUSCIMOL; NEROLIDOL; TUMOR NECROSIS FACTOR ALPHA; 4 AMINOBUTYRIC ACID A RECEPTOR; CYTOKINE; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CARRAGEENAN-INDUCED PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG TRANSPORT; EXPERIMENTAL PAIN; FORMALIN TEST; GABAERGIC SYSTEM; HOT PLATE TEST; INFLAMMATION; LATENT PERIOD; LICKING; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PERITONEUM LAVAGE; PERITONEUM MACROPHAGE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; ROTAROD TEST; WRITHING TEST; ANIMAL; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; EDEMA; IMMUNOLOGY; MACROPHAGE; METABOLISM; ORAL DRUG ADMINISTRATION; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PERITONITIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; KATP CHANNELS; MACROPHAGES; MALE; MICE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PERITONITIS; RECEPTORS, GABA-A; ROTAROD PERFORMANCE TEST; SESQUITERPENES;

EID: 84947996426     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/fcp.12166     Document Type: Article

References (40)

1. Loeser J.D., Treede R.D. The Kyoto protocol of IASP basic pain terminology. Pain (2008) 137 473-477.
2. Schnakers C., Chatelle C., Demertzi A., Majerus S., Laureys S. What about pain in disorders of consciousness? AAPS J. (2012) 14 437-444.
3. Chapman C.R., Gavrin J. Suffering: the contributions of persistent pain. Lancet (1999) 353 2233-2237.
4. Liew F.Y. The role of innate cytokines in inflammatory response. Immunol. Lett. (2003) 85 131-134.
5. Javan M., Ahmadiani A., Semnanian S., Kamalinejad M. Antinociceptive effects of Trigonella foenum-graecum leaves extract. J. Ethnopharmacol. (1997) 58 125-129.
6. De Sousa D.P. Medicinal essential oils: chemical, pharmacological and therapeutic aspects, 1st edn. Nova Science Publishers, New York, 2012, 236 p.
7. Huang C.C., Lin K.J., Cheng Y.W., Hsu C.A., Yang S.S., Shyur L.F. Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis. J. Nutr. Biochem. (2013) 24 516-530.
8. Almeida R.N., Agra Mde F., Maior F.N., de Sousa D.P. Essential oils and their constituents: anticonvulsant activity. Molecules (2011) 16 2726-2742.
9. Orofino Kreuger M.R., Grootjans S., Biavatti M.W., Vandenabeele P., D'Herde K. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs (2012) 23 883-896.
10. de Oliveira Júnior W.M., Benedito R.B., Pereira W.B. et al. Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice. Fundam. Clin. Pharmacol. (2013) 27 419-426.
11. Perimal E.K., Akhtar M.N., Mohamad A.S. et al. Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin. Pharmacol. Toxicol. (2011) 108 155-162.
12. Marques A.M., Barreto A.L., Batista E.M. et al. Chemistry and biological activity of essential oils from Piper claussenianum (Piperaceae). Nat. Prod. Commun. (2010) 5 1837-1840.
13. Mattan R.S., Vieira M.A.R., Marchese J.A., Ming L.C., Marques M.O.M. Shade level effects on yield and chemical composition of the leaf essential oil of Pothomorphe umbellata (L.) Miquel. Sci. Agric. (2010) 67 414-418.
14. Wattenberg L.W. Inhibition of azoxymethane-induced neoplasia of the large bowel by 3-hydroxy-3, 7, 11-trimethyl-1, 6, 10-dodecatriene (nerolidol). Carcinogenesis (1991) 12 151-152.
15. Arruda D.C., D'Alexandri F.L., Katzin A.M., Uliana S.R. Antileishmanial activity of the terpene nerolidol. Antimicrob. Agents Chemother. (2005) 49 1679-1687.
16. Silva M.P., Oliveira G.L., de Carvalho R.B. et al. Antischistosomal activity of the terpene nerolidol. Molecules (2014) 19 3793-3803.
17. McGinty D., Letizia C.S., Api A.M. Addendum to fragrance material review on Nerolidol (isomer unspecified). Food Chem. Toxicol. (2010) 48 S43-S45.
18. Pículo F., Guiraldeli Macedo C., de Andrade S.F., Luis Maistro E. In vivo genotoxicity assessment of nerolidol. J. Appl. Toxicol. (2011) 31 633-639.
19. Nogueira Neto J.D., de Almeida A.A., da Silva Oliveira J., Dos Santos P.S., de Sousa D.P., de Freitas R.M. Antioxidant effects of nerolidol in mice hippocampus after open field test. Neurochem. Res. (2013) 38 1861-1870.
20. Dunham N.W., Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharm. Assoc. Am. Pharm. Assoc. (1957) 46 208-209.
21. Koster R., Anderson M., De Debeer E.J. Acetic acid for analgesic screening. Fed. Proc. (1959) 18 412-418.
22. Hunskaar S., Fasmer O.B., Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods (1985) 14 69-76.
23. Mohamad A.S., Akhtar M.N., Khalivulla S.I. et al. Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. Basic Clin. Pharmacol. Toxicol. (2011) 108 400-405.
24. Sani M.H., Taher M., Susanti D. et al. Mechanisms of α-mangostin-induced antinociception in a rodent model. Biol. Res. Nurs. (2015) 17 68-77.
25. Oliveira A.M., Conserva L.M., de Souza Ferro J.N. et al. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. Int. J. Mol. Sci. (2012) 13 1598-1611.
26. Vidyalakshmi K., Kamalakannan P., Viswanathan S., Ramaswamy S. Antinociceptive effect of certain dihydroxy flavones in mice. Pharmacol. Biochem. Behav. (2010) 96 1-6.
27. Pinheiro B.G., Silva A.S., Souza G.E. et al. Chemical composition, antinociceptive and anti-inflammatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud. J. Ethnopharmacol. (2011) 138 479-486.
28. Lima D.K., Ballico L.J., Rocha Lapa F. et al. Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents. J. Ethnopharmacol. (2012) 142 274-282.
29. Oyemitan I.A., Olayera O.A., Alabi A. et al. Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice. J. Ethnopharmacol. (2015) 166 240-249.
30. McNamara C.R., Mandel-Brehm J., Bautista D.M. et al. TRPA1 mediates formalin-induced pain. Proc. Natl Acad. Sci. USA (2007) 104 13525-13530.
31. Orlandi L., Vilela F.C., Santa-Cecília F.V., Dias D.F., Alves-da-Silva G., Giusti-Paiva A. Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. J. Ethnopharmacol. (2011) 137 1469-1476.
32. Ward S.J., Takemori A.E. Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice. J. Pharmacol. Exp. Ther. (1983) 224 525-530.
33. Rogers H., Birch P.J., Harrison S.M. et al. GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br. J. Pharmacol. (1992) 106 783-789.
34. Green G.M., Dickenson A. GABA-receptor control of the amplitude and duration of the neuronal responses to formalin in the rat spinal cord. Eur. J. Pain (1997) 1 95-104.
35. Basbaum A.I., Bautista D.M., Scherrer G., Julius D. Cellular and molecular mechanisms of pain. Cell (2009) 139 267-284.
36. Souto A.L., Tavares J.F., da Silva M.S. et al. Anti-inflammatory activity of alkaloids: an update from 2000 to 2010. Molecules (2011) 16 8515-8534.
37. Vinegar R., Schreiber W., Hugo R. Biphasic development of carrageenin edema in rats. J. Pharmacol. Exp. Ther. (1969) 166 96-103.
38. Tavares A.C., Gonçalves M.J., Cruz M.T. et al. Essential oils from Distichoselinum tenuifolium: chemical composition, cytotoxicity, antifungal and anti-inflammatory properties. J. Ethnopharmacol. (2010) 130 593-598.
39. Hall J.C., Heel K.A., Papadimitriou J.M., Platell C. The pathobiology of peritonitis. Gastroenterology (1998) 114 185-196.
40. Silva R.O., Sousa F.B., Damasceno S.R. et al. Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundam. Clin. Pharmacol. (2014) 28 455-464.