Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Journal of Ethnopharmacology

Volumn 142, Issue 1, 2012, Pages 274-282

  Lima, Daniella K S ^a   Ballico, Laudir J ^a   Rocha Lapa, Fernanda ^b,c   Gonçalves, Hilda P ^a   De Souza, Lauro Mera ^b   Iacomini, Marcello ^b   Werner, Maria Fernanda De Paula ^b   Baggio, Cristiane Hatsuko ^b   Pereira, Isabela Tiemy ^b   Da Silva, Luisa Mota ^b   Facundo, Valdir A ^a   Santos, Adair Roberto Soares ^c  

^a UNIVERSIDADE FEDERAL DE RONDÔNIA   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Anti inflammation; Antinociception; Essential oil; Gastroprotection; Piper aleyreanum

Indexed keywords

ALCOHOL; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; BETA ELEMENE; BETA PINENE; CAMPHENE; CARYOPHYLLENE OXIDE; ESSENTIAL OIL; FORMALDEHYDE; GLUTATHIONE; MYRTENAL; NALOXONE; PINOCARVONE; PIPER ALEYREANUM EXTRACT; PLANT EXTRACT; SPATHULENOL; UNCLASSIFIED DRUG; VERBENONE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIULCER ACTIVITY; ARTICLE; CELL COUNT; LOCOMOTION; MALE; MASS FRAGMENTOGRAPHY; MONONUCLEAR CELL; MOTOR COORDINATION; NEUTROPHIL; NONHUMAN; PHYTOCHEMISTRY; PIPER (PLANT); PIPER ALEYREANUM; PLEURISY; RAT; STOMACH LESION; STOMACH MUCOSA; STOMACH ULCER;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-ULCER AGENTS; CARRAGEENAN; ETHANOL; FORMALDEHYDE; GLUTATHIONE; MALE; MICE; MOTOR ACTIVITY; OILS, VOLATILE; PAIN; PHYTOTHERAPY; PIPER; PLEURISY; RATS; RATS, WISTAR; STOMACH ULCER;

ANIMALIA; MUS; RATTUS; RODENTIA;

EID: 84861964350     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.05.016     Document Type: Article

References (71)

1. Amran, A.A., Zakaria, Z., Othman, F., Das, S., Al-Mekhlafi, H.M., Nordin, N.A., 2011. Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of Piper sarmentosum on experimental rabbits fed with cholesterol diet. Lipids Health Disease 10, 1-8.
2. +-ATPase activity and formation of nitric oxide. Journal of Ethnopharmacology 113, 433-440.
3. Bezerra, D.P., Castro, F.O., Alves, A.P., Pessoa, C., Moraes, M.O., Silveira, E.R., Lima, M.A., Elmiro, F.J., Costa-Lotufo, L.V., 2006. In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal Medicinal Biology Research 39, 801-807.
4. Bezerra, D.P., Pessoa, C., Moraes, M.O., Alencar, N.M., Mesquita, R.O., Lima, M.W., Alves, A.P., Pessoa, O.D., Chaves, J.H., Silveira, E.R., Costa-Lotufo, L.V., 2008. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. Journal Applied Toxicology 28, 599-607.
5. Bi, L.C., Kaunitz, J.D., 2003. Gastroduodenal mucosal defense: an integrated protective response. Current Opinion Gastroenterology 19, 526-532.
6. Bokesch, H.R., Gardella, R.S., Rabe, D.C., Bottaro, D.P., Linehan, W.M., McMahon, J.B., McKee, T.C., 2011. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. Chemical Pharmaceutical Bulletin (Tokyo) 59, 1178-1179.
7. Calixto, J.B., 2005. Twenty-five years of research on medicinal plants in Latin America: a personal view. Journal of Ethnopharmacology 100, 131-134.
8. Calixto, J.B., Otuki, M.F., Santos, A.R.S., 2003. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappa B). Planta Medica 69, 973-983.
9. Calixto, J.B., Otuki, M.F., Santos, A.R.S., 2004. Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Medica 70, 93-103.
10. Calixto, J.B., Scheidt, C., Otuki, M., Santos, A.R.S., 2001. Biological activity of plant extracts: novel analgesic drugs. Expert Opinion on Emerging Drugs 6, 261-279.
11. Chiou, W.F., Peng, C.H., Chen, C.F., Chou, C.J., 2003. Anti-inflammatory properties of piperlactam S: modulation of complement 5a-induced chemotaxis and inflammatory cytokines production in macrophages. Planta Medica 69, 9-14.
12. Cícero, Bezerra, Felipe, F., Trajano Sousa Filho, J., de Oliveira Souza, L.E., Alexandre Silveira, J., Esdras de Andrade Uchoa, D., Rocha Silveira, E., Deusdênia Loiola Pessoa, O., de Barros Viana, G.S., 2007. Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice. Phytomedicine 14, 605-612.
13. Corne, S.J., Morrisey, S.M., Woods, R.J., 1974. A method for the quantitative estimation of gastric barrier mucus. Journal of Physiology 224, 116-117.
14. da Silva, J.K., Andrade, E.H., Guimarães, E.F., Maia, J.G., 2010. Essential oil composition, antioxidant capacity and antifungal activity of Piper divaricatum. Natural Product Communications 5, 477-480.
15. da Silva, J.K., Andrade, E.H., Kato, M.J., Carreira, L.M., Guimarães, E.F., Maia, J.G., 2011. Antioxidant capacity and larvicidal and antifungal activities of essential oils and extracts from Piper krukof?i. Natural Product Communications 6, 1361-1366.
16. De Campos, R.O., Alves, R.V., Kyle, D.J., Chakravarty, S., Mavunkel, B.J., Calixto, J.B., 1996. Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist. European Journal Pharmacology 316, 277-286.
17. Facundo, V.A., Ferreira, S.A.P., Morais, S.M., 2007. Essencial oils of Piper dumosum Rudge and Piper aleyreanum C.DC (Piperaceae) from Brazilian amazonian forest. The Journal of Essecial Oil Research 19, 165-166.
18. Facundo, V.A., Morais, S.M., 2003. Constituents of Piper aleyreanum (Piperaceae). Biochemical Systematics and Ecology 13, 111-113.
19. Ganguly, S., Mula, S., Chattopadhyay, S., Chatterjee, M., 2007. An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide. Journal Pharmacy and Pharmacology 59, 711-718.
20. Guimarães, E.F., Giordano, L.C.S., 2004. Piperaceae do nordeste brasileiro I: Estado do Ceará. Rodriguésia 55, 21-46.
21. Henriques, M.G., Rae, G.A., Cordeiro, R.S., Williams, T.J., 1992. Endothelin-1 inhibits PAF-induced paw oedema and pleurisy in the mouse. British Journal Pharmacology 106, 579-582.
22. Hunskaar, S., Hole, K., 1987. The formalin test in mice: dissociation between inflamatory and non-inflammatory pain. Pain 30, 103-114.
23. Julius, D., Basbaum, A.I., 2001. Molecular mechanisms of nociception. Nature 413, 203-210.
24. Koroishi, A.M., Foss, S.R., Cortez, D.A., Ueda-Nakamura, T., Nakamura, C.V., Dias Filho, B.P., 2008. In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes. Journal Ethnopharmacology 117, 270-277.
25. Lawrence, T., Willoughby, D.A., Gilroy, D.W., 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Reviews Immunology 2, 787-795.
26. Mabberley., D.J., 1997. The Plant-Book. A Portable Dictionary of the Higther Plants, 2nd edition Cambridge University Press, Cambridge 874 p.
27. Maciel, M.A., Pinto, A.C., Arruda, A.C., Pamplona, S.G., Vanderlinde, F.A., Lapa, A.J., Echevarria, A., Grynberg, N.F., Côlus, I.M., Farias, R.A., Luna Costa, A.M., Rao, V.S., 2000. Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. Journal Ethnopharmacology 70, 41-55.
28. Magalhães, L.G., de Souza, J.M., Wakabayashi, K.A., da Laurentiz, R., Vinhólis, A.H., Rezende, K.C., Simaro, G.V., Bastos, J.K., Rodrigues, V., Esperandim, V.R., Ferreira, D.S., Crotti, A.E., Cunha, W.R., Silva, M.L., 2012. In vitro Efficacy of the Essential Oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni. Parasitological Research 110, 1747-1754.
29. Majdalawieh, A.F., Carr, R.I., 2010. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). Journal Medicinal Food 13, 371-381.
30. Malmberg, A.B., Yaksh, T.L., 1992. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. Journal of Pharmacology and Experimental Therapeutics 263, 136-146.
31. Marques, A.M., Barreto, A.L., Batista, E.M., Curvelo, J.A., Velozo, L.S., Moreira, D.L., Guimarães, E.F., Soares, R.M., Kaplan, M.A., 2010. Chemistry and biological activity of essential oils from Piper claussenianum (Piperaceae). Natural Product Communications 5, 1837-1840.
32. Marques, J.V., Kitamura, R.O., Lago, J.H., Young, M.C., Guimarães, E.F., Kato, M.J., 2007. Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. Journal Natural Products 70, 2036-2039.
33. Menegazzi, M., Di Paola, R., Mazzon, E., Genovese, T., Crisafulli, C., Dal Bosco, M., Zou, Z., Suzuki, H., Cuzzocrea, S., 2008. Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice. Pharmacology Research 58, 22-31.
34. Misni, N., Othman, H., Sulaiman, S., 2011. The effect of Piper aduncum Linn. (Family: Piperaceae) essential oil as aerosol spray against Aedes aegypti (L.) and Aedes albopictus Skuse. Tropical Biomedicine 28, 249-258.
35. Monzote, L., García, M., Montalvo, A.M., Scull, R., Miranda, M., 2010. Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum. Memórias Instituto Oswaldo Cruz 105, 168-173.
36. Morikawa, T., Matsuda, H., Yamaguchi, I., Pongpiriyadacha, Y., Yoshikawa, M., 2004. New amides and gastroprotective constituents from the fruit of Piper chaba. Planta Medica 70, 152-159.
37. Nantel, F., Denis, D., Gordon, R., Northey, A., Cirino, M., Metters, K.M., Chan, C.C., 1999. Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. British Journal Pharmacology 128, 853-859.
38. Navickiene, H.M., Alecio, A.C., Kato, M.J., Bolzani, V.D., Young, M.C., Cavalheiro, A.J., Furlan, M., 2000. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 55, 621-626.
39. Parmar, V.S., Jain, S.C., Bisht, K.S., Jain, R., Taneja, P., Jha, A., Tyagi, O.D., Prasad, A.K., Wengel, J., Olsen, C.E., Boll, P.M., 1997. Phytochemistry of the genus Piper. Phytochemistry 46, 597-673.
40. Potrich, F.B., Allemand, A., da Silva, L.M., Dos Santos, A.C., Baggio, C.H., Freitas, C.S., Mendes, D.A., Andre, E., Werner, M.F., Marques, M.C., 2010. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. Journal of Ethnopharmacology 130, 85-92.
41. Quílez, A., Berenguer, B., Gilardoni, G., Souccar, C., de Mendonça, S., Oliveira, L.F., Martín-Calero, M.J., Vidari, G., 2010. Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav. Journal of Ethnopharmacology 128, 583-589.
42. Repetto, M.G., Llesuy, S.F., 2002. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Brazilian Journal of Medical and Biological Research 35, 523-534.
43. Robert, A., Nezamis, J.E., Lancaster, C., Hauchar, A.J., 1979. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77, 433-443.
44. Rodrigues Silva, D., Baroni, S., Svidzinski, A.E., Bersani-Amado, C.A., Cortez, D.A., 2008. Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). Journal of Ethnopharmacology 116, 569-573.
45. Rodrigues, A.L., da Silva, G.L., Mateussi, A.S., Fernandes, E.S., Miguel, O.G., Yunes, R.A., Calixto, J.B., Santos, A.R.S., 2002. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extracts of Siphocampylus verticillatus. Life Sciences 70, 1347-1358.
46. Rodrigues, R.V., Lanznaster, D., Longhi-Balbinot, D.T., Gadotti, V.M., Facundo, V.A., Santos, A.R.S., 2009. Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum. Biological Pharmaceutical Bulletin 32, 1809-1812.
47. Saleh, T.S., Calixto, J.B., Medeiros, Y.S., 1996. Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy. British Journal Pharmacology 118, 811-819.
48. Saleh, T.S., Calixto, J.B., Medeiros, Y.S., 1997. Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy. European Journal of Pharmacology 331, 43-52.
49. Salleh, W.M., Ahmad, F., Yen, K.H., Sirat, H.M., 2011. Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. International Journal Molecular Sciences 12, 7720-7731.
50. Santos, A.R.S., Calixto, J.B., 1997. Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides 31, 381-389.
51. Santos, A.R.S., Miguel, O.G., Yunes, R.A., Calixto, J.B., 1999. Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action. Journal of Pharmacology and Experimental Therapeutics 289, 417-426.
52. Santos, A.R.S., Vedana, E.M., De Freitas, G.A., 1998. Antinociceptive effect of meloxicam in reurogenic and inflammatory nociceptive models in mice. Inflammation Research 47, 302-307.
53. Santos, P.R.D., Moreira, D.L., Guimarães, E.F., Kaplan, M.A.C., 2001. Essential oil analysis of 10 Piperaceae species from the Brazilian Atlantic forest. Phyto-chemistry 58, 547-551.
54. Saragusti, A.C., Bustos, P.S., Pierosan, L., Cabrera, J.L., Chiabrando, G.A., Santos, A.R.S., Ortega, M.G., 2012. Involvement of the L-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth. Journal of Ethnopharmacology 140, 117-122.
55. Sarris, J., Panossian, A., Schweitzer, I., Stough, C., Scholey, A., 2011. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. European Neuropsychopharmacology 21, 841-860.
56. Sedlak, J., Lindsay, R.H., 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical Biochemistry 25, 192-205.
57. Sherwood, E.R., Toliver-Kinsky, T., 2004. Mechanisms of the inflammatory response. Best Practice & Research Clinical Anaesthesiology 18, 385-405.
58. Siegmund, S., 2003. Animal models in gastrointestinal alcohol research-a short appraisal of the different models and their results. Best Practice & Research Clinical Gastroenterology 17, 519-542.
59. Singh, N., Kumar, S., Singh, P., Raj, H.G., Prasad, A.K., Parmar, V.S., Ghosh, B., 2008. Piper longum Linn. Extract inhibits TNF-alpha-induced expression of cell adhesion molecules by inhibiting NF-kappaB activation and microsomal lipid peroxidation. Phytomedicine 15, 284-291.
60. Sireeratawong, S., Vannasiri, S., Sritiwong, S., Itharat, A., Jaijoy, K., 2010. Anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from root of Piper sarmentosum Roxb. Journal Medical Association Thailand 93, S1-S6.
61. Steinmeyer, J., 2005. Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs. Arthritis Research 2, 379-385.
62. Shu, Y.Z., 1998. Recent natural products based drug development: a pharmaceutical industry perspective. Journal of Natural Products 61, 1053-1071.
63. Sunila, E.S., Kuttan, G., 2004. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of Ethnopharmacology 90, 339-346.
64. Tjolsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H., Hole, K., 1992. The formalin test: an evaluation of the method. Pain 51, 5-17.
65. Tomlinson, A., Appleton, I., Moore, A.R., Gilroy, D.W., Willis, D., Mitchell, J.A., Willoughby, D.A., 1994. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. British Journal Pharmacology 113, 693-698.
66. Van den Dool, H., Kratz, P.D., 1963. A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography. Journal Chromatography A 11, 463-471.
67. Wallace, J.L., 2008. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiological Reviews 88, 1547-1565.
68. Wallace, J.L., McKnight, W., Reuter, B.K., Vergnolle, N., 2000. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119, 706-714.
69. Xie, H., Yan, M.C., Jin, D., Liu, J.J., Yu, M., Dong, D., Cai, C.C., Pan, S.L., 2011. Studies on antidepressant and antinociceptive effects of ethyl acetate extract from Piper laetispicum and structure-activity relationship of its amide alkaloids. Fitoterapia 82, 1086-1092.
70. Yao, C.Y., Wang, J., Dong, D., Qian, F.G., Xie, J., Pan, S.L., 2009. Laetispicine, an amide alkaloid from Piper laetispicum, presents antidepressant and antinociceptive effects in mice. Phytomedicine 16, 823-829.
71. Zakaria, Z.A., Patahuddin, H., Mohamad, A.S., Israf, D.A., Sulaiman, M.R., 2010. In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. Journal Ethnopharmacology 128, 42-48.